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Evaluation of DNA damage profile in obese women and its association to risk of metabolic syndrome,polycystic ovary syndrome and recurrent preeclampsia

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Genes & Diseases 2018年第4期5卷 367-373页

作者： Moushira zaki Walaa Basha Hala T.el-Bassyouni Safinaz el-Toukhy Tamer Hussein Biological Anthropology Department Medical Research DivisionNational Research CentreCairoEgypt Clinical Genetics Department National Research CentreCairoEgypt Medical Biochemistry Department Medical Research DivisionNational Research CentreCairoEgypt Reproductive Health Research Department Medical Research DivisionNational Research CentreCairoEgypt

Metabolic syndrome(MS)is a cluster of metabolic *** and MS are always accompanied by elevated oxidative stress which might affect cellular biomolecules such as *** aim of the present study is to investigate DNA damage profile in obese premenopausal women and its relation to the risk of MS,polycystic ovary syndrome(PCOS)and history of recurrent *** study included 90 obese women included cases with MS(nZ30),PCOS(n Z30)and previous history of recurrent preeclampsia(nZ30)and,age-matched healthy non-obese control women(n Z 50).The assessment of leukocyte DNA damage was done by comet assay for all cases and *** and biochemical parameters have been *** showed that mean percent of DNA damage was significantly higher in MS,PCOS as well as in women with the recurrent preeclampsia as compared to healthy *** high level of mean DNA damage frequency in obese women was significantly associated with the increased number of metabolic syndrome *** with 2,3 and 3e5 components showed significantly higher levels of DNA damage than ***,cases with 3e5 MS components showed significant higher DNA compared to those with the two *** PCOS,significant positive association between the mean frequency of DNA damage and waist circumference was *** study suggests that metabolic abnormalities,PCOS and recurrent pre-eclampsia might be contributed in development of DNA damage in obese *** damage can serve as an early marker for obesity complications in premenopausal women.

关键词： DNA damage Metabolic components Obesity PCOS Recurrent preeclampsia

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Optimized Ensemble Algorithm for Predicting Metamaterial Antenna Parameters

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Computers, Materials & Continua 2022年第6期71卷 4989-5003页

作者： el-Sayed M.el-kenawy Abdelhameed Ibrahim Seyedali Mirjalili Yu-Dong Zhang Shaima elnazer Rokaia M.zaki Department of Communications and electronics Delta Higher Institute of Engineering and TechnologyMansoura35111Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Computer Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansoura35516Egypt Centre for Artificial Intelligence Research and Optimization Torrens University AustraliaFortitude ValleyQLD 4006Australia Yonsei Frontier Lab Yonsei UniversitySeoul03722Korea School of Computing and Mathematical Sciences University of LeicesterLeicesterLE17RHUK Nile Higher Institute for Engineering and Technology MansouraEgypt Computer and Information Technology College Taif UniversityTaifSaudi Arabia Higher Institute of Engineering and Technology Kafrelsheikh Department of electrical Engineering Shoubra Faculty of EngineeringBenha UniversityEgypt

Metamaterial Antenna is a subclass of antennas that makes use of metamaterial to improve *** antennas can overcome the bandwidth constraint associated with tiny *** learning is receiving a lot of interest in optimizing solutions in a variety of *** learning methods are already a significant component of ongoing research and are anticipated to play a critical role in today’s *** accuracy of the forecast is mostly determined by the model *** purpose of this article is to provide an optimal ensemble model for predicting the bandwidth and gain of the Metamaterial *** Vector Machines(SVM),Random Forest,K-Neighbors Regressor,and Decision Tree Regressor were utilized as the basic *** Adaptive Dynamic Polar Rose Guided Whale Optimization method,named AD-PRS-Guided WOA,was used to pick the optimal features from the *** suggested model is compared to models based on five variables and to the average ensemble *** findings indicate that the presented model using Random Forest results in a Root Mean Squared Error(RMSE)of(0.0102)for bandwidth and RMSE of(0.0891)for *** is superior to other models and can accurately predict antenna bandwidth and gain.

