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Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro Kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are scarce.AIM To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical issues.METHODS We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease center.All consecutive UC patients who received TOF between May 2018 and February 2020 were enrolled.Patients were followed up until August 2020.The primary outcome was the clinical response rate at week 8.Secondary outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week 48.RESULTS The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,respectively.The overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after re-increase.All 6 patients with herpes zoster(HZ)developed the infection after achieving remission by TOF.CONCLUSION TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-αagents.Most relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off TOF.Special attention is needed for tapering and HZ.

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

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Recent Advances for Global Perspectives on Etiology, Pathophysiology, Clinical Presentations, and Management of Moyamoya Disease

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World Journal of Neuroscience 2024年第1期14卷 6-23页

作者： maiko Charles Mkwambe Dongchi Zhao Youping Deng Department of Pediatrics Zhongnan Hospital of Wuhan University Wuhan China

Moyamoya disease (MMD) is a condition characterized by the gradual narrowing and blockage of blood vessels in the brain, specifically those in the circle of Willis and the arteries that supply it. This results in reduced blood flow and oxygen to the brain, leading to progressive symptoms and potential complications. The underlying pathophysiological mechanism remains elucidated. However, recent studies have highlighted numerous etiologic factors: abnormal immune complex responses, susceptibility genes, branched-chain amino acids, antibodies, heritable diseases, and acquired diseases, which may be the great potential triggers for the development of moyamoya disease. Its clinical presentation has varying degrees from transient asymptomatic events to significant neurological deficits. Moyamoya disease (MMD) shows different patterns in children and adults. Children with MMD are more susceptible to ischemic events due to decreased blood flow to the brain. Conversely, adults with MMD are more prone to hemorrhagic events involving brain bleeding. Children with MMD may experience a range of symptoms including motor impairments, sensory issues, seizures, headaches, dizziness, cognitive delays, or ongoing neurological problems. Although adults may present with similar clinical symptoms as children, they are more prone to experiencing sudden onset intraventricular, subarachnoid, or intracerebral hemorrhages. One of the challenges in moyamoya disease is the potential for misdiagnosis or delayed diagnosis, particularly when physicians fail to consider MMD as a possible cause in stroke patients. This review aims to provide a comprehensive overview of recent global studies on the pathophysiology of MMD, along with advancements in its management. Additionally, the review will delve into various surgical treatment options for MMD, as well as its rare occurrence alongside atrioventricular malformations. Exciting prospects include the use of autologous bone marrow transplant and the potential role of Connexin 43 protein treatment i

关键词： Moyamoya Disease (MMD) Etiology Pathophysiology Clinical Presentations Management Future Promising Avenues

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Review on Hydroxyurea Usage in Young Children with Sickle Cell Disease: Examining Hemoglobin Induction, Potential Benefits, Responses, Safety, and Effectiveness

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International Journal of Clinical Medicine 2024年第1期15卷 1-18页

作者： maiko Charles Mkwambe Youping Deng Dongchi Zhao Department of Pediatrics Zhongnan Hospital of Wuhan University Wuhan China

Sickle cell disease (SCD) is a prevalent condition, particularly in the countries of sub-Saharan Africa, where the presence of specific genes associated with Malaria contributes to its high prevalence. Patients with sickle cell disease frequently experience painful episodes necessitating hospitalization, and their hemoglobin levels are typically lower than those of the general population. There are different treatment options available to manage complications, such as transfusing blood, hydroxyurea, and strong anti-pains. However, with all these treatments, patients still commonly experience pain crises and suffer from organ damage. Hydroxyurea, the sole approved medication for sickle cell anemia in developed and developing countries, is widely used in children despite being primarily indicated for adults. Multiple studies have demonstrated the efficacy of hydroxyurea in inducing HbF production in young children with SCD. Elevated HbF levels have been associated with improved clinical outcomes, including a reduction in vaso-occlusive crises, acute chest syndrome, and the need for blood transfusions. Furthermore, increased HbF levels have been shown to ameliorate disease-related organ damage, such as pulmonary hypertension and sickle cell retinopathy. The response to hydroxyurea treatment in young children with SCD is variable. Some patients achieve substantial increases in HbF levels and experience significant clinical benefits, while others may have a more modest response. Factors influencing the response include baseline HbF levels, genetic modifiers, treatment adherence, and dose optimization. Safety is a crucial consideration when using hydroxyurea in young children. Studies have shown that hydroxyurea is generally well-tolerated, with the most common adverse effects being myelosuppression, gastrointestinal symptoms, and dermatological manifestations. However,long-term effects and potential risks, such as renal dysfunction and reproductive impacts, require further investigation. The effectiveness of hydroxyur

