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Tribology of enzymatically degraded cartilage mimicking early osteoarthritis

Friction 2023年第9期11卷 1724-1740页

作者： Ke REN Miguel Alejandro REINA MAhEChA maike hübner Zhiwei CUI hans J.KAPER hugo C.VAN DER VEEN Prashant K.ShARMA Department of Biomedical Engineering University Medical Centre GroningenUniversity of GroningenGroningen 9713AVthe Netherlands Department of Mechanical Engineering Eindhoven University of TechnologyEindhoven 5600MBthe Netherlands Department of Orthopedic Surgery University Medical Centre GroningenUniversity of GroningenGroningen 9700RBthe Netherlands

healthy cartilage is a water-filled super lubricious *** type II provides it structural stability,and proteoglycans absorb water to keep the cartilage in a swollen condition,providing it the ability to creep and provide weeping ***(OA)is a degenerative and debilitating disorder of diarthrodial joints,where articular cartilage damage originates from enzymatic degradation and mechanical damage(wear).The objective of this research is to observe the level of cartilage damage present in knee arthroplasty patients and to understand the friction and creep behavior of enzymatically degraded bovine cartilage in ***(Lat)and medial(Med)condylar cartilages from OA patients undergoing total knee arthroplasty showed signs of enzymatic degradation and mechanical *** cartilages were exposed to collagenase III and chondroitinase ABC to degrade collagen and proteoglycans,*** loss of proteoglycans or collagen network and morphological changes were observed through histology and the atomic force microscope(AFM),respectively.A significant effect on creep due to enzymatic treatment was not *** the enzymatic treatment was found to significantly decrease the coefficient of friction(COF)at 4 N,while higher COF was shown from chondroitinase ABC degraded cartilage at 40 *** III treatment leads to the release of intact proteoglycans at the sliding interface,while chondroitinase ABC treatment leads to the loss of chondroitin sulfate(CS)from the *** ABC-digested bovine cartilage mimicked patient samples the best because of the similar distributions of proteoglycans,collagen network,and friction behavior.

关键词： lubrication cartilage boundary lubrication osteoarthritis(OA)

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Paramutation： A heritable Change in Gene Expression by Allelic Interactions In Trans

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Molecular Plant 2009年第4期2卷 578-588页

作者： maike Stam Swammerdarn Institute for Life Sciences Universiteit van Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands

Epigenetic gene regulation involves the stable propagation of gene activity states through mitotic, and sometimes even meiotic, cell divisions without changes in DNA sequence. Paramutation is an epigenetic phenomenon involving changes in gene expression that are stably transmitted through mitosis as well as meiosis. These heritable changes are mediated by in trans interactions between homologous DNA sequences on different chromosomes. During these in trans interactions, epigenetic information is transferred from one allele of a gene to another allele of the same gene, resulting in a change in gene expression. Although paramutation was initially discovered in plants, it has recently been observed in mammals as well, suggesting that the mechanisms underlying paramutation might be evolutionarily conserved. Recent findings point to a crucial role for small RNAs in the paramutation process. In mice, small RNAs appear sufficient to induce paramutation, whereas in maize, it seems not to be the only player in the process. In this review, potential mechanisms are discussed in relation to the various paramutation phenomena.

关键词： Paramutation in trans interactions epigenetics epigenetic memory RNAi RdDM physical pairing silencing.

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Evaluation of the use of surrogate Laminaria digitata in eco-hydraulic laboratory experiments

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Journal of hydrodynamics 2014年第3期26卷 374-383页

作者： PAUL maike hENRY Pierre-Yves T. Forschungszentrum Küste Leibniz Universit?t Hannover Department of Marine Technology Norwegian University of Science and Technology

Inert surrogates can avoid husbandry and adaptation problems of live vegetation in laboratories. Surrogates are generally used for experiments on vegetation-hydrodynamics interactions, but it is unclear how well they replicate field conditions. here, surrogates for the brown macroalgae Laminaria digitata were developed to reproduce its hydraulic roughness. Plant shape, stiffness and buoyancy of L. digitata were evaluated and compared to the properties of inert materials. Different surrogate materials and shapes were exposed to unidirectional flow. It is concluded that buoyancy is an important factor in low flow conditions and a basic shape might be sufficient to model complex shaped plants resulting in the same streamlined shape.

