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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第12期13卷 915-925页

作者： Iman mohseni A.R.Khalim RASHID Department of Civil Engineering Universiti Kebangsaan Malaysia(National University of Malaysia)

Concrete precast multicell box-girder(MCB) bridges combine aesthetics with torsional stiffness *** analytical studies indicate that currently available specifications are unable to consider the effect of the twisting moment(torsional moment) on bridge *** straight bridges the effect of torsion is negligible and the transverse reinforced design is governed by other ***,in the case of skewed bridges the effect of the twisting moment should be ***,an in-depth study was performed on 90 concrete MCB bridges with skew angles ranging from 0° to 60°.For each girder the bridge actions were determined under the American Association of State Highway and Transportation Officials(AASHTO) live load *** analytical results show that torsional stiffness and live load positions greatly affected the bridges' *** addition,based on a statistical analysis of the obtained results,several skew correction factors are proposed to improve the precision of the simplified Henry's method,which is widely used by bridge engineers to predict bridge *** relationship between the bending moment and secondary moments was also investigated and it was concluded that all secondary actions increase with an increase in skewness.

关键词： Distribution factor Live loads Skewed bridges Grillage analysis

Synthesis and antibacterial activity of ethyl 2-amino-6-methyl-5-oxo-4-aryl-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylate

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Chinese Chemical Letters 2014年第3期25卷 431-434页

作者： Sakineh Asghari Samaneh Ramezani Mojtaba mohseni Department of Organic Chemistry Faculty of ChemistryUniversity of Mazandaran Nano and Biotechnology Research Group University of Mazandaran Department of Microbiology Faculty of SciencesUniversity of Mazandaran

The three-component reaction of 4-hydroxy-l-methyl-2（1H）-quinolinone, aromatic aldehydes and ethyl cyanoacetate was carried out in the presence of a catalytic amount of 4-dimethyl aminopyridine （DMAP） in aqueous ethanol. The reactions result in the formation of pyranoquinoline derivatives in excellent yields. Antibacterial activity has been evaluated against Gram positive and Gram negative bacteria for some of the synthesized compounds. The results indicated that these compounds are moderately effective against bacterial growth and their effectiveness is highest against Pseudomonas aeruginosa.

关键词： Three-component reactionPyranoquinoline4-Dimethyl aminopyridine (DMAP)Antibacterial activity

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道德型领导对亲组织非伦理行为的影响

道德型领导对亲组织非伦理行为的影响

作者： mohseni HAFIZULLAH 山西大学

学位级别：硕士

人类行为的复杂性和工作的多样性导致了一种新现象的出现,这种现象被称为亲组织非伦理行为,引起了行为科学家的注意。作为一个相当新的概念,组织心理学在这一领域缺乏足够的研究。亲组织非伦理行为在商业界中产生了很大的影响,能够破坏... 详细信息

人类行为的复杂性和工作的多样性导致了一种新现象的出现,这种现象被称为亲组织非伦理行为,引起了行为科学家的注意。作为一个相当新的概念,组织心理学在这一领域缺乏足够的研究。亲组织非伦理行为在商业界中产生了很大的影响,能够破坏人与人之间的信任,同时也会对社会团体或组织的声誉带来负面影响。此外,工作环境中的亲组织非伦理行为被定义为违反企业道德型的一种不良行为。本论文的目的是要了解导致员工参与亲组织非伦理行为的不同前因,但这种行为也被定义为能够使组织受益的行为。在本文中,我们旨在研究道德型领导对亲组织非伦理行为(UPB)的间接影响。借鉴社会认同理论,与主管的认同(社会认同)被假设为连接道德型领导和亲组织非伦理行为的中介。此外,我们旨在调查道德勇气在道德型领导与UPB之间的关系中的调节作用。基于分布在伊朗共和国不同机构和行政部门的350名员工的样本,所有问卷均以电子方式完成。我们使用两个不同的样本进行了两项研究:一项以150名员工为样本,另一项以伊朗200名企业员工为样本。为了检验这些假设,线性回归分析已用于支持4个假设,其中SPSS Statistics 21、Amos和Andrew Hayes(2013)的Process v3.4.1获得了区间偏差校正指数(使用5,000个引导样本),包括对条件过程的分析。此外,结果还表明,道德勇气调节了与主管认同对道德型领导与UPB之间关系的中介作用。我们通过证明道德型领导通过其对与主管的认同的影响间接地对UPB产生矛盾的影响来为文献做出贡献,因此可以更好地理解道德型领导如何以及何时影响UPB。将使后续行中的分析更加明确。作者认为,组织应该表达他们的意图和行动来减少这种行为倾向。本文有望通过总结现有著作的亮点来帮助该领域的进一步研究。

