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Monitoring dioxins and PCBs in eggs as sensitive indicators for environmental pollution and global contaminated sites and recommendations for reducing and controlling releases and exposure

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Emerging Contaminants 2022年第1期8卷 254-279页

作者： Jindrich Petrlik Lee Bell Joe diGangi Serge Molly allo'o allo'o Gilbert Kuepouo Griffins Ochieng Ochola Valeriya Grechko Nikola Jelinek Jitka Strakova Martin Skalsky Yuyun Ismawati drwiega Jonathan N.Hogarh Eric Akortia Sam Adu-Kumi Akarapon Teebthaisong Maria Carcamo Bjorn Beeler Peter Behnisch Claudia Baitinger Christine Herold Roland Weber International Pollutants Elimination Network(IPEN) GooteborgSweden Arnika e Toxics and Waste Programme Delnicka 13PragueCzech Republic National Toxics Network(NTN) PerthAustralia National SAICM Focal Point President of the Tenth Conference of the Parties to the Rotterdam ConventionMinistry of ForestryFisheries and EnvironmentLibrevilleGabon Centre de Recherche et d‘Education pour le developpement(CREPd) YaoundeCameroon Centre for Environmental Justice and development(CEJAd) NairobiKenya university of Chemistry and Technology Technicka 5PragueCzech Republic Arnika e Citizens'Support Center Delnicka 13PragueCzech Republic Nexus3 Foundation Denpasar80223Indonesia department of Environmental Science Kwame Nkrumah University of Science and TechnologyKumasiGhana Ghana Atomic Energy Commission National Nuclear Research InstituteAccraRepublic of Ghana Chemicals Control and Management Centre Environmental Protection AgencyAccraGhana Ecological Alert and Recovery e Thailand(EARTH) NonthaburiThailand La Red de Accion en Plaguicidas y sus Alternativas para America Latina MontevideoUruguay Biodetection Systems BV(BdS) Science Park 4061098 XHAmsterdamthe Netherlands Bund für umwelt und Naturschutz(BuNd) Germany POPs Environmental Consulting D-73527Schw€abisch GmündGermany

This review compiles information on PCdd/F-and PCB-contaminated eggs from 20 years of global egg monitoring around emission sources in four continents conducted by the International Pollutants Elimination Network(IPEN)and Arnika as well as a compilation of data from scientific *** monitored 127 pooled egg samples including samples from 113 chicken flocks at potential PCdd/F-and PCB-contaminated sites around priority sources listed in the Stockholm Convention(*** incinerators,metal industries,cement plants,and open burning).99(88%)of pooled egg samples were above the Eu maximum limits for PCdd/Fs(2.5 pg PCdd/F-TEQ/g fat)or the sum of PCdd/Fs and dioxinlike PCBs(5 pg PCdd/F-PCB-TEQ/g fat).Children consuming such eggs exceed the tolerable weekly intake(TWI).This demonstrates that close to 90%of these areas were not safe for the production of free-range *** out of the 113 egg samples(14%)were contaminated above 50 pg TEQ/g fat and exceeded the Eu maximum limit more than 10 *** the 26 pooled egg samples around incinerators 24(92%)exceeded the limit with a mean of 43.1 pg TEQ/g fat(2.6e234 pg TEQ/g).All 21 egg samples around metal industries(4.4e112.6 pg TEQ/g fat)were above limits with mean concentration of 26.0 pg TEQ/g *** all 7 egg samples measured at e-waste recycling sites were above limits(mean 308 pg TEQ/g fat).In 58(51%)pooled egg samples the PCB-TEQ was above 5 pg TEQ/g fat exceeding the Eu maximum limit with dioxin-like PCBs *** highlights the role of commercial PCBs for global contamination with dioxin-like *** was discovered that around metal industries,shredder plants,open burning sites of e-waste and dump sites,a high share of contamination was caused by *** clearly shows severe PCB release from the end-of-life management of PCB-containing equipment in developing *** highly contaminated eggs were found at many sites where plastic was *** highest contaminated egg sample ev

