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稀有金属材料与工程 2006年第A3期35卷 455-458页

作者： Takeo Hyodo Kumiko Murayama Yasuhiro Shimizu makoto egashira Department of Materials Science and Engineering Faculty of EngineeringNagasaki University1-14 Bunkyo-machiNagasaki 852-8521Japan

Preparation of large mesoporous tin dioxide (lm-SnO_2) under various conditions was attempted by utilizing a self-assembly of a triblock copolymer,P123:(EO)_(20)(PO)_(70)(EO)_(20) or F127:(EO)_(106)(PO)_(70)(EO)_(106)(EO:ethylene oxide and PO: propylene oxide).The sensor fabricated from calcined lm-SnO_2 powder,which had been prepared by using P123 as a template,Na_2SnO_3 as a tin source,and TEOS as an additive ([TEOS]/[Na_2SnO_3]=0.5 in the precursor solution),showed the largest response to 1×10^(-3) hydrogen at 350℃among the sensors *** existence of two kinds of SnO_2 particles with different sizes (ca.100 nm and several nm in diameter) may be important to improve the hydrogen sensing properties drastically.

关键词： mesoporous tin dioxide triblock copolymer triethoxyorthosilicate hydrogen gas sensor

Liquid–liquid equilibrium extraction of ethanol with mixed solvent for bioethanol concentration

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Chinese Journal of Chemical Engineering 2016年第2期24卷 253-258页

作者： Hiroaki Habaki Haihao Hu Ryuichi egashira Department of International Development Engineering Graduate School of Science and EngineeringTokyo Institute of Technology

The extraction of ethanol with the solvents of aldehydes mixed with m-xylene was studied for the bioethanol concentration *** and benzaldehyde were selected as extraction solvents,with which the solubility of water is small,expecting large distribution coefficient of *** liquid–liquid two-phase region was the largest with m-xylene solvent,followed by benzaldehyde and *** region of two liquid–liquid phase became larger with the mixed solvent of m-xylene and furfural than that with furfural *** NRTL model was applied to the ethanol–water–furfural–m-xylene system,and the model could well express the liquid–liquid equilibrium of the *** any solvent used in this study,the separation selectivity of ethanol relative to water decreased as the distribution coefficient of ethanol *** separation selectivity with m-xylene was the largest among the employed solvents,but the distribution coefficient was the *** solvent mixture of furfural and m-xylene showed relatively high distribution coefficient of ethanol and separation selectivity,even in the higher mass fraction of m-xylene in the solvent *** ethanol extraction with a countercurrent multistage extractor by a continuous operation was simulated to evaluate the extraction *** ethanol content could be concentrated in the extract phase with relatively small number of extraction stages but low yield of ethanol was obtained.

关键词： Bioethanol Solvent extraction NRTL model

Efficacy of combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients: A randomized study

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World Journal of Gastroenterology 2017年第45期23卷 8062-8072页

作者： Haruki Uojima Hisashi Hidaka Tsuyoshi Nakayama Ji Hyun Sung Chikamasa Ichita Shinnosuke Tokoro Sakue Masuda Akiko Sasaki Kazuya Koizumi Hideto egashira makoto Kako Department of Gastroenterology Shonan Kamakura General Hospital Department of Gastroenterology Internal MedicineKitasato University School of Medicine Department of Gastroenterology Shonan Atsugi Hospital

AIM To assess the effects of a combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites *** A two-center,randomized,open-label,prospective study was conducted. Japanese patients who met the criteria were randomized to trial group and the combination diuretic group(received 7.5 mg of tolvaptan) or the conventional diuretic group(received 40 mg of furosemide) for 7 d in addition to the natriuretic drug which was used prior to enrolment in this study. The primary endpoint was the change in body weight from the baseline. Vital signs,fluid intake,and laboratory and urinary data were assessed to determine the pharmacological effects after administration of aquaretic and natriuretic *** A total of 56 patients were randomized to receive either tolvaptan(n = 28) or furosemide(n = 28). In the combination and conventional diuretic groups,the average decrease in body weight from the baseline was 3.21 ± 3.17 kg(P < 0.0001) and 1.75 ± 2.36 kg(P = 0.0006),respectively,when measured on the final dosing day. Following 1 wk of treatment,a significantly greater reduction in body weight was observed in the combination diuretic group compared to that in the conventional diuretic group(P = 0.0412).CONCLUSION Compared to a conventional diuretic therapy with only a natriuretic drug,a combination diuretic therapy with natriuretic and aquaretic drugs is more effective for patients with cirrhotic ascites.

