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Effects of improved amino acid balance diet on lysine mammary utilization, whole body protein turnover and muscle protein breakdown on lactating sows

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2031-2043页

作者： Sai Zhang Juan C.Marini Vengai Mavangira Andrew Claude Julie Moore mahmoud A.mohammad Nathalie L.Trottier Department of Animal Science Michigan State UniversityEast Lansing 48824USA State Key Laboratory of Swine and Poultry Breeding Industry Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640PR China USDA/ARS Children’s Nutrition Research Center and Pediatric Critical Care Medicine Department of PediatricsBaylor College of MedicineHoustonTX 77030USA Department of Large Animal Clinical Sciences Michigan State UniversityEast LansingMI 48824USA Present address:Department of Animal Science Cornell UniversityFrank Morrison Hall507 Tower RoadIthacaNY 14853‑4801USA

Background The study objective was to test the hypothesis that low crude protein(CP)diet with crystalline amino acids(CAA)supplementation improves Lys utilization efficiency for milk production and reduces protein turnover and muscle protein *** lactating multiparous Yorkshire sows were allotted to 1 of 2 isocaloric diets(10.80 MJ/kg net energy):control(CON;19.24%CP)and reduced CP with“optimal”AA profile(OPT;14.00%CP).Sow body weight and backfat were recorded on d 1 and 21 of lactation and piglets were weighed on d 1,14,18,and 21 of *** d 14 and 18,a subset of 9 sows(CON=4,OPT=5)was infused with a mixed solution of 3-[methyl-2H3]histidine(bolus injection)and[13C]bicarbonate(priming dose)first,then a constant 2-h[13C]bicarbonate infusion followed by a 6-h primed constant[1-13C]lysine *** blood and milk sampling were performed to determine plasma and milk Lys enrichment,Lys oxidation rate,whole body protein turnover,and muscle protein *** Over the 21-d lactation period,compared to CON,sows fed OPT had greater litter growth rate(P<0.05).Compared to CON,sows fed OPT had greater efficiency of Lys(P<0.05),Lys mammary flux(P<0.01)and whole-body protein turnover efficiency(P<0.05).Compared to CON,sows fed OPT tended to have lower whole body protein breakdown rate(P=0.069).Muscle protein breakdown rate did not differ between OPT and CON(P=0.197).Conclusion Feeding an improved AA balance diet increased efficiency of Lys and reduced whole-body protein turnover and protein *** results imply that the lower maternal N retention observed in lactating sows fed improved AA balance diets in previous studies may be a result of greater partitioning of AA towards milk rather than greater body protein breakdown.

关键词： Amino acid Efficiency Lactating sows Protein breakdown Protein turnover Reduced protein diet

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Recent advances in myeloid-derived suppressor cell biology

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Frontiers of Medicine 2021年第2期15卷 232-251页

作者： mahmoud mohammad Yaseen Nizar mohammad Abuharfeil Homa Darmani Ammar Daoud Department of Biotechnology and Genetic Engineering Department of Applied Biology Faculty of Science and Arts Department of Internal Medicine Faculty of MedicineJordan University of Science and TechnologyIrbid 22110Jordan

In recent years,studying the role of myeloid-derived suppressor cells(MDSCs)in many pathological inflammatory conditions has become a very active research *** the role of MDSCs in cancer is relatively well established,their role in non-cancerous pathological conditions remains in its infancy resulting in much *** objectives in this review are to address some recent advances in MDSC research in order to minimize such confusion and to provide an insight into their function in the context of other *** following topics will be specifically focused upon:(1)definition and characterization of MDSCs;(2)whether all MDSC populations consist of immature cells;(3)technical issues in MDSC isolation,estimation and characterization;(4)the origin of MDSCs and their anatomical distribution in health and disease;(5)mediators of MDSC expansion and accumulation;(6)factors that determine the expansion of one MDSC population over the other;(7)the Yin and Yang roles of ***,the functions of MDSCs will be addressed throughout the text.