关键词： PCdd/PCdF dl-PCBs PBdd/PBdF Contaminated sites Monitoring Egg dR CALuX

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Magnesium Enhances the Hepatorenal Protective Effects of Lippia multiflora Aqueous Leaves Extract in Streptozotocin-diabetic Rats

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Journal of Biosciences and Medicines 2023年第10期11卷 35-45页

作者： Yapo Fulgence allo Viviane Jocelyne Zannou-Tchoko Kouamé Hermann Yéboué Brou André Konan Jacques Yao datté Biology and Health Laboratory UFR Biosciences Félix Houphou&eumlt-Boigny University Abidjan C&ocircte d’Ivoire

Purpose: This study was conducted in order to evaluate the antidiabetic effects of the aqueous extract of Lippia multiflora supplemented with magnesium on some biochemical markers of the kidneys and liver in type 2 diabetic rats. Method: 7 groups of 4 STZ-diabetic rats received separately orally Glucophageup>®up> (Glu 10 mg/kg), the plant extract (LiMAE 200 - 600 mg/kg) and the plant extract supplemented with magnesium (LiMAE-Mg 200 - 600 mg/kg). After a daily treatment of 21 days, serum biochemical parameters were assayed in 16 hr-fasted rats. Results: diabetes caused a significant (p Conclusion: The addition of magnesium to the extract of Lippia multiflora caused a greater reduction in the levels of urea, creatinine, ALT and AST increased in STZ-diabetic rats. Magnesium would therefore enhance the nephroprotective and hepatoprotective effects of Lippia multiflora in diabetic rats.

关键词： Lippia multiflora diabetes Streptozotocin Nephroprotective Hepatoprotective

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Polymer-mediated immunocamouflage of red blood cells: Effects of polymer size on antigenic and immunogenic recognition of allogeneic donor blood cells

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Science China(Life Sciences) 2011年第7期54卷 589-598页

作者： WANG dunCheng dana L. KYLuIK Kari L. MuRAd Wendy M. TOYOFuKu Mark d. SCOTT Canadian Blood Services Vancouver V6T 1Z3 British Columbia Canada Centre for Blood Research and the department of Pathology and Laboratory Medicine university of British Columbia Vancouver V6T 1Z3 British Columbia Canada department of Biology College of St. Rose Albany 12208 New York USA

developing a practical means of reducing alloimmunization in chronically transfused patients would be of significant clinical benefit. Immunocamouflaging red blood ceils （RBCs） by membrane grafting of methoxypoly（ethylene glycol）（mPEG） may reduce the risk of allo-immunization. The results of this study showed that antibody recognition of non-ABO antigens was sig- nificantly reduced in an mPEG-dose- and polymer size-dependent manner, with higher molecular weight mPEGs providing better immunoprotection. Furthermore, in vivo immunogenicity was significantly reduced in mice serially transfused with mPEG-modified xenogeneic （sheep; sRBCs）, allogeneic （C57B1/6）, or syngeneic （Balb/c） RBCs. Following a primary transfu- sion of sRBCs, mice receiving mPEG-sRBCs showed a 〉90% reduction in anti-sRBC IgG antibody levels. After two transfusions, mice receiving mPEG-sRBCs showed reductions of 〉80% in anti-sRBC IgG levels. Importantly, mPEG-modified autologous cells did not induce neoantigens or an immune （IgG or IgM） response. These data suggest that the global immuno- camouflage of RBCs by polymer grafting may provide a safe and cost-effective means of reducing therisk of alloimmunization.

