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Clarifying sub-genomic positions of QTLs for flowering habit and fruit quality in u.S. strawberry (Fragaria×ananassa) breeding populations using pedigree-based QTL analysis

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Horticulture Research 2017年第1期4卷 85-93页

作者： Sujeet Verma Jason d Zurn Natalia Salinas Megan M Mathey Beatrice denoyes James F Hancock Chad E Finn Nahla V Bassil Vance M Whitaker IFAS/department of Horticulture University of FloridaGulf Coast Research and Education Center14625 CR 672Wimauma33598FLUSA uSdA-ARS National Clonal Germplasm Repository 33447 Peoria RoadCorvallis97333ORUSA department of Horticulture Oregon State University4017 Agriculture and Life Sciences BuildingCorvallis97331ORUSA department of Horticulture UMR 1332 Biologie du Fruit et PathologieINRAUniv.BordeauxVillenave d’OrnonF-33140France Michigan State university East Lansing48824MIUSA uSdA-ARS HCRU3420 NW Orchard AvenueCorvallis97330ORUSA

The cultivated strawberry(Fragaria×ananassa)is consumed worldwide for its flavor and nutritional *** analysis of commercially important traits in strawberry are important for the development of breeding methods and tools for this *** several quantitative trait loci(QTL)have been previously detected for fruit quality and flowering traits using low-density genetic maps,clarity on the sub-genomic locations of these QTLs was *** discoveries in allo-octoploid strawberry genomics led to the development of the IStraw90 single-nucleotide polymorphism(SNP)array,enabling high-density genetic maps and finer resolution QTL *** this study,breeder-specified traits were evaluated in the Eastern(Michigan)and Western(Oregon)united States for a common set of breeding populations during 2 *** QTLs were validated for soluble solids content(SSC),fruit weight(FWT),pH and titratable acidity(TA)using a pedigree-based QTL analysis *** fruit quality,a QTL for SSC on linkage group(LG)6A,a QTL for FWT on LG 2BII,a QTL for pH on LG 4CII and two QTLs for TA on LGs 2A and 5B were *** addition,a large-effect QTL for flowering was detected at the distal end of LG 4A,coinciding with the FaPFRu *** haplotype analysis in the FaPFRu region indicated that the homozygous recessive genotype was highly predictive of seasonal *** probes in the FaPFRu region may help facilitate marker-assisted selection for this trait.

关键词： breeding straw Fragaria

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经G-CSF动员的外周血干细胞对异基因骨髓移植后复发的治疗

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德国医学 2000年第1期17卷 1-3页

作者： W.Siegert J.Beyer d.Kingreen R.Blasczyk H.Baurmann N.Schwella J.Schleicher A.Kirsch d.Huhn 李荣福 Abteilmag Inhere Medizin und Poliklinik mS Hmatologie und Onkologie Virchow Klinikum Augustenburgerplatz 1 D-13353 Berlin Germany 广州暨南大学医学院

通过原骨髓移植供者的淋巴细胞输注(dLI)能成功地治疗异基因骨髓移植(allo-BMT)后白血病复发。该方法能使50%～70%的慢性期 CML 患者和10%～20%的 AML 或 ALL 患者达到完全缓解。大部分慢性期 CML 患者可达到持久的缓解,其2年生存率为67... 详细信息

通过原骨髓移植供者的淋巴细胞输注(dLI)能成功地治疗异基因骨髓移植(allo-BMT)后白血病复发。该方法能使50%～70%的慢性期 CML 患者和10%～20%的 AML 或 ALL 患者达到完全缓解。大部分慢性期 CML 患者可达到持久的缓解,其2年生存率为67%。而在急性白血病复发的患者,其长期效果不甚理想,平均生存时间 AML 为8个月,ALL 为4个月。

关键词：骨髓移植白血病复发 G-CSF

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脑室周围结节状异位在癫痫发病中的作用

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 15-16页

作者： Aghakhani Y. Kinay d. Gotman J. F. dubeau 郭俊 3801university St. MontréalQue. H3A 2B4 Canada

