脑室周围结节状异位在癫痫发病中的作用

作     者：Aghakhani Y. Kinay D. Gotman J. F. Dubeau 郭俊 

作者机构：3801University St. MontréalQue. H3A 2B4 Canada 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第8期

页      面：15-16页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：结节状异位 局灶性癫痫 发作间期 棘波 杏仁核 新皮质 结节区 手术切除范围 切除术 最佳预测 

摘      要：A temporal resection in patients with periventricular nodular heterotopia (PNH ) and intractable focal seizures yields poor results. To define the role of hete rotopic grey matter tissue in epileptogenesis and to improve outcome, we perform ed stereoencephalography (SEEG) recordings in eight patients with uni-or bilate ral PNH and intractable focal epilepsy. The SEEG studies aimed to evaluate the m ost epileptogenic areas and included the allo-and neocortex and at least one no dule of grey matter. Interictal spiking activity was found in ectopic grey matte r in three patients, in the cortex overlying the nodules in five and in the mesi al temporal structures in all. At least one heterotopion was involved at seizure onset in six patients, synchronous with the overlying neocortex or ipsilateral hippocampus. Two patients had their seizures originating in the mesial temporal structures only. Six patients had surgery and the resected areas included the se izure onset, with follow-up from 1 to 8 years. An amygdalo-hippocampectomy was performed in two (Engel class Id and III), an amygdalo-hippocampectomy plus re moval of an adjacent heterotopion in two (class Ia), and a resection of two cont iguous nodules plus a small rim of overlying occipital cortex in one patient (cl ass Id). One patient with bilateral PNH had three adjacent nodules resected and an ipsilateral amygdalo-hippocampectomy resulting in a reduction of the number of seizures by 25-50%. The best predictor of surgical outcome is the presence of a focal epileptic generator; this generator may or may not include the PNH. I nvasive recording is required in patients with PNH; it improves localization and is the key to better outcome.