关键词： Effectiveness Hydroxyurea Sickle Cell Disease Sickle Cell Anemia Minimally Effective Dose Maximum Tolerated Dose

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Elevated plasma cryofibrinogen in patients with active inflammatory bowel disease is morbigenous

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World Journal of Gastroenterology 2006年第10期12卷 1621-1625页

作者： Koji Sawada Ryouki Takahashi Abbi R Saniabadi maiko ohdo Takashi Shimoyama Department of Gastroenterology Fujimoto Hospital MedicineOsaka and Department of GastroenterologyHyogo College of MedicineNishinomiyaJapan Wakamoto Pharmaceuticals Sagami Laboratory KanagawaJapan Japan Immunoresearch Laboratories.Takasaki Japan Department of Gastroenterology Hyogo College of Medicine NishinomiyaJapan

瞄准：在活跃的煽动性的肠疾病(IBD ) 调查冷沉纤维蛋白(CF ) 的角色。方法：CF 是在 284 个题目的 assayed：61 与活跃并且 63 与不活跃的 ulcerative (UC ) ， 45 有 proctocolectomy， 35 与活跃并且 20 与不活跃的 Crohn 的疾病(CD... 详细信息

瞄准：在活跃的煽动性的肠疾病(IBD ) 调查冷沉纤维蛋白(CF ) 的角色。方法：CF 是在 284 个题目的 assayed：61 与活跃并且 63 与不活跃的 ulcerative (UC ) ， 45 有 proctocolectomy， 35 与活跃并且 20 与不活跃的 Crohn 的疾病(CD ) ， 40 与另外的疾病和 20 健康控制。胰岛素禁止者(TI ) 和 TI 抗体(TI-Ab ) 被 ELISA 在血浆和 CF 建筑群测量。结果：在活跃 UC 的 CF 与所有另外的组(c2<0.001 ) 相比惊人地高。同样， CF 比在不活跃的 CD 或在控制(c2<0.01 ) 在活跃 CD 是显著地更高的。在 UC，高 CF 和 TI-Ab 与对操作的需要被联系。进一步，在血浆的高 CF， CF/fibrinogen 比率，低 TI 和高 TI-Ab 与疾病活动或倔强被联系到药。提高的 CF 没与相似 C 反应的蛋白质和白血房间除了红细胞沉降率数的尖锐反应物被联系，建议那提高的 CF 不是急性炎的后果。结论：在活跃 IBD 的提高的 CF 看起来是致病。CF 经由二主要机制支持 IBD， TI (一种反煽动性的物质) 熄灭并且损害由形成蛋白质总数的微脉管的灌注。CF 可以也用作长期的 IBD 的一个简历标记。另外的研究被保证充分在 IBD 评估 CF 的角色，结果应该贡献 IBD 的致病的更好的理解。

关键词：等离子体冷纤维蛋白原疾病炎症药物抗体

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Risk and Protective Factors Associated with Depression and Anxiety among Pregnant Women during the COVID-19 Pandemic

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Health 2024年第1期16卷 37-51页

作者： maiko Manaka Miyako Tsuda Moe Fujitani Ai Sawada Nanae Akatsuka Ayako Sasaki Faculty of Nursing Osaka Medical and Pharmaceutical University Takatsuki Japan Osaka City Juso Hospital Osaka Japan Osaka City General Hospital Osaka Japan

