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Resveratrol Modulates Bone Mineral Density and Bone Mineral Content in A Rat Model of Male Hypogonadism

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Chinese Journal of Integrative Medicine 2023年第2期29卷 146-154页

作者： Hussein F.Sakr Boudaka Ammar Amira alKharusi I al-Lawati mahmoud alKhateeb Basim H Elesawy Department of Physiology College of Medicine and Health SciencesSultan Qaboos UniversityMuscat 123Oman Medical Physiology Department Faculty of MedicineMansouraUniversityMansoura 35516Egypt Basic Medical Sciences Department College of Medicine at King Saud bin Abdulaziz University for Health Sciences(KSAU-HS)Riyadh 11481Saudi Arabia Department of Clinical Laboratory Sciences College of Applied Medical SciencesTaif UniversityTaif 21944Saudi Arabia

Objective: To determine whether resveratrol(Res) can correct osteoporosis induced in a rat model of male hypogonadism. Methods: Thirty-two rats were randomly divided into 4 groups, 8 in each group;1) a control sham group: underwent a similar surgical procedure for induction of orchiectomy(ORCD) without ligation of any arteries or veins or removal of the testis and epididymis;2) a control + Res-treated group(Con+Res):underwent sham surgery similar to the control, but was then treated with Res, as described below;3) an ORCDinduced group: bilateral ORCD surgery as described above, and 4) a ORCD+Res-treated group: bilateral ORCD surgery followed by Res treatment. Res treatment began 4 weeks after ORCD and continued for 12 weeks. After 12 weeks, bone mineral density(BMD) and bone mineral content(BMC) were measured in the tibia and femur of each rat’s right hind leg. Blood levels of bone turnover indicators such as deoxypyridinoline(Dpd), N-telopeptide of type Ⅰ collagen(NTXⅠ), alkaline phosphatase(alP), and osteocalcin(OC), as well as receptor activator of nuclear factor kappa B(RANK) and osteoprotegerin(OPG) were assessed. Results: ORCD significantly decreased BMD(Pale hypogonadism, possible via restoration of the normal balance between RANK and OPG.

关键词： osteoporosis male hypogonadism resveratrol receptor activator of nuclear factor-kappa

Controlling hyperchaotic complex systems with unknown parameters based on adaptive passive method

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Chinese Physics B 2013年第6期22卷 268-276页

作者： Gamal M.mahmoud Emad E.mahmoud Ayman A.Arafa Department of Mathematics Faculty of ScienceTaibah UniversityAl-Madeenah Al-MunawwarahP.O.Box 344Kingdom of Saudi Arabia Department of Mathematics Faculty of ScienceSohag UniversitySohag 82524Egypt College of Applied Medical Sciences TurabahTaif UniversityKingdom of Saudi Arabia

The aim of this paper is to study the control of hyperchaofic complex nonlinear systems with unknown parameters using passive control theory. An approach is stated to design the passive controller and estimate the unknown parameters based on the property of the passive system. The feasibility and effectiveness of the proposed approach is demonstrated through its application to the hyperchaotic complex Lu system, as an example. The estimated values of the unknown parameters are calculated. The analytical form of the complex controller is derived and used in the numerical simulation to control the hyperchaotic attractors of this example. Block diagrams of this example using Matlab/Simulink are constructed after and before the control to ensure the validity of the analytical results. Other examples of hyperchaotic complex nonlinear systems can be similarly treated.

关键词： control passive control hyperchaotic complex

Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation

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Chemical Research in Chinese Universities 2022年第4期38卷 847-855页

作者： CHEN sisi ZHANG Lei YUAN Quan TAN Jie Molecular Science and Biomedicine Laboratory(MBL) Institute of Chemical Biology and Nanomedicine(ICBN)State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha410082P.R.China

The interaction between biomolecules with their target ligands plays a great role in regulating biological *** are short oligonucleotide sequences that can specifically recognize target biomolecules via structural complementarity and thus regulate related biological *** the past ten years,aptamers have made great progress in target biomolecule recognition,becoming a powerful tool to regulate biological *** present,there are many reviews on aptamers applied in biomolecular recognition,but few reviews pay attention to aptamer-based regulation of biological ***,we summarize the approaches to enhancing aptamer affinity and the advancements of aptamers in regulating enzymatic activity,cellular immunity and cellular ***,this review discusses the challenges and future perspectives of aptamers in target recognition and biological functions regulation,aiming to provide some promising ideas for future regulation of biomolecular functions in a complex biological environment.

