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高分子通报 2014年第12期 5-8页

作者： makoto shimizu Department of Chemistry for Materials Graduate School of EngineeringMie University

About 15years have passed since I first attended the International Conference on Fine Chemistry and Functional Polymers(FCFP).One day,I was asked by *** of Kanazawa University to attend the conference,and after a while *** sent me a kind invitation *** is the beginning of my first trip to *** of Osaka University was also very active

关键词： invitation asked letter passed attended beginning imino esters accomplishment unsaturated

Unexpected and Intriguing Reactivity of Imino Compounds

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复旦学报（自然科学版） 2005年第5期44卷 619-620页

作者： makoto shimizu Department of Chemistry for Materials Mie University Tsu Mie 514-8507 Japan

We have recently discovered a tandem N-alkylation-C-allylation reaction of α-imino esters with organoaluminum reagents and allyltributyltin[1]. In this reaction, iminium salts were readily prepared in situ by the oxidation of aluminum enolates, and the subsequent nucleophilic addition proceeded smoothly to afford N-alkylation-C-allylation products in good yields. During these studies, we focused on the generation of iminium species 2 by oxidizing a readily accessible and stable enol derivative with oxidants. A convenient method has been found for the generation of α-alkoxycarbonyl iminium salts 2 from ketene silyl acetals and the subsequent reaction with nucleophiles[2].

关键词：亚氨基化合物亚氨基脂烷氧羰基氧化铝

Titanium Iodies Mediated Intriguing Transformation of Organic Molecules

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复旦学报（自然科学版） 2007年第5期46卷 560-页

作者： makoto shimizu Department of Chemistry for Materials Graduate School of EngineeringMie UniversityTsuMie 514-8507Japan

1 Results Titanium iodides have been found to be good reagents for iodination,reductive formation of enolates,pinacol coupling,and so *** new reactions will be discussed:(1) Iodination: Titanium(Ⅳ) iodide is a good iodination reagent for olefins and *** olefins are iodotitanated with titanium (Ⅳ) iodide to give,after quenching with water,iodoalkanes in moderate to good *** gives α-iodostyrene,whereas 2,2-diiodoalkanes are major products from 1-alkynes when they...

关键词： titanium tetraiodide iodination lewis acid reduction

Double Nucleophilic Addition of Ketene Silyl (THIO)Acetals and Trimethylsilyl Cyanide to N-Allylideneamine

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复旦学报（自然科学版） 2007年第5期46卷 586-页

作者： Isao Mizoia Iwao Hachiya makoto shimizu Department of Chemistry for Materials Mie University

1 Results We have already published a double nucleophilic addition reaction of α,β-unsaturated imines with several nucleophiles such as ketene silyl acetals, trimethylsilyl cyanides, trimethylsilyl azides and thiols[1]. However, it was not easy to use N-allylideneamine 2 derived from acrolein for such reactions. Since there is no substituent at the β-position, imine 2 has high reactivity and are prone to be polymerization. We report the first synthesis of N-allylideneamines 2 using the isomerization of ...

关键词： double nucleophilic addition reaction regioselectivity N-allylideneamine silica gel ketene silyl acetal

Ventricular Fibrillation Caused by Traumatic Coronary Artery Dissection

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Case Reports in Clinical Medicine 2015年第4期4卷 119-123页

作者： Jun-ya Ishikawa Naoto Morimura Eri Nagai Kyota Nakamura makoto shimizu Keiji Uchida Department of Emergency Medicine Yokohama Municipal Citizen’s Hospital Yokohama Japan Advanced Critical Care and Emergency Medical Center Yokohama City University Medical Center Yokohama Japan Department of Anesthesiology Kanagawa Cancer Center Yokohama Japan Department of Cardiology International Goodwill Hospital Yokohama Japan Cardiovascular Center Yokohama City University Medical Center Yokohama Japan

