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Decoding molecular mechanisms:brain aging and Alzheimer's disease

Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： mahnoor hayat Rafay Ali Syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

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Diabetes mellitus:Is Pakistan the epicenter of the next pandemic?

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Chronic Diseases and Translational Medicine 2024年第1期10卷 75-77页

作者： Muhammad Bilal Shahid mahnoor Saeed Hamza Naeem Usha Kumari King Edward Medical University LahorePakistan Dow University of Health Sciences KarachiPakistan

To the Editor,Diabetes mellitus(DM)is an endocrine disorder of chronic hyperglycemia diagnosed by fasting blood sugar levels of≥126 mg/dL or glycated hemoglobin(HbA1c)levels of≥6.5%.Type 1 DM involves a lack of insulin secretion by the pancreas,whereas the human body's resistance to insulin combined with impaired function of beta cells causes type 2 DM.

关键词： impaired Diabetes mellitus

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Web GIS-Based Temporal Analysis of Climatic Factors Impacting Heat Stroke in Karachi

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Journal of Geographic Information System 2024年第1期16卷 61-69页

作者： Ali Atif mahnoor Rehman Muhammad Butt Syed Mahmood Shahid Ghazi Rashid Mehmood Department of Management Victoria University Sydney Australia Department of Geography Government College University Lahore Pakistan Department of Space Science University of the Punjab Lahore Pakistan Centre of Geographic Information System University of The Punjab Lahore Pakistan

This study focuses on the impact of climate change, specifically the increasing threat of heatwaves, in Pakistan, with a particular emphasis on the city of Karachi. The Pakistan Meteorological Department (PMD) analysed a century of climatic data to reveal warming trends, attributing them to human-induced factors. The vulnerability of Pakistan to climate change is highlighted, given its warm climate and location in a region where temperature increases are expected to surpass global averages. The study examines the past three decades, noting a significant rise in the frequency of hot days, especially in Karachi, where heatwaves have become more prevalent. The aims and objectives of the study involve identifying temporal changes in temperature, rainfall, humidity, and wind speed from 1984 to 2014 in Karachi. The literature review emphasizes the health implications of heatwaves, citing increased mortality during such events globally. The study incorporates a comprehensive temporal analysis, addressing gaps in previous research by considering multiple climate indicators responsible for heatwaves. The methodology involves statistical analyses, including linear regression and Pearson correlation, applied to temperature data and urbanization parameters. Results indicate an increasing trend in heat index temperature, with heatwave vulnerability peaking in the last three decades. Heat Index Temperature Anomalies show a clear surge, emphasizing the need for new indices to control critical heat stress conditions. The study concludes that tropical climate variability, particularly heat index, is linked to extreme hot days, urging measures to reduce population vulnerability. The findings underscore the importance of policy strategies, such as integrated coastal zone management, to mitigate the adverse health effects of heatwaves in Karachi’s vulnerable population.

关键词： IPCC Heat Wave Heat Index PMD

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Targeting Cancers: Uncovering the Potential Roles of Potato Tissue Culture as Anti-Cancer Agents - A Secondary Publication

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Proceedings of Anticancer Research 2024年第3期8卷 36-50页

作者： Tehseen Sajid Jallat Khan Zulqarnain Abbas Hafiz Muhammad Sultan mahnoor Mazhar Muhammad Zubair Muhammad Dilshad Kashif Kareem Institute of Biological Science Ground FloorBasic Sciences and Humanities BuildingKhwaja Fareed University of Engineering&Information TechnologyKFUEITRYKPakistan Institute of Plant Protection(Plant Pathology) MNS-University of Agriculture MultanPakistan Crop Diseases Research Institute(CDRI) National Agricultural Research Centre NARCIslamabadPakistan School of Chemistry University of Punjab LahorePakistan

Plant tissue culture is a technique that enhances the quality and quantity of potatoes. Potatoes are a significant crop and are primarily used in the world. It is a staple food in many countries, where millions of tonnes are produced annually. It is an essential source of many nutrients, such as proteins, carbohydrates, vitamins, and beta-carotene. In addition, potatoes are being used as therapeutic agents against cancer and other human diseases as well. Potatoes are on the third list after wheat and rice. To overcome food shortages and malnutrition, there are two methods used for producing potatoes: the first is sexual, which is seed propagation, and the second is asexual, which is plant tissue culture propagation. Conventional potato breeding is a uniform method, but it is unsafe because there is a risk of pathogen attack. In a laboratory setting, the tissue culture of potatoes produced millions of plants with nutrient-rich medium under controlled environmental conditions that prevent pest attacks. Some environmental stresses, such as salinity and water scarcity, affect potato yield and production;however, applying nanoparticles like organic, inorganic, and silicon dioxide enhances potato quality and combats stress. Biotechnology has proven to be helpful in addressing all these issues. This review discusses the significance of potatoes, their production through the tissue culture technique, and the application of nanoparticles to improve the growth, and impact of potatoes on human health.

