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High resolution sequence stratigraphy of the Mishrif Formation(Cenomanian-Early Turonian)at zubair oilfield(al-rafdhiah dome),southern Iraq

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Petroleum Research 2024年第1期9卷 61-71页

作者： Aymen A.Lazim maher J.Ismail maher M.Mahdi Geoscience Department Zubair Field Operation DivisionBasra Oil CompanyIraq Basrah Oil Company WQ1 FODBasrahIraq University of Basrah College of ScienceGeology Dept.BasrahIraq

The Mishrif Formation(Cenomanian-E Turonian)is one of the most important geological formations in the Middle East and Iraq because it contains enormous petroleum *** is considered to be the first reservoir in the region,and is still being studied because of its economic *** carbonate of the Mishrif Formation derives from a variety of depositional settings,including mid-ramp,shoal,lagoon,and *** five main microfacies discussed in this paper are wackestone,packstone,grainstone,floatstone,and *** most frequent fossilised components found in the Mishrif Formation are rudists,benthic foraminifera,echinoderms,burrows molluscs,and *** to the microfacies and analysed wireline log data,the sequence stratigraphy of the studied formation is composed of two regression *** parasequences of transgressive-regressive cycles make up the depositional sequence of the Mishrif *** standard depositional environments seem to demonstrate a gradual regression,beginning with a short period of the outer ramp,then a steady period of the mid-ramp,and ending in the intertidal ***,the study recorded two regional maximum flooding surfaces:K-135 and *** former is present in the lowermost part of the formation,while the other lies in the *** study shows a close relationship between facies(environments)and hydrocarbon *** increased accumulation focuses on the lower part of the studied formation,and seems to be lower in the upper part of the formation as a result of changes in the environment of deposition.

关键词： Mishrif formation Cenomanian Sequence stratigraphy Zubair oilfield Iraq

Mesenchymal stem cell-based TRAIL delivery inhibits the metastatic state of clinical therapy-resistant progressive neuroblastoma

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World Journal of Pediatrics 2024年第3期20卷 287-293页

作者： Dinesh Babu Somasundaram Andrew maher Sheeja Aravindan Zhongxin Yu Brian MBesch Natarajan Aravindan Department of Radiation Oncology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Stephenson Cancer Center Oklahoma CityOKUSA Department of Pathology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Radiation Biology Laboratory University of Oklahoma Health Sciences CenterBSEB 302F941 Stanton L.Young BoulevardOklahoma CityOK 73104USA

Progressive neuroblastomas(pNBs)that defy current intensive multimodal clinical therapy(IMCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line IMCT actively evolve to acquire genetic and molecular rearrangements and display unparalleled plasticity and evolution,which causes frequent relapses in a rapidly accelerating timeline[2-4].

关键词： neuroblastoma clinical evolve

A Comprehensive Review on Charging Topologies and Power Electronic Converter Solutions for Electric Vehicles

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 675-694页

作者： Abdelfatah Ali Hossam H.H.Mousa Mostafa F.Shaaban maher A.Azzouz Ahmed S.A.Awad the Department of Electrical Engineering American University of Sharjah26666 SharjahUnited Arab Emirates the Department of Electrical Engineering South Valley University83523 QenaEgypt the Department of Electrical and Computer Engineering University of WindsorWindsorON N9B 3P4 Canada Electrical Engineering Department Qatar UniversityDoha 2713Qatar Department of Electrical and Computer Engineering Sultan Qaboos UniversityMuscat123Oman

Electric vehicles(EVs)are becoming more popular worldwide due to environmental concerns,fuel security,and price *** performance of EVs relies on the energy stored in their batteries,which can be charged using either AC(slow)or DC(fast)***,EVs can also be used as mobile power storage devices using vehicle-to-grid(V2G)*** electronic converters(PECs)have a constructive role in EV applications,both in charging EVs and in ***,this paper comprehensively investigates the state of the art of EV charging topologies and PEC solutions for EV *** examines PECs from the point of view of their classifications,configurations,control approaches,and future research prospects and their impacts on power *** can be classified into various topologies:DC-DC converters,AC-DC converters,DC-AC converters,and AC-AC *** address the limitations of traditional DC-DC converters such as switching losses,size,and high-electromagnetic interference(EMI),resonant converters and multiport converters are being used in high-voltage EV ***,power-train converters have been modified for high-efficiency and reliability in EV *** paper offers an overview of charging topologies,PECs,challenges with solutions,and future trends in the field of the EV charging station applications.