关键词： non-human primates(rhesus macaques) myeloid-derived pro-inflammatory cells(MDPCs) autoimmune disorders alloimmune responses pregnancy mature MDSCs multiple sclerosis Yin-Yang law of MDSCs

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Electrospun Aloe Vera Extract Loaded Polycaprolactone Scaffold for Biomedical Applications:A Promising Candidate for Corneal Stromal Regeneration

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Journal of Bionic Engineering 2024年第4期21卷 1949-1959页

作者： Amin Orash mahmoud Salehi mohammad Rafienia Narsimha Mamidi Saeed Heidari Keshel Alireza Baradaran-Rafii Department of Chemistry and Nanotechnology School of Engineering and ScienceTecnologico de MonterreyMonterreyNuevo Leon64849Mexico Biosensor Research Center Isfahan University of Medical SciencesIsfahan81746-73461Iran Wisconsin Center for NanoBioSystems School of PharmacyUniversity of Wisconsin-MadisonMadisonWisconsin53705USA Medical Nanotechnology Research Center Shahid Beheshti University of Medical SciencesTehran19857-17443Iran Department of Ophthalmology Ophthalmic Research CenterLabbafinejad Medical CenterShahid Beheshti University of Medical SciencesTehran19395-4631Iran Department of Ophthalmology Morsani College of MedicineUniversity of South FloridaTampaFL33612USA Department of Tissue Engineering and Applied Cell Science School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehran19857-17443Iran

Corneal diseases,the second leading cause of global vision loss affecting over 10.5 million people,underscores the unmet demand for corneal tissue *** the scarcity of fresh donor corneas and the associated risks of immune rejection,corneal tissue engineering becomes *** nanofibrous scaffolds that mimic the natural corneal structure is crucial for creating transparent and mechanically robust corneal equivalents in tissue ***,Aloe Vera Extract(AVE)/Polycaprolactone(PCL)nanofibrous scaffolds were primed using *** electrospun AVE/PCL fibers exhibit a smooth,bead-free morphology with a mean diameter of approximately 340±95 nm and appropriate light *** measurements reveal Young’s modulus and ultimate tensile strength values of around 3.34 MPa and 4.58 MPa,respectively,within the range of stromal *** addition,cell viability of AVE/PCL fibers was measured against Human Stromal Keratocyte Cells(HSKCs),and improved cell viability was *** cell-fiber interactions were investigated using scanning electron *** conclusion,the incorporation of Aloe Vera Extract enhances the mechanical,optical,hydrophilic,and biological properties of PCL fibers,positioning PCL/AVE fiber scaffolds as promising candidates for corneal stromal regeneration.

关键词： Corneal stromal regeneration Aloe vera extract Polycaprolactone Electrospinning

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自体结膜角巩膜缘移植治疗原发性翼状胬肉

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国际眼科杂志 2008年第3期8卷 456-459页

作者： mahmoud Jabbbarvand mohammad Reza Khalili mohammad Taher Rajabi 德黑兰大学医学院眼科伊朗德黑兰市

目的：评价自体结膜角巩膜缘移植术治疗原发性翼状胬肉的有效性。方法：原发性翼状胬肉患者15例（15眼），接受自体结膜角巩膜缘移植术。切除翼状胬肉后，植片的角膜缘部分与翼状胬肉切除处的角膜缘对位缝合，植片的上皮面向上。纤维血... 详细信息

目的：评价自体结膜角巩膜缘移植术治疗原发性翼状胬肉的有效性。方法：原发性翼状胬肉患者15例（15眼），接受自体结膜角巩膜缘移植术。切除翼状胬肉后，植片的角膜缘部分与翼状胬肉切除处的角膜缘对位缝合，植片的上皮面向上。纤维血管组织在原翼状胬肉区遮盖角膜1mm以上定为复发。结果：随访平均8mo，所有的患者既无一例复发也无并发症发生。结论：单纯翼状胬肉切除联合自体结膜角巩膜缘移植是一种治疗原发性翼状胬肉安全有效的手术方法。

关键词：结膜角巩膜缘自体移植原发性翼状胬肉角巩膜缘干细胞移植结膜移植

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未热解厚热障涂层的隔热能力和黏接强度

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Transactions of Nonferrous Metals Society of China 2024年第4期34卷 1226-1236页

作者： mohammad IZADINIA Reza SOLTANI mahmoud HEYDARZADEH SOHI Javad MOSTAGHIMI School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehranIran Centre for Advanced Coating Technologies Department of Mechanical and Industrial EngineeringUniversity of TorontoTorontoOntarioCanada

