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东京国立博物馆文化使命的发展

博物馆管理 2024年第4期 18-23页

作者： [日]藤原诚 [日]杨锐(译) 金燕(译) 日本东京国立博物馆东京中国国家博物馆北京100006

东京国立博物馆始建于1872年,是日本历史最悠久的国立博物馆。作为这座博物馆的第29任馆长,我与职员们共同提出了两大目标,并逐步实施。本文将介绍这两大目标,以及为履行博物馆的文化使命,我们是如何结合近年的发展情况实施各项举措的... 详细信息

东京国立博物馆始建于1872年,是日本历史最悠久的国立博物馆。作为这座博物馆的第29任馆长,我与职员们共同提出了两大目标,并逐步实施。本文将介绍这两大目标,以及为履行博物馆的文化使命,我们是如何结合近年的发展情况实施各项举措的。第一个目标是“建立具有全球影响力的博物馆”。在152年的历史中,东京国立博物馆展出了来自世界各地的文化遗产。

关键词：文化使命国立博物馆全球影响力逐步实施文化遗产馆长历史

Initial 3-month dynamics of dehydroepiandrosterone sulfate can predict responsiveness to primary androgen deprivation therapy in patients with metastatic prostate cancer

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Asian Journal of Andrology 2019年第6期21卷 635-636页

作者： Akihiro Yano makoto Kagawa Hideki Takeshita Yohei Okada makoto Morozumi Satoru Kawakami Department of Urology Saitama Medical CenterSaitama Medical UniversityKawagoeSaitama 350-8550Japan.

Dear Editor,Intensive treatments such as primary androgen deprivation therapy(pADT)plus docetaxel or abiraterone acetate are reportedly beneficial in metastatic prostate cancer(mPCa)patients with high-volume disease or high-risk features,respectively.1,2 High-volume or high-risk features are determined exclusively via pretreatment *** patient responsiveness to pADT,which is one of the major determinants of survival in these patients,would be advantageous with regard to making primary treatment *** an initial 3-month period is possible,short-term serum parameter dynamics can be used to predict pADT ***-specific antigen(PSA)and alkaline phosphatase(ALP)dynamics have been indicated as potential predictors.3,4 Although pADT can reportedly cause a 20%-30%decrease in adrenal androgen levels,5 it is not known whether the dynamics of adrenal androgens shortly after the initiation of pADT can predict pADT *** aim of the current study was to identify predictors of pADT responsiveness among pretreatment parameters and 3-month dynamics(D3m)of serum parameters including the adrenal androgen,dehydroepiandrosterone sulfate(DHEAS).

关键词： patients metastatic cancer

Change in microstructural characteristics of laser powder bed fused Al–Fe binary alloy at elevated temperature

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Journal of Materials Science & Technology 2022年第2期97卷 38-53页

作者： Xing Qi Naoki Takata Asuka Suzuki makoto Kobashi Masaki Kato Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan Aichi Center for Industry and Science Technology 1267-1 AkiaiYakusa-choToyota 470-0356Japan

The present study addressed the change in the microstructure of Al-2.5 wt%Fe binary alloy produced using laser powder bed fusion(L-PBF)technique by thermal exposure at 300℃,and the associated mechanical and thermal properties were systematically examined as ***-semi-cylindrical patterns corresponding to melt pools in the microstructure were macroscopically observed for the asmanufactured *** change in the melt-pool morphology was observed after thermal exposure for1000 *** the melt pools,a large number of the nanoscale metastable Al6 Fe phase particles were uniformly distributed inside columnar grains of theα-Al matrix containing concentrated solute Fe in *** sequential formation and coarsening of stableθ-Al13 Fe4 phases were observed upon exposure to a 300℃ environment,but a considerable amount of nano-sized metastable Al6 Fe phases remained even after 1000 ***,the thermal exposure continuously reduced the concentration of solute Fe atoms in theα-Al *** significant grain growth was found inα-Al matrix after 1000 h owing to the pinning effect of the dispersed fine particles on grain boundary *** results demonstrate a sluggish change in microstructural morphologies of the Al-2.5 wt%Fe *** quantified microstructural parameters addressed dominant strengthening contributions by the solid solution of Fe element and Orowan strengthening mechanism by fine Al-Fe intermetallics in the L-PBF-produced *** high strength level was sustained even after being exposed to 300℃ for long *** superior balance of mechanical properties and thermal conductivity can be achieved in the experimental alloys by taking advantage of the various microstructural parameters related to the Al-Fe intermetallic phases andα-Al matrix.