关键词： Metamaterial antenna machine learning ensemble model feature selection guided whale optimization support vector machines

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Spinal genesis of Mayer waves

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Neural Regeneration Research 2020年第10期15卷 1821-1830页

作者： George zaki Ghali Michael George zaki Ghali Emil zaki Ghali United States Environmental Protection Agency ArlingtonVAUSA Department of Toxicology Purdue UniversityWest LafayetteINUSA Department of Neurological Surgery Houston Methodist HospitalHoustonTXUSA Department of Neurobiology and Anatomy Drexel University College of MedicinePhiladelphiaPAUSA Department of Medicine Inova Alexandria HospitalAlexandriaVAUSA Department of Cardiothoracic Surgery El Gomhoureya General HospitalAlexandriaEgypt

Variability in cardiovascular spectra was first described by Stephan Hales in *** and Hering initially noted respirophasic variation of the arterial pressure waveform in 1865 and Sigmund Mayer noted a lower frequency oscillation of the same in anesthetized rabbits in *** low frequency oscillations were noted by Barcroft and Nisimaru in 1932,likely representing vasogenic *** the origins of Traube Hering and very low frequency oscillatory variability in cardiovascular spectra are well described,genesis mechanisms and functional significance of Mayer waves remain in *** theories have posited baroreflex and central supraspinal mechanisms for genesis of Mayer *** studies have demonstrated the persistence of Mayer waves following high cervical transection,indicating a spinal capacity for genesis of these *** suggest a general tendency for central sympathetic neurons to oscillate at the Mayer wave frequency,the presence of multiple Mayer wave oscillators throughout the brainstem and spinal cord,and possible contemporaneous genesis by baroreflex and vasomotor mechanisms.

关键词： Mayer waves genesis origins central sympathogenesis spinal cord cervical transection

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Versatile synthesis of cadalene and iso-cadalene from himachalene mixtures:Evidence and application of unprecedented rearrangements

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Chinese Chemical Letters 2020年第7期31卷 1851-1854页

作者： Mustapha Ait el Had Abdelouahd Oukhrib Mohamed zaki Martine Urrutigoity Ahmed Benharref Remi Chauvin Laboratoire de Chimie Biomoleculaire Substances Naturelies et Reactivite(URAC 16)Faculte des Sciences SemlaliaUniversite Cadi AyyadB.P.2390MarrakechMorocco CNRS LCC(Laboratoire de Chimie de Coordination)BP 4409931077Toulouse Cedex 4France INP-ENSIACET 4 allee Emile Monso31030Toulouse CedexFrance Universite de Toulouse UPSICT-FR 259931062Toulouse Cedex 9France

From a mixture of α-,β-and y-himachalenes extracted from waste wood of Atlas cedar(Cedrus atlantica),cadalene(1,6-dimethyl-4-isopropylnaphthalene)and iso-cadalene(1,6-dimethyl-3-isopropylnaphthalene)were produced in two steps with up to 71%±5%yield through the ar-himachalene intermediate using I2 and/or AlCl3 as *** selectivity is shown to sharply depend on the operating conditions:while I2/AlCl3 in dichloromethane promotes the formation of cadalene,the formation of iso-cadalene is favored in the presence of AlCl3 in *** bicyclic aromatic compounds were thus obtained through unique rearrangements involving sequential C—C bond cleavage/fo rmation and hydride transfer *** the absence of AlCl3 or I2,dihydrocurcumene was also found to be formed with up to 70%selectivity.A tentative mechanism is proposed and discussed.

关键词： Aromatic reactivity Cadalenes Dihydrocurcumene Himachalenes Rearrangements

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Maternal-Fetal Hepatitis E Transmission:Is It Underestimated?

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Journal of Clinical and Translational Hepatology 2014年第2期2卷 117-123页

作者： Maysaa el Sayed zaki Mohammed Magdy Abd el Razek Hassan Magdy Abd el Razek Clinical Pathology Mansoura Faculty of Medicine Egypt Mansoura University Hospital Egypt

Hepatitis E virus (HEV) is an enterically transmitted virus;and several modes of transmission have been proposed, including blood transfusion, person to person transmission, and transplacental transmission. HEV during pregnancy is asso-ciated with an unfavorable prognosis for mothers and in severe cases can cause acute fulminate hepatitis and death. Transplacental transmission of HEV usually results in unfa-vorable outcomes of pregnancy, mainly fetal loss, preterm labor, and hepatic dysfunction in neonates. In this review, we will summarize the effects of HEV on maternal-fetal health in various clinical situations.