关键词：道德型领导与主管的认同道德勇气亲组织非伦理行为

Green bio-synthesis of Ni/montmorillonite nanocomposite using extract of Allium jesdianum as the nano-catalyst for electrocatalytic oxidation of methanol

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Chinese Journal of Chemical Engineering 2020年第10期28卷 2555-2565页

作者： Mohammad Hossein Sheikh-mohseni Sajjad Sedaghat Pirouz Derakhshi Aliakbar Safekordi Department of Chemistry Science and Research BranchIslamic Azad UniversityTehranIran Department of Chemistry Shahr-e-Qods BranchIslamic Azad UniversityShahr-e-QodsIran Department of Chemistry North Tehran BranchIslamic Azad UniversityTehranIran

In this work,synthesis of Ni nanoparticles was carried out successfully by water extract of Allium jesdianum as a biochemical reducing agent in the presence of montmorillonite clay(MMT)as a natural solid support for the first *** the electrochemical activity of the synthesized nanocomposite was investigated in methanol electrocatalytic *** with high cation exchange capacity and nano layer structure was exposed to ion exchange conditions in nickel *** Ni^2+ion exchanged form was used in this process as a source of ions and also capping *** extract of Allium jesdianum used as a reducing agent due to abundant availability of phenolic and flavonoid *** synthesized Ni/MMT nanocomposite was characterized using UV–Vis spectroscopy(UV–Vis),Fourier Transform Infrared Spectroscopy(FT-IR),X-ray diffraction(XRD),Scanning Electron Microscopy(SEM),Transmission electron microscopy(TEM)and Energy-dispersive X-ray spectroscopy(EDX).The surface of prepared modified electrode has been characterized using SEM to evaluate the morphology,showing uniform dispersion of Ni nanoparticles with mean diameter of 12 to 20 *** modified carbon paste electrode was then used in methanol electrocatalytic oxidation *** oxidation on the proposed modified electrode surface occurs at 0.6 V and 0.3 V in alkaline and acidic medium ***,the results showed the better performance of modified electrode toward methanol electrocatalytic oxidation in comparison with carbon paste electrode that is modified by ion exchanged *** transfer coefficients and apparent charge transfer rate constant for the modified electrode in the absence of methanol in alkaline medium were respectively found as:αa=0.53,αc=0.37 and ks=1.6×10^-1 s^-***,the average value of catalytic rate constant for the electrocatalytic oxidation of methanol by the prepared nano-catalyst was estimated to be about 0.9 L·mol^-1·s^-1 by chronoamperometry *** prepare

关键词： Green biosynthesis Nanoparticles Montmorillonite Biocatalysis Methanol electrocatalytic oxidation Fuel cell

WDR76 Exerts Oncogene Function in Hepatocellular Carcinoma Via the G2/M Checkpoint Signaling Pathway

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WDR76 Exerts Oncogene Function in Hepatocellular Carcinoma V...