A temporal resection in patients with periventricular nodular heterotopia (PNH ) and intractable focal seizures yields poor results. To define the role of hete rotopic grey matter tissue in epileptogenesis and to improve outcome, we perform ed stereoencephalography (SEEG) recordings in eight patients with uni-or bilate ral PNH and intractable focal epilepsy. The SEEG studies aimed to evaluate the m ost epileptogenic areas and included the allo-and neocortex and at least one no dule of grey matter. Interictal spiking activity was found in ectopic grey matte r in three patients, in the cortex overlying the nodules in five and in the mesi al temporal structures in all. At least one heterotopion was involved at seizure onset in six patients, synchronous with the overlying neocortex or ipsilateral hippocampus. Two patients had their seizures originating in the mesial temporal structures only. Six patients had surgery and the resected areas included the se izure onset, with follow-up from 1 to 8 years. An amygdalo-hippocampectomy was performed in two (Engel class Id and III), an amygdalo-hippocampectomy plus re moval of an adjacent heterotopion in two (class Ia), and a resection of two cont iguous nodules plus a small rim of overlying occipital cortex in one patient (cl ass Id). One patient with bilateral PNH had three adjacent nodules resected and an ipsilateral amygdalo-hippocampectomy resulting in a reduction of the number of seizures by 25-50%. The best predictor of surgical outcome is the presence of a focal epileptic generator; this generator may or may not include the PNH. I nvasive recording is required in patients with PNH; it improves localization and is the key to better outcome.

关键词：结节状异位局灶性癫痫发作间期棘波杏仁核新皮质结节区手术切除范围切除术最佳预测

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用马利兰、环磷酰胺、足叶乙甙为预处理方案对急性髓系白血病患者异基因骨髓移植治疗第一次完全缓解时的高剂量化疗

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德国医学 2000年第1期17卷 4-6页

作者： A.R.Zander C.Berger N.Krger M.Stockschlder W.Krǜger M.Horstmann J.Grimm W.Zeller Hkabisch R.Erttmann P.Schnrock R.Kuse d.Braumann H.J.Illiger W.Fiedler M.deWitt K.d.Hossfeld H.J.Weh 祁明芳 Bone Marrow Transplantaion unit Universittskrankenhaus EppendorfD-20246 Hamburg Germany 广州暨南大学医学院第一附属医院

大剂量化疗和全身放疗(TBI)后,组织相合的同胞造血干细胞移植已用于急、慢性白血病的治疗。它对第一次完全缓解(CR1)的急性髓系白血病(AML)患者,长期无病生存率可达50%,而对复发的急性白血病患者,长期无病生存率约为10%～20%。异基因骨... 详细信息

大剂量化疗和全身放疗(TBI)后,组织相合的同胞造血干细胞移植已用于急、慢性白血病的治疗。它对第一次完全缓解(CR1)的急性髓系白血病(AML)患者,长期无病生存率可达50%,而对复发的急性白血病患者,长期无病生存率约为10%～20%。异基因骨髓移植(allo-BMT)预处理方案有 TBI+化疗和单用化疗两种。

关键词：急性白血病骨髓移植马利兰环磷酰胺

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影响小病和轻伤儿童到小儿急诊科就诊的因素

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 20-20页

作者： Hendry S.J. Beattie T.F. Heaney d. 郭战宏 Emergency department Bri stol Royal Hospital for Children Upper Maudlin Street Bristol BS2 8BJ United Kingdom Dr.

Aims: To gather information on children with minor illness or injury presentin g to a paediatric accident and emergency (A&E) department and the decision maki ng process leading to their attendance. Methods: Prospective questionnaire based survey of 465 children selected by systematic sampling from A&E offenders allo cated to the lowest triage category. Results: The study population was statistic ally representative of the total population of A&E offenders. The lower depriva tion categories were over represented. Educational attainment, childcare experie nce, and parental coping skills were important in relation to A&E attendance. M ore children attended with injury as opposed to illness. There were no significa nt demographic differences between those children who presented directly to A&E and those who made prior contact with a GP. Just under half the study populatio n had made contact with a general practitioner (GP) before attending A&E. The m ajority of those children were directly referred to A&E at that point. GPs refe rred equivalent numbers of children with illness and injury. Conclusions: Parent s and GPs view paediatric A&E departments as an appropriate place to seek treat ment for children with minor illness or injury.

关键词：急诊科研究人群儿童数人口统计学全科医师系统抽样法决策过程

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