关键词： Hepatitis E virus Vertical transmission Prevention

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Gene expression of 49 kDa apyrase,cytoskeletal proteins,ATPase,ADPase and amino acid contents of Pisum sativum(L.)cells germinated in Euryops arabicus(*** Jaub.&Spach)water extract

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BIOCelL 2019年第2期43卷 81-87页

作者： mahmoud MOUSTAFA SAAD ALAMRI HOIDA zaki NAGLAA LOUTFY TAREK TAHA ALI SHATI MOHAMED ALKAHTANI SAJDA SIDDIQI Department of Biology College of ScienceKing Khalid University9004AbhaKingdom of Saudi Arabia(KSA) Department of Botany Faculty of ScienceSouth Valley UniversityQenaEgypt Environmental Biotechnology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)City of Scientific Research and Technological Applications(SRTA-City)New Borg El-Arab City21934AlexandriaEgypt

The present research reports of quick and marked changes induced by plant extract of Euryops arabicus in the gene expression of 49-kDa apyrases,cytoskeletal proteins,ATPases,ADPase and amount of amino acid of pea(Pisum sativum ***).Pellets of cytoskeletals proteins(27000 xg)were probed with anti-apyrase antibody,biotinylated anti-rat,actin and alpha and beta-tubulin for Western *** and ADPase activities were determined based on the hydrolytic efficacy of adenine triphosphate and adenine *** 72 hours,the abundance of apyrases,cytoskeletal proteins and amount of amino acid in pellets of 27000 xg of germinated pea seeds in *** extracts were sharply increased than those sown in distilled *** the samples exhibited that the stems had more amount from apyrases,cytoskeletal proteins,amino acids and ATPase and ADPase activities than primary leaves and primary roots that were germinated either on *** water extract or in distilled *** on the enzyme’s capability to hydrolyse nucleotide triphosphate and nucleotide diphosphate as well as the direct association between expression of 49-kDa apyrase and cytoskeletal proteins,*** water extract had an important effect on plant germinations.

关键词： Cytoskeletal proteins ATPase ADPase Pisum sativum Euryops arabicus

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Communication-less Management Strategy for electric Vehicle Charging in Droop-controlled Islanded Microgrids

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1227-1238页

作者： Abdullah Azhar Al-Obaidi Mohammed zaki el-Sharafy Hany E.Z.Farag Saifullah Shafiq Ali Al-Awami Independent electricity System Operator(IESO) MississaugaCanada Department of electrical Engineering and Computer Science York UniversityTorontoCanada University of Queensland StLucia QLD 4067Australia Department of electrical Engineering King Fahd University of Petroleum&MineralsDhahranSaudi Arabia

Adopting high penetration levels of electric vehicles(EVs) necessitates the implementation of appropriate charging management systems to mitigate their negative impacts on power distribution networks. Currently, most of the proposed EV charging management techniques rely on the availability of high-bandwidth communication links. Such techniques are far from realization due to(1) the lack of utility-grade communication systems in many cases such as secondary(low-voltage) power distribution systems to which EVs are connected, rural areas, remote communities, and islands, and(2) existing fears and concerns about the data privacy of EV users and cyber-physical security. For these cases, appropriate local control schemes are needed to ensure the adequate management of EV charging without violating the grid operation requirements. Accordingly, this paper introduces a new communication-less management strategy for EV charging in droop-controlled islanded microgrids. The proposed strategy is autonomous, as it is based on the measurement of system frequency and local bus voltages. The proposed strategy implements a social charging fairness policy during periods when the microgrid distributed generators(DGs) are in short supply by allocating more system capacity to the EVs with less charging in the past. Furthermore, a novel communication-less EV load shedding scheme is incorporated into the management strategy to provide relief to the microgrid during events of severe undervoltage or underfrequency occurrences due to factors such as high loading or DG outages. Numerical simulations demonstrate the superiority of the proposed strategy over the state-of-the-art controllers in modulating the EV charging demand to counteract microgrid instability.

关键词： Charging battery management communication-less control droop control electric vehicle islanded microgrid

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Association of vitamin D receptor gene polymorphism(VDR)with vitamin D deficiency,metabolic and inflammatory markers in Egyptian obese women

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Genes & Diseases 2017年第3期4卷 176-182页

作者： Moushira zaki Sanaa Kamal Walaa ABasha Eman Youness Wafaa Ezzat Hala el-Bassyouni Khalda Amr Biological Anthropology Department National Research CentreGizaEgypt Medical Biochemistry Department National Research CentreGizaEgypt Internal Medicine Department National Research CentreGizaEgypt Clinical Genetics Department National Research CentreCairoEgypt Medical Molecular Genetics Department National Research CentreEgypt

