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Statics of space syntax:Analysis of daylighting

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Frontiers of Architectural Research 2019年第3期8卷 311-318页

作者： Khaled Tarabieh Khaled nassar mahmoud Abdelrahman Islam mashaly Architecture Dept. American University in CairoNew Cairo 11835Egypt Construction Engineering Dept. American University in CairoNew Cairo 11835Egypt Department of Building School of Design and EnvironmentThe National University of SingaporeSingapore

Space syntax involves a set of techniques for analyzing the spatial configurations of various spaces at building and urban *** spaces,such as prayer halls,are exam ples of buildings where observers experience space mostly from a single point of ***,traditional space syntax is mainly used in the analysis of visibility and space cognition in terms of isovists and graph-based *** other aspects of space cognition,such as day lighting,artificial lighting,and glare,are carried in the isolation of the space syntax *** paper proposes the scaling of the space syntax field for the inclusion of other parameters,such as daylighting,and integration of the associated performative measures to space syntax analysis of the mosque typology to aid in the studying of overall space cognition based on com fort and environmental *** present a case study on a typical mosque layout using m ulti-objective optim *** analysis presented in the paper has im plications for the architectural designs of spaces with respect to glare m anagem ent and daylight ***,it is unique and builds on our previous work for the exploration of comfort,visibility,and proximity thresholds for stationary observers.

关键词： Space syntax Daylighting mosque Cognition multi-objective optimization Genetic algorithms(GA)

Glucagon-like peptide-1 receptor agonists as a possible intervention to delay the onset of type 1 diabetes:A new horizon

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World Journal of Diabetes 2024年第2期15卷 133-136页

作者： mahmoud nassar Ajay Chaudhuri Husam Ghanim Paresh Dandona Department of Internal medicine Division of EndocrinologyDiabetes and MetabolismJacobs School of Medicine and Biomedical SciencesUniversity of BuffaloBuffaloNY 14221United States

Type 1 diabetes(T1D)is a chronic autoimmune condition that destroys insulinproducing beta cells in the pancreas,leading to insulin deficiency and *** management of T1D primarily focuses on exogenous insulin replacement to control blood glucose ***,this approach does not address the underlying autoimmune process or prevent the progressive loss of beta *** research has explored the potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)as a novel intervention to modify the disease course and delay the onset of ***-1RAs are medications initially developed for treating type 2 *** exert their effects by enhancing glucose-dependent insulin secretion,suppressing glucagon secretion,and slowing gastric *** evidence suggests that GLP-1RAs may also benefit the treatment of newly diagnosed patients with *** article aims to highlight the potential of GLP-1RAs as an intervention to delay the onset of T1D,possibly through their potential immunomodulatory and anti-inflammatory effects and preservation of *** article aims to explore the potential of shifting the paradigm of T1D management from reactive insulin replacement to proactive disease modification,which should open new avenues for preventing and treating T1D,improving the quality of life and long-term outcomes for individuals at risk of T1D.

关键词： Type 1 diabetes Semaglutide Glucagon-like peptide-1 receptor agonists Insulin therapy Autoimmune response Blood glucose monitoring Β-cell preservation Early screening Teplizumab Randomized controlled trials

Emerging therapeutic options for non-alcoholic fatty liver disease:A systematic review

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World Journal of Hepatology 2023年第8期15卷 1001-1012页

作者： Jasmine Tidwell Natalie Balassiano Anjiya Shaikh mahmoud nassar Department of Internal medicine University of ConnecticutFarmingtonCT 06032United States Department of Internal medicine Icahn School of Medicine at Mount Sinai/NYC Health+Hospitals/QueensNew YorkNY 11432United States Department of Internal medicine Division of EndocrinologyDiabetes and MetabolismJacobs School of Medicine and Biomedical SciencesUniversity of BuffaloBuffaloNY 14221United States

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)has become a prevalent cause of chronic liver disease and ranks third among the causes of *** the United States alone,annual medical costs are approximately 100 billion ***,there is no Federal Drug Administration(FDA)-approved medication for its ***,various clinical trials are investigating several therapeutic classes that could potentially treat *** is valuable to have a compilation of the data available on their *** To assess the efficacy of cyclophilin inhibitors,fibroblast growth factor 21 analogs(FGF21),and dual and pan peroxisome proliferator-activated receptor(PPAR)agonists for treating *** A comprehensive literature search using keywords including cyclophilin inhibitor,FGF agonist,pan-PPAR agonists,dual-PPAR agonist,NAFLD,nonalcoholic steatohepatitis,and fatty liver was conducted on October 29,2022,in Pubmed,EmBASE,Cochrane Library,Scopus and Web of *** and human research,case reports,and published articles in English from all countries with patients aged 18 and above were *** articles with a National Institutes of Health(NIH)Quality Assessment score of five or higher out of eight points were *** that were narrative or systematic reviews,abstracts,not in English,focused on patients under 18 years old,did not measure outcomes of interest,were inaccessible,or had a low NIH Quality Assessment score were *** article was screened by two independent researchers evaluating relevance and *** were scored based on the NIH Quality Assessment Score;then,pertinent data was extracted in a spreadsheet and descriptively *** Of the 681 records screened,29 met the necessary criteria and were included in this *** records included 12 human studies and 17 animal ***,there were four studies on cyclophilin inhibitors,four on FGF agonists/analogs,eleven on pan-PPAR