关键词： bending modulus buoyancy hydraulic forcing Laminaria digitata plant surrogate

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A Review of Testing Object‑Based Environment Perception for Safe Automated Driving

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Automotive Innovation 2022年第3期5卷 223-250页

作者： Michael hoss maike Scholtes Lutz Eckstein Institute for Automotive Engineering RWTH Aachen UniversitySteinbachstr.752074 AachenGermany

Safety assurance of automated driving systems must consider uncertain environment *** paper reviews litera-ture addressing how perception testing is realized as part of safety *** paper focuses on testing for verification and validation purposes at the interface between perception and planning,and structures the analysis along the three axes(1)test criteria and metrics,(2)test scenarios,and(3)reference ***,the analyzed literature includes related safety standards,safety-independent perception algorithm benchmarking,and sensor *** is found that the realiza-tion of safety-oriented perception testing remains an open issue since challenges concerning the three testing axes and their interdependencies currently do not appear to be sufficiently solved.

关键词： Automated driving Environment perception Safety assurance Testing

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From Tpex to Tex: a journey through CD8^(+) T cell responses in cancer immunotherapy

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4419-4420页

作者： Julia M.Messmer maike Effern Michael holzel Institute of Experimental Oncology University Hospital BonnUniversity of Bonn53127BonnGermany

In a recent study published in Cell,Rahim et *** that a subset of progenitor exhausted CD8+T cells(Tpex)in uninvolved,regional lymph nodes(uiLNs)are clonally related to exhausted CD8^(+)T cells(Tex)in tumors of patients with head and neck squamous cell carcinoma(hNSCC)and following adjuvant immune checkpoint blockade(ICB)these clones expanded in the tumor suggestive of migration from the uiLNs and differentiation into an exhaustion state.1 The work by Rahim et *** the great value of neoadjuvant ICB clinical trials to better understand the dynamics of T cell responses in patients.

关键词： al. Tpe patients

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Detrimental role of hydrogen evolution and its temperature-dependent impact on the performance of vanadium redox flow batteries

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Journal of Energy Chemistry 2019年第5期28卷 57-62页

作者： Abdulmonem Fetyan Gumaa A. El-Nagar Iver Lauermann maike Schnucklake Jonathan Schneider Christina Roth Institute for Chemistry and Biochemistry Freie Universitat BerlinTakustr.3D-14195 BerlinGermany Chemistry Department Faculty of ScienceCairo UniversityCairo 12613Egypt helmholtz-Zentrum Berlin fur Materialien und Energie Hahn-Meitner-Platz 114109 BerlinGermany

This paper addresses the damaging role of the parasitic hydrogen evolution reaction (hER) in the negative half-cell of a vanadium redox flow battery (VRFB) on state-of-the-art carbon felt electrodes at different temperatures. It was found that increasing the temperature resulted in a better catalytic performance for both the positive and negative half-cell reactions. In addition, increasing the temperature significantly enhanced the undesired hER at the negative side. Operating the VRFB cell at higher temperature led to a decrease in the coulombic efficiency attributed to the higher hydrogen production. More pronounced hydrogen production caused an oxidation on the surface of the carb on fibers and a degradation of the electrode as indicated from scanning electron microscopy and X-ray photoelectron spectroscopy measurements. This observed degradation results in fading of the overall performance of the vanadium redox flow battery over time.

关键词： hydrogen evolution Carbon felt Degradation Electrode Redox flow batteries

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Physiochemical Properties of Resistant Starch and Its Enhancement Approaches in Rice

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Rice science 2021年第1期28卷 31-42页

作者： Ding Yi Wang maike Shen Yi Shu Xiaoli Wu Dianxing Song Wenjian State Key Laboratory of Rice Biology/Key Laboratory of the Ministry of Agriculture for the Nuclear Agricultural Sciences Zhejiang UniversityHangzhou 310058China Agricultural Technology Extension Center Zhejiang UniversityHangzhou 310058China

With changes in food preferences and life styles,more and more attentions have been focused on healthier ***,resistant starch(RS)which can resist digestion in the human intestine has been recognized and *** RS diet shows great benefit for the human health,and breeding high RS rice variety is a great target for realizing dietary *** provide guidance for RS improvement in rice,this review summarized the unique physiochemical properties of RS and the possible approaches,*** regulation,for enhancing RS content in rice,and proposed the potential ways to obtain rice variety with high RS content.