关键词： methoxypoly(ethylene glycol) erythrocyte blood group antigens mice alloimmunization

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LORENZO MuNARI-PIERPAOLO VIENNA——I SEPSIdAE dELLA TORBIERA d'ISEO SEPSIdAE OF THE PEAT-BOG OF ISEO(Italy)(diptera,Brachycera)

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Natural disaster Reduction in China 1976年第1期 43-46页

作者： RICERCHE NELLE TORBIERE d’ISEO(Brescia) Odonata.Redia LVI:231-269 2 tab. 10 fig.

allorehé nel n.10 del 1973,p.104 di questo Annuario comparve unarticolo dal titolo《Ricerche nelle torbiere di Iseo(Brescia),la redazione au-spicò che alla prima pubblicazione sui ditteri Ephydridae di Canzoneri eMeneghini facessero seguito altri lavori,allo scopo di fornire un quadro sul-le caratteristiche bio-ecologiche del suddetto particolare ambiente di *** studio compiuto dai due ditterologi veneziani emersero alcuni daticorologici alquanto interessanti sia per la fauna lombarda,sia per quella

关键词： Ta IX Italy LORENZO MuNARI-PIERPAOLO VIENNA diptera,Brachycera I SEPSIdAE dELLA TORBIERA d’ISEO SEPSIdAE OF THE PEAT-BOG OF ISEO

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allogeneic stem cell transplantation-A curative treatment for paroxysmal nocturnal hemoglobinuria with PIGT mutation:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5702-5707页

作者： Laurence Schenone Anne-Béatrice Notarantonio Véronique Latger-Cannard Veronique Fremeaux-Bacchi Marcelo de Carvalho-Bittencourt Marie-Thérèse Rubio Marc Muller Maud d'Aveni department of Hematology CHRU de NancyNancy F-54000France Genetic Laboratory CHRU de NancyNancy F-54000France IMoPA CNRS 7365University of LorraineNancy F-54000France Hematology Laboratory Cytometry PlatformCHRU de NancyNancy F-54000France Immunology Laboratory Hôpital Européen George PompidouParis 75015France Immunology Laboratory CHRU de NancyNancy F-54000France

BACKGROuNd Patients with paroxysmal nocturnal hemoglobinuria(PNH)have a clonal population of blood cells deficient in glycosylphosphatidylinositol-anchored(GPIanchored)proteins,most of the time resulting from a mutation in the X-linked gene *** report a patient with PNH resulting from a rare biallelic PIGT mutation on chromosome *** SuMMARY A 47-year-old man was referred to our hospital for febrile *** patient reported a history of recurrent urticaria and arthralgia and he presented during 3 mo recurrent acute dermo-hypodermitis and aseptic *** on clinical cases published with PIGT-PNH,with clinically typical PNH and autoinflammatory symptoms,we treated our patients with repeated infusions of eculizumab to decrease autoinflammatory symptoms and then we performed an allogeneic stem cell transplantation(allo-SCT)with a mismatched unrelated *** patient experienced no acute Graft vs Host disease(GvHd)and a moderate chronic GvHd and is now considered cured at 24 mo after *** This case report suggests that allo-SCT should be considered to cure PIGT-PNH patients.

关键词： Paroxysmal nocturnal hemoglobinuria allogeneic stem cell transplantation PIGT mutation Recurrent meningitidis Autoinflammatory symptoms Case report

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Harnessing the synergy of perfusable muscle flap matrix and adipose-derived stem cells for prevascularization and macrophage polarization to reconstruct volumetric muscle loss

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Bioactive Materials 2023年第4期22卷 588-614页

作者： Qixu Zhang Yulun Chiu Youbai Chen Yewen Wu Lina W.dunne Rene d.Largo Edward I.Chang david M.Adelman Mark V.Schaverien Charles E.Butler department of Plastic Surgery The University of Texas MD Anderson Cancer CenterHoustonTX77030USA department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX77030USA department of Plastic Surgery Chinese PLA General HospitalBeijing100853China

