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Utility of Tracing as a Memory Storage Method

World Journal of Neuroscience 2017年第2期7卷 216-222页

作者： makana tsutsui Masako Notoya Daisuke Kimura Ken Nakatani Takashi Fujita Nobuyuki Sunahara Katsumi Inoue Japanese Red Cross Kanazawa Hospital Ishikawa Japan Health Medical Department Kytogakuen University Kyoto Japan Department of Rehabilitation Sciences Faculty of Allied Health Sciences Kansai University of Welfare Sciences Osaka Japan Division of Occupational Therapy Faculty of Care and Rehabilitation Seijoh University Aichi Japan School of Health Sciences College of Medical Pharmaceutical and Health Sciences Kanazawa University Ishikawa Japan

Although many studies have explored the utility of tracing as a rehabilitation approach for patients with aphasia and alexia and for Japanese patients with various disabilities, this may be the first study to demonstrate the superiority of tracing over copying for enhancing long-term memory. We investigated the utility of tracing as a memory storage method. Young and elderly participants learned a figure from the Rey-Osterrieth complex figure test by copying or tracing its outline. They were asked to reproduce the figure after 3 min and 3 days. Although the copying group performed better than the tracing group in immediate recall after 3 min, the performance of the tracing and copying groups after 3 days was similar. Among younger participants, the tracing group achieved higher scores than the copying group after 3 days;however, the difference was not statistically significant. Copying as a learning strategy has a substantial temporal gradient of memory loss;tracing may be more appropriate for improving long-term memory. This result could have considerable practical usefulness, e.g., among professionals who provide memory training for the elderly. Tracing, which uses visuomotor memory, is acquired earlier than transcription. Tracing may be effective for rehabilitation because it is a developmentally appropriate approach to early instruction.

关键词： Visual Memory Learning Long-Term Memory

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Novel CD9-targeted therapies in gastric cancer

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World Journal of Gastroenterology 2015年第11期21卷 3206-3213页

作者： Yoko Murayama Kenji Oritani Shusaku tsutsui Department of Gastro-enterology and Hepatology Itami City Hospital Department of Hematology/Oncology Graduate School of MedicineOsaka University

There are 33 human tetraspanin proteins,emerging as key players in malignancy,the immune system,fertilization,cellular signaling,adhesion,morphology,motility,proliferation,and tumor ***9,a member of the tetraspanin family,associates with and influences a variety of cell-surface *** these interactions,CD9 modifies multiple cellular events,including adhesion,migration,proliferation,and ***9 is therefore considered to play a role in several stages during cancer *** CD9 expression is generally related to venous vessel invasion and metastasis as well as poor *** found that treatment of mice bearing human gastric cancer cells with anti-CD9 antibody successfully inhibited tumor progression via antiproliferative,proapoptotic,and antiangiogenic effects,strongly indicating that CD9 is a possible therapeutic target in patients with gastric ***,we describe the possibility of CD9 manipulation as a novel therapeutic strategy in gastric cancer,which still shows poor prognosis.

关键词： CD9 Tetraspanin Gastric cancer Tumo-rigenicity The

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Using Machine Reading to Understand Alzheimer's and Related Diseases from the Literature

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Journal of Data and Information Science 2017年第4期2卷 81-94页

作者： Satoshi tsutsui Yi Bu Ying Ding School of Informatics Computingand EngineeringIndiana UniversityBloomingtonIN 47408USA School of Information Management Wuhan UniversityWuhan 430072China

Purpose： This paper aims to better understand a large number of papers in the medical domain of Alzheimer＇s disease （AD） and related diseases using the machine reading approach. Design/methodology/approach： The study uses the topic modeling method to obtain an overview of the field, and employs open information extraction to further comprehend the field at a specific fact level. Findings： Several topics within the AD research field are identified, such as the Human Immunodeficiency Virus （HIV）/Acquired Immune Deficiency Syndrome （AIDS）, which can help answer the question of how A1DS/HIV and AD are very different yet related diseases. Research limitations： Some manual data cleaning could improve the study, such as removing incorrect facts found by open information extraction. Practical implications： This study uses the literature to answer specific questions on a scientific domain, which can help domain experts find interesting and meaningful relations among entities in a similar manner, such as to discover relations between AD and AIDS/HIV. Origlnality/value： Both the overview and specific information from the literature are obtained using two distinct methods in a complementary manner. This combination is novel because previous work has only focused on one of them, and thus provides a better way to understand an important scientific field using data-driven methods.