关键词： Cancer Nanoparticle Potato Tissue culture

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Exciton-polariton based WS_(2)polarization modulator controlled by optical Stark beam

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Opto-Electronic Advances 2022年第11期5卷 54-60页

作者： mahnoor Shahzadi Chuyuan Zheng Sheraz Ahmad Shanshan Wang Weili Zhang School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China College of Petroleum Engineering China University of PetroleumBeijing 102249China

The recent era of fast optical manipulation and optical devices owe a lot to exciton-polaritons being lighter in mass,faster in speed and stronger in nonlinearity due to hybrid light-matter *** room temperature existence of polaritons in two dimensional materials opens up new avenues to the design and analysis of all optical devices and has gained the researchers ***,spin-selective optical Stark effect is introduced to form a waveguide effect in uniform community of polaritons,and is used to realize polarization modulation of *** proposed device basically takes advantage of the spin-sensitive properties of optical Stark effect of polaritons inside the WS_(2)microcavity so as to guide different modes and modulate polarization of *** is shown that polaritonic wavepacket of different mode profiles can be generated by changing intensity of the optical Stark beam and the polarization of polaritons can be controlled and changed periodically along the formed waveguide by introduction birefringence that is sensitive to polarization degree of the optical Stark beam.

关键词： Stark beam polaritons modulator TMDs polarization degree

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Understanding China's Democracy

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Beijing Review 2023年第14期66卷 20-21页

作者： mahnoor Makhdoom The Daily Mail

Without any research and without learning much about the democratic systems in socialist republics, and above all, without realizing how much development China has accomplished under its concept of democracy, the West, particularly the United States, has constantly tried to impose its own values on China and feels that they are the sole criteria for democracy on planet Earth.

关键词： planet tried own

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Comprehensively analyzing the genetic alterations,and identifying key genes in ovarian cancer

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Oncology Research 2023年第2期31卷 141-156页

作者： QINGLING TANG WARDA ATIQ SHAISTA mahnoor MOSTAFA A.ABDEL-MAKSOUD MOHAMMED AUFY HAMID YAZ JIANYU ZHU Department of Gynecology and Obstetrics Shanghai Songjiang District Jiuting HospitalShanghai20000China Department of Medicine Fatima Jinnah Medical UniversityLahore42000Pakistan Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia Department of Pharmaceutical Sciences Division of Pharmacology and ToxicologyUniversity of ViennaVienna1010Austria Department of Trauma Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China

Though significant improvements have been made in the treatment methods for ovarian cancer(OC),the prognosis for OC patients is still *** hub genes associated with the development of OC and utilizing them as appropriate potential biomarkers or therapeutic targets is highly *** this study,the differentially expressed genes(DEGs)were identified from an independent GSE69428 Gene Expression Omnibus(GEO)dataset between OC and control *** DEGs were processed to construct the protein-protein interaction(PPI)network using ***,hub genes were identified through Cytohubba analysis of the *** and survival profiling of the hub genes were validated using GEPIA,OncoDB,and *** exploring promoter methylation levels and genetic alterations in hub genes,MEXPRESS and cBioPortal were utilized,***,DAVID,HPA,TIMER,CancerSEA,ENCORI,DrugBank,and GSCAlite were used for gene enrichment analysis,subcellular localization analysis,immune cell infiltration analysis,exploring correlations between hub genes and different diverse states,lncRNA-miRNA-mRNA co-regulatory network analysis,predicting hub gene-associated drugs,and conducting drug sensitivity analysis,*** total,8947 DEGs were found between OC and normal samples in *** STRING and Cytohubba analysis,4 hub genes including TTK(TTK Protein Kinase),(BUB1 mitotic checkpoint serine/threonine kinase B)BUB1B,(Nucleolar and spindle-associated protein 1)NUSAP1,and(ZW10 interacting kinetochore protein)ZWINT were selected as the hub ***,it was validated that these 4 hub genes were significantly up-regulated in OC samples compared to normal controls,but overexpression of these genes was not associated with overall survival(OS).However,genetic alterations in those genes were found to be linked with OS and disease-free(DFS)***,this study also revealed some novel links between TTK,BUB1B,NUSAP1,and ZWINT overexpression and promoter meth

关键词： Ovarian cancer Prognosis Diagnosis Therapeutic targets

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Exciton-polariton in WS_2 microcavity in the presence of the optical Stark effect

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Chinese Optics Letters 2019年第2期17卷 70-73页

作者： mahnoor Shahzadi Weili Zhang M.T.Khan School of Information and Communication Engineering University of Electronic Science and Technology of China Electrical Engineering Department University of Lahore

Exciton-polaritons offer an exceptional platform for future photoelectronic and quantum information applications. The influence of the optical Stark effect on exciton-polaritons in a microcavity embodied with a monolayer WS2 is studied. A polarization dependent model is proposed to study the change of strongly coupled excitons and photons in a WS2 microcavity. It is revealed through both steady and dynamical states analysis that an outside optical Stark pulse can effectively vary the polariton characteristics, such as dispersion, exciton, and photon fractions, through blue shifting of excitonic resonance. Thus, the analysis and control of exciton-polaritons in a WS2 microcavity via a spin-selective trigger could be achievable.