作者： mohseni Ghazal 山东大学

学位级别：硕士

研究背景:肝癌是致死率最高的胃肠道疾病之一,其中肝细胞癌(Hepatocellular carcinoma,HCC)是最常见的肝癌类型,发生率约占所有肝癌类型的90%。肝细胞癌是全球第六大常见癌症,也是癌症相关死亡的第三大原因,患者的五年生存率为19.6%,且... 详细信息

研究背景:肝癌是致死率最高的胃肠道疾病之一,其中肝细胞癌(Hepatocellular carcinoma,HCC)是最常见的肝癌类型,发生率约占所有肝癌类型的90%。肝细胞癌是全球第六大常见癌症,也是癌症相关死亡的第三大原因,患者的五年生存率为19.6%,且晚期和转移期的病人生存率仅为2.5%。乙肝病毒(Chronic hepatitis B virus,HBV)和丙肝病毒(Chronic hepatitis C virus,HCV)的感染被认为是肝细胞癌发生的主要原因,并且非酒精性脂肪肝(Nonalcoholic fatty liver disease,NAFLD)也会增加肝细胞癌的风险。据报道肝细胞癌是由不同的病理机制所引起的,其中细胞周期调节紊乱是主要机制之一,许多不同类型的蛋白质被发现可以调节肝细胞癌的细胞周期进程,进而参与肿瘤的发生发展。WDR-containing蛋白是包含多个WD40重复结构域的蛋白质家族,可以参与真核生物的多种功能调节,包括细胞周期调节、细胞凋亡、信号转导、RNA合成和加工以及染色质组装等。其中,WDR76(WD repeat-containing protein 76)是重要的WDR-containing蛋白之一,存在于异染色质和细胞核中,并与DNA修复蛋白进行共定位。基于WDR76的三维结构,WDR结构域可以作为许多结合蛋白的相互作用位点,参与DNA损伤识别和修复,染色质结合,DNA甲基化水平调节等不同的生物学过程。研究发现WDR76在不同类型的癌症中起着关键作用,但其对肝细胞癌的细胞周期的影响尚不清楚。研究目的:本研究主要探讨在肝细胞癌的发生发展中,WDR76及其相关基因通过调控细胞周期和细胞增殖,影响肝细胞癌进展的功能机制。材料方法:本研究利用癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库分析发现WDR76与肝癌之间存在相关性。利用免疫组织化学染色(Immunohistochemistry,IHC)检测WDR76在肿瘤组织和正常组织中的表达差异,并使用蛋白质免疫印迹法(Western blotting)检测 WDR76 在不同类型的肝癌细胞系(Huh-7,HepG2,SkHep1 and PLCPRF5)和正常肝细胞系(THLE-2)中的表达差异。采用实时细胞分析(Real-time cell analysis,RTCA)与克隆形成技术检测WDR76对肝癌细胞增殖能力的影响。采用流式细胞术分析WDR76与肝癌细胞周期进程的调控关系。采用实时荧光定量PCR(quantitative real-time PCR,qRT-PCR)技术检测G2/M检查点信号通路相关基因的表达水平,并检测其与WDR76表达的相关性。研究结果:通过TCGA、GEO在线数据库和Kaplan-Meier Plotter生存曲线分析,发现WDR76在肝癌组织中高表达并且与患者的不良预后相关。通过Western blotting检测发现,相比于正常肝细胞系,WDR76在不同类型的肝癌细胞系中高表达。IHC结果显示,与正常组织相比,WDR76在肝癌组织中高表达。在Huh-7细胞系中,利用慢病毒稳转技术过表达或敲低WDR76,采用RTCA和克隆形成实验检测发现,相比于对照组,过表达WDR76可以促进肝癌细胞的增殖能力;敲低WDR76则结果相反。在Huh-7细胞系中过表达或敲低WDR76后,利用caspase3/7细胞活性凋亡试剂盒检测发现,相比于对照组,过表达WDR76会抑制肝癌细胞的凋亡;敲低WDR76则结果相反。此外,流式细胞术的实验结果表明,在Huh-7细胞系中过表达WDR76可以刺激G2/M检查点信号的激活,通过qRT-PCR检测G2/M检查点相关的基因的表达水平,包括BUB1有丝分裂检查点丝氨酸/苏氨酸激酶(BUB1 mitotic checkpoint serine/threonine kinase,BUB1),细胞分裂周期蛋白6(Celldivisioncycle protein6,CDC6),细胞分裂周期蛋白45(Cell division cycle protein 45,CDC45),检查点激酶 1(Checkpoint kinase 1,CHEK1)和驱动蛋白家族成员4A(Kinesin Family Member 4A,KIF4A),实验结果表明,过表达WDR76后,这些基因的mRNA水平显著上升。研究结论:本研究发现WDR76在肝癌组织与细胞系中高表达。WDR76在肝癌细胞中的高表达可以促进细胞增殖、抑制细胞凋亡,并通过调节G2/M检查点信号通路促进肝细胞癌的发生和发展,提示WDR76是肝癌的潜在治疗靶点。