关键词： Machine reading Alzheimer's disease Knowledge discovery Data mining

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Microfluidic Device for Simple Diagnosis of Plant Growth Condition by Detecting miRNAs from Filtered Plant Extracts

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Plant Phenomics 2024年第2期6卷 364-376页

作者： Yaichi Kawakatsu Ryo Okada Mitsuo Hara Hiroki tsutsui Naoki Yanagisawa Tetsuya Higashiyama Akihide Arima Yoshinobu Baba Ken-ichi Kurotani Michitaka Notaguchi Bioscience and Biotechnology Center Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Graduate School of Bioagricultural Sciences Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Department of Molecular and Macromolecular Chemistry Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoyaAichi 464-8603Japan Graduate School of Science Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Institute of Transformative Bio-Molecules Nagoya UniversityNagoya 464-8601Japan Department of Biological Sciences Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Institute of Nano-Life-Systems Institutes of Innovation for Future SocietyNagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan Department of Biomolecular Engineering Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan Institute of Quantum Life Science National Institutes for Quantum Science and Technology(QST)Anagawa 4-9-1Inage-kuChiba 263-8555Japan Department of Botany Graduate School of ScienceKyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto 606-8502Japan

Plants are exposed to a variety of environmental stress,and starvation of inorganic phosphorus can be a major constraint in crop *** plants,in response to phosphate deficiency in soil,miR399,a type of microRNA(miRNA),is *** detecting miR399,the early diagnosis of phosphorus deficiency stress in plants can be ***,general miRNA detection methods require complicated experimental ***,simple and rapid miRNA detection methods are required for early plant nutritional diagnosis.

关键词： mirnas plant device simple growth from condition detecting diagnosis extracts

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Inflammatory pseudotumor of the liver and spleen diagnosed by percutaneous needle biopsy

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World Journal of Gastroenterology 2012年第1期18卷 90-95页

作者： Tsukasa Kawaguchi Kiyoshi Mochizuki Takashi Kizu Masanori Miyazaki Takayuki Yakushijin Shusaku tsutsui Eiichi Morii Tetsuo Takehara Department of Gastroenterology and Hepatology Osaka University Hospital Department of Pathology Osaka University Hospital

An inflammatory pseudotumor (IPT) is a relatively rare lesion characterized by chronic inf iltration of inflammatory cells and areas of f ibrosis. IPTs are diff icult to diagnose because of the absence of specif ic symptoms or of characteristic hematological or radiological f indings. In this study, a case of a woman aged over 70 years was reported, who presented with a general malaise lasting more than two months. A computed tomography scan demonstrated a diffusely spread lesion of the liver with a portal vein occlusion and a splenic lesion surrounded by a soft density layer. Since the percutaneous liver biopsy showed f indings that suggested an IPT, although the radiological f indings did not exclude the possibility of a malignancy, we performed a percutaneous spleen biopsy to enable a more defi nitive diagnosis. The microscopic f indings from the spleen specimen lead us to a diagnosis of IPT involving the liver and spleen. Sub-sequent steroid pulse therapy was effective, and rapid resolution of the disease was observed.