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Cyclophilin inhibitors Fibroblast growth factor 21 analogs Dual peroxisome proliferator-activated receptor agonists Pan peroxisome proliferator-activated receptor agonists

Impact of erythropoietin therapy on cardiorenal syndrome:A systematic review with meta-analysis

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World Journal of Cardiology 2023年第5期15卷 273-283页

作者： Rubal Bhangal Ivan Cancarevic mahmoud nassar Zaryab Umar Department of Internal medicine Icahn School of Medicine at Mount Sinai/NYC Health+Hospitals QueensNew YorkNY 11432United States Department of Internal medicine Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Internal medicine NYC Health+Hospital QueensNew YorkNY 11432United States

BACKGROUND Heart and kidney dysfunction frequently coexist in patients with acute heart failure due to the overlap between these two organ *** syndrome(CRS)results from pathology occurring in the heart and kidneys along with the consequences of dysfunction in one organ contributing to dysfunction in the other and vice *** To evaluate the use of erythropoietin(EPO)in patients with CRS and its effects on hemoglobin(Hb),major cardiovascular(CV)events,and hospitalization *** On February 24,2022,searches were conducted using Pubmed,mEDLINE,and EmBASE,and 148 articles were identified.A total of nine studies were considered in this systematic *** assessed the included articles based on the National Heart,Lung,and Blood Institute quality assessment tools for controlled intervention and observational cohort or cross-sectional *** assessment of bias risk was conducted on the chosen studies,and data relevant to our review was *** The systematic review of these studies concluded that most existing literature indicates that EPO improves baseline Hb levels and decreases myocardial remodeling and left ventricular dysfunction without reducing CV *** addition,the effect of EPO on the hospitalization rate of patients with CRS needs to be further studied since this relationship is *** studies,such as randomized controlled clinical trials and prospective cohort studies,should be conducted to enhance the literature on the potential of EPO therapy in patients with *** Our systematic review suggests that EPO therapy may have a significant role in managing *** review highlights the potential benefits of EPO in improving baseline Hb levels,reducing the risk of major CV events,improving cardiac remodeling,myocardial function,New York Heart Association class,and B-type natriuretic peptide ***,the effect of EPO treatment on hospitalization remains unclear and needs further exploration.

关键词： Cardiorenal syndrome Anemia Cardiovascular disease End-stage renal disease Erythropoietin Congestive heart failure

Antioxidant and antiangiogenic activities of the essential oils of myristica fragrans and morinda citrifolia

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Asian Pacific Journal of Tropical medicine 2012年第4期5卷 294-298页

作者： Suthagar Pillai Piaru Roziahanim mahmud Amin malik Shah Abdul majid Zeyad Daoud mahmoud nassar School of Pharmaceutical Sciences Universiti Sains Malaysia11800 PenangMalaysia

Objective:Toinvestigate the anti-angiogenic activity and antioxidant properties of myristica fragrans（***）（nutmeg） and morinda citrifolia（***）（mengkudu） oils. methods:The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essenlial oils were delermined by beta-carotene/ linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various ***:The results showed that nutmeg oil has higher antioxidant activity than mengkudu *** nutmeg oil effectively inhibited the oxidation of linoleic acid with（88.68±0.1）%while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is（69.44±0.4）%.The nutmeg oil and mengkudu oil showed reducing power with an EC50 value of 181.4μg/mL and 3 043.0μg/mL,*** anliangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC50 of 77.64μg/mL comparing to mengkudu oil which exhibits IC50 of 109.30μg/***:Bioactive compound（s） will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.

关键词： Essential oil Antiangiogenic Antioxidant myristica fragrans morinda citrifolia

ABO incompatibility in renal transplantation

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World Journal of Transplantation 2021年第9期11卷 388-399页

作者： mahmoud mohamed Tara Sweeney Duaa Alkhader mahmoud nassar Ahmed Alqassieh Sofia Lakhdar Nso Nso Tibor Fulop Ahmed Daoud Karim m Soliman Department of medicine North Mississippi Medical CenterTupeloMS 38804United States Department of medicine Medical University of South CarolinaCharlestonSC 29425United States Department of Surgery Medical University of South CarolinaCharlestonSC 29425United States Department of medicine Icahn School of Medicine at Mount SinaiNYC Health and HospitalsQueensNew YorkNY 11432United States Department of medicine Kasr Alainy Medical SchoolCairo UniversityCairo 11562Egypt

ABO blood group incompatibility(ABO-I)was historically considered an absolute contraindication to kidney transplantation due to the significant risk of acute antibody-mediated rejection and early graft ***,the urge to minimize the gap between the candidates’number on the waitlist for kidney transplants and the available kidney donors encourage investigation into finding ways to use organs from ABO-I kidney donors,especially in the era of using more potent immunosuppression *** review aims to discuss a general overview of ABO-I kidney transplantation and the different protocols adopted by some transplant centers to meaningfully overcome this barrier.