Muscle flaps must have a strong vascular network to support a large tissue volume and ensure successful *** developed porcine stomach musculofascial flap matrix(PdSF)comprising extracellular matrix(ECM)and intact *** had a dominant vascular pedicle,microcirculatory vessels,a nerve network,well-retained 3-dimensional(3d)nanofibrous ECM structures,and no allo-or ***-depth proteomic analysis demonstrated that PdSF was composed of core matrisome proteins(e.g.,collagens,glycoproteins,proteoglycans,and ECM regulators)that,as shown by Gene Ontology term enrichment analysis,are functionally related to musculofascial biological ***,PdSF􀀀human adipose-derived stem cell(hASC)synergy not only induced monocytes towards IL-10􀀀producing M2 macrophage polarization through the enhancement of hASCs’paracrine effect but also promoted the proliferation and interconnection of both human skeletal muscle myoblasts(HSMMs)and human umbilical vein endothelial cells(HuVECs)in static triculture ***,PdSF was successfully prevascularized through a dynamic perfusion coculture of hASCs and HuVECs,which integrated with PdSF and induced the maturation of vascular networks in *** a xenotransplantation model,PdSF demonstrated myoconductive and immunomodulatory properties associated with the predominance of M2 macrophages and regulatory T *** a volumetric muscle loss(VML)model,prevascularized PdSF augmented neovascularization and constructive remodeling,which was characterized by the predominant infiltration of M2 macrophages and significant musculofascial tissue *** results indicate that hASCs’integration with PdSF enhances the cells’dual function in immunomodulation and *** in part to this PdSF-hASC synergy,our platform shows promise for vascularized muscle flap engineering for VML reconstruction.

关键词： Muscle flap fabrication Extracellular matrix decellularization Vascularization Macrophage polarization Volumetric muscle loss

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Changes of Fiscal and Financial Capacity in a Reforming China

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China & World Economy 2003年第3期11卷 28-35页

作者： Zhou Li, Associate Professor, Renmin university of China Post Ph.d., Center for China Studies, Tsinghua university.

China finds itself in a dual transitional period forboth its economy and its society with the govern-ment playing key role. The government is obliged tomaintain and reinforce its capacity to mobilize and.allo-cate social resources, to maintain a stable developmentof both the economy and *** paper,concernedwith the source of funds, has divided national capacityinto national fiscal capacity and national *** calculation and analysis of the fiscal ca-pacity and financial capacity,we will explain the role ofthe finance industry as "secondary public finance."

关键词： of is in Changes of Fiscal and Financial Capacity in a Reforming China

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纤维母细胞生长因子对复合皮肤移植成活和收缩的影响

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中华整形烧伤外科杂志 1993年第1期9卷 41-44,79页

作者：方承辉 Robb E C 于光曙 Alexander J W Warden G d 北京医科大学第一医院烧伤科 100034 美国Cincinnati Shriners烧伤研究所

我们曾报道应用同基因表层皮片(IE)和同种异基因真皮(Ad)组成复合皮肤移植物(CSG)可一次完成全层皮肤缺损的永久性修复。但由于IE不能及时获得足够血运,IE常有部分坏死,CSG后期收缩仍较明显。在本研究中我们进一步用纤维母细胞生长因子(... 详细信息

我们曾报道应用同基因表层皮片(IE)和同种异基因真皮(Ad)组成复合皮肤移植物(CSG)可一次完成全层皮肤缺损的永久性修复。但由于IE不能及时获得足够血运,IE常有部分坏死,CSG后期收缩仍较明显。在本研究中我们进一步用纤维母细胞生长因子(FGF)预先处理Ad获得较好效果。经观察17周表明,FGF组皮片坏死率和坏死面积较对照组明显下降(Pd未被排斥。

关键词：纤维母细胞生长因子皮肤移植

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纤维母细胞生长因子对复合皮肤移植成活和收缩的影响

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中华烧伤杂志 1993年第1期 41-44+79页

作者：方承辉 Robb E C 于光曙 Alexander J W Warden G d 北京医科大学第一医院烧伤科美国Cincinnati Shriners烧伤研究所北京医科大学第一医院烧伤科美国Cincinnati Shriners烧伤研究所美国Cincinnati Shriners烧伤研究所 100034 100034

