Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia

作     者：Suthagar Pillai Piaru Roziahanim Mahmud Amin Malik Shah Abdul Majid Zeyad Daoud Mahmoud Nassar 

作者机构：School of Pharmaceutical SciencesUniversiti Sains Malaysia11800 PenangMalaysia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第4期

页      面：294-298页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 

基　　金：funded by Universiti Sains Malaysia Research University(RU)Grant(1001/PFARMASI/813021) 

主　　题：Essential oil Antiangiogenic Antioxidant Myristica fragrans Morinda citrifolia 

摘      要：Objective:Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans（***）（nutmeg） and Morinda citrifolia（***）（mengkudu） oils. Methods:The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essenlial oils were delermined by beta-carotene/ linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various ***:The results showed that nutmeg oil has higher antioxidant activity than mengkudu *** nutmeg oil effectively inhibited the oxidation of linoleic acid with（88.68±0.1）%while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is（69.44±0.4）%.The nutmeg oil and mengkudu oil showed reducing power with an EC50 value of 181.4μg/mL and 3 043.0μg/mL,*** anliangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC50 of 77.64μg/mL comparing to mengkudu oil which exhibits IC50 of 109.30μg/***:Bioactive compound（s） will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.