Vitamin D deficiency might contribute to the pathogenesis of metabolic syndrome and could cause immune *** aim of this study is to analyze the associations between Vitamin D receptor(VDR)gene polymorphism,serum 25-hydroxy vitamin D,metabolic and inflammatory biomarkers in Egyptian obese *** study included 201 obese women with vitamin D deficiency and 249 obese matched age healthy controls with sufficient vitamin D *** age ranged between 25 and 35 *** biomarkers(interleukin-6 and C-reactive protein)and serum 25(OH)D were measured by enzyme-linked immunosorbent *** resistance(IR)was determined by the homeostasis model assessment of insulin resistance(HOMA-IR).Vitamin D receptor(VDR)gene polymorphisms of FokI,ApaI,and TaqI were studied by PCR using the restriction fragment length polymorphism(RFLP)*** women with vitamin D deficiency had significant higher values of inflammatory and metabolic parameters compared to ***-logistic regression showed associations between 25(OH)D deficiency and metabolic components when comparing cases with ***,cases carrying polymorphic alleles showed significant lower levels of serum 25(OH)D and higher HOMA-IR,blood pressure levels and lipid parameters compared to those with the wild type homozygote in obese cases with vitamin D *** D deficiency in Egyptian obese women with vitamin D deficiency is associated with abnormal metabolic components and abnormal inflammatory ***,VDR polymorphisms play important role in immune and inflammation status.

关键词： Inflammatory biomarkers Obese women Vitamin D deficiency Vitamin D receptor(VDR)gene polymorphism Egyptian

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Recovery of some valuable elements from lamprophyre dykes in the Abu Rusheid area, Southeastern Desert, Egypt

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Chinese Journal Of Geochemistry 2012年第1期31卷 64-73页

作者： zaki D.I. Shawky N. el-Sheikh E.M. Ahmed F.Y. Ibrahim M.E. Nuclear Materials Authority El MaadiP.O.Box 530 CairoEgypt Chemistry Dept. Faculty of Science for GirlAl-Azhar UniversityEgypt

In the Abu Rusheid area, Southeastern Desert of Egypt, polymineralized (HREEs, U, Zn and Pb) lam-prophyre dykes are recently recorded. The lamprophyre dykes cut cataclastic rocks along share zones in NNW-SSE trends. The secondary U-minerals are essentially represented by uranophane, kasolite, torbernite and autunite. Ex-perimental work was carried out on the lamprophyre dykes for the recovery of uranium and other valuable elements (e.g. Zn, Pb and Al) from 50 kg of technological sample. The optimum conditions were: 100 g/L sulfuric acid con-centration, 1:5 S/L (solid/liquid) and soaking for 15 days at room temperature. The leaching efficiencies for the re-covery of uranium and other elements like Al, Zn and Pb were 40, 33.6, 98.8 and 78, respectively.

关键词：有价元素煌斑岩岩脉沙漠埃及价值最佳工艺条件实验工作

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Effects of penicillamine, hypotaurine, and epinephrine on motility, hyperactivity, acrosome reaction of fresh ram sperm

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Asian pacific Journal of Reproduction 2017年第6期6卷 283-288页

作者： K.H.el-Shahat M.I.Taysser M.R.Badr K.A.zaki Department of Theriogenology Faculty of Veterinary MedicineCairo University Department of Animal Reproduction and Artificial Insemination Reproduction Research Institute Agriculture Research CenterEgypt el-Shieh Zaied Veterinary Clinic Egypt

Objective:To determine the effects of different concentrations of penicillamine, hypotaurine, and epinephrine (PHE) as well as incubation time on motility, hyperactivity and acrosome reaction (AR) of ram spermin ***: Freshly ejaculated spermatozoa from three ram were collected, pooled and subjected to swim up technique in modified sperm Tyrode's albumin lactate pyruvate medium supplemented with different concentrations of PHE (10, 20, 30, 40, 50, 75 and 100 mM/mL). Then best concentrations were compared and examined for motility, hyperactivity and ***: A high concentrations of PHE (30, 40, 50, 75 and 100mM/mL) showed a significant increase in motility when compared to control immediately after dilution and exist for the first and second hour of incubation period. However, when longer incubation time were used, a significant (Pelationship was detected where the maximum value of total AR was shown in spermatozoa treated with 75 mM/mL PHE for 4 h. Conclusions: To obtain better motility, hyperactivity and AR, treatment of ram spermatozoa with 75 mM/mL PHE for 4 h before being used in insemination was considered the best concentration of PHE to be used in the process ofin-vitro fertilization.

关键词： Ram sperm Capcitation Hyperactivation Acrosome reaction PHE VF

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