关键词：肝细胞癌 WDR76 细胞周期调节 G2/M检查点信号通路

Islet transplantation and antioxidant management: A comprehensive review

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World Journal of Gastroenterology 2009年第10期15卷 1153-1161页

作者： Seyed Sajad mohseni Salehi Monfared Bagher Larijani Mohammad Abdollahi Faculty of Pharmacy Pharmaceutical Sciences Research Centre Tehran University of Medical Sciences Tehran *** Iran Endocrinology and Metabolism Research Center Tehran University of Medical Sciences Tehran *** Iran

Islet transplantation as a promising treatment for type 1 diabetes has received widespread attention. Oxidative stress plays an essential role in cell injury during islet isolation and transplantation procedures. Antioxidants have been used in various studies to improve islet transplantation procedures. The present study reviews the role of oxidative stress and the benefits of antioxidants in islet transplantation procedures. The bibliographical databases Pubmed and Scopus were searched up to November 2008. All relevant human and animal in-vivo and in-vitro studies, which investigated antioxidants on islets, were included. Almost all the tested antioxidants used in the in-vitro studies enhanced islet viability and insulin secretion. Better control of blood glucose after transplantation was the major outcome of antioxidant therapy in all in-vivo studies. The data also indicated that antioxidants improved islet transplantation procedures. Although there is still insuffi cient evidence to draw definitive conclusions about the efficacy of individual supplements, the benefi ts of antioxidants in islet isolation procedures cannot be ignored.

关键词：抗氧化剂胰岛移植胰岛分泌胰岛素抗氧化治疗管理 PubMed 氧化应激胰岛分离

Three-component synthesis and antibacterial evaluation of some novel 1,2-dihydroisoquinoline derivatives

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Chinese Chemical Letters 2014年第11期25卷 1441-1444页

作者： Sakineh Asghari Nastaran Malekian Roya Esmaeilpour Mohammad Ahmadipour Mojtaba mohseni Department of Organic Chemistry Faculty of Chemistry University of Mazandaran Nano and Biotechnology Research Group University of Mazandaran Department of Microbiology Faculty of Science University of Mazandaran

Isoquinoline reacts with dialkyl acetylenedicarboxylates in the presence of kojic acid or8-hydroxyquinoline to generate 1,2-dihydroisoquinoline derivatives. The simplicity, mild reaction conditions and high yields of products make it an interesting process compared to other approaches. The compounds have been analyzed for antibacterial activity against Gram negative and Gram positive bacteria. The results indicated that 1,2-dihydroisoquinolines derived from kojic acid are effective against all of the studied bacteria especially against Bacillus subtilis, while the products obtained from8-hydroxyquinoline are active only against Gram positive bacteria.

