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Comparison between two commercial immunoassays:*** ALLERG-O-LIQ versus Phadia ImmunoCAP~ System in detecting allergen-specific IgE and total IgE values

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Journal of Nanjing Medical University 2008年第5期22卷 273-278页

作者： Baoqing Suna mahler michael Mei Jiang Jing Li Nanshan Zhong Guangzhou Institute of Respiratory Diseases the First Affiliated Hospital of Guangzhou Medical College Guangzhou 510120 Guangdong province China Dr Fooke Laboratorien GmbH Neuss Germany

Objective： Beside patient＇ s history and skin prick testing（SPT） the detection of specific IgE（slgE） represents an important tool of allergy diagnostics. In recent years different technologies for the detection of slgE have been developed. The objective of this study is the comparison of the ALLERG-O-LIQ with the ImmunoCAW System using seven inhalant and four food allergens. Methods： Sera from patients were collected and tested for slgE to inhalant（dl, d2, d5, i6, el, e5 and m3） and food allergens（fl, f2, f24, f24） by ALLERG-O-LIQ（Dr. Fooke Laboratorien GmbH） and by ImmunoCAP System（Phadia）. Further, samples were also tested for total IgE in both systems. Results： Prevalence of positive test results varied between 0/20（f24） and 11/20（e5） for ALLERG-O-LIQ and between 3/18（f23） and ll/20（dl/d5） for ImmunoCAP. The qualitative agreement between both methods was found between 75%（f24） and 100%（d2） depending on the allergen. Overall qualitative agreement for inhalant（n = 140）, food（n = 78） and all allergens（n = 218） tested was 92.1%（kappa = 0.84）, 83.3%（kappa = 0.58）, 89.0%（kappa = 0.77）, respectively. Sensitivity, specificity, positive predictive value （PPV）, negative predictive value（NPV） and diagnostic efficiency（DE） were found at 88.2%, 95.8%, 95.2%, 89.6%, 92.1%（inhalant allergens）, 62.5%, 92.6%, 78.9%, 84.7%, 83.3%（food allergens） and 81.5%, 94.4%, 91.5%, 87.5%, 89.0%（all allergens）. Conclusion： Good to excellent qualitative agreement between ALLERG-O-LIQ and ImmunoCAP for the detection of specific and total IgE could be observed. The degree of agreement depended on the allergen and was higher in the group of inhalant allergens. The ALLERG-O-LIQ System represents a reliable test for the detection of specific and total IgE.

关键词： specific IgE allergy diagnostics allergen

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Consensus views on competencies and teaching methods for an interprofessional curriculum on complementary and integrative medicine:A Delphi study

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Journal of Integrative Medicine 2021年第3期19卷 282-290页

作者： Angelika Homberg Katja Krug Nadja Klafke Katharina Glassen Cornelia mahler Svetla Loukanova Department of General Practice and Health Services Research University Hospital HeidelbergHeidelberg69120 HeidelbergGermany Department of Nursing Science University Hospital Tübingen72076 TubingenGermany

Objective:A collaborative team is necessary to help patients achieve their healthcare goals using complementary *** present,healthcare professionals do not feel sufficiently qualified to provide this *** study sought to identify competencies and teaching methods for interprofessional training on complementary and integrative medicine at medical ***:Sixty-five German-speaking experts with various professional backgrounds were invited to take part in a three-round Delphi *** the first round,predefined competencies were assessed on a seven-point Likert scale,and participants were invited to propose additional competencies that would be evaluated in the subsequent *** competencies were ranked based on the participant assessments and were assigned to four relevance *** the second and third rounds,suitable teaching methods were identified using free-text fields and multiple-choice *** a final workshop,participants synthesized the outcomes of the previous sessions and derived key competencies that would be a benefit to undergraduate interprofessional training in complementary and integrative medicine at medical ***:The three rounds plus final worksop were attended by 50,40,36 and 11 *** competencies that these experts determined to be highly relevant to teaching complementary and integrative medicine emphasized,in particular,the respectful treatment of patients and the importance of taking a medical *** these highly relevant competencies,three key targets were agreed upon in the final workshop:students are able to 1)classify and assess complementary medical terms and methods;2)work collaboratively and integrate patients into the interprofessional team;3)involve patients and their relatives respectfully and empathetically in all healthcare *** achieve these competency goals,the following teaching methods were highlighted:students discuss therapy options based on authentic patient c

