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Endoscopic retrograde cholangiopancreatography with rendezvous cannulation reduces pancreatic injury

World Journal of Gastroenterology 2013年第36期19卷 6026-6034页

作者： Fredrik Swahn Sara Regnér Lars Enochsson Lars Lundell Johan Permert magnus Nilsson Henrik Thorlacius Urban Arnelo Division of Surgery Department of Clinical Science Intervention and TechnologyKarolinska Institutet Department of Surgical Gastroenterology Karolinska University Hospital Department of Clinical Science Lund University Skne University Hospital Department of Surgery Skne University Hospital

AIM:To examine whether rendezvous endoscopic retrograde cholangiopancreatography(ERCP)is associated with less pancreatic damage,measured as leakage of proenzymes,than conventional ***:Patients(n=122)with symptomatic gallstone disease,intact papilla and no ongoing inflammation,were prospectively enrolled in this case-controldesigned ***-one patients were subjected to laparoscopic cholecystectomy and if intraoperative cholangiography suggested common bile duct stones(CBDS),rendezvous ERCP was performed intraoperatively(n=40).Patients with a negative cholangiogram constituted the control group(n=41).Another 41 patients with CBDS,not subjected to surgery,underwent conventional *** proenzymes,procarboxypeptidase B and trypsinogen-2 levels in plasma,were analysed at 0,4,8 and 24 *** proenzymes were determined in-house with a double-antibody enzyme linked immunosorbent *** amylase was measured by an enzymatic colourimetric modular analyser with the manufacturer’s *** samples were blinded at ***:Post ERCP pancreatitis(PEP)occurred in3/41(7%)of the patients cannulated with conventional ERCP and none in the rendezvous *** serum levels indicating pancreatic leakage were significantly higher in the conventional ERCP group compared with the rendezvous ERCP group regarding pancreatic amylase levels in the 4-and 8-h samples(P=0.0015;P=0.03),procarboxypeptidase B in the4-and 8-h samples(P<0.0001;P<0.0001)and trypsinogen-2 in the 24-hour samples(P=0.03).No differences in these markers were observed in patients treated with rendezvous cannulation technique compared with patients that underwent cholecystectomy alone(control group).Post procedural concentrations of pancreatic amylase and procarboxypeptidase B were significantly correlated with pancreatic duct cannulation and ***:Rendezvous ERCP reduces pancreatic enzyme leakage compared with conventional ERCP cannulation ***,l

关键词： Common bile duct stones Procarboxypeptidase B Trypsinogen-2 Pancreatic amylase Intraoperative endoscopic retrograde cholangiopancreatography

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A comparison of process performance during the anaerobic mono-and co-digestion of slaughterhouse waste through different operational modes

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Journal of Environmental Sciences 2018年第2期30卷 149-156页

作者： Jhosané Pagés-Díaz Ileana Pereda-Reyes Jose Luis Sanz magnus Lundin Mohammad J.Taherzadeh Ilona Sárvári Horváth Process Engineering Centre (CIPRO) Universidad Tecnológica de La Habana "José Antonio Echeverría" (Technical University of Havana "José A. Echeverría") (Cujae) Swedish Centre for Resource Recovery University of Bor?s Department of Molecular Biology Autonomous University of Madrid

The use of consecutive feeding was applied to investigate the response of the microbial biomass to a second addition of substrates in terms of biodegradation using batch tests as a promising alternative to predict the behavior of the process. Anaerobic digestion（AD） of the slaughterhouse waste（SB） and its co-digestion with manure（M）, various crops（VC）, and municipal solid waste were evaluated. The results were then correlated to previous findings obtained by the authors for similar mixtures in batch and semi-continuous operation modes. AD of the SB failed showing total inhibition after a second feeding. Co-digestion of the SB ＋ M showed a significant improvement for all of the response variables investigated after the second feeding, while co-digestion of the SB ＋ VC resulted in a decline in all of these response variables. Similar patterns were previously detected, during both the batch and the semi-continuous modes.

