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Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus

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World Journal of Gastroenterology 2019年第11期25卷 1366-1377页

作者： Tarek Besheer Hatem elalfy Mohamed Abd el-Maksoud Ahmed Abd el-Razek Saher Taman Khaled Zalata Wagdy elkashef Hossam Zaghloul Heba elshahawy Doaa Raafat Wafaa elemshaty Eman elsayed Abdel-Hady el-Gilany mahmoud el-bendary Department of Tropical Medicine and Hepatology Mansoura Faculty of Medicine-Mansoura University Department of Diagnostic Radiology Mansoura Faculty of Medicine-Mansoura University Department of Pathology Mansoura Faculty of Medicine-Mansoura University Department of Clinical Pathology Mansoura Faculty of Medicine-Mansoura University Department of Public Health and Preventive Medicine Mansoura Faculty of Medicine-Mansoura University

BACKGROUND Diffusion-weighted magnetic resonance imaging has shown promise in the detection and quantification of hepatic fibrosis. In addition, the liver has numerous endogenous micro-RNAs(miRs) that play important roles in the regulation of biological processes such as cell proliferation and hepatic *** To assess diffusion-weighted magnetic resonance imaging and miRs in diagnosing and staging hepatic fibrosis in patients with chronic hepatitis *** This prospective study included 208 patients and 82 age-and sex-matched controls who underwent diffusion-weighted magnetic resonance imaging of the abdomen, miR profiling, and liver biopsy. Pathological scoring was classified according to the METAVIR scoring system. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with pathological *** The ADC value decreased significantly with the progression of fibrosis, from controls(F0) to patients with early fibrosis(F1 and F2) to those with late fibrosis(F3 and F4)(median 1.92, 1.53, and 1.25 × 10^(-3) mm^2/s, respectively)(P = 0.001).The cut-off ADC value used to differentiate patients from controls was 1.83 × 10^(-3) mm^2/s with an area under the curve(AUC) of 0.992. Combining ADC and miR-200 b revealed the highest AUC(0.995) for differentiating patients from controls with an accuracy of 96.9%. The cut-off ADC used to differentiate early fibrosis from late fibrosis was 1.54 × 10^(-3) mm^2/s with an AUC of 0.866. The combination of ADC and miR-200 b revealed the best AUC(0.925) for differentiating early fibrosis from late fibrosis with an accuracy of 80.2%. The ADC correlated with miR-200 b(r =-0.61, P = 0.001), miR-21(r =-0.62, P = 0.001), and miR-29(r = 0.52,P = 0.001).CONCLUSION Combining ADC and miRs offers an alternative surrogate non-invasive diagnostic tool for diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C.

关键词： Diffusion Magnetic resonance imaging Fibrosis Liver Hepatitis C virus Micro-RNA

Fusion Navigation Technique for Management of Difficult to Access Hepatocellular Carcinoma: A Single Center Experience

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Open Journal of Gastroenterology 2020年第12期10卷 329-340页

作者： Ahmed M. el Nakib Sahar Zakria Mohamed Hassany mahmoud el-bendary Tropical Medicine and Hepatogastroentrology Department Mansoura Faculty of Medicine Mansoura University Mansoura Egypt National Hepatology and Tropical Medicine Research Institute Cairo Egypt

Introduction: Sonography is the most universally used imaging technique for planning and performing thermal ablation in Hepatocellular carcinoma patients due to its efficiency and safety. However, the presence of HCC nodules that are hardly visible on traditional sonography is a major drawback to its use during thermal ablation. Real-time image fusion (fusion imaging) or real-time virtual sonography is a new technology that has been developed. Aim: To determine the value of fusion/navigation guided percutaneous thermal ablation in the management of hepatocellular carcinoma that has poor conspicuity at conventional sonography. Subjects and Methods: This study included 70 HCC patients (BCLC A and B). Percutaneous radiofrequency ablation was done via real-time image fusion for 14 patients with poorly visible HCC nodules (study group), while Percutaneous radiofrequency ablation was done via traditional sonography for 56 patients with HCC nodules (control group). Results: The median time to reach the tumor was significantly shorter by using fusion navigation technique (P = 0.034). By using fusion navigation technique 92% of the lesions were completely ablated while 55% only were completely ablated by using ultrasonography (P = 0.014). One year after the procedure , by using fusion navigation technique 92% of the patients had complete response and only 55% of the patients had complete response by using conventional ultrasonography (P = 0.011). The survival distributions for both interventions were statistically significantly different, χ2 = 10.12, P = 0.001. Conclusion: Fusion imaging-guided percutaneous RFA is a reasonable and efficient treatment of patients with HCC undetectable by traditional ultrasonography.