关键词： Tolvaptan Liver cirrhosis Diuretic effect Ascites Hepatic edema

Multi-Physics CFD Simulations in Engineering

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Journal of Thermal Science 2013年第4期22卷 287-293页

作者： makoto Yamamoto Tokyo University of Science Department of Mechanical Engineering 6-3-1 NiijukuKatsushika-ku Tokyo 125-8585 Japan

Nowadays Computational Fluid Dynamics （CFD） software is adopted as a design and analysis tool in a great number of engineering fields. We can say that single-physics CFD has been suffciently matured in the practical point of view. The main target of existing CFD software is single-phase flows such as water and air. However, many multi-physics problems exist in engineering. Most of them consist of flow and other physics, and the interactions between different physics are very important. Obviously, multi-physics phenomena are critical in devel- oping machines and processes. A multi-physics phenomenon seems to be very complex, and it is so difficult to be predicted by adding other physics to flow phenomenon. Therefore, multi-physics CFD techniques are still under research and development. This would be caused from the facts that processing speed of current computers is not fast enough for conducting a multi-physics simulation, and furthermore physical models except for flow physics have not been suitably established. Therefore, in near future, we have to develop various physical models and ef- ficient CFD techniques, in order to success multi-physics simulations in engineering. In the present paper, I will describe the present states of multi-physics CFD simulations, and then show some numerical results such as ice accretion and electro-chemical machining process of a three-dimensional compressor blade which were obtained in my laboratory. Multi-physics CFD simulations would be a key technology in near future.

关键词： Computational fluid dynamics Multi-physics Engineering problems

Artificial Sweat for Humanoid Finger

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Journal of Bionic Engineering 2014年第1期11卷 98-108页

作者： makoto Tomimoto NSSL Ltd. 87-2 Ohkuri Nishigamo Kita Kyoto 603-8828 Japan

To achieve favorable Frictional Tactile Sensation （FTS） for robot and humanoid fingers, this report investigated the effects of human finger sweat on Friction Coefficient （FC） and verified the effectiveness of artificial sweat on FTS tbr a humanoid finger. The results show that the model sweat （salt and urea water faked real sweat） increases the FC of the real finger sliding on the high hygroscopic and rough surface （paper）, whereas on the low hygroscopic and smooth surface （PMMA）, the sweat forms a fluid film and decreases FC, restricting severe finger adhesion. Further, the film formation and capillary adhesion force of sweat were discussed. The experimental results with the artificial sweats （ethanol and water） and humanoid finger （silicone rubber skin with tactile sensors） verifies the effectiveness. The artificial sweat restricts severe adhesion （stick-slip vibration）, and enhances cognitive capability of FTS.

关键词： humanoid finger artificial sweat tactile sensation adhesion friction coefficient,

Condyloma acuminatum of the anal canal,treated with endoscopic submucosal dissection

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World Journal of Gastroenterology 2016年第8期22卷 2636-2641页

作者： Akiko Sasaki Takeshi Nakajima Hideto egashira Kotaro Takeda Shinnosuke Tokoro Chikamasa Ichita Sakue Masuda Haruki Uojima Kazuya Koizumi Takeshi Kinbara Taku Sakamoto Yutaka Saito makoto Kako Gastroenterology Medicine Center Shonan Kamakura General Hospital 1370-1 Okamoto Kamakura Endoscopy Division National Cancer Center Hospital5-1-1 Tsukiji Chuoku Diagnostic Pathology Shonan Kamakura General Hospital 1370-1 Okamoto Kamakura

Condyloma acuminatum(CA) is a common sexually transmitted disease caused by human papilloma virus infection. Not all individuals develop persistent, progressive disease, but careful follow up is required with moderate-to-severe dysplasia to prevent progression to malignancy. Standard therapies include surgical treatments(trans-anal resection and transanal endoscopic microsurgery) and immunotherapeutic and topical methods(topical imiquimod); however, local recurrence remains a considerable problem. Here, we report a case with superficial CA of the anal canal, treated with endoscopic submucosal dissection(ESD). A 28-year-old man presented with a chief complaint of hematochezia. Digital exam did not detect a tumor. Screening colonoscopy revealed 10-mm long, whitish condyles extending from the anal canal to the lower rectum. The lesion covered almost the whole circumference, and only a small amount of normal mucosa remained. Magnifying endoscopy with narrow band imaging showed brownish hairpin-shaped, coiled capillaries. Although histopathological diagnosis by biopsy revealed CA, accurate histological differentiation between CA, papilloma, and squamous cell carcinoma can be difficult with a small specimen. Therefore, weperformed diagnostic ESD, which provides a complete specimen for precise histopathological evaluation. The pathological diagnosis was CA, with moderate dysplasia(anal intraepithelial neoplasia 2). There was no recurrence at 16 mo after the initial ESD. Compared to surgical treatment, endoscopic diagnosis and resection could be performed simultaneously and the tumor margin observed clearly with a magnifying chromocolonoscopy, resulting in less recurrence. These findings suggest that endoscopic resection may be an alternative method for CA that prevents recurrence.

