Magnesium Enhances the Hepatorenal Protective Effects of Lippia multiflora Aqueous Leaves Extract in Streptozotocin-Diabetic Rats
Magnesium Enhances the Hepatorenal Protective Effects of Lippia multiflora Aqueous Leaves Extract in Streptozotocin-Diabetic Rats作者机构：Biology and Health Laboratory UFR Biosciences Félix Houphouët-Boigny University Abidjan Côte d’Ivoire
出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)
年 卷 期：2023年第11卷第10期
页 面：35-45页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Lippia multiflora Diabetes Streptozotocin Nephroprotective Hepatoprotective
摘 要：Purpose: This study was conducted in order to evaluate the antidiabetic effects of the aqueous extract of Lippia multiflora supplemented with magnesium on some biochemical markers of the kidneys and liver in type 2 diabetic rats. Method: 7 groups of 4 STZ-diabetic rats received separately orally Glucophage® (Glu 10 mg/kg), the plant extract (LiMAE 200 - 600 mg/kg) and the plant extract supplemented with magnesium (LiMAE-Mg 200 - 600 mg/kg). After a daily treatment of 21 days, serum biochemical parameters were assayed in 16 hr-fasted rats. Results: Diabetes caused a significant (p Conclusion: The addition of magnesium to the extract of Lippia multiflora caused a greater reduction in the levels of urea, creatinine, ALT and AST increased in STZ-diabetic rats. Magnesium would therefore enhance the nephroprotective and hepatoprotective effects of Lippia multiflora in diabetic rats.
维普期刊数据库