关键词： Fusion Navigation Hepatocellular Carcinoma Radiofrequency Ablation

New Year’s greeting and overview of World Journal of Virology in 2021

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World Journal of Virology 2021年第2期10卷 30-33页

作者： Dong-Mei Wang En-Qiang Chen mahmoud el-bendary Science Editor Development Department Baishideng Publishing Group IncPleasantonCA 94566United States Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Tropical Medicine and Hepatology Faculty of MedicineMansoura UniversityMansoura 35111Egypt

The 2020 year-end wrap-up session of Baishideng Publishing Group was held on December 31,*** staff attended this *** shared our key results area and made a business plan regarding the journal *** Journal of Virology(WJV)is now abstracted and indexed in PubMed and PubMed *** received 23 manuscripts and published 9 papers which included 6 articles reporting coronavirus 19 in *** the other hand,we made major strategies for WJV’s development in *** present,WJV only has 28 Editorial Board members and cannot receive many *** must redouble our efforts to invite more highly influential scientists to join our Editorial Board member and write high-quality manuscripts.

关键词： World Journal of Virology Publication Editorial board Virology

Epidemiological Aspects of Intrafamilial Spread of HCV Infection in Egyptian Population: A Pilot Study

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Open Journal of Gastroenterology 2014年第5期4卷 228-236页

作者： mahmoud el-bendary Gamal Esmat Mustafa Neamatallah Emily Kamel Tarek Besheer Hatem elalfy Maged el-Setouhy Dalia Omran Department of Community Environmental and Occupational Medicine Ain-Shams Faculty of Medicine Ain-Shams University Cairo Egypt Medical Biochemistry Department Mansoura Faculty of Medicine Mansoura University Mansoura Egypt Public Health & Preventive Medicine Department Mansoura Faculty of Medicine Mansoura University Mansoura Egypt Tropical Medicine & Hepatology Department Cairo Faculty of Medicine Cairo University Giza Egypt Tropical Medicine & Hepatology Department Mansoura Faculty of Medicine Mansoura University Mansoura Egypt

Aim: Liver disease is a leading cause of morbidity and mortality among Egyptians. The major cause is infection with HCV, with 70 000 up to 140 000 newly reported cases annually. The objectives of this study were to determine the prevalence of anti-HCV antibodies among household contacts of HCV index cases and to identify the possible risk factors of transmission of HCV among Egyptian families. Material and Methods: The present external pilot study (double centre study) was performed on a convenient sample of 125 index cases and their 321 household family contacts recruited from Mansoura & Cairo University where 2 questionnaires were used to collect data from the index & their related contacts. The all were exposed to clinical examinations, routine laboratory testing & screening for the prevalence of Anti-HCV antibodies. Results: The prevalence of anti-HCV seropositivity among household contacts of index cases was found to be 13.7% which husbands of female index cases ranked first followed by wives of male index cases (36.36% versus 17.86% respectively,

关键词： HCV Intrafamilial Transmission Epidemiology

A Hybrid Cybersecurity Algorithm for Digital Image Transmission over Advanced Communication Channel Models

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Computers, Materials & Continua 2024年第4期79卷 201-241页

作者： Naglaa F.Soliman Fatma E.Fadl-Allah Walid el-Shafai mahmoud I.Aly Maali Alabdulhafith Fathi E.Abd el-Samie Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of electronics and Communications Faculty of EngineeringZagazig UniversityZagazig44519Egypt Security Engineering Lab Computer Science DepartmentPrince Sultan UniversityRiyadh11586Saudi Arabia Department of electronics and electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt

The efficient transmission of images,which plays a large role inwireless communication systems,poses a significant challenge in the growth of multimedia ***-quality images require well-tuned communication *** Single Carrier Frequency Division Multiple Access(SC-FDMA)is adopted for broadband wireless communications,because of its low sensitivity to carrier frequency offsets and low Peak-to-Average Power Ratio(PAPR).Data transmission through open-channel networks requires much concentration on security,reliability,and *** data need a space away fromunauthorized access,modification,or *** requirements are to be fulfilled by digital image watermarking and *** paper ismainly concerned with secure image communication over the wireless SC-FDMA systemas an adopted communication *** introduces a robust image communication framework over SC-FDMA that comprises digital image watermarking and encryption to improve image security,while maintaining a high-quality reconstruction of images at the receiver *** proposed framework allows image watermarking based on the Discrete Cosine Transform(DCT)merged with the Singular Value Decomposition(SVD)in the so-called DCT-SVD *** addition,image encryption is implemented based on chaos and DNA *** encrypted watermarked images are then transmitted through the wireless SC-FDMA *** linearMinimumMean Square Error(MMSE)equalizer is investigated in this paper to mitigate the effect of channel fading and noise on the transmitted *** subcarrier mapping schemes,namely localized and interleaved schemes,are compared in this *** study depends on different channelmodels,namely PedestrianAandVehicularA,with a modulation technique namedQuadratureAmplitude Modulation(QAM).Extensive simulation experiments are conducted and introduced in this paper for efficient transmission of encrypted watermarked *** addition,different variants of SC-FDMA bas

关键词： Cybersecurity applications image transmission channel models modulation techniques watermarking and encryption

A Model for a Dual Universe

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第1期10卷 52-66页

作者： Tharwat mahmoud el-Sherbini Physics Department Faculty of Science Cairo University Cairo Egypt

A model for a dual universe is proposed, based on the assumption that simultaneously with our universe an anti-matter counterpart was initiated immediately following the Big Bang. At the heart of the model is a primordial anti-particle that differentiates itself from its counterpart, a previously hypothesized S-particle responsible for the formation of our own universe, through its course of rotation. The angular rotation of the anti-particle, in accordance with space-time rotation, together with the counter rotation of the S-particle, resulted in a time difference in the formation processes of both universes and consequently led to a large distance between the spatial locations occupied by our universe and its dual counterpart in the same space-time continuum. The existence of this anti-matter universe might solve the present mystery of matter anti-matter asymmetry and thus explain why hardly any free anti-matter can be observed in our universe. Moreover, the model implicates the possibility of the presence of a repulsive gravitational force exerted by the clusters of anti-particles in the anti-matter universe upon our universe. The repulsive gravitational force from the clusters of antiparticles in the dual universe as a whole upon our universe is completely different from the electrostatic repulsive force between similarly charged particles. It is also different from that due to possible gravitational or anti-gravitational interaction between individual matter and antimatter or particle and its antiparticle that might violate the CPT invariance, the theory of general relativity or the law of energy conservation. It is rather, a kind of negative gravity that affects our universe as a whole, due to the opposite course of rotation of the dual anti-universe relative to ours. The effect of this opposite rotation of the dual universe can cause anti-gravitational waves that penetrate our universe interacting with the space-time mesh around the galaxies in our universe a

关键词： Cosmology Antimatter High Energy Astrophysics Particle Physics

Bearing capacity of circular footings on multi-layered sand-waste tire shreds reinforced with geogrids

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1085-1094页

作者： mahmoud Ghazavi Ehsan Khosroshahi Faculty of Civil Engineering K.N.Toosi University of TechnologyTehranIran

