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Management of proximal tibial stress fracture associated with advanced knee osteoarthritis:A systematic review

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Chinese Journal of Traumatology 2024年第3期27卷 147-152页

作者： Mukesh Kumar Saini mahendra singh Devendra singh Prem Manohar Seervi Pera Jayavardhan Reddy Neelam Ramana Reddy Department of Orthopaedics Dr SN Medical CollegeJodhpur342011India Department of Orthopaedics Star HospitalsB Block Banjara HillsHyderabad500034India

Purpose:Tibial stress fracture associated with knee osteoarthritis is an unusual and difficult clinical *** is no clear existing treatment guideline for this uncommon clinical *** aim of this study is to review the impact of various treatment options for patients with advanced knee osteoarthritis associated with proximal tibial stress ***:The study was performed using the databases of PubMed and *** index for non-randomized studies score was used to evaluate the included studies’*** concluded data included the treatment approach,reported outcome measure,and time to fracture *** literature search was started in December 2021 and accomplished in January 2022.A narrative description of the different methods and comparison of their results were ***:Out of total assessed 69 studies,9 studies were included in our *** commonest treatment approach used was total knee arthroplasty by long tibial stem *** mean preoperative knee society score and knee functional score were 30.62 and 23.17,*** mean postoperative knee society knee score was 86.87,while the functional score was *** average reported time to achieve fracture union was 4 months(a range of 2.07-5.50 months).Conclusion:The optimal clinical outcome for treating either acute or mobile tibial stress fracture in patients with advanced knee osteoarthritis can be achieved with long stem total knee ***,due to heterogeneity of data,comparison of different treatment options for chronic proximal tibial stress fracture mal-union/non-union coexisting with knee osteoarthritic and such inferences need to be judged cautiously.

关键词： Tibial stress fracture Knee osteoarthritis Total knee arthroplasty

Analysis of the urethral stricture score and patient-related factors as predictors of outcomes following oral mucosal graft urethroplasty

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Asian Journal of Urology 2024年第3期11卷 473-479页

作者： Nikita Shrivastava Rahul Jena Deepak Prakash Bhirud mahendra singh Gautam Ram Choudhary Arjun singh Sandhu Department of Urology All India Institute of Medical SciencesJodhpurRajasthanIndia

Objective:The complexity of urethral strictures can predict outcomes following *** previously described urethral stricture score(U score)considered only stricture-related factors to grade the complexity of urethral strictures and to predict recurrence post urethroplasty,but not considered patient-related factors for the *** aimed to study the correlation of both of these factors to the outcomes of oral mucosal graft ***:We retrospectively reviewed data of 101 patients who underwent oral mucosal graft urethroplasty in our institute with a minimum follow-up of 6 *** patient characteristics and stricture-related parameters were *** U score was calculated for all patients which consisted of the length,location,number,and etiology of *** and multivariate Cox proportional hazard regression models were used to determine significant risk factors of ***:The mean follow-up of patients was 15 *** was seen in 28 patients and the mean time for detection of recurrence was 8 months of *** Charlson Comorbidity Index,history of previous intervention,length of strictures,location of strictures,number of strictures,history of smoking,and etiology were independent predictors of recurrence following *** on these parameters,we formulated the modified U score(MU score).The scores ranged from 0 to 6 and a score of>2 was found to be predictive of *** comparing receiver operating characteristic curves for both scores by the DeLong test,the MU score had larger area under the curve than the U ***:The MU scoring system is the first of its kind attempt taking into consideration both patient-and stricture-related factors to predict recurrence following oral mucosal graft urethroplasty.

关键词： Urethral stricture Urethral stricture score Recurrence Urethroplasty

Comment on: Observation of peripheral refraction in myopic anisometropia in young adults

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1385-1386页

作者： Suraj Kumar Chaurasiya mahendra singh Pradeep Agarwal Yu-Qin Du Yue-Hua Zhou Ming-Wei Ding Ming-Xu Zhang Yu-Juan Guo Shan-Shan Ge Department of Optometry and Vision Science CL Gupta Eye InstituteRam Ganga Vihar Phase II(Extn.)MoradabadUttar Pradesh 244001India Department of Paediatric and Neuro Ophthalmology CL Gupta Eye InstituteRam Ganga Vihar Phase II(Extn.)MoradabadUttar Pradesh 244001India Eye School of Chengdu University of TCM Ineye Hospital of Chengdu University of TCMChengdu 610036Sichuan ProvinceChina Beijing Ming Vision and Ophthalmology Beijing 100010China

Dear Editor,We read with great interest the recently published article titled“Observation of peripheral refraction in myopic anisometropia in young adults”by Du et al[1].The study conducted at the InEye Hospital of Chengdu University of TCM provides valuable insights into the relationship between anisometropia and peripheral refraction in myopic young *** commend the authors for their thorough investigation and adherence to ethical *** the study contributes significantly to our understanding of myopic anisometropia,we would like to draw attention to some limitations that merit consideration for a comprehensive interpretation of the findings.