关键词： Al-Fe alloy Laser powder bed fusion Phase transformation Microstructure Tensile properties

Influence of automated driving on driver’s own localization:a driving simulator study

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Journal of Intelligent and Connected Vehicles 2018年第3期1卷 99-106页

作者： Ryuichi Umeno makoto Itoh Satoshi Kitazaki University of Tsukuba IbarakiJapan National Institute of Advanced Industrial Science and Technology Tsukuba CenterTsukuba CentralIbarakiJapan

Purpose–Level 3 automated driving,which has been defined by the Society of Automotive Engineers,may cause driver drowsiness or lack of situation awareness,which can make it difficult for the driver to recognize where he/she ***,the purpose of this study was to conduct an experimental study with a driving simulator to investigate whether automated driving affects the driver’s own localization compared to manual ***/methodology/approach–Seventeen drivers were divided into the automated operation group and manual operation *** in each group were instructed to travel along the expressway and proceed to the specified *** automated operation group was forced to select a course after receiving a Request to Intervene(RtI)from an automated driving ***–A driver who used the automated operation system tended to not take over the driving operation correctly when a lane change is immediately required after the ***/value–This is a fundamental research that examined how the automated driving operation affects the driver's own *** experimental results suggest that it is not enough to simply issue an RtI,and it is necessary to tell the driver what kind of circumstances he/she is in and what they should do next through the *** conclusion can be taken into consideration for engineers who design automatic driving vehicles.

关键词： Automated vehicles Autonomous driving Advanced driver assistant systems Driver behaviors and assistance Human-machine interfaces Request to intervene

Gray zone lymphoma effectively treated with cyclophosphamide,doxorubicin,vincristine,prednisolone,and rituximab chemotherapy:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5708-5716页

作者： Nobumasa Hojo makoto Nagasaki Yasuha Mihara Department of General Medicine National Hospital Organization Hamada Medical CenterHamada City 697-8511ShimaneJapan Department of Pathology National Hospital Organization Hamada Medical CenterHamada City 697-8511ShimaneJapan Clinical Resident National Hospital Organization Hamada Medical CenterHamada City 697-8511ShimaneJapan

BACKGROUND B-cell lymphoma,unclassifiable,with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma(BCLu-DLBCL/cHL),also referred to as gray zone lymphoma(GZL),is known to share features with cHL and ***,GZL is often difficult to *** is no consensus regarding the optimal therapeutic *** reported cases of GZL have been in Caucasian and Hispanic individuals,and its incidence is lower in African-American and Asian populations,including the Japanese *** SUMMARY A 69-year-old female presented at our hospital with a growing mass on the right side of her *** elastic,soft mass measuring 9 cm×6 cm was palpable in the right cervical *** analyses showed pancytopenia,increased serum lactate dehydrogenase levels,and markedly increased levels of soluble interleukin-2 *** computed tomography(CT)and fluorodeoxyglucose positron emission tomography(PET)/CT revealed multiple lesions throughout her *** was diagnosed with GZL based on the characteristic pathological findings,the immunophenotype[CD20+,PAX5+,OCT2+/BOB1(focal+),CD30+,CD15-],and the strong positive expression of neoplastic programmed cell death protein ligand 1(PD-L1)in her lymphoma *** lymphoma was stage IV according to the Lugano classification and high-risk according to the International Prognostic Index for aggressive non-Hodgkin *** patient received cyclophosphamide,doxorubicin,vincristine,prednisolone,and rituximab(R-CHOP)chemotherapy because the tumor cells were CD20+.She has remained in complete remission for 3 *** GZL was diagnosed based on histopathology and immunophenotyping with ancillary PD-L1 positivity.R-CHOP chemotherapy was an effective treatment.

关键词： Classical Hodgkin lymphoma Diffuse large B-cell lymphoma Gray zone lymphoma Programmed cell death protein ligand 1 R-CHOP Case report

Evaluation of the Effectiveness of Awareness Messages for Road Traffic Hazards in Experimental Tests

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Automotive Innovation 2018年第1期1卷 76-84页

作者： Ai Takeda makoto Kondo Tetsushi Mimuro Graduate School of Systems Science and Technology Akita Prefectural University84-4 EbinokuchiYurihonjoAkita 015-0055Japan Akita Prefectural University 84-4 EbinokuchiYurihonjoAkita 015-0055Japan

Advanced driver assistance systems, especially autonomous emergency braking and forward collision warnings, have becomepopular in Japan. To reduce the number of road traffic accidents, safety information should be provided to a driver earlier thanavoidance or warning messages so as to avoid a risky situation. A series of actual running tests was conducted to evaluate theactivation timing and effectiveness of awareness messages. Objective analysis showed that the drivers could avoid an obstaclewith a sufficient safety margin thanks to any of the awareness messages. Subjective ratings showed that the best timing is 10 sbefore encountering the obstacle. The results of objective analysis are limited in the present paper, and further analyses arerequired.