The presence of waste tires poses an environmental challenge as they occupy a significant amount of land and are expensive to dispose in ***,reusing waste tires can address this issue when waste tires are used in geotechnical *** determine the viability of this approach,laboratoryscale tests were conducted to investigate load-bearing capacity of circular footings on sand-tire shred(STS)mixtures with shredded waste tire contents of 5%e15%by weight and three different widths of *** investigation focused on analyzing the thickness of layers composed of STS mixtures,the soil cap,and the impact of geogrids on bearing *** results indicate that a specific mixture of sand and tire shreds provides the highest footing-bearing *** addition,the optimal shred content and size were found to be 10%by weight and 2 cm×10 cm,***,for a given tire shred width,a particular length provides the largest bearing *** results agree well with that of previous research conducted by the first author and his colleagues in direct shear and California bearing ratio(CBR)*** primary finding of this research is that the use of two-layered STS mixtures reinforced by geogrids significantly enhances the bearing capacity.

关键词： Geogrid Sand Waste tire shred Bearing capacity Waste tire shred optimization Tire shred aspect ratio

Source localization based on field signatures:Laboratory ultrasonic validation

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Journal of electronic Science and Technology 2024年第3期22卷 47-56页

作者： mahmoud Eissa Dmitry Sukhanov Department of Radiophysics Tomsk State UniversityTomsk634050Russia Higher Institute for Applied Sciences and Technology(HIAST) Damascus31983Syria

Location awareness in wireless networks is essential for emergency services,navigation,gaming,and many other *** article presents a method for source localization based on measuring the amplitude-phase distribution of the field at the base *** existing scatterers in the target area create unique scattered field interference at each source *** unique field interference at each source location results in a unique field signature at the base station which is used for source *** the proposed method,the target area is divided into a grid with a step of less than half the *** grid node is characterized by its field signature at the base *** signatures corresponding to all nodes are normalized and stored in the base station as fingerprints for source *** normalization of the field signatures avoids the need for time synchronization between the base station and the *** a source transmits signals,the generated field signature at the base station is normalized and then correlated with the stored *** maximum correlation value is given by the node to which the source is the *** simulations and results of experiments on ultrasonic waves in the air show that the ultrasonic source is correctly localized using broadband field signatures with one base station and without time *** proposed method is potentially applicable for indoor localization and navigation of mobile robots.

关键词： Base station Field signature Fingerprints Localization Ultrasonic frequencies

Novel Sustainable Cellulose Acetate Based Biosensor for Glucose Detection

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Journal of Renewable Materials 2024年第2期12卷 369-380页

作者： M.F.elkady E.M.el-Sayed mahmoud Samy Omneya A.Koriem H.Shokry Hassan Chemical and Petrochemical Engineering Department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt Fabrication Technology Research Department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt Department of Public Works Engineering Faculty of EngineeringMansoura UniversityMansoura35516Egypt Environmental Engineering Department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt electronic Materials Research Department Advanced Technology and NewMaterials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt

In this study,green zinc oxide(ZnO)/polypyrrole(Ppy)/cellulose acetate(CA)film has been synthesized via solvent *** film was used as supporting material for glucose oxidase(GOx)to sensitize a glucose *** nanoparticles have been prepared via the green route using olive leaves extract as a ***/Ppy nanocomposite has been synthesized by a simple in-situ chemical oxidative polymerization of pyrrole(Py)monomer using ferric chloride(FeCl3)as an oxidizing *** produced materials and the composite films were characterized using X-ray diffraction analysis(XRD),scanning electron microscope(SEM),Fourier transform infrared(FTIR)and thermogravimetric analysis(TGA).Glucose oxidase was successfully immobilized on the surface of the prepared film and then ZnO/Ppy/CA/GOx composite was sputtered with platinum electrode for the current determination at different initial concentrations of *** measurements proved the suitability and the high sensitivity of the constructed biosensor for the detection of glucose levels in different *** performance of the prepared biosensor has been assessed by measuring and comparing glucose concentrations up to 800 *** results affirmed the reliability of the developed biosensor towards real samples which suggests the wide-scale application of the proposed biosensor.

关键词： Biosensors composite films glucose polypyrrole green ZnO cellulose acetate