关键词： Charging station charging topology electric vehicle power electronic converter vehicle-to-grid

Effect of No Tillage and Conventional Tillage on Wheat Grain Yield Variability: A Review

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Journal of Environmental & Earth Sciences 2024年第1期6卷 57-70页

作者： Kenza Kadiri Hassani Moussadek Rachid Baghdad Bouamar Zouahri Abdelmjid Dakak Houria maher Hassnae Bouabdli Abdelhak Laboratory of Geosciences Department of GeologyFaculty of SciencesIbn Tofail UniversityKenitra B.P.242Morocco International Center for Agricultural Research in the Dry Areas(ICARDA) Rabat P.O.Box 1014Morocco Research Unit on Environment and Conservation of Natural Resources Regional Center of RabatNational Institute of Agricultural ResearchRabat P.O.Box 6356Morocco Georesources Environmentalist Consultant/Expert Associate Professor at Casablanca School of Architecture and Landscape-Honoris United UniversitiesCasablancaB.P.20100Morocco Laboratory of Materials Nanotechnology and EnvironmentDepartment of ChemistryFaculty of SciencesMohammed V UniversityRabat B.P.703Morocco

Conservation Agriculture(CA)covers more than 205 million hectares in the *** made it possible to face and mitigate the challenges of climate change,reducing soil erosion and providing multiple ecosystem *** first elementary factor influenced is the yield *** has a direct effect on farmers’choices for sustainable *** present article records a review focused on wheat yield average positive change compared between conventional tillage(CT)and no tillage(NT)*** international database collected showed that NT is adaptable *** results of wheat yield differentiation showed the influence of crop rotation depending on stations located in different climatic *** more than 40 years of research,specialists have succeeded in demonstrating the importance of crop productivity like *** whole integrates also experimentations where the initiation starts more than ten years.

关键词： Climate change No tillage Crop rotation Wheat Yield

A hybrid machine-learning model for solar irradiance forecasting

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CLEAN ENERGY 2024年第1期8卷 100-110页

作者： Almarzooqi, Ameera M. Maalouf, maher El-Fouly, Tarek H. M. Katzourakis, Vasileios E. El Moursi, Mohamed S. Chrysikopoulos, Constantinos, V Khalifa Univ Dept Ind & Syst Engn POB 127788 Abu Dhabi U Arab Emirates Khalifa Univ Abu Dhabi Elect Engn & Comp Sci Dept Abu Dhabi U Arab Emirates Khalifa Univ Dept Civil Infrastruct & Environm Engn POB 127788 Abu Dhabi U Arab Emirates Tech Univ Crete Sch Chem & Environm Engn Khania 73100 Greece

Nowcasting and forecasting solar irradiance are vital for the optimal prediction of grid-connected solar photovoltaic (PV) power plants. These plants face operational challenges and scheduling dispatch difficulties due to the fluctuating nature of their power output. As the generation capacity within the electric grid increases, accurately predicting this output becomes increasingly essential, especially given the random and non-linear characteristics of solar irradiance under variable weather conditions. This study presents a novel prediction method for solar irradiance, which is directly in correlation with PV power output, targeting both short-term and medium-term forecast horizons. Our proposed hybrid framework employs a fast trainable statistical learning technique based on the truncated-regularized kernel ridge regression model. The proposed method excels in forecasting solar irradiance, especially during highly intermittent weather periods. A key strength of our model is the incorporation of multiple historical weather parameters as inputs to generate accurate predictions of future solar irradiance values in its scalable framework. We evaluated the performance of our model using data sets from both cloudy and sunny days in Seattle and Medford, USA and compared it against three forecasting models: persistence, modified 24-hour persistence and least squares. Based on three widely accepted statistical performance metrics (root mean squared error, mean absolute error and coefficient of determination), our hybrid model demonstrated superior predictive accuracy in varying weather conditions and forecast horizons. A novel prediction method for solar irradiance, targeting both short-term and medium-term forecast horizons, is proposed to improve PV power production. The hybrid framework employs a fast trainable statistical learning technique based on the truncated-regularized kernel ridge regression model. Graphical Abstract

关键词： solar power generation kernel ridge regression hybrid model forecasting BATTERY ENERGY-STORAGE POWER PV RADIATION PREDICTION CELLS

The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory

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Oncology Research 2024年第6期32卷 1037-1045页