关键词：纤维母细胞生长因子皮肤移植

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异基因造血干细胞移植后T辅助细胞亚群重建研究

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中华血液学杂志 2013年第9期34卷 745-750页

作者：赵翔宇赵晓甦王亚哲常英军吕萌王洪涛韩婷婷黄晓军北京大学人民医院、北京大学血液病研究所北京市造血干细胞移植治疗血液病重点实验室100044

目的研究异基因造血干细胞移植（***）后Cd4＋T细胞及Cd8＋T细胞中Cd25＋Foxp3＋（Cd4＋Treg细胞或Cd8＋Treg细胞）、IL一17a（Thl7细胞或Tcl7细胞）及IFN．7（Thl细胞或Tcl细胞）表达以及Cd4＋Cd25。Cdl27＋效应性T细胞（Tcon细胞）重... 详细信息

目的研究异基因造血干细胞移植（***）后Cd4＋T细胞及Cd8＋T细胞中Cd25＋Foxp3＋（Cd4＋Treg细胞或Cd8＋Treg细胞）、IL一17a（Thl7细胞或Tcl7细胞）及IFN．7（Thl细胞或Tcl细胞）表达以及Cd4＋Cd25。Cdl27＋效应性T细胞（Tcon细胞）重建，比较HLA相合与不合allo—HSCT后T细胞亚群重建的异同。方法收集2011年12月至2012年10月在北京大学血液病研究所进行allo—HSCT后未发生急性移植物抗宿主病的成年血液病患者20例，其中HLA相合10例、HLA不合10例，并留取10份健康供者外周血标本作为健康对照。采用8色流式细胞学检测技术检测Cd4＋T细胞及Cd8＋T细胞上Cd25＋Foxp3＋、Cd127、IL-17a及IFN-γ表达。结果@HLA全合组与不合组患者移植后2个月内Cd3＋T细胞、Cd4＋T细胞、Cd8＋T细胞数量重建两组问差异无统计学意义。②HLA相合组Cd4＋Treg细胞[＋30d，8．46（0．36～27．41）细胞数／μl对1．10（0．04～8．03）细胞数／μl，P〈0．05；＋60d，8．50（1．16-36．20）细胞数／μl对2．73（0．34～6．84）细胞数／μl，P〈0．05]、Cd4＋Cd25-Cd127＋效应性T细胞[＋30d，72．69（3．85～211．73）细胞数μl对13．41（0．48～96．17）细胞数／μl，P〈0．05；＋60d，100．85（16．28～267．20）细胞数μl对47．75（6．34～143．04）细胞数／gl，P〈0．05]、Thl7细胞[＋30d，2．34（0．02～6．87）细胞数／μl对0．20（0．02～1．34）细胞数／μl，P〈0．05；＋60d，1．90（0．36～7．82）细胞数／μl对0．46（0．03～1．39）细胞数似l，P〈0．05]、Tcl7细胞数量（＋30d，1．08（0．07～15．03）细胞数／μl对0．25（0．01～0．81）细胞数／pl，P〈0．05；＋60d，1．85（0．63～26．57）细胞数仙l对0．46（0．01～3．66）细胞数仙l，P〈0．05]在＋30d及＋60d均明显高于HLA不合组，Thl细胞及Tcl细胞数量重建两组间差异无统计学意义。⑧Thl与Thl7细胞比值及Tcl与Tcl7的比值，HLA不合组均高于HLA相合组患者。结论HLA相合与不合allo-HSCT后T细胞亚群重建存在差异，这种差异有可能部分解释HLA相合与不合allo-HSCT后移植物抗宿主病发病率及累及部位的不同。

关键词： Th1细胞调节性 Th17细胞 Th1细胞造血干细胞移植

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