关键词： Observation young insight

Bearing capacity of foundations on rock slopes intersected by non-persistent discontinuity

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International Journal of Mining Science and Technology 2020年第5期30卷 669-674页

作者： Divya Shaunik mahendra singh Department of Civil Engineering Indian Institute of Technology RoorkeeRoorkee 247667India

Rocks encountered in foundations of heavy structures are invariably intersected by discontinuities(joints).In the past,several studies have been performed by researchers to incorporate the effect of fully persistent joints in the assessment of the load-carrying capacity of ***,in the field,the joints are non-persistent,and an assumption of full persistency will underestimate the ***,Shaunik&singh have studied the influence of non-persistency,number of joint segments and discontinuity orientation on the strength behaviour of rock specimens(Shaunik and singh,2019).Bell’s approach can be used to obtain the bearing capacity of shallow foundations placed in jointed *** the present study,results of the experimental work(Shaunik and singh,2019)conducted by Shaunik&singh have been used to suggest expressions by extending Bell’s approach for computing bearing capacity of the foundation placed near the crown of a rock *** to use design charts are also presented for field ***,a real-life problem from Indian Garhwal Himalayas is considered,and the approach suggested in this study is utilised to obtain the bearing capacity of a bridge foundation as a function of uniaxial compressive strength(UCS)of intact rock,joint friction,spacing and orientation of joint,nonpersistency and number of joint segments.

关键词： Uniaxial compressive strength(UCS) Joint segment Discontinuity Non-persistency Bell’s approach

Strength behaviour of a model rock intersected by non-persistent joint

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第6期11卷 1243-1255页

作者： Divya Shaunik mahendra singh Department of Civil Engineering Indian Institute of Technology Roorkee

Several constructions in the field of civil engineering quite often need to deal with *** behaviour of rock intersected by a discontinuity or a set of discontinuities has been a topic of keen interest for engineering *** popular attributes of discontinuities that have been given due importance are their frequency,orientation and surface ***-persistency,however,has been given little *** article presents an experimental study wherein focus has been made on the effect of non-persistency of the joint on the uniaxial compressive strength(UCS)of a model rock for various geometries such as orientation,discontinuity length ratio and number of joint *** applicability of single plane of weakness theory(SPWT)to assess the strength of jointed specimens has also been *** has been noticed that SPWT captures the strength behaviour only for a narrow range of discontinuity *** an improvement,an approach is suggested by extending concepts of degree of persistence and joint factor to have a better understanding towards strength behaviour of rocks intersected by non-persistent joints.

关键词： Uniaxial compressive strength (UCS) Joint segment Non-persistency Joint factor

Seismic analysis of structures with a fractional derivative model of viscoelastic dampers

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Earthquake Engineering and Engineering Vibration 2002年第2期1卷 251-260页

作者： Tsu-sheng Chang mahendra P.singh Department of Engineering Science and Mechanics.Virginia Polytechnic Institute and State Universigy.Blacksburg Virginia24061.USA

Viscoelastic dampers are now among some of the preferred energy dissipation devices used for passive seismic response *** evaluate the performance of structures installed with viscoelastic dampers,different analytical models have been used to characterize their dynamic force deformation *** fractional derivative models have received favorable attention as they can capture the frequency dependence of the material stiffness and damping properties observed in the tests very ***,accurate analytical procedures are needed to calculate the response of structures with such damper *** paper presents a modal analysis approach,similar to that used for the analysis of linear systems,for solving the equations of inotion with fractional derivative terms for arbitrary forcing functions such as those caused by earthquake induced ground *** uncoupled modal equations still have fractional derivatives,but can be solved by numerical or analytical *** numerical and analytical procedures are *** procedures are then used to calculate the dynamic response of a multi-degree of fleedom shear beam structure excited by ground motions. Numerical results demonstrating the response reducing effect of viscoelastic dampers are also presented.

关键词： viscoelastic damper fractioal derivative seismic response

Rifabutin reduces systemic exposure of an antimalarial drug 97/78 upon co-administration in rats:an in-vivo & in-vitro analysis

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 620-625页

作者： Yeshwant singh mahendra Kumar Hidau Shio Kumar singh Pharmacokinetics & Metabolism Division CSIR-Central Drug Research Institute Academy of Scientific and Innovative Research