关键词： Undergraduate education Interprofessional education Complementary medicine Delphi study Curriculum Competency

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The aryl hydrocarbon receptor and the gut–brain axis

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Cellular & Molecular Immunology 2021年第2期18卷 259-268页

作者： Andreia Barroso João Vitor mahler Pedro Henrique Fonseca-Castro Francisco J.Quintana Ann Romney Center for Neurologic Diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Faculdade de Medicina FMUSP Universidade de São PauloSão PauloSPBrazil Broad Institute of MIT and Harvard CambridgeMAUSA

The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for *** half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and *** this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.

关键词： Aryl hydrocarbon receptor Autoimmune diseases Infectious diseases cancer

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第一交响曲提坦 D大调总谱

第一交响曲提坦 D大调总谱

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2002年

作者：马勒 mahler

本书收录了德国作曲家马勒创作的《D大调第一交响曲》的总谱，共四个乐章，充分显示了马勒独特音乐语言的一切特征。

关键词：艺术音乐各国音乐作品

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Micro Trace Resistive Technology

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印制电路信息 2013年第6期21卷 73-76页

作者： Bruce P.mahler Ohmega Technologies Inc.

Micro trace resistive technology allows thin film resistors to be built within a printed circuit trace that is less than 100 microns *** standard subtractive printed circuit board processes,it is ideal for high-density interconnect(HDI)designs where passive component placement is difficult or *** utilizing the differential processes unique to the OhmegaPlynickel phosphorous(NiP)resistive material,copper traces can be imaged and etched to define resistor widths that are precise and sharply defined,resulting in the creation of miniature resistors with consistent ohmic *** low inductance and good tolerances,micro trace resistors are ideal for line termination and pull-up/down applications.

关键词：微细线路电阻技术超薄薄电阻微米电子线路

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Classification Method fo Urban Solid Waste Disposal Sites

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Journal of Environmental Protection 2011年第4期2卷 473-481页

作者： Adriana Soares de Schueler Claudio Fernando mahler 不详

One of the environmental liabilities left by abandoned urban waste disposal sites, closed without the correct procedures, is the risk of exposure to their effluents, whose emissions may occur for many years. The purpose of the proposed methodology, referred to as SISTAVAFE, an assessment system of a closed landfill, is to contribute in the risk assess- ment of exposure to leachate as well as to suggest procedures for site monitoring, according to different levels of care and urgency. The method is based on four matrices that help make an initial evaluation of the risk source, potential target and the surface and underground environmental paths. This paper only addresses the contamination caused by liquid effluents.

关键词： Environmental Impact Solid Waste Landfill Later Occupation Risk of Exposure Leachate Classification Tool Multi-Criteria Analysis

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Analytical Model of Landslide Risk Using GIS

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Open Journal of Geology 2012年第3期2卷 182-188页

作者： Claudio F.mahler Erika Varanda Luiz C.D.de Oliveira Department of Civil Engineering COPPEFederal University of Rio de JaneiroRio de JaneiroBrazil Transpetro S/A Rio de JaneiroBrazil Centro Federal de Educacao Tecnologica Celso Suckow da Fonseca/UnED-Petropolis Rio de JaneiroBrazil

This paper presents a model for quantitative risk analysis with the application of geographic information systems (GISs) using Bayesian theory. It was used for the thematic integration of maps in a natural state (vegetation, geological-geo- technical, natural drainage and gradient). A landslide susceptibility map was produced based on this integration associated with vulnerability data (time and housing construction standards) and risk criteria. A quantitative risk map for a specific area was also drawn up from this

关键词： Risk Landslide GIS Bayesian Theory

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Direct Electrochemical Determination of Glyphosate Herbicide Using a Screen-Printed Carbon Electrode Modified with Carbon Black and Niobium Nanoparticles

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Journal of Analysis and Testing 2023年第4期7卷 425-434页