Background: The coronavirus disease (COVID-19) pandemic has impacted perinatal women’s mental health. However, protective factors associated with depression among pregnant Japanese women during the pandemic have not been reported. Purpose: The present study investigated the risk and protective factors associated with depression and anxiety among pregnant women during the COVID-19 pandemic. Methods: An online questionnaire was administered to 157 pregnant women between October 2022 and May 2023 at two general hospitals in Japan. The Japanese versions of the Patient Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7) were used to assess symptoms of depression and anxiety. The χ2 test or Fisher’s exact test and multivariate logistic regression model were used to examine factors associated with depression and anxiety among pregnant women. Results: Overall, 47.1% and 35.7% of the pregnant women reported depressive and anxiety symptoms, respectively. A “history of mental illness” was a risk factor for depression and anxiety among pregnant women during the COVID-19 pandemic. Additionally, unmarried status was a risk factor for anxiety among pregnant women, whereas outdoor and indoor exercises were protective factors against depression and anxiety, respectively. Conclusions: Exercise may have protected pregnant women from depression and anxiety during the COVID-19 pandemic. Encouraging exercise may help maintain the mental health of pregnant women who do not have exercise restrictions.

关键词： Depression Anxiety Factors Pregnancy COVID-19 Pandemic

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The Development of a Feeding Coparenting Scale for Japanese Parents of Fifth- and Sixth-Grade Elementary School Children

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Open Journal of Nursing 2024年第1期14卷 27-39页

作者： maiko Yasuzato Tae Kawahara Yuichi Nakayama Cin Cin Tan Akemi Yamazaki Division of Health Sciences Area of Nursing Science Graduate School of Medicine Osaka University Osaka Japan Graduate School of Nursing Osaka Metropolitan University Osaka Japan Department of Psychology University of Toledo Ohio USA

Aim: Recently, the role of feeding coparenting has gained attention in the child eating research field. The Feeding Coparenting Scale (FCS), a measure of how caregivers interact with their partners when feeding their children was developed in the United States in 2019. However, there is no valid and reliable measure to assess feeding coparenting among caregivers of school-aged children in Japan. Therefore, this study aimed to develop a Japanese version of the FCS (FCS-J) questionnaire for caregivers with school-aged children. Methods: This was a web-based cross-sectional survey completed by caregivers of children aged 10-12 years. A preliminary survey using interviews and a web-based survey was conducted and found that the translated items of the FCS into Japanese were understandable to Japanese people. The developed survey was administered to parents of children at an elementary school. The reliability of the survey was assessed using both test-retest reliability and internal consistency analysis. Exploratory factor analysis was used to test construct validity, and known population validity was examined in relation to attributes, marital satisfaction, and feeding tasks. Results: Findings with 135 parents of school-aged children showed good internal reliability and validity of the FCS-J. The mean score for the overall FCS-J score was 46.2 (SD = 6.2), with Cronbach’s α of 0.72. For the subscales, Cronbach’s α ranged from 0.75 to 0.79. In sum, the present study’s results support the three-factor structure of the FCS in Japanese caregivers in Japan. Conclusions: The developed FCS-J was found to have a certain degree of reliability and validity. In this study, a Japanese version of the FCS-J was developed. .

关键词： Child Coparenting Parents Feeding Coparenting

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Fragmented QRS complex with an additional R-wave attenuated by short RR interval in a patient with acute pulmonary embolism and cardiogenic shock

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Journal of Geriatric Cardiology 2022年第12期19卷 995-1000页

作者： Koji Takahashi Hiromasa Nakahara Eiji Arimitsu Satoshi Imamine Yoshiyasu Obata Kimio Nakanishi Yoshiyasu Taniguchi maiko Amano Chika Omori Takafumi Okura Department of Community Emergency Medicine Ehime University Graduate School of MedicineEhimeJapan Department of Cardiology Yawatahama City General HospitalEhimeJapan Department of Internal Medicine Oozu City HospitalEhimeJapan Department of Clinical Laboratory Oozu City HospitalEhimeJapan

Registries and hospital discharge datasets of unselected patients with pulmonary embolism show 30-day all-cause mortality rates of approximately 10%.[1]Clinical findings from histories and physical examinations,such as age,systemic blood pressure,and respiratory rate at presentation,classify patients into risk classes of increasing risk of death and other adverse medical outcomes.