关键词： functions. complementarity enzymatic

An exclusive fine-needle biopsy approach to sampling solid lesions under EUS guidance:a prospective cohort study

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Gastroenterology Report 2020年第5期8卷 349-354,I0001页

作者： Lindsey M.Temnykh mahmoud A.Rahal Zahra Zia Mohammad A.al-Haddad Department of Internal Medicine Indiana University School of MedicineIndianapolisINUSA Division of Gastroenterology and Hepatology Department of Internal MedicineIndiana University School of MedicineIndianapolisINUSA

Background Endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB)is increasingly utilized to enhance the cytological yield of sampling solid lesions,but its superiority over existing fine-needle aspiration(FNA)platforms has not been clearly *** aim of our study was to compare the diagnostic accuracy and procedural outcomes of FNB using a new Franseen-tip needle to that of a traditional FNA in sampling solid lesions under EUS *** Consecutive patients with solid lesions referred for EUS-FNB sampling were ***-related outcomes were collected prospectively including patient demographics,number of passes performed,diagnostic sample adequacy,adverse events,and recovery *** Acquire needle was used to sample all lesions in the study *** EUSFNA procedures performed to sample solid lesions using the Expect needle were utilized as *** There were 180 patients undergoing EUS-FNB compared to 183 patients undergoing EUS-FNA procedures for solidlesion *** procedure time was significantly shorter in patients who underwent FNB compared to FNA(mean:37.4 vs 44.9 minutes,Pall passes,shorter procedure time,and improved diagnostic *** may replace FNA as the primary sampling modality of choice in all solid lesions.

关键词： endoscopic ultrasound fine-needle biopsy fine-needle aspiration pancreatic tumors

Conocarpus Biochar Induces Changes in Soil Nutrient Availability and Tomato Growth Under Saline Irrigation

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Pedosphere 2016年第1期26卷 27-38页

作者： Adel Rabie A.USMAN Mohammad I.al-WABEL Yong S.OK Abdulaziz al-HARBI mahmoud WAHB-alLAH Ahmed Hamdy EL-NAGGAR Mahtab AHMAD Abdulelah al-FARAJ Abdulrasoul al-OMRAN Soil Sciences Department College of Food Agricultural SciencesKing Saud UniversityP.O.Box 2460Riyadh 11451(SaudiArabia) Department of Soils and Water Faculty of AgricultureAssiut UniversityAssiut 71526(Egypt) Korea Biochar Research Center Kangwon National UniversityChunehon 200-701(Korea) lant Production Department College of Food and Agricultural SciencesKing Saud UniversityP.O.Box 2460Riyadh 11451(Saudi Arabia) Vegetable Crops Department Faculty of AgricultureAlexandria UniversityAlexandria 21321(Egypt) Department of Soil Science Faculty of AgricultureAin Shams University68 HadayekShobraP.O.Box 11241Cairo 11241(Egypt) Agricultral Engineering Department College of Food&Agricultural SciencesKing Saud UniversityP.O.Box 2460Riyadh 11451(Saudi Arabia)

Thermally modified organic materials commonly known as biochar have gained popularity of being used as a soil *** information, however, is available on the role of biochar in alleviating the negative impacts of saline water on soil productivity and plant growth. This study, therefore, was conducted to investigate the effects of Conocarpus biochar(BC) and organic farm residues(FR) at different application rates of 0.0%(control), 4.0% and 8.0%(weight/weight) on yield and quality of tomatoes grown on a sandy soil under drip irrigation with saline or non-saline water. The availability of P, K, Fe, Mn, Zn and Cu to plants was also investigated. The results demonstrated clearly that addition of BC or FR increased the vegetative growth, yield and quality parameters in all irrigation treatments. It was found that salt stress adversely affected soil productivity, as indicated by the lower vegetative growth and yield components of tomato plants. However, this suppressing effect on the vegetative growth and yield tended to decline with application of FR or BC, especially at the high application rate and in the presence of biochar. Under saline irrigation system, for instance, the total tomato yield increased over the control by 14.0%–43.3% with BC and by 3.9%–35.6% with FR. These could be attributed to enhancement effects of FR or BC on soil properties, as indicated by increases in soil organic matter content and nutrient availability. Therefore, biochar may be effectively used as a soil amendment for enhancing the productivity of salt-affected sandy soils under arid conditions.

关键词： drip irrigation organic farm residues organic matter content salt stress sandy soils soil amendment soil productivity

ANalYTICal MODELS BASED DISCRETE-TIME QUEUEING FOR THE CONGESTED NETWORK

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第1期3卷 68-89页

作者： MOFLEH al-DIABAT HUSSEIN ABDEL-JABER FADI THABTAH OSMAN ABOU-RABIA mahmoud KISHTA Computer Science Department al-al-Bayt University Jordan Department of Computer Science The World Islamic Sciences&Education(W.I.S.E.)University Amman Jordan Management Information System Department Philadelphia University AmmanJordan Department of Mathematics and Computer Science Laurentian University Sudbury ONCanada Dean of Academic Research Philadelphia University AmmanJordan

Congestion is one of the well-studied problems in computer networks,which occurs when the request for network resources exceeds the buffer *** active queue management techniques such as BLUE and RED have been proposed in the literature to control congestions in early *** this paper,we propose two discrete-time queueing network analytical models to drop the arrival packets in preliminary stages when the network becomes *** first model is based on Lambda Decreasing and it drops packets from a probability value to another higher value according to the buffer *** the second proposed model drops packets linearly based on the current queue *** compare the performance of both our models with the original BLUE in order to decide which of these methods offers better quality of *** comparison is done in terms of packet dropping probability,average queue length,throughput ratio,average queueing delay,and packet loss rate.