作者： Julia Oliveira Fernandes Cassiano Augusto Rolim Bernardino Juliana dos Santos Fernandes Claudio Fernando mahler Bernardo Ferreira Braz Luiz Henrique Carpenter dos Santos Rodrigo JoséCorrêa Ricardo Erthal Santelli Braulio Soares Archanjo Emerson Schwingel Ribeiro Fernando Henrique Cincotto Departament of Analytical Chemistry Institute of ChemistryFederal University of Rio de JaneiroRio de Janeiro 21941-909Brazil Departament of Civil Engineering COPPEFederal University of Rio de JaneiroRio de Janeiro 21941-598Brazil National Institute of Science&Technology of Bioanalytics(INCTBio) CampinasSão Paulo 13083-862Brazil Departament of Inorganic Chemistry Institute of ChemistryFederal University of Rio de JaneiroRio de Janeiro 21941-909Brazil Unesp National Institute of Alternative Technologies for DetectionToxicological Assessment and Removal of Micropollutants and Radioactives(INCT-DATREM)AraraquaraSão Paulo 14800-060Brazil National Institute of Metrology Quality and TechnologyInmetroAv.Nossa Senhora das Graças50XerémDuque de Caxias 25250-020Brazil

Glyphosate is a herbicide that has been widely used worldwide and is used in agricultural areas to control weeds and unwanted *** sensors developed from different nanomaterials have high efficiency,excellent cost-benefit,and fast analysis time for detecting traces of environmental *** study aimed to produce an electrochemical sensor with disposable screen-printed electrodes based on carbon black modified with niobium nanoparticles to determine glyphosate in aqueous *** morphology,structure and electrochemical performance of the sensor were characterized by scanning electron microscopy,energy-dispersive X-ray spectroscopy,X-ray diffraction and cyclic *** pulse voltammetry in BR buffer solution at pH 5.0 allowed the generation of a method to quantify glyphosate concentration in a linear range of 5.90-172.30μmol/L(1.00-29.13μg/mL),with a limit of detection calculated at 3.07μmol/L(0.52μg/mL).The method efficiently quantified glyphosate in real water samples and showed no interference from K^(+),Na^(+),Ca^(2+),Mg^(2+)ions or thiamethoxam,imidacloprid and carbendazim pesticides.

关键词： Glyphosate Electrochemical sensor Carbon black Niobium nanoparticles

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Properties of a Lateritic Red Soil for Pollutant Containment

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Journal of Environmental Protection 2011年第7期2卷 923-931页

作者： Maria Eugenia Gimenez Boscov Waldemar Coelho Hachich Claudio Fernando mahler E. de Oliveira 不详

In many regions of Brazil, lateritic clays are the natural candidates for the construction of compacted clay liners of waste disposal sites because of their availability and appropriate geotechnical characteristics. Lateritic soils have been extensively used in recent decades in dam and road construction, but little is known about the migration of pollutants through compacted layers of such soils. This paper describes the characteristics of a lateritic clay, representing a group of soils of significant occurrence in the State of S?o Paulo, to be employed in a clay liner of a waste disposal site. Laboratory tests to assess permeability, adsorption and diffusion of six metals through the compacted soil showed that permeability criterion may be met in the field, that the soil presents a modest capacity to retain cadmium and that constituent metal oxides may be dissolved from the soil grains by acidic solutions.

关键词： Compacted Clay Liner Lateritic Soil Permeability Cadmium Adsorption

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一个全球性战略——控制AIDS

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中国社会医学杂志 1989年第3期6卷 171-172页

作者： mahler H 胡盛平

自AIDS 首次确诊以来已整整7年了。1981年的时候,没有人预料到,AIDS 病毒感染会成为一个异常广泛的、空前紧迫的新的全球性问题。拥有智慧、勇气和意志的人类与疾病(这是一种难对付的致死性感染)之间的抗争很少有这么严峻过。这个对社... 详细信息

自AIDS 首次确诊以来已整整7年了。1981年的时候,没有人预料到,AIDS 病毒感染会成为一个异常广泛的、空前紧迫的新的全球性问题。拥有智慧、勇气和意志的人类与疾病(这是一种难对付的致死性感染)之间的抗争很少有这么严峻过。这个对社会、经济、人口、文化和政治有重大而广泛影响的全球性问题需要全球作出反应。经过若干年的初步行动后,显然,要控制住AIDS 非全世界的共同努力不可。正如天花的消灭,只有当世界各国集合在WHO 的旗帜下方才实现了一样,要根除AI-

关键词：全球性战略全球性问题病毒感染疾病传播社会影响全球计划实验室技术流行病学模型世界卫生大会全球性发展

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