关键词： Exciton-polariton WS2 microcavity

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纳米填料填充环氧树脂复合材料的制备与电气性能研究

纳米填料填充环氧树脂复合材料的制备与电气性能研究

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作者： mahnoor Fiaz 华北电力大学(北京)

学位级别：硕士

作为最广泛应用的热固型树脂,环氧树脂目前在电气和微电子行业领域具有广泛的应用前景。与纯环氧树脂体系相比,环氧基纳米复合材料在电气和机械性能方面表现出一些优势。在本研究中,通过改性将纳米级填料成功地引入到环氧树脂中。为改... 详细信息

作为最广泛应用的热固型树脂,环氧树脂目前在电气和微电子行业领域具有广泛的应用前景。与纯环氧树脂体系相比,环氧基纳米复合材料在电气和机械性能方面表现出一些优势。在本研究中,通过改性将纳米级填料成功地引入到环氧树脂中。为改善环氧树脂复合材料的绝缘性能,将纤维素纳米纤维（CNF）、金属有机骨架（MOF）和钛酸钡碳氮化碳聚多巴胺（BaTiO3-C3N4-PDA）作为填料加入环氧树脂中,制备不同负载量的环氧树脂复合材料,并对复合填料的微观结构进行了表征和分析,对复合材料的热性能、介电性能、表面电荷消散性能等电气性能进行了测试和分析。实验结果发现,适当的添加纳米填料可以有效改善环氧树脂复合材料的电气绝缘性能和电荷消散性能。其中添加CNF后复合材料的击穿场强出现下降,但是随着填料质量分数的上升,复合材料的电荷消散能力呈现逐步上升并超过纯环氧树脂。添加MOF的环氧树脂复合材料有着比纯环氧树脂更低的介电损耗、更高的击穿场强。通过将钛酸钡为核,在外层包裹石墨相氮化碳（g-C3N4）和盐酸多巴胺（HPDA）形成三层式结构,有效阻止通电过程中自由电荷进入材料内部。在击穿场强变化不大的前提下,添加7%质量分数的BaTiO3-C3N4-PDA复合材料的电荷消散能力提高了30%。论文表明通过将纳米填料填充环氧树脂复合材料的方式可以有效的调控和改善环氧树脂的基本性能。本研究对环氧树脂复合材料在电气绝缘领域实际应用价值具有理论和实践意义。

关键词：聚合物电介质纳米填料纤维素纳米纤维金属有机骨架钛酸钡环氧树脂复合材料

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Clinical outcomes and lipid-laden macrophages in Electronic cigarette/Vaping product use-Associated Lung Injury(EVALI)in a South Texas population

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Discussion of Clinical Cases 2021年第1期8卷 1-6页

作者： mahnoor Mir Moeezullah Beg Jay I.Peters Sandra G.Adams Department of Medicine UT Health San AntonioSan AntonioTXUSA Department of Medicine Pulmonary/Critical Care DivisionUT Health San AntonioSan AntonioTXUSA South Texas Veterans Health Care System San AntonioTXUSA

Objective:To describe the clinical features,proportion of lipid-laden alveolar macrophages in bronchoalveolar lavage(BAL),and short-term and 6-month to 12-month outcomes of patients with Electronic cigarette/Vaping product use-Associated Lung Injury(EVALI).Methods:Retrospective review of clinical characteristics,radiographs,and BAL samples for all patients with a history of vaping who presented with acute hypoxemic respiratory failure to the University Hospital in San Antonio,Texas from 9/2019 to 6/2020 was ***:We report 16 cases(15 men;median age,30 years[range 19-75])of EVALI with a history of vaping Tetrahydrocannabinol(THC),nicotine,or *** most common presenting symptoms were tachycardia,dyspnea,cough,and *** patients required supplemental oxygen,including two who required noninvasive positive pressure ventilation,and five who required mechanical *** 16 patients had bilateral ground-glass opacities(GGO)with peripheral sparing on chest computerized tomography(CT).Cultures were negative,except for one patient who tested positive for ***-19 PCR was done in one individual which was *** demonstrated lipid-laden macrophages on Oil-Red-O stain on fresh(i.e.,without fixative)BAL in the majority of patients(N=12)with a mean lipid-saturation percentage of 78%[range,44%-100%]and the mean Colombo count of 194[range,101-359].Fifteen patients were treated with systemic *** median length of hospital stay was 10 *** discharge,three patients required supplemental *** of those who had follow-up imaging showed resolution of *** patient had a relapse of symptoms and was again treated with systemic corticosteroids and mycophenolate,with resolution of *** patients who were evaluated after discharge denied vaping post-discharge(two patients were not able to be contacted and did not keep follow-up appointments).Conclusions:Successful diagnosis and management of EVALI requires

关键词： EVALI Vaping Acute lung injury Lipid-laden macrophages Diffuse ground glass opacities

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