关键词： ABO incompatibility Renal transplantation Kidney Transplants

Coronavirus disease 2019 and renal transplantation

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World Journal of Clinical Cases 2021年第27期9卷 7986-7997页

作者： mahmoud nassar Nso Nso Jonathan Ariyaratnam Jasmine Sandhu mahmoud mohamed Bahaaeldin Baraka Atif Ibrahim mostafa Alfishawy David Zheng Harangad Bhangoo Karim m Soliman matthew Li Vincent Rizzo Ahmed Daoud Department of medicine Icahn School of Medicine at Mount Sinai(NYC Health and Hospitals:Queens)New YorkNY 10029United States Department of medicine University of Tennessee Health Science CenterMemphisTN 38163United States Department of Oncology Southend University HospitalNHS Foundation TrustEssex SS00RYUnited Kingdom Renal Division Department of MedicineUniversity of Tennessee Health Science CenterMemphisTN 38163United States Infectious Diseases Infectious Diseases Consultants and Academic Researchers of Egypt IDCARECairo 0000Egypt Department of medicine Medical University of South CarolinaCharlestonSC 29425United States Department of Clinical Pharmacy Icahn School of Medicine at Mount Sinai(NYC Health and Hospitals:Queens)New YorkNY 10029United States Department of medicine Icahn School of Medicine at Mount Sinai(NYC Health and Hospitals:Queens)New YorkNY 11373United States Department of medicine Kasr Alainy Medical SchoolCairo UniversityCairo 11562Egypt

Ever since the severe acute respiratory syndrome virus causing coronavirus disease 2019(COVID-19)struck the world,global health strategies have changed *** to the Centers for Disease Control and Prevention,kidney transplant recipients are stratified as being high risk of developing fatal illness from COVID-19 *** transplant is the gold-standard treatment for end-stage kidney disease *** the pandemic,significant concerns have emerged regarding continuation of kidney transplant surgeries and management of kidney transplant recipients *** added risk of immunosuppression in this cohort was and remains a theoretical concern,posing a potential risk of transplantation rather than *** comprehensive review aims to cover most of the faced challenges in kidney transplantation in different stages of the *** addition,it will elucidate the epidemiology,nature,course of the disease,surgical consideration in donors and recipients as well as role of immunosuppression and management of COVID-19 infected kidney transplant recipients during these extraordinary circumstances.

关键词： Renal transplantation COVID-19 SARS-CoV-2 Kidney failure

Effect of Colouring Process on Pitting Susceptibility of Austenitic Stainless Steel

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Journal of materials Science & Technology 2008年第3期24卷 400-406页

作者： S.S.mahmoud m.m.Ahmed Chemistry Department University College of Girls for ArtsScience and EducationAin Shams University

Colouring of the austenitic stainless steel alloy （20.45% Cr, 8.57% Ni） was carried out in NaNO3-KNO3 eutectic melt without and with additions of Na2O2, NaCl and their mixtures at different temperatures ranging from 400-600℃, under open-circuit and galvanostatic anodic polarization conditions. The produced colours greatly depend on the thickness of oxide films, which in turn depends on the composition of the molten bath and its temperature. The more attractive, bright, adherent and uniform coloured oxide films can be obtained at 400, 450 and 500℃ in molten nitrate bath containing NaCl and Na2O2 mixtures. The pitting corrosion susceptibility of the coloured oxide films was tested in FeCl3 and NaCl as corrosive media. The obtained results indicate that the pitting corrosion susceptibility of the coloured oxide films greatly depends on the previous operating conditions of the colouring process of the stainless steel specimens such as the composition of molten bath, temperature and technique of colouring process.

关键词： Stainless steel alloy Pitting corrosion Colouring processes

Distributed H2/H∞ Filter Design for Discrete-Time Switched Systems

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 158-168页

作者： Nezar m.Alyazidi magdi S.mahmoud Systems Engineering Department King Fahd University for Petroleum and Minerals

This paper addresses an infinite horizon distributed H2/H∞ filtering for discrete-time systems under conditions of bounded power and white stochastic signals. The filter algorithm is designed by computing a pair of gains namely the estimator and the coupling. Herein, we implement a filter to estimate unknown parameters such that the closed-loop multi-sensor accomplishes the desired performances of the proposed H2 and H∞ schemes over a finite horizon. A switched strategy is implemented to switch between the states once the operation conditions have changed due to disturbances. It is shown that the stability of the overall filtering-error system with H2/H∞ performance can be established if a piecewise-quadratic Lyapunov function is properly constructed. A simulation example is given to show the effectiveness of the proposed approach.

关键词： Bounded power stochastic disturbance discretetime systems H2/H∞ filtering infinite horizon multi-sensor switched systems