关键词： Analytical models congestion control discrete-time queueing simulation

Safety and efficacy of posterior sub-Tenon＇s carboplatin injection versus intravitreal melphalan therapy in the management of retinoblastoma with secondary vitreous seeds

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 445-455页

作者： Azza Mohamed Ahmed Said Mohamed Gamil al Hazem Omar Rashed Anwaar mahmoud Rady Department of Ophthalmology Faculty of Medicine Ain Shams University Cairo 11566 Egypt Oncology and Radiation Medicine Department Faculty of Medicine Ain Shams University Cairo 11566 Egypt

AIM： To evaluate the safety and efficacy of posterior sub-Tenon＇s carboplatin injection compared to intravitreal melphalan injection in the management of retinoblastoma （RB） with secondary vitreous seeds. The outcome measures were vitreous seeds regression, need for other treatment modalities to achieve ocular salvage and treatment side effects. METHODS： A prospective interventional comparative nonrandomized study included RB eyes developed secondary vitreous seeds during the period of follow up. They subdivided into two groups： study group Ⅰ where posterior sub-Tenon＇s carboplatin （20 mg/2 mL） was injected and study group Ⅱ where intravitreal melphalan （20 μg/0.1 mL） was injected. The injections repeated every 2-4wk. RESULTS： Thirty-three eyes were included in the study. Seventeen eyes （16 patients） in study group Ⅰ and 16 eyes （16 patients） in study group Ⅱ. Ten eyes （30.3%） were completely salvaged following local chemotherapies, Ocular salvage was 23.5% following posterior sub-Tenon＇s carboplatin injection versus 37.5% following intravitreal melphalan raised to 47.1% and 75% with addition of external beam radiotherapy （EBR） with no statistically significant difference between the study groups （P=0.16）. A statistically significant correlation was found between ocular salvage rate and type of vitreous seeds either dust, spheres and clouds （r=0.42, P=-0.015） and eyes harbor new solid tumor growth （r=0.35, P=0.045）. The mean and median follow up periods following local chemotherapy injections were 2.0y in the study group Ⅰand 2.37y in the study group Ⅱ. Few complications were reported： periorbital edema in all eyes and ocular motility disturbances in 13 eyes （76.5%） following posterior sub-Tenon＇s carboplatin injection. Vitreous hemorrhage developed in 2 eyes （12.5%） and localized retinopathy in 5 eyes （31.25%） following intravitreal melphalan. ~ CONCLUSION： Local chemotherapy for treatment of RB with secondary vitreous seeds is safe and can salvage 30.3% of eyes

关键词： intravitreal melphalan posterior sub-Tenon'scarboplatin retinoblastoma secondary vitreous seeds

Experimental Study on Friction Reducing and Anti Wear Property of a Water-Based Lubricant with Polyether Added

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稀有金属材料与工程 2012年第S1期41卷 276-279页

作者： Zhang Chaohui Liu sisi Liu Junming Beijing Jiaotong Univ Sch Mech Elect & Control Engn Beijing 100044 Peoples R China

The wear behaviors of steel-steel pair on condition of a water-based lubricant with copolymer of acylamino polyoxyethylene polyoxypropylene ether(KE-1)included as additives are investigated with the help of the universal *** on friction and wear are carried *** a reference,some tests with pure water are also performed for *** results show that the prepared water-based lubricant has a good effect on the characteristics associated with friction reducing and anti-wear processes,which lay some credence to its utilization in practical industrial tribo-systems.

关键词： acylamino-polyoxyethylene-polyoxypropylene-ether water-based lubricant anti-wear property

User Scheduling and Slicing Resource allocation in Industrial Internet of Things

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China Communications 2023年第6期20卷 368-381页

作者： sisi Li Yong Zhang Siyu Yuan Tengteng Ma Beijing University of Posts and Telecommunications Beijing 100876China Beijing Key Laboratory of Work Safety Intelligent Monitoring Beijing University of Posts and TelecommunicationsBeijing 100876China Strategy Development Institute China Telecom Corporation Limited Beijing Research InstituteBeijing 102209China

Heterogeneous base station deployment enables to provide high capacity and wide area *** slicing makes it possible to allocate wireless resource for heterogeneous services on *** two promising technologies contribute to the unprecedented service in *** establish a multiservice heterogeneous network model,which aims to raise the transmission rate under the delay constraints for active control terminals,and optimize the energy efficiency for passive network terminals.A policygradient-based deep reinforcement learning algorithm is proposed to make decisions on user association and power control in the continuous action *** results indicate the good convergence of the algorithm,and higher reward is obtained compared with other baselines.

关键词： wireless communication resource allocation reinforcement learning heterogeneous network network slicing Internet of Things