对比研究使用未热解粉末制备的厚热障涂层(UPTTBC)和传统TBC、厚TBC(TTBC)及密集垂直裂纹(DVC)TTBC 4种涂层的隔热能力和黏接强度。采用降温法测试涂层的隔热能力;根据ASTM C633标准,采用拉拔试验检测涂层的黏接强度。结果显示,UPTTBC和... 详细信息

对比研究使用未热解粉末制备的厚热障涂层(UPTTBC)和传统TBC、厚TBC(TTBC)及密集垂直裂纹(DVC)TTBC 4种涂层的隔热能力和黏接强度。采用降温法测试涂层的隔热能力;根据ASTM C633标准,采用拉拔试验检测涂层的黏接强度。结果显示,UPTTBC和DVC TTBC的黏接强度分别比TTBC高35%和25%。这可能是由于UPTTBC结构中存在亚微米尺度的未熔化区域,起到了阻止裂纹扩展的作用。此外,隔热测试的结果表明,DVCTTBC涂层的隔热能力最差,为0.28℃/μm,而UPTTBC涂层的隔热能力最强,为0.40℃/μm。由于UPTTBCs显微组织中存在亚微米区域,使涂层展现出优越的隔热能力。相反,DVCTTBC因其致密的结构,具有最低的隔热能力。

关键词：厚热障涂层密集垂直裂纹热障涂层未热解粉末黏接强度隔热能力

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叶酸共轭氧化石墨烯纳米粒声光动力白血病治疗：最新的癌症治疗模式

叶酸共轭氧化石墨烯纳米粒声光动力白血病治疗：最新的癌症治疗模...

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作者： mahmoud MATAR mohammad ABU RAKHEY 山东大学

学位级别：硕士

背景:癌症仍然是目前研究人员的研究热点以及研究难题。白血病是造血干细胞恶性克隆性疾病,其特征是白细胞分化不良并不受调节的增殖。根据受累细胞的类型和增殖程度,将疾病分为髓系和淋巴系白血病,急性和慢性白血病。在成人和儿科患者... 详细信息

背景:癌症仍然是目前研究人员的研究热点以及研究难题。白血病是造血干细胞恶性克隆性疾病,其特征是白细胞分化不良并不受调节的增殖。根据受累细胞的类型和增殖程度,将疾病分为髓系和淋巴系白血病,急性和慢性白血病。在成人和儿科患者中最常见的类型是急性、髓性和淋巴细胞性白血病(AML,ALL),每年每10万人中的发病率和死亡率分别为(4.2、1.7例)和(2.8、0.4例)。慢性粒细胞白血病(CML)约占成人新诊断白血病病例的15%至20%,每年每10万人中的发病率和死亡率分别为1.8和0.4例。化疗、放疗、手术以及联合治疗是被广泛应用的可以治愈或根除肿瘤的方法。尽管化疗是治疗癌症的非常有效的方法,但它往往伴随着严重的副作用。并且肿瘤治疗后存在着复发的风险且更易发生耐药以及放疗抵抗。因此,探寻新的治疗方法对于准确治疗肿瘤和预防癌症转移是必要的。光动力疗法(PDT)治疗方法已被用来治疗不同种类的癌症。PDT涉及光敏药物的摄入,随后用对应于目标区域的敏化剂吸收波长的光照射。影响PDT癌症治疗的因素有癌组织中的光敏剂定位以及传递到该组织的适当光剂量。声动力疗法(SDT)治疗方法已从PDT发展而来,以克服其光照浸润深度浅的缺点。SDT涉及对声波敏感的药物摄入和随后使目标区域暴露于超声波。SDT治疗可以穿透多达几十厘米的组织。因此,SDT结束了 PDT的障碍和主要限制。声光生物调节疗法(SPBMT)是包括摄入光敏剂和声敏剂的一种治疗方法,。多年来,PDT一直与SDT分开进行,在癌症治疗方面取得了不同程度的成功。PDT已被用于对浅表癌症的治疗,而在与SDT结合使用时,对白血病、深部肿瘤和转移扩散转移到肺、肝和骨的肿瘤显示出的显著的疗效。番荔枝(Graviola)是一种小型直立常绿热带果树,高5-6m,属于番荔枝科。graviola通过改变细胞代谢用于癌症治疗,graviola提取物在体外和体内表现出显著的选择性肿瘤抑制作用。目的:本工作旨在评估活化的graviola纳米复合材料用于白血病靶向治疗的疗效。这项工作是在体外(两种白血病细胞系)和体内(90只白血病诱导小鼠)进行的;。激光和超声波被用作能源。材料和方法:在这项工作中,通过生物物理学研究了活化graviola纳米复合材料靶向治疗白血病的生物学有效性[形状、尺寸、吸光度和光致发光使用SEM、TEM、X射线衍射和能量色散(XRD,EDX扫描),UV/Visible扫描光谱仪,PL扫描光谱仪,和傅里叶变换红外光谱(FTIR扫描)],生化[SRB细胞活力和细胞毒性IC50,抗氧化酶活性;超氧化物歧化酶、过氧化氢酶、谷胱甘肽还原酶、谷胱甘肽-s-转移酶、总抗氧化能力(SOD、CAT、GR、GST和TAC)、丙二醛MDA、肝功能检查;丙氨酸氨基转移酶ALT和天冬氨酸氨基转移酶AST,肾功能检查;肌酐和尿素、p53、Bax、Caspase(9,3)、NFkB、TNFalpha、VEGF、Bcl-2 qRT-PCR 相对基因表达],以及血液学[全血细胞计数CBC]分析。结果:结果表明,graviola纳米复合材料是一种潜在的用于癌症治疗的光声敏剂,并且在体外和体内都对抑制癌细胞具有显著作用。结论:我们的研究结果表明,活化的graviola纳米复合材料可用作声光动力治疗(SPDT)癌症靶向的天然纳米增敏剂。