作者： maher KURDI ALAA ALKHOTANI ABDULRAHMAN SABBAGH EYAD FAIZO AHMED I.LARY AHMED K.BAMAGA MAJID ALMANSOURI BADR HAFIZ THAMER ALSHARIF SALEH BAEESA Department of Pathology Faculty of MedicineKing Abdulaziz UniversityRabighSaudi Arabia Department of Pathology College of MedicineUmm Al-Qura UniversityMakkahSaudi Arabia Department of Surgery Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Surgery Faculty of MedicineUniversity of TabukTabukSaudi Arabia Section of Neurosurgery Department of SurgeryKing Abdulaziz Medical CityJeddahSaudi Arabia Department of Pediatrics Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Clinical Biochemistry Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Neurosciences King Faisal Specialist Hospital and Research CenterJeddahSaudi Arabia Department of Surgery King Abdulaziz Specialist HospitalTaifSaudi Arabia

Background:The dysregulation of Isocitrate dehydrogenase(IDH)and the subsequent production of 2-Hydroxyglutrate(2HG)may alter the expression of epigenetic proteins in Grade 4 *** interplay mechanism between IDH,O-6-methylguanine-DNA methyltransferase(MGMT)-promoter methylation,and protein methyltransferase proteins-5(PRMT5)activity,with tumor progression has never been ***:A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype *** groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR ***-cohort statistical significance was ***:Both IDH-mutant WHO grade 4 astrocytomas(n=22,64.7%)and IDH-wildtype glioblastomas(n=12,35.3%)had upregulated PRMT5 gene expression except in one *** of the 22 IDH-mutant tumors,10(45.5%)tumors showed MGMT-promoter methylation and 12(54.5%)tumors had unmethylated *** IDH-wildtype tumors had unmethylated *** was a statistically significant relationship between MGMT-promoter methylation and IDH in G4 astrocytoma(p-value=0.006).Statistically significant differences in progression-free survival(PFS)were also observed among all G4 astrocytomas that expressed PRMT5 and received either temozolomide(TMZ)or TMZ plus other chemotherapies,regardless of their IDH or MGMT-methylation status(p-value=0.0014).Specifically,IDH-mutant tumors that had upregulated PRMT5 activity and MGMT-promoter methylation,who received only TMZ,have exhibited longer ***:The relationship between PRMT5,MGMT-promoter,and IDH is not ***,accumulation of D2-hydroxyglutarate(2-HG),which partially activates 2-OG-dependent deoxygenase,may not affect their *** IDH-wildtype glioblastomas,the 2HG-2OG pathway is typically inactive,leading to PRMT5 *** alone,compared to TMZ-plus,can increase PFS in upregulated PRMT5 ***,using a PRMT5 inhibitor in G4

关键词： Grade 4 astrocytoma Glioblastoma Isocitrate dehydrogenase(IDH) O-6-methylguanine-DNA methyltransferase(MGMT) Protein methyltransferase proteins-5(PRMT5) Progression-free survival(PFS)

Preimplantation genetic testing for embryos predisposed to hereditary cancer:Possibilities and challenges

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Cancer Pathogenesis and Therapy 2024年第1期2卷 1-14页

作者： Mohammed H.Albujja maher Al-Ghedan Lakshmidevi Dakshnamoorthy Josep Pla Victori Department of Forensic Sciences Naif Arab University for Security SciencesRiyadh 11452Saudi Arabia Genetics Laboratory Thuriah Medical CenterRiyadh 11523Saudi Arabia Department of Genetic Counselling VI-RMA GlobalValencia 46004Spain

Preimplantation genetic testing(PGT),which was developed as an alternative to prenatal genetic testing,allows couples to avoid pregnancies with abnormal chromosomes and the subsequent termination of the affected *** used for early onset monogenic conditions,PGT is now used to prevent various types of inherited cancer conditions based on the development of PGT technology,assisted reproductive techniques(ARTs),and in vitro fertilization(IVF).This review provides insights into the potential benefits and challenges associated with the application of PGT for hereditary cancer and provides an overview of the existing literature on this test,with a particular focus on the current challenges related to laws,ethics,counseling,and ***,this review predicts the future potential applications of this *** PGT may be utilized to predict and prevent hereditary cancer,each case should be comprehensively *** motives of couples must be assessed to prevent the misuse of this technique for eugenic purposes,and non-pathogenic phenotypes must be carefully *** cases that require this technology should also be carefully considered based on legal and ethical *** may be the preferred treatment for hereditary cancer cases;however,such cases require careful case-by-case ***,this study concludes that multidisciplinary counseling and support for patients and their families are essential to ensure that PGT is a viable option that meets all legal and ethical concerns.