Coronary artery dissection due to blunt chest trauma (traumatic coronary artery dissection [TCAD]) may heal spontaneously, and some surgeons believe that conservative or elective treat-ments are sufficient, provided that there are no progressing ischemic symptoms. However, we report a patient who experienced sudden ventricular fibrillation (VF) during initial medical care for trauma injuries. The 32-year-old woman was riding in a passenger car when an accident occurred, and was subsequently transported to our emergency department. Twelve-lead electrocardiography revealed ST segment elevation in leads II, III, and aVF, although her vital signs remained stable. Therefore, we prioritized assessing the trauma at other sites, and VF suddenly occurred. Coronary angiography was performed with repeated defibrillation and chest compressions, which resulted in recovery of spontaneous circulation. Occlusion was observed in the right coronary artery, which we treated with balloon angioplasty. However, intravascular ultrasonography (IVUS) subsequently revealed coronary artery dissection, a stent was placed, and the patient successfully recovered. Therefore, IVUS may be useful for diagnosing TCAD, and swift intervention is needed if TCAD is detected.

关键词： Coronary Artery Dissection Blunt Chest Trauma Ventricular Fibrillation Acute Myocardial Infarction Intravascular Ultrasonography

Space–time finite element method with domain reduction techniques for dynamic soil–structure interaction problems

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International Journal of Mechanical System Dynamics 2024年第2期4卷 117-130页

作者： Vikas Sharma Shion shimizu Kazunori Fujisawa Division of Environmental Science and Technology Graduate School of AgricultureKyoto UniversityKyotoJapan

Design of earth structures,such as dams,tunnels,and embankments,against the vibrational loading caused by high-speed trains,road traffic,underground explosions,and,more importantly,earthquake motion,demands solutions of the dynamic soil–structure Interaction(SSI)*** paper presents a velocity-based space–time finite element procedure,v-ST/finite element method(FEM),to solve dynamic SSI *** main goal of this study is to present the computation details of implementing viscous boundary conditions of Lysmer–Kuhlemeyer to truncate the unbounded soil ***,additional time-dependent boundary conditions,in terms of the free-field response,are included to facilitate energy flow from the far field to the computation domain at the vertical truncated *** the FEM,seismic input motion is applied to an effective nodal force vector,which can be obtained explicitly in the numerical ***,the response of a concrete gravity dam resting on an elastic half-space to the horizontal component of earthquake motion is computed and successfully compared with the results of semidiscrete FEM using the Newmark-βmethod.

关键词： absorbing boundary domain reduction FEM soil-structure interactions space-time

Mogroside IIE,an in vivo metabolite of sweet agent,alleviates acute lung injury via Pla2g2a-EGFR inhibition

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Food Science and Human Wellness 2024年第1期13卷 299-312页

作者： Weichao Lü Guoqing Ren Kuniyoshi shimizu Renshi Li Chaofeng Zhang State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China Sino-Jan Joint Lab of Natural Health Products Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China Faculty of Agriculture Kyushu UniversityFukuoka 819-0395Japan

In the face of increasingly serious environmental pollution,the health of human lung tissues is also facing serious *** IIE(M2E)is the main metabolite of sweetening agents mogrosides from the anti-tussive Chinese herbal Siraitia *** study elucidated the anti-inflammatory action and molecular mechanism of M2E against acute lung injury(ALI).A lipopolysaccharide(LPS)-induced ALI model was established in mice and MH-S cells were employed to explore the protective mechanism of M2E through the western blotting,co-immunoprecipitation,and quantitative real time-PCR *** results indicated that M2E alleviated LPS-induced lung injury through restraining the activation of secreted phospholipase A2 type IIA(Pla2g2a)-epidermal growth factor receptor(EGFR).The interaction of Pla2g2a and EGFR was identified by *** addition,M2E protected ALI induced with LPS against inflammatory and damage which were significantly dependent upon the downregulation of AKT and m TOR via the inhibition of ***2g2a may represent a potential target for M2E in the improvement of LPS-induced lung injury,which may represent a promising strategy to treat ALI.