关键词： Active safety Advanced driver assistance systems Awareness message Onboard information system Traffic hazard

Chronic heat stress induces renal fibrosis and mitochondrial dysfunction in laying hens

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畜牧与生物技术杂志:英文版 2023年第5期14卷 2002-2011页

作者： Fumika Nanto‑Hara makoto Yamazaki Hitoshi Murakami Haruhiko Ohtsu Division of Meat Animal and Poultry Research Institute of Livestock and Grassland ScienceNational Agriculture and Food Research Organization(NILGS)2 IkenodaiTsukubaIbaraki 305‑0901Japan

Background Heat stress in laying hens negatively affects egg production and shell quality by disrupting the homeo-stasis of plasma calcium and phosphorus *** the kidney plays an important role in calcium and phos-phorus homeostasis,evidence regarding the effect of heat stress on renal injury in laying hens is yet to be ***,the aim of this study was to evaluate the effects of chronic heat stress on renal damage in hens during laying *** A total of 16 white-leghorn laying hens(32 weeks old)were randomly assigned to two groups(n=8).One group was exposed to chronic heat stress(33°C for 4 weeks),whereas the other group was maintained at 24°*** Chronic heat exposure significantly increased plasma creatinine and decreased plasma albumin levels(P<0.05).Heat exposure also increased renal fibrosis and the transcription levels of fibrosis-related genes(COLA1A1,αSMA,and TGF-β)in the *** results suggest that renal failure and fibrosis were induced by chronic heat exposure in laying *** addition,chronic heat exposure decreased ATP levels and mitochondrial DNA copy number(mtDNA-CN)in renal tissue,suggesting that renal mitochondrial dysfunction occurs under conditions of heat *** mitochondria leak mtDNAs into the cytosol and mtDNA leakage may activate the cyclic GMP-AMP synthase(cGAS)stimulator of interferon genes(STING)signaling *** results showed that chronic heat exposure activated the cGAS-STING pathway as indicated by increased expression of MDA5,STING,IRF7,MAVS,and NF-κB ***,the expression of pro-inflammatory cytokines(IL-12)and chemokines(CCL4 and CCL20)was upregulated in heat-stressed *** These results suggest that chronic heat exposure induces renal fibrosis and mitochondrial damage in laying *** damage by heat stress may activate the mtDNA-cGAS-STING signaling and cause subse-quent inflammation,which contributes to the progression of renal fibrosis and

关键词： cGAS-STING Heat stress Laying hens Mitochondrial DNA Renal fibrosis

Evaluation of seismic behavior of box culvert buried in the ground through centrifuge model tests and numerical analysis

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Underground Space 2019年第2期4卷 147-167页

作者： Hitoshi Yatsumoto Yasuo Mitsuyoshi Yasuo Sawamura makoto Kimura Maintenance Division Hanshin Expressway Company LimitedJapan Obayashi Corporation Construction DivisionJapan Department of Civil and Earth Resources Engineering Kyoto UniversityJapan

Japan has yet to establish a seismic design for road box culverts(RBCs)because past major earthquakes did not damage *** recent years,structures with enlarged sectional dimensions(the purpose of which is to optimize the internal space in RBCs)have become ***,the unknown seismic strength of such large RBCs makes RBC seismic designs increasingly *** seismic design methods have been developed for and applied to rectangular underground structures,e.g.,cut-and-cover tunnels,which are structurally similar to *** these methods are applicable to RBCs,it is uncertain whether they can be applied directly because there are currently no evaluation results from model tests on RBCs,which have unique structural features,e.g.,no haunch at the bottom of the ***,we verify a seismic behavior of an RBC and develop a method for evaluating it in order to establish a seismic design for *** conducted centrifuge model tests subjected to seismic force and a numerical analysis using an elastoplastic finite analysis method,in addition,we validated this analysis by comparing the test and analytical *** test results show RBCs will most likely develop rocking rotation when the ground strain exceeds approximately 0.08%.A comparison of the numerical and experimental results shows that this analysis can estimate the shear deformation behavior with approximately 90%accuracy in square cross-section ***,this analysis has tendency to underestimate the axial forces in each case and to overestimate the bending moments of some members in the case of wide cross-sections.

关键词： Box culvert Centrifuge model test Numerical analysis Shear deformation Rocking rotation

Re-evaluation of physical interaction between plant peroxisomes and other organelles using live-cell imaging techniques

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Journal of Integrative Plant Biology 2019年第7期61卷 836-852页

作者： Kazusato Oikawa makoto Hayashi Yasuko Hayashi Mikio Nishimura Biomacromolecules Research Team RIKEN Center for Sustainable Resource Science2-1 HirosawaWakoSaitama 351-0198Japan Department of Bioscience Nagahama Institute of Bio-Scie nee and Technology1266 Tamura-ChoNagahama 526-0829Japan Department of Biology Faculty of scienceNiigata UniversityNiigata 950-2181Japan Department of Cell Biology National Institute for Basic BiologyOkazaki 444-8585Japan

The dynamic behavior of organelles is essential for plant survival under various environmental conditions. Plant organelles, with various functions,migrate along actin filaments and contact other types of organelles, leading to physical interactions at a specific site called the membrane contact site. Recent studies have revealed the importance of physical interactions in maintaining efficient metabolite flow between *** this review, we first summarize peroxisome function under different environmental conditions and growth stages to understand organelle interactions. We then discuss current knowledge regarding the interactions between peroxisome and other organelles, i.e., the oil bodies, chloroplast, and mitochondria from the perspective of metabolic and physiological regulation, with reference to various organelle interactions and techniques for estimating organelle interactions occurring in plant cells.

关键词： physical interaction plant peroxisomes live-cell