关键词：白血病纳米重力光动力疗法声动力疗法

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Performance Comparison of Hyper-V and KVM for Cryptographic Tasks in Cloud Computing

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Computers, Materials & Continua 2024年第2期78卷 2023-2045页

作者： Nader Abdel Karim Osama A.Khashan Waleed K.Abdulraheem Moutaz Alazab Hasan Kanaker mahmoud E.Farfoura mohammad Alshinwan Department of Intelligent Systems Faculty of Artificial IntelligenceAl-Balqa Applied UniversityAl-Salt1705Jordan Research and Innovation Centers Rabdan AcademyP.O.Box 114646Abu DhabiUnited Arab Emirates Department of Information Systems and Networks TheWorld Islamic Sciences and Education UniversityAmman11947Jordan Department of Cyber Security Isra UniversityAmman1162Jordan Faculty of Science and Information Technology Al-Zaytoonah University of JordanAmman11733Jordan Middle East University Research Unit Middle East UniversityAmman11831Jordan

As the extensive use of cloud computing raises questions about the security of any personal data stored there,cryptography is being used more frequently as a security tool to protect data confidentiality and privacy in the cloud environment.A hypervisor is a virtualization software used in cloud hosting to divide and allocate resources on various pieces of *** choice of hypervisor can significantly impact the performance of cryptographic operations in the cloud *** important issue that must be carefully examined is that no hypervisor is completely superior in terms of performance;Each hypervisor should be examined to meet specific *** main objective of this study is to provide accurate results to compare the performance of Hyper-V and Kernel-based Virtual Machine(KVM)while implementing different cryptographic algorithms to guide cloud service providers and end users in choosing the most suitable hypervisor for their cryptographic *** study evaluated the efficiency of two hypervisors,Hyper-V and KVM,in implementing six cryptographic algorithms:Rivest,Shamir,Adleman(RSA),Advanced Encryption Standard(AES),Triple Data Encryption Standard(TripleDES),Carlisle Adams and Stafford Tavares(CAST-128),BLOWFISH,and *** study’s findings show that KVM outperforms Hyper-V,with 12.2%less Central Processing Unit(CPU)use and 12.95%less time overall for encryption and decryption operations with various file *** study’s findings emphasize how crucial it is to pick a hypervisor that is appropriate for cryptographic needs in a cloud environment,which could assist both cloud service providers and end *** research may focus more on how various hypervisors perform while handling cryptographic workloads.