关键词： rice resistant starch starch modification physiochemical property

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Barriers and Facilitators in Interorganizational Disaster Response: Identifying Examples Across Europe

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International Journal of Disaster Risk Science 2020年第1期11卷 46-58页

作者： Claudia Berchtold maike Vollmer Philip Sendrowski Florian Neisser Larissa Müller Sonja Grigoleit Department for Technology Analysis and Strategic Planning(TASP) Fraunhofer Institute for Technological Trend Analysis53879 EuskirchenGermany

Disaster response actors are facing new challenges, which encompass not only new and ever more complex threats but also the need to collaborate across organizational boundaries and even state *** on scale, these interactions have to work across governance setups, political and legal conditions, organizational cultures, as well as personal preferences and experiences that vary among actors, organizations, and countries. But which concrete measures are taken by crisis management actors at different scales to bridge these challenges and which of these could serve others as example to address comparable challenges in their contexts? This study made attempts to analyze whether certain solutions across organizations and states exist that facilitate effective interorganizational crisis management in the member states of the European Union(EU). It is based on selected expert interviews with representatives of different types of disaster response organizations(health services,police services, fire services, and other crisis management organizations) from seven EU member states(Germany,Netherlands, United Kingdom, Ireland, Italy, Austria, and Greece).

关键词： Disaster response European union Interorganizational crisis management Transboundary cooperation

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Effectiveness of psychosocial interventions for pediatric patients with scoliosis:a systematic review

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World Journal of Pediatric Surgery 2023年第2期6卷 63-69页

作者： maike van Niekerk Ann Richey John Vorhies Connie Wong Kali Tileston Pediatric Orthopaedic Surgery Stanford UniversityStanfordCaliforniaUSA Lane Medical Library Stanford UniversityStanfordCaliforniaUSA

Background Pediatric patients affected by scoliosis have complex psychological and social care needs,and may benefit from psychosocial *** therefore aimed to summarize evidence of the efficacy of psychosocial interventions for this patient *** Literature was identified by searching Medline,PsycINFO,Embase,EBSCO Cumulated Index to Nursing and Allied health Literature(CINAhL),and Cochrane Central Register of Controlled Trials(CENTRAL)from database inception to 20 March *** that evaluated the effectiveness of psychosocial interventions for pediatric patients diagnosed with scoliosis and reported at least one quantitative outcome were *** eligibility,data extraction,and quality assessment(using the Cochrane Collaboration's Risk of Bias Tool and Methodological Index for Non-Randomized Studies)were performed by two independent *** are presented using narrative *** We identified ten studies,all of which focused on adolescent idiopathic *** included a total of 1007 participants,most of whom were *** studies focused on patients undergoing bracing,six on patients undergoing spinal surgery,and one on patients *** compliance monitoring and counseling were found to significantly improve brace compliance quality and *** mental healthcare delivery by nurses after spinal surgery was similarly found to improve *** studies examined the efficacy of brief educational interventions;most did not report clear evidence of their *** methodological quality of studies was often unclear due to limitations in articles'reporting *** Research on the efficacy of psychosocial interventions for pediatric patients with scoliosis is limited,with interventions involving frequent patient-provider interactions showing the most *** clinical and research efforts should focus on developing and testing psychosocial interventions for

关键词： patients scoliosis nurse

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On the Impact of Precursor Unfolding during Protein Import into Chloroplasts

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Molecular Plant 2010年第3期3卷 499-508页

作者： maike Ruprecht Tihana Bionda Takehiro Sato Maik S. Sommer Toshiya Endo Enrico Schleiff Goethe University Cluster of Excellence Macromolecular Complexes Centre of Membrane Proteomics Department of Biosciences Molecular Cell Biology of Plants Max-von-Laue Str. 9 D-60438 Frankfurt Germany Department of Chemistry Graduate School of Science and Institute for Advanced Research Nagoya University Chikusa-ku Nagoya 464-8602 Japan Present address: Department of Molecular and Cellular Medicine Texas A&M University System Health Science Center College Station TX 77843-11114 USA

Protein translocation across membranes is a fundamental cellular process. The majority of the proteins of organelles such as mitochondria and chloroplasts is synthesized in the cytosol and subsequently imported in a posttranslational manner. The precursor proteins have to be unfolded at least for translocation, but it has also been assumed that they are unfolded during transport to the organelle in the cytosol. Unfolding is governed by chaperones and the translocon itself. At the same time, chaperones provide the energy for the import process. The energetic properties of the chloroplast translocon were studied by import of the Ig-like module of the muscle protein titin fused to the transit peptide of the chloroplast targeted oxygen evolving complex subunit of 33 kDa （OE33）. Our results suggest that p（OE33）titin is folded prior to import and that translocation is initiated by unfolding after having bound to the translocon at the chloroplast surface. Using a set of stabilizing and destabilizing mutants of titin previously analyzed by atomic force microscopy and as passenger for mitochondrial translocation, we studied the unfolding force provided by the chloroplast translocon. Based on these results, a model for translocation is discussed.

关键词： Chloroplasts import precursor protein titin energetic of translocation.

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