关键词： Co-digestion Biomethane potential test Second feeding Specific methanogenic activity Slaughterhouse waste

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Characterisation of a novel, multifunctional, co-processed excipient and its effect on release profile of paracetamol from tablets prepared by direct compression

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 739-742页

作者： Eraga Sylvester Okhuelegbe Arhewoh Matthew Ikhuoria Uhumwangho Michael Uwumagbe Iwuagwu magnus Amara Department of Pharmaceutics and Pharmaceutical Technology Faculty of Pharmacy University of Benin

Objective: To characterise a novel multifunctional pharmaceutical excipient and investigate its ef ect on paracetamol release from tablets prepared by direct ***: The excipient was prepared by co-processing gelatinized maize starch with sodium carboxymethyl cellulose and microcrystalline cellulose in a ratio of 2:1:1, dried and pulverized into powder. The excipient formulated was characterized using Fourier transform infrared spectroscopy and dif erential scanning calorimetry. The excipient was used to prepare batches of tablets by direct compression with drug-excipient ratios of 1:1, 1:2, 1:3 and 1:4. Parameters evaluated on tablets include crushing strength, friability and in vitro dissolution studies. Results: Differential scanning calorimetry analysis revealed a crystalline excipient while Fourier transform infrared spectroscopy showed no interaction between the excipient and paracetamol. Tablets from all the batches gave average crushing strength values between 3.47 and 4.88 kp. The 1:1 and 1:2 tablet batches were comparable to each other while 1:3 and 1:4 were also comparable to one another in their dissolution proi les. The dissolution parameters of the 1:4 batch was faster with- m∞(90.5%), t50%(3.5 min), t70%(11.6 min) while that of ratio 1:1 was the least with- m∞(48.6%), m5min(23.8%). Their release kinetics followed a KorsmeyerPeppas model with a super case-II transport ***: The drug-excipient ratios of 1:3 and 1:4 gave pharmaceutically acceptable tablets that met the British Pharmacopoeia specii cations. The t50% value of the 1:4 batch of tablets may i nd its usefulness in formulating drugs for which a fast onset of action is desired.

关键词： Co-processed excipient Dissolution proiles Paracetamol tablet Direct compression

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A comparative UV-HPLC analysis of ten brands of ibuprofen tablets

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Asian Pacific Journal of Tropical Biomedicine 2015年第10期5卷 880-884页

作者： Sylvester Okhuelegbe Eraga Mathew Ikhuoria Arhewoh Rosemary Ngozi Chibuogwu magnus Amara Iwuagwu Department of Pharmaceutics and Pharmaceutical Technology Faculty of Pharmacy University of Benin

Objective: To investigate the pharmaceutical equivalence of ten brands of ibuprofen tablets(400 mg) purchased from pharmacies in Benin City, ***: The drug samples were subjected to uniformity of weight, crushing strength,friability, melting point, disintegration and dissolution tests following acceptable and official protocols. The ibuprofen content was determined using UV and high performance liquid chromatography ***: Crushing strength values of the drug samples ranged between 6 and 16 kp while the disintegration times were between 7.43 and 10.40 min(for uncoated tablets) and3.25–37.32 min(for coated tablets). Friability values were less than 1% and the melting points of recrystallized ibuprofen from the samples ranged from 73.5 to 76.0 C. The amount of ibuprofen released within 1 h ranged between 18% and 102% and two brands failed the content of active ingredient in the UV method of assay while all the brands passed the test using ***: Ibuprofen(400 mg) tablets marketed in Benin City, Nigeria vary in pharmaceutical quality.

关键词： pharmaceutical tablets ingredient passed melting d

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In Situ Etching for Total Control Over Axial and Radial Nanowire Growth

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Nano Research 2010年第4期3卷 264-270页

作者： magnus T.Borgström Jesper Wallentin Johanna Trägårdh Peter Ramvall Martin Ek LReine Wallenberg Lars Samuelson Knut Deppert Solid State Physics Lund UniversityBox 118S-22100LundSweden Polymer&Materials Chemistry/nCHREM Lund UniversityS-22100 LundSweden H.H.Wills Physics Laboratory University of BristolTyndall AvenueBristol BS81TLUnited Kingdom

We report a method using in situ etching to decouple the axial from the radial nanowire growth pathway,independent of other growth *** a wide range of growth parameters can be explored to improve the nanowire properties without concern of tapering or excess structural defects formed during radial *** demonstrate the method using etching by HCl during InP nanowire *** improved crystal quality of etched nanowires is indicated by strongly enhanced photoluminescence as compared to reference nanowires obtained without etching.