关键词： Preimplantation genetic testing Hereditary cancer Late-onset diseases Ethics Legal restrictions

Outcome of Nurses with Occupational Dermatitis

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Open Journal of Nursing 2024年第6期14卷 239-251页

作者： Amira Omrane Chayma Harrathi Asma Kheder maher Maoua Malek Ben Abdelkader Taoufik Khalfallah Najib Mrizak Mohamed Akrout Mohamed Adnene Henchi Hichem Bel Hadj Ali Department of Occupational Medicine and Ergonomics Taher Sfar Teaching Hospital Mahdia Tunisia Department of Occupational Medicine Houcine Bouzaiene Teaching Hospital Gafsa Tunisia Department of Occupational Medicine Farhat Hached Teaching Hospital Sousse Tunisia Department of Occupational Medicine and Ergonomics Fattouma Bourguiba Teaching Hospital Monastir Tunisia Department of Dermatology Fattouma Bourguiba Teaching Hospital Monastir Tunisia

Background: Occupational dermatitis is considered as the second most common occupational disease. It accounts for 25% of all lost workdays. Several international studies reported a prevalence of occupational dermatitis in healthcare workers between 17% and 55%. This study aims to identify factors that affect the professional outcome of nurses suffering from occupational dermatitis. Methods: This was a multicenter cross-sectional study concerning nurses declared having occupational dermatitis in the central region of Tunisia. A synoptic sheet related to socio-professional and administrative data was completed. A self-administered Questionnaire going over medical and occupational characteristics was completed during a direct interview. Results: The study involved forty nurses working in four public hospitals in the center of Tunisia. Only 37 workers were included in the study. A professional reclassification was introduced among 19 workers (51% of study population). Work-station adaptation was requested in 14 cases (38%). Exposure to allergens in the workplace was eliminated in 20 cases. Two study participants were transferred to other departments (5.4%) and three people retired (8.1%). A statistically significant association was found between professional reclassification and a history of allergic manifestations (p = 0.003). Similarly, a significant association was found between professional reclassification and the allergic agent (p = 0.014). Workstation layout was significantly associated with a history of allergic manifestations (p = 0.039), the palm hand location (p = 0.04), professional eviction (p Conclusion: This study identified the main factors influencing the occupational outcome of nurses suffering from occupational dermatitis. This outcome depended on a history of atopy (especially allergic rhinitis) and sensitization to allergens (thiuram mix).

关键词： Nursing Occupational Dermatitis Hospital

Arsenobetaine and thio-arsenic species in marine macroalgae and herbivorous animals: Accumulated through trophic transfer or produced in situ?

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Journal of Environmental Sciences 2016年第11期28卷 131-139页

作者： Simon Foster william maher Ecochemistry Laboratory Institute for Applied Ecology University of Canberra

Arsenobetaine（AB） and thio-arsenoribosides were measured in common macroalgae species（8 phaeophyta, 4 rhodophyta and 2 chlorphyta）, along the Australian south east coast line. As well, arsenic species profiles were measured for two common marine herbivores, the sea urchin Centrostephanus rodgersii and the fish Odax cyanomelas that graze on these macroalgae to understand if trophic transfer of these species would account for their presence in marine herbivores. AB was found in seven of the fourteen macroalgae species investigated but does not contributed significantly to any of the macroalgae arsenic content（0.01-1.2 μg/g）. AB was found in only two of the brown macroalgae and all the red and green macroalgae（with the exception of Corallina officinalis）. Thio-arsenic species were found sporadically, but not in high concentrations in any of the macroalgae *** present in macroalgae is likely to be associated with epiphytic organisms while thio-arsenoribosides are likely to be produced by decaying parts of damaged macroalgae.A laboratory feeding experiment in which the herbivorous gastropod, Austrocochlea constricta, was fed macroalgae containing thio-arsenoribosides for a 24 hr period every three days showed that these are readily accumulated over a short period. Thio-arsenoribosides in herbivores are therefore probably obtained through trophic transfer. Some AB is also obtained through trophic transfer; however, the presence of trimethylated arsonioribosides,a hypothesized precursor of AB formation in herbivores, suggests that some AB is produced within herbivores from the transformation of arsenoribosides accumulated from their diet.

关键词： Arsenobetaine Arsenic Metabolism Thio-arsenosugars Macroalgae Gastropods