关键词： Kojic acid 8-Hydroxyquinolone Dialkyl acetylenedicarboxylates 1 2-Dihydroisoquinoline Isoquinoline Antibacterial activity

Synthesis, Characterization and Solvatochromism Investigation of Mixed Ligand Chelate Copper（Ⅱ） Complexes with Acetyleacetonate and Three Diamine Ligands

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Chinese Journal of Chemistry 2012年第8期30卷 1873-1880页

作者： Golchoubian Hamid Afshar Zahra mohseni Moayyedi Golasa Bruno Giuseppe Rudbari Hadi Amiri Department of Chemistry University of Mazandaran Babol-sar Postal Code 47416-95447 Iran Dipartimento di Chimica Inorganica Vill. S. Agata Salita Sperone 31 Universith di Messina 98166 Messina Italy

The syntheses of three mixed ligand chelate copper（II） complexes of the type [Cu（L）（acac）（H2O）]BPh4 where acac=acetyleacetonate; L=N,N-dimethyl,N′-benzylethane-1,2-diamine （L1）, N,N-dimethyl, N′-2-methylbenzylethane-1,2-diamine （L2） or N,N-dimethyl,N′-2-chlorobenzylethane-1,2-diamine （L3） are reported and characterized by elemental analyses, spectroscopic and molar conductance measurements. The X-ray structure of complex 1 shows that the central copper atom is placed in a distorted square pyramidal geometry made by acac and diamine chelate in the base and a H2O molecule on the apex. The prepared complexes are fairly soluble in a large number of organic solvents and show positive solvatochromism. Calculations of SMLR （stepwise multiple linear regression） method was utilized to find the best model explaining the observed solvatochromic behavior and showed that among different solvent parameters, donor number （DN） is a dominant factor responsible for the shift in the d-d absorption band of the complexes to the lower wavenumber with increasing its values. The importance of substituent effect in diamine ligand on the spectral and SMLR measurements is also discussed.

关键词： mixed-chelate solvatochromism X-ray crystal structure SMLR method diamine copper(Ⅱ) tetra-phenylborate

Nonsingular Terminal Sliding Mode Control With Ultra-Local Model and Single Input Interval Type-2 Fuzzy Logic Control for Pitch Control of Wind Turbines

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IEEE/CAA Journal of Automatica Sinica 2021年第3期8卷 690-700页

作者： Saber Abrazeh Ahmad Parvaresh Saeid-Reza mohseni Meisam Jahanshahi Zeitouni Meysam Gheisarnejad Mohammad Hassan Khooban Department of Electrical and Electronics Engineering Shiraz UniversityShiraz ***Iran Department of Electrical Engineering Shahid Bahonar University of KermanKerman 76169-14111Iran Sharif University of Technology Tehran ***Iran Shiraz University of Technology Shiraz ***Iran Department of Electrical Engineering Najafabad BranchIslamic Azad UniversityIsfahan ***Iran Department of Electrical and Computer Engineering Aarhus University8200 AarhusDenmark

As wind energy is becoming one of the fastestgrowing renewable energy resources,controlling large-scale wind turbines remains a challenging task due to its system model nonlinearities and high external *** main goal of the current work is to propose an intelligent control of the wind turbine system without the need for model *** this purpose,a novel model-independent nonsingular terminal slidingmode control(MINTSMC)using the basic principles of the ultralocal model(ULM)and combined with the single input interval type-2 fuzzy logic control(SIT2-FLC)is developed for non-linear wind turbine pitch angle *** the suggested control framework,the MINTSMC scheme is designed to regulate the wind turbine speed rotor,and a sliding-mode(SM)observer is adopted to estimate the unknown phenomena of the *** auxiliary SIT2-FLC is added in the model-independent control structure to improve the rotor speed regulation and compensate for the SM observation estimation *** examinations and comparative analyses were made using a real-time softwarein-the-loop(RT-SiL)based on the dSPACE 1202 board to appraise the efficiency and applicability of the suggested modelindependent scheme in a real-time testbed.

关键词： Interval type-2(IT2)fuzzy logic control modelindependent nonsingular terminal sliding-mode control(MINTSMC) pitch angle control real-time software-in-the-loop(RT-SiL)

Designing New Controller for Fed-batch Cultivation of Recombinant ***

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