Objective: To determine the potential drug-drug interactions between anti-malarial candidate 97/78 and anti-tubercular drug rifabutin in-vivo in rats followed by in-vitro investigation of the underlying mechanisms of drug interaction. Methods: Single oral dose study was conducted in male and female rats at 40 mg/kg and 70 mg/kg for 97/78 and rifabutin respectively. Results: It was reported that rifabutin co-administration altered pharmacokinetics of 97/63(active metabolite of 97/78). A significant decrease was reported in the systemic exposure of 97/63 by a factor of 3-4. The AUC0-last values were(4.03 ± 0.60) and(5.44 ± 1.15) μg·h·m L-1 upon 97/78 administration alone, while the values were decreased to(1.13 ± 0.10) and(1.23 ± 1.13) μg·h·m L-1 upon rifabutin co-administration in male and female rats respectively. Statistically significant differences were also reported in Cmax and Tmax values upon rifabutin co-administration. In-vitro drug metabolism study in rat liver microsomes has shown that the metabolism of 97/63 was increased by 10%-12% upon rifabutin co-incubation. The extent of plasma protein binding of 97/63 was found to be decreased from 54%-55% to 6%-8% upon rifabutin addition. Conclusions: It was concluded that rifabutin co-administration altered PK parameters of 97/63 in SD rats. However, no intersex influences were reported in the interaction pattern. The results obtained in the in-vivo study were well correlated with the invitro findings and can further be applied to explore other aspects of potential drug interactions between these two drugs.

关键词： Accumulation Relative bioavailability Sex effect Pharmacokinetics

Monitoring and evaluation of building ventilation system fans operation using performance curves

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能源与人工环境(英文) 2020年第3期1卷 307-318页

作者： mahendra singh Muhyiddine Jradi Hamid Reza Shaker Center for Energy Informatics University of Southern DenmarkCampusvej 555230Denmark

Ventilation fans are an important component of any mechanically ventilated *** fan performance could significantly affect the whole building performance *** are several issues such as dirty blades,mechanical wear,aging of fans could impact the fan’s *** present work,a novel,indirect and data-driven methodology is introduced to monitor the ventilation fan unit *** proposed method is able to perform continuous monitoring of ventilation fan unit in *** real-time performance of 3 Air handling unit(AHU)fans is examined in an academic *** fan performance is modeled with the help of manufacturer data and compared against the real-time *** data-driven models are developed and *** first model is used to compute expected total fan pressure at a given airflow rate while second is a Support Vector Regression(SVR)model,to predict the fan *** performance monitoring of the ventilation fan unit is determined in terms of expected and actual fan energy *** indicated a significant performance gap in three ventilation fan unit in a case building known as OU44,located in city Odense,*** advantage of this method comprises simplicity,no direct human intervention and scalability to the series of ventilation units.

关键词： Buildings Ventilation system Fan unit Performance curve Modeling Fan efficiency Energy consumption HVAC Performance testing Support vector regression(SVR) Polynomial regression

Understanding human-leopard conflict in the ‘Mid-hill’ region of western Nepal

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Journal of Mountain Science 2023年第12期20卷 3464-3475页

作者： LAMICHHANE Saroj THAPA Arjun THAPA mahendra singh PANTHI Saroj GIORDANO Anthony J School of Forestry and Natural Resources Management Institute of ForestryKirtipur 44613Nepal Institute of Fundamental Research and Studies(InFeRS) Baniyatar 44608Nepal Institute of Zoology Chinese Academy of SciencesBeijing 100101China Institute of Forestry Office of DeanKirtipur 44613Nepal Ministry of Industry TourismForest and EnvironmentKaski 33700Nepal SPECIES-The Society for the Preservation of Endangered Carnivores and their International Ecology Study VenturaCA 93006USA

Livestock rearing and agriculture are the main sources of community-based livelihoods in western *** the rural mid-hills region of Gandaki Province,leopards are the top predator and frequently depredate livestock and attack *** patterns of human-leopard conflicts(HLC) in Nepal are poorly known at the provincial and national scales,which are essential to formulating effective conflict mitigation strategies and implementing them in the *** study aims to analyze the spatiotemporal pattern of HLC by applying Maxent modeling to covariates relating to known and registered conflict cases(n=842) collected from Nepalese government *** found that cases of HLC have been increasing significantly over the past five *** also concluded that mid-elevation,south-facing slopes were more susceptible to HLC,but that mean annual temperature was by far the most important predictor of HLC;overall livestock density and proximity to roads were also important,but secondarily *** we found the increase in human fatalities to 2.16/year was significant(p0.05).However,we also found an increasing trend in livestock depredation rates for this same five-year period(p<0.05),which averaged 159.6 head/year among incidents *** also found that winter was the main season when depredations occurred,and that goats were the most depredated of all livestock.A total US $86,892.25($17,378.45/year) of economic losses were incurred by communities during this time,with 78.57% of the total value reimbursed as compensatory relief through the government’s relief *** recommend that the use of predator-proof livestock corrals,greater awareness in local communities about wildlife behavior,better animal husbandry and security practices,and a more efficient compensation program,can improve coexistence between leopard populations and human communities in western Nepal.

关键词： Coexistence Compensation Economic loss Human-wildlife conflict Livestock depredation Maximum entropy Problem animals Sustainable livelihood