关键词： Cloud computing performance virtualization hypervisors Hyper-V KVM cryptographic algorithm

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Bearing capacity of circular footings on multi-layered sand-waste tire shreds reinforced with geogrids

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1085-1094页

作者： mahmoud Ghazavi Ehsan Khosroshahi Faculty of Civil Engineering K.N.Toosi University of TechnologyTehranIran

The presence of waste tires poses an environmental challenge as they occupy a significant amount of land and are expensive to dispose in ***,reusing waste tires can address this issue when waste tires are used in geotechnical *** determine the viability of this approach,laboratoryscale tests were conducted to investigate load-bearing capacity of circular footings on sand-tire shred(STS)mixtures with shredded waste tire contents of 5%e15%by weight and three different widths of *** investigation focused on analyzing the thickness of layers composed of STS mixtures,the soil cap,and the impact of geogrids on bearing *** results indicate that a specific mixture of sand and tire shreds provides the highest footing-bearing *** addition,the optimal shred content and size were found to be 10%by weight and 2 cm×10 cm,***,for a given tire shred width,a particular length provides the largest bearing *** results agree well with that of previous research conducted by the first author and his colleagues in direct shear and California bearing ratio(CBR)*** primary finding of this research is that the use of two-layered STS mixtures reinforced by geogrids significantly enhances the bearing capacity.

关键词： Geogrid Sand Waste tire shred Bearing capacity Waste tire shred optimization Tire shred aspect ratio

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Source localization based on field signatures:Laboratory ultrasonic validation

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Journal of Electronic Science and Technology 2024年第3期22卷 47-56页

作者： mahmoud Eissa Dmitry Sukhanov Department of Radiophysics Tomsk State UniversityTomsk634050Russia Higher Institute for Applied Sciences and Technology(HIAST) Damascus31983Syria

Location awareness in wireless networks is essential for emergency services,navigation,gaming,and many other *** article presents a method for source localization based on measuring the amplitude-phase distribution of the field at the base *** existing scatterers in the target area create unique scattered field interference at each source *** unique field interference at each source location results in a unique field signature at the base station which is used for source *** the proposed method,the target area is divided into a grid with a step of less than half the *** grid node is characterized by its field signature at the base *** signatures corresponding to all nodes are normalized and stored in the base station as fingerprints for source *** normalization of the field signatures avoids the need for time synchronization between the base station and the *** a source transmits signals,the generated field signature at the base station is normalized and then correlated with the stored *** maximum correlation value is given by the node to which the source is the *** simulations and results of experiments on ultrasonic waves in the air show that the ultrasonic source is correctly localized using broadband field signatures with one base station and without time *** proposed method is potentially applicable for indoor localization and navigation of mobile robots.

关键词： Base station Field signature Fingerprints Localization Ultrasonic frequencies

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A comparative study of bifacial versus monofacial PV systems at the UK’s largest solar plant

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Clean Energy 2024年第4期8卷 248-260页

作者： Ghadeer Badran mahmoud Dhimish School of Physics Engineering and TechnologyUniversity of YorkYorkYO105DDUnited Kingdom

This paper presents an extensive analysis of the UK’s largest bifacial photovoltaic(PV)power plant,located in North *** in January 2020,this trailblazing facility,with a total installed capacity of 34.7 MW,is a benchmark for the evaluation of bifacial solar technology within the *** pioneering study provides a thorough comparative assessment of bifacial and monofacial PV systems through a methodical investigation of their energy production,degradation rates,and spectral responses over a 4-year operational *** findings reveal that bifacial PV modules,distributed across four segments of the power plant,demonstrate a remarkable average power gain ranging between 15.12%and 17.31%compared with monofacial *** experiencing marginally higher annual degradation rates-1.17%for bifacial compared with 0.91%for monofacial systems-bifacial modules show superior resilience and energy yield,particularly during winter months when albedo effects are pronounced due to snow *** study also highlights the strategic importance of spectral response analysis in optimizing PV *** modules have shown greater efficiency in capturing infrared radiation-a property that could be exploited to enhance overall energy yield under specific environmental *** empirical data indicate a consistent performance of bifacial modules with an average normalized energy output clustering around the expected efficiency ***,the results of this study are pivotal for understanding the practical implications of deploying bifacial PV technology on a large *** provide valuable data for stakeholders in the solar energy sector,guiding future installations and innovations in solar panel technology.

关键词： photovoltaic bifacial PV system energy efficiency renewable energy

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