关键词： MOVPE nanowire growth in situ etching photoluminescence

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Soluble urokinase-plasminogen activator receptor (suPAR) and natural phosphorylcholine IgM antibodies in patients at clinical onset of diabetes mellitus

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Journal of Diabetes Mellitus 2011年第4期1卷 96-103页

作者： magnus Hillman Mona Landin-Olsson Department of Clinical Sciences Lund University Department of Medicine Helsingborg Hospital

We have studied the presence of novel inflammatory markers as soluble urokinase plasminogen activator receptor (suPAR) and natural IgM antibodies directed against phosphorylcholine (αPC-IgM) in Swedish diabetic patients (n = 164) and in healthy control subjects (n = 41). SuPAR is expressed by several types of immune cells and has been shown to be a marker of disease severity and predict mortality during infections. It has also been associated with low-grade inflammation. High levels of αPC-IgM have been shown to negatively associate with the risk of cardiovascular disease and vascular inflammation. This has been suggested to be more common among diabetic patients than in the background population. The patients were 15-34 years of age and were included in the diabetes incidence study in Sweden (DISS). They were all clinically diagnosed to have either T1D (n = 82) or T2D (n = 82). All subjects were matched in gender and age. Commercially available ELISA was used to detect suPAR and αPC-IgM. We found that suPAR levels were higher in diabetic patients (n = 164, Q2 = 4.5 mg/L) compared to in healthy control subjects (n = 41, Q2 = 2.7 mg/L;p 2 = 4.9) compared to in patients classified with T1D (n = 82;p=0.0002). The difference between T2D and T1D was even more obvious when LADA (n = 17) was extracted from the T2D group. SuPAR levels did also correlate with BMI (rs = 0.50;p s = 0.23;p s = 0.58;p < 0.0001). Titers of αPC-IgM did not significantly differ between patients and controls. This is the first study to show the difference in suPAR levels between T1D and T2D patients. The high levels of suPAR in T2D patients indicate a strong activation of the immune system and its relation to disease progression needs to be further investigated. However, our data do not support a role for αPC-IgM in the development of diabetes.

关键词： Diabetes Mellitus Low-Grade Inflammation

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Waste Tire Rubber-based Refrigerants for Solid-state Cooling Devices

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Chinese Journal of Polymer Science 2020年第7期38卷 769-775,I0007页

作者： Nicolau Molina Born Erik Oda Usuda Mariana da Silva Gigliotti Denílson JoséMarcolino de Aguiar William Imamura Lucas Soares Paixao Alexandre magnus Gomes Carvalho Catalan Institute of Nanoscience and Nanotechnology(ICN2) 08860BellaterraBarcelonaSpain The Institute of Photonic Sciences(ICFO) 08193CastelldefelsBarcelonaSpain Universidade Federal de Sāo Paulo(UNIFESP) 00972-270DiademaSPBrazil Instituto de Física"Gleb Wataghin" Universidade Estadual de Campinas(UNICAMP)13083-970CampinasSPBrazil Universidade Tecnológica Federal do Paraná(UTFPR) 84017-220Ponta GrossaPRBrazil Faculdade de Engenharia Mec(a)nica Universidade Estadual de Campinas(UNICAMP)13083-860CampinasSPBrazil Departamento de Engenharia Mec(a)nica Universidade Estadual de Maringá(UEM)870-900MaringáPRBrazil

Management of discarded tires is a compelling environmental issue *** there are several approaches developed to recycle waste tire rubbers,their application in solid-state cooling is still *** the high barocaloric potential verified for elastomers,the use of waste tire rubber(WTR)as a refrigerant in solid-state cooling devices is very ***,we investigated the barocaloric effects in WTR and polymer blends made of vulcanized natural rubber(VNR)and WTR,to evaluate its feasibility for solid-state cooling *** adiabatic temperature changes and the isothermal entropy changes reach giant values,as well as the performance parameters,being comparable or even better than most barocaloric materials in ***,pure WTR and WTR-based samples also present a faster thermal exchange than VNR,consisting of an additional advantage of using these discarded ***,the present findings evidence the encouraging perspectives of employing waste rubbers in solid-state cooling based on barocaloric effects,contributing to both the recycling of polymers and the sustainable energy technology field.