关键词： Inflammatory pseudotumor Percutaneous liver biopsy Percutaneous spleen biopsy Steroid pulse therapy

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Gravity Survey along the Mizuho Traverse Routes, East Antarctica: SEAL Seismic Exploration in 1999-2000

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International Journal of Geosciences 2013年第10期4卷 1392-1400页

作者： Shigeru Toda Hiroki Miyamachi Hiroshi Murakami Tomoki tsutsui Masaki Kanao Department of Earth and Environmental Sciences Faculty of Science Kagoshima University Kagoshima Japan Department of Earth Sciences Faculty of Education Aichi University of Education Kariya Japan Faculty of Engineering and Resource Science Akita University Akita Japan National Institute of Polar Research Tokyo Japan Technical Center for Seismological Observations Ltd. Tsukuba Japan

A gravity survey was conducted along the Mizuho traverse routes in austral summer of 1999-2000 by the 41st Japanese Antarctic Research Expedition (JARE-41). The main purpose of the survey was to obtain detail gravity anomaly along the traverse routes, where deep seismic exploration was simultaneously conducted in order to obtain a fine crustal structure of the Mizuho Plateau. By using SCINTREX (CG-3M) gravity meter, the survey was carried out at 160 sites with about 1 km interval in a distance of 190 km from S16 to Z20 on the traverse routes. Free-air and Bouguer anomalies were calculated using precise locations by GPS measurements, by taking into account an effect of the thick icesheet. The furrowed negative Free-air anomalies are identified around H192, where middle points of the whole traverse routes. Two bedrock elevation models derived both by seismic refraction analyses and radio-echo sounding might correspond to the bottom and the top of a mixture layer composed from ice-moraine rocks over the bedrock surface. Thickness of the crust estimated by Bouguer anomalies is 0.5 - 1 km larger toward inland at the terminal point of Z20 along the profile.

关键词： Gravity Survey Mizuho Traverse Routes Bedrock Elevation Bouguer Gravity Anomaly Crustal Structure

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Echocardiographic Parameters as Cardiovascular Mortality Predictors in Chronic Hemodialysis Patients

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International Journal of Clinical Medicine 2014年第12期5卷 635-643页

作者： Misato Koeda Tetsuya Ogawa Kyoko Ito Takaaki tsutsui Kosaku Nitta Department of Medicine Kidney Center Tokyo Women’s Medical University Tokyo Japan Department of Medicine Medical Center East Tokyo Women’s Medical University Tokyo Japan Department of Nephrology Hidaka Hospital Gunma Japan

Background: Hemodialysis (HD) patients have high rates of cardiovascular (CV) mortality. Although structural and functional echocardiographic alterations in HD patients have been the subject of several survival analysis studies, the prognostic value of these alterations is not well established. The aim of this study was to determine the prognostic value of echocardiographic parameters in chronic HD patients. Objectives: One hundred eighteen HD patients were clinically evaluated and underwent Doppler echocardiography, being followed for 45.7 ± 13.6 months. The outcome measures were CV mortality. The predictive value of echocardiographic variables was evaluated by Cox regression model and survival curves were constructed using the Kaplan-Meier method and log-rank test to compare them. Results: CV diseases accounted for 46.4% of all deaths during the follow-up period. We found that the event-free survival rates in one and two years were 96.5% and 83.0%, respectively. Diabetes and E/e' ratio were predictors of CV outcome by multivariate analyses. Conclusion: Diabetes and diastolic dysfunction are independent predictors of CV mortality in chronic HD patients.

关键词： Diastolic Dysfunction Echocardiography Hemodialysis Cardiovascular Mortality Prognosis

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Effectiveness of Aromatherapy Treatment in Alleviating Fatigue and Promoting Relaxation of Mothers during the Early Postpartum Period

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Open Journal of Nursing 2018年第3期8卷 196-209页

作者： Kyoko Asazawa Yoshihiro Kato Ryosuke Koinuma Nao Takemoto Shiho tsutsui Department of Nursing Tokyo Healthcare University Tokyo Japan Tokyo Medical Center Tokyo Japan