关键词： Condylomata acuminate Recurrence Endoscopy Dissection Carcinoma in situ

Innovative nanocrystal-based technologies for ceramic devices with novel electronic functions

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Journal of Advanced Ceramics 2012年第2期1卷 79-88页

作者： makoto KUWABARA 4-36-501 Shimoshirouzu-kita KasugaFukuoka 816-0854Japan

There has been a great progress in the synthesis of a variety of inorganic colloidal nanocrystals(NCs)with highly controlled size and shape in the last *** achievement has promoted comprehensive researches on the fabrication and engineering of NC devices with novel structure and function with the aim of utilizing them in a wide area of applications,including electronics and optoelectronics,by using various NC assembling and patterning ***,colloidal NCs having been extensively investigated so far are mostly metals,semiconductors and magnetic materials,and only limited investigations on oxide NCs from a point of view of NC ceramic engineering have been ***,innovative nanocrystal-based technologies necessary for the fabrication of NC ceramic devices with novel and gigantic electronic functions,limiting the materials to perovskite oxides,and a new perspective on the future ceramic technology are discussed.

关键词： nanocrystals electronic functions Perovskite bottom-up process

Modulation of Pain and Itch by Spinal Glia

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Neuroscience Bulletin 2018年第1期34卷 178-185页

作者： makoto Tsuda Department of Life Innovation Graduate School of Pharmaceutical Sciences Kyushu University Department of Molecular and System Pharmacology Graduate School of Pharmaceutical Sciences Kyushu University

Chronic pain and itch are a pathological operation of the somatosensory system at the levels of primary sensory neurons, spinal cord and brain. Pain and itch are clearly distinct sensations, and recent studies have revealed the separate neuronal pathways that are involved in each sensation. However, the mechanisms by which these sensations turn into a pathological chronic state are poorly understood. A proposed mechanism underlying chronic pain and itch involves abnormal excitability in dorsal horn neurons in the spinal cord. Furthermore, an increasing body of evidence from models of chronic pain and itch has indicated that synaptic hyperexcitability in the spinal dorsal horn might not be a consequence simply of changes in neurons, but rather of multiple alterations in glial cells. Thus, understanding the key roles of glial cells may provide us with exciting insights into the mechanisms of chronicity of pain and itch, and lead to new targets for treating chronic pain and itch.

关键词： Neuropathic pain Chronic itch Microglia Astrocytes Spinal dorsal horn

New Steel Making Process through Reduction and Sintering of Cementite Powder

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材料热处理学报 2004年第5期25卷 76-79页

作者： N. OUCfflDA M. egashira K. NAKASHIMA T. TSUCHIYAMA S. TAKAKI Department of Materials Science and Engineering Kyushu UniversityDepartment of Materials Science and Engineering Kyushu University Sumitomo Metal Industries Ltd.Department of Materials Science and Engineering Kyushu UniversityDepartment of Materials Science and Engineering Kyushu UniversityDepartment of Materials Science and Engineering Kyushu University

A new steel making process through reduction and sintering treatment of cementite powder was proposed, and microstructure of the material obtained by this process was examined by scanning electron microscopy and EBSP analysis. The cementite powder obtained by mechanical alloying was compacted under high pressure up to lOOOMPa, and then reduced during sintering in a hydrogen (H2) gas atmosphere at elevated temperatures. The cementite compacts were completely reduced by the sintering at 1073K to 1273K for 18ks. The relative density of sintered material became 95% or more when the temperature was elevated above 1173K. The SEM observation and EBSP analysis indicated that the obtained steel has equiaxed ferrite-pearlite structure with grain size of around Sum and the crystallographic orientations of ferrite grains are randomly distributed.

关键词：碳化铁粉末冶金破碎比烧结

Perspective for Future Medicine:Multidisciplinary Computational Anatomy-Based Medicine with Artificial Intelligence

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Cyborg and Bionic Systems 2021年第1期2021卷 64-66页

作者： makoto Hashizume Kyushu University and Kitakyushu Koga Hospital Japan

Multidisciplinary computational anatomy(MCA)is a new frontier of science that provides a mathematical analysis basis for the comprehensive and useful understanding of“dynamic living human anatomy.”It defines a new mathematical modeling method for the early detection and highly intelligent diagnosis and treatment of incurable or intractable *** MCA is a method of scientific research on innovative areas based on the medical images that are integrated with the information related to:(1)the spatial axis,extending from a cell size to an organ size;(2)the time series axis,extending from an embryo to post mortem body;(3)the functional axis on physiology or metabolism which is reflected in a variety of medical image modalities;and(4)the pathological axis,extending from a healthy physical condition to a diseased *** aims to integrate multiple prediction models such as multiscale prediction model,temporal prediction model,anatomy function prediction model,and anatomypathology prediction *** intelligence has been introduced to accelerate the calculation of statistic mathematical *** future perspective is expected to promote the development of human resources as well as a new MCA-based scientific interdisciplinary field composed of mathematical statistics,information sciences,computing data science,robotics,and biomedical engineering and clinical *** MCA-based medicine might be one of the solutions to overcome the difficulties in the current medicine.

关键词： anatomy prediction overcome