关键词： Mogroside IIE Acute lung injury Secreted phospholipase A2 type IIA(Pla2g2a) Epidermal growth factor receptor(EGFR)

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锂离子电池凝胶聚合物电解质研究进展

高分子学报 2011年第2期21卷 125-131页

作者：张鹏李琳琳何丹农吴宇平清水真复旦大学化学系上海市分子催化和功能材料重点实验室上海200433 纳米技术及应用国家工程研究中心上海200241 日本三重大学工学部材料化学系

使用聚合物电解质可以避免传统液态锂离子电池的漏液问题,提高电池的安全性能和能量密度,并可实现电池的薄型化、轻便化和形状可变等优点.目前,聚合物电解质的研究集中在凝胶型的复合和多孔聚合物电解质两大类.本文对各类凝胶聚合物电... 详细信息

使用聚合物电解质可以避免传统液态锂离子电池的漏液问题,提高电池的安全性能和能量密度,并可实现电池的薄型化、轻便化和形状可变等优点.目前,聚合物电解质的研究集中在凝胶型的复合和多孔聚合物电解质两大类.本文对各类凝胶聚合物电解质的特点、功能及研究情况逐一进行了介绍,对凝胶聚合物电解质的发展趋势进行了展望.

关键词：凝胶聚合物电解质锂离子电池复合凝胶聚合物电解质多孔凝胶聚合物电解质离子电导率

Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology

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Neural Regeneration Research 2025年第9期20卷 2589-2590页

作者： Mikio shimizu Tatsusada Okuno Department of Neurology Osaka University Graduate School of MedicineSuitaJapan Department of Neurology Osaka General Medical CenterOsakaJapan

Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal *** with ALS develop skeletal muscle weakness,resulting in death from respiratory paralysis,which usually occurs 2-4 years after clinical onset(Goutman et al.,2022).

关键词： paralysis sclerosis

Effectiveness of antibiotic prophylaxis for acute esophageal variceal bleeding in patients with band ligation: A large observational study

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World Journal of Gastroenterology 2024年第3期30卷 238-251页

作者： Chikamasa Ichita Sayuri shimizu Tadahiro Goto Uojima Haruki Naoya Itoh Masao Iwagami Akiko Sasaki Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Health Data Science Yokohama City UniversityYokohama 236-0027KanagawaJapan TXP Research TXP Medical Co.Ltd.Chiyoda-ku 101-0042TokyoJapan Department of Clinical Epidemiology and Health Economics School of Public HealthThe University of TokyoBunkyo-ku 113-0033TokyoJapan Department of Genome Medical Sciences Project Research InstituteNational Center for Global Health and MedicineIchikawa 272-8516ChibaJapan Division of Infectious Diseases Aichi Cancer CenterNagoya 464-8681AichiJapan Department of Health Services Research Institute of MedicineUniversity of TsukubaTsukuba 305-8575IbarakiJapan

BACKGROUND Esophageal variceal bleeding is a severe complication associated with liver cirrhosis and typically necessitates endoscopic *** current standard treatment is endoscopic variceal ligation(EVL),and Western guidelines recom-mend antibiotic prophylaxis following ***,given the impro-vements in prognosis for variceal bleeding due to advancements in the management of bleeding and treatments of liver cirrhosis and the global concerns regarding the emergence of multidrug-resistant bacteria,there is a need to reassess the use of routine antibiotic prophylaxis after *** To evaluate the effectiveness of antibiotic prophylaxis in patients treated for *** We conducted a 13-year observational study using the Tokushukai medical database across 46 *** were divided into the prophylaxis group(received antibiotics on admission or the next day)and the non-prophylaxis group(did not receive antibiotics within one day of admission).The primary outcome was composed of 6-wk mortality,4-wk rebleeding,and 4-wk spontaneous bacterial peritonitis(SBP).The secondary outcomes were each individual result and in-hospital mortality.A logistic regression with inverse probability of treatment weighting was used.A subgroup analysis was conducted based on the Child-Pugh classification to determine its influence on the primary outcome measures,while sensitivity analyses for antibiotic type and duration were also *** Among 980 patients,790 were included(prophylaxis:232,non-prophylaxis:558).Most patients were males under the age of 65 years with a median Child-Pugh score of *** composite primary outcomes occurred in 11.2%of patients in the prophylaxis group and 9.5%in the non-prophylaxis *** significant differences in outcomes were observed between the groups(adjusted odds ratio,1.11;95%confidence interval,0.61-1.99;P=0.74).Individual outcomes such as 6-wk mortality,4-wk rebleeding,4-wk onset of SBP,and in-hospital mo

关键词： Esophageal varices Endoscopic hemostasis Antibiotic prophylaxis Liver cirrhosis Inverse probability of treatment weighting