Background: This study aimed to determine the effectiveness of aroma hand treatment in alleviating fatigue and promoting relaxation of mothers in their early postpartum period. Methods: This is a quasi-experimental study with a two-group pretest-post-test design which used purposive sampling and non-random assignment of 242 consenting Japanese early postpartum mothers who were patients from a hospital maternity unit in Tokyo, Japan. The intervention involved a 20-minute aroma hand treatment using an effleurage method. The participants selected from 5 essential oils: pure lavender, ylang-ylang, citron, rosewood, and sweet orange. Relaxation promotion and fatigue alleviation as the main outcomes were measured using self-administered valid and reliable questionnaires. Statistical analysis was performed using the two-sample t-test, two-way factorial ANOVA, and simple main effect test. SPSS ver. 23.0 (SPSS, Chicago, IL, USA) was used for data analysis at a 5% significance level. Results: Of 242 participants (intervention group, n = 122;comparison group, n = 120), 229 participants (intervention group, n = 115;comparison group, n = 114) were analyzed per protocol. The intervention group showed a significant improvement in relaxation (t = 6.43, p < 0.001). A significant difference in the simple main effect test of relaxation (F = 37.58, p < 0.001) was found. However, there was no significant reduction in fatigue. The majority (88.4%) of the participants indicated high satisfaction with the aroma hand treatment, and 90.5% evaluated the length of intervention time as appropriate. Conclusions: The aroma hand treatment effectively promoted relaxation of early postpartum mothers, but was less effective in alleviating their fatigue. Based on their high satisfaction rate, aroma hand treatment using essential oils may be considered effective in promoting relaxation of early postpartum mothers.

关键词： Aromatherapy Postpartum Period Fatigue Relaxation

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三菱新型2.8L4缸柴油机

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汽车与新动力 1996年第1期 3-10页

作者： Osaki N tsutsui Y Kakoi Y 陈其萃

在轻型载重汽车市场,以柴油机为动力的越野四轮驱动客货两用汽车为主和由此派生的厢式货车,由于燃油经济性好,赢得了用户的青睐。特别是在日本市场,这类汽车的销量迅速增长,比过去5年的总销售量增加约2倍,其中柴油机稳占90%左右。在这... 详细信息

在轻型载重汽车市场,以柴油机为动力的越野四轮驱动客货两用汽车为主和由此派生的厢式货车,由于燃油经济性好,赢得了用户的青睐。特别是在日本市场,这类汽车的销量迅速增长,比过去5年的总销售量增加约2倍,其中柴油机稳占90%左右。在这样的情况下,用户对柴油汽车的要求变得越来越高,主要是要求高功率、低噪声、低振动和排烟少,与对汽油机的要求类似。另一方面,柴油机的废气排放法规也逐渐变得严格起来,且在不久的将来会变得很严格。三菱汽车公司已在生产一种排量为2.5L的4缸柴油机(4D56系列),用于轻型载重汽车。但考虑到上述要求,又研制了4M40系列。这种全新设计的2.8L的4缸柴油机于1993年7月发表,装在"NEW PAJERO"汽车上。本文介绍4 M40系列柴油机的设计特点。

关键词：柴油机设计

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In Situ Synchrotron X-ray Diffraction Studies of Single-walled Carbon Nanotubes for Electric Double-layer Capacitors

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Journal of Chemistry and Chemical Engineering 2015年第8期9卷 509-513页

作者： Yukihiro Yoshida Masato tsutsui Ayar Al-zubaidi Yosuke Ishii Shinji Kawasaki Nagoya Institute of Technology Gokiso Showa Nagoya Aichi 4668555 Japan.

In situ synchrotron X-ray diffraction experiments of SWCNT （single-walled carbon nanotube） electrode in alkali halide aqueous electrolyte at several applied potentials were performed, and the change in the diffraction pattern of SWCNTs was observed. It was found that the position of the 100 diffraction peak does not change with applied potential while the peak intensity decreases with anion adsorption. It was concluded that the space inside the tube would be the important ion adsorption site for the well-gown SWCNT bundles.

关键词： Carbon nanotubes synchrotron X-ray EDLC

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