关键词： Waste tire rubber Solid-state cooling Barocaloric effect Tire recycling Sustainable energy

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Recent developments in pathogenesis,diagnosis and therapy of Barrett's esophagus

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World Journal of Gastroenterology 2015年第21期21卷 6479-6490页

作者： magnus Halland David Katzka Prasad G Iyer Division of Gastroenterology and Hepatology Mayo Clinic RochesterMN 55905United States

The burden of illness from esophageal adenocarcinoma continues to rise in the Western world,and overall prognosis is *** that Barrett's esophagus(BE),a metaplastic change in the esophageal lining is a known cancer precursor,an opportunity to decreasedisease development by screening and surveillance might *** review examines recent updates in the pathogenesis of BE and comprehensively discusses known risk *** definitions and challenges are outlined,coupled with an in-depth review of *** challenges and potential solutions related to screening and surveillance are *** effectiveness of currently available endoscopic treatment techniques,particularly with regards to recurrence following successful endotherapy and potential chemopreventative agents are also *** field of BE is rapidly evolving and improved understanding of pathophysiology,combined with emerging methods for screening and surveillance offer hope for future disease burden reduction.

关键词： Barrett's esophagus gastroesophagealreflux disease Esophageal cancer Esophagus

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Exercise cardiac power and the risk of heart failure in men:A population-based follow-up study

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Journal of Sport and Health Science 2022年第2期11卷 266-271页

作者： Sudhir Kurl Sae Young Jae Timo H.Makikallio Ari Voutilainen magnus J.Hagnas Jussi Kauhanen Jari A.Laukkanen Institute of Public Health and Clinical Nutrition Department of MedicineUniversity of Eastern FinlandKuopio 70210Finland Department of Sports Informatics College of Arts and Physical EducationUniversity of SeoulSeoul 130-743Republic of Korea Division of Cardiology Department of Internal MedicineUniversity Hospital of OuluOulu 90220Finland Department of Internal Medicine Lapland Central HospitalRovaniemi 96400Finland Faculty of Sport and Health Sciences University of JyvaskylaJyvaskyla 40620Finland Central Finland Health Care District Jyvaskyla 40620Finland

Background:Little is known about exercise cardiac power(ECP),defined as the ratio of directly measured maximal oxygen uptake with peak systolic blood pressure during exercise,on heart failure(HF)*** examined the association of ECP and the risk of ***:This was a population-based cohort study of 2351 men from eastern *** average time to follow-up was 25 *** participated at baseline in an exercise stress test.A total of 313 cases of HF ***:Men with low ECP(13.92 mL/mmHg,the highest quartile),after adjusting for *** ECP was associated with a 1.96-fold risk(95%CI:1.38-2.78,p<0.001)of HF after additional adjustment for conventional risk *** further adjustment for left ventricular hypertrophy,the results hardly changed(hazards ratio=1.87,95%CI:1.31-2.66,p<0.001).One SD increase in ECP(3.16 mL/mmHg)was associated with a decreased risk of HF by 28%(95%CI:17%-37%).Conclusion:ECP provides a noninvasive and easily available measure from cardiopulmonary exercise tests in predicting ***,ECP did not provide additional value over maximal oxygen uptake.

关键词： Exercise cardiac power Heart failure Men

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Prevention of allergic diseases:is it possible?

Prevention of allergic diseases:is it possible?

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中华医学会2010年全国变态反应学术会议暨中欧变态反应高峰论坛

作者： magnus Wickman 瑞典Karolinska学院 Sachs儿童医院

For about 30 years investigators have tried to identify risk factors but also protective factors for onset of asthma during childhood in *** rhinitis and especially for eczema much less knowledge has been gained in re...

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