关键词： mortality patients Clinical

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Saline Drinking Water and Salt in Diet:An Approximate Picture of the Situation in a Coastal Area of Southeastern Bangladesh

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International Journal of Disaster Risk Science 2017年第2期8卷 109-120页

作者： maiko Sakamoto Department of International Studies Graduate School of Frontier SciencesThe University of Tokyo

Coastal areas of Bangladesh have been facing increasing salinity of surface water and groundwater.This study provides the approximate scope of the problem in a coastal area of southeastern Bangladesh by using less-accurate,but lower-cost salinity measuring devices that enable local people to assess the situation.Ten local women were employed to monitor 10 tube wells each on a weekly basis,from mid-February to mid-May,during the2016 dry season.Geographical Information System and time series clustering were used to visualize the spatial distribution and seasonal change of the salinity levels.In addition,the tube well users were asked about the salt consumption in their daily diet.One-third of the monitored tube wells were found to contain more sodium than the tolerable level in terms of taste suggested by the World Health Organization.However,the mean salinity level across all monitored tube wells was much lower.The salinity level varied depending on the depth of the tube wells rather than their locations or altitudes,and those deeper than 200 m were likely to be salt free.The results of the diet survey showed that wealthier households tended to use more salt in their daily diets,but at the same time they tended to have deeper tube wells that are less likely to contain high levels of sodium.

关键词： Bangladesh Climate change Drinking water salinity Participatory water monitoring

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Anesthesia-induced neurotoxicity in an animal model of the developing brain:mechanism and therapies

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Neural Regeneration Research 2016年第9期11卷 1407-1408页

作者： maiko Satomoto Koshi Makita Department of Anesthesiology Graduate School of Medical and Dental SciencesTokyo Medical and Dental University

Children are being exposed to an increasingly greater variety of anesthetics with advances in pediatric and obstetric surgery. Recent animal and retrospective human data suggest that the general anes- thetics commonly used in pediatric medicine could he damaging to the developing brain when used at clinical concentrations. In viw~ primate and rodent models have shown that neonatal exposure to clinical concentrations of anesthetics causes neural apoptosis and long-term cognitive impairment. Many general anesthetics.

关键词： Anesthesia-induced neurotoxicity in an animal model of the developing brain NADPH

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Microarray Analysis of the Developing Rat Mandible

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Acta Biochimica et Biophysica Sinica 2007年第6期39卷 399-405页

作者： Hideo KABURAGI Naoyuki SUGANO maiko OSHIKAWA Ryosuke KOSHI Naoki SENDA Kazuhiro KAWAMOTO Koichi ITO Department of Periodontology. Nihon University School of Dentistry Tokyo 101-8310 Japan Department of Periodontology. Nihon University School of Dentistry Tokyo 101-8310 Japan Division of Advanced Dental Treatment Dental Research Center Nihon University School of Dentistry Tokyo 101-8310 Japan Department of Periodontology. Nihon University School of Dentistry Tokyo 101-8310 JapanDivision of Advanced Dental Treatment Dental Research Center

To analyze the molecular events that occur in the developing mandible, we examined the expression of 8803 genes from samples taken at different time points during rat postnatal mandible development. Total RNA was extracted from the mandibles of 1-day-old, 1-week-old, and 2-week-old rats. Complementary RNA (cRNA) was synthesized from cDNA and biotinylated. Fragmented cRNA was hybridized to RGU34A GeneChip arrays. Among the 8803 genes tested, 4344 were detectable. We identified 148 genes with significantly increased expression, and 19 genes with significantly decreased expression. A comprehensive analysis appears to be an effective method of studying the complex process of development.

关键词： gene expression microarray rat mandible

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