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Longitudinal changes in personalized platelet count metrics are good indicators of initial 3-year outcome in colorectal cancer

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World Journal of Clinical Cases 2022年第20期10卷 6825-6844页

作者： Zoltan Herold magdolna Herold Julia Lohinszky Attila Marcell Szasz magdolna dank Aniko Somogyi Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest 1083Hungary Department of Internal Medicine and Hematology Semmelweis UniversityBudapest 1088Hungary

BACKGROUND Platelet count or complete blood count(CBC)-based ratios including lymphocyteto-monocyte(LMR),neutrophil-to-lymphocyte(NLR),hemoglobin-to-platelet(HPR),red blood cell count distribution width-to-platelet(RPR),and platelet-tolymphocyte(PLR)ratio are good predictors of colorectal cancer(CRC)*** change in time is not well documented,*** To investigate the effect of longitudinal CBC ratio changes on CRC survival and their possible associations with clinicopathological properties,comorbidities,and anamnestic *** A retrospective longitudinal observational study was conducted with the inclusion of 835 CRC patients,who attended at Semmelweis University,*** ratios and two additional newly defined personalized platelet count metrics(pPLT_(D)and pPLT_(S),the platelet counts relative to the measurement at the time of CRC diagnosis and to the one 4-6 wk after tumor removal surgery,respectively)were *** The 835 CRC patients had a total of 4608 measurements(5.52 visits/patient,in average).Longitudinal survival models revealed that the increases/decreases in LMR[hazard ratio(HR):0.4989,P<0.0001],NLR(HR:1.0819,P<0.0001),HPR(HR:0.0533,P=0.0038),pPLT_(D)(HR:4.9229,P<0.0001),and pPLT_(S)(HR:4.7568,P<0.0001)values were poor prognostic signs of disease-specific *** same was obtained for all-cause *** abnormal changes occurred within the first 3 years after the diagnosis of *** and PLR had an only marginal effect on diseasespecific(P=0.0675)and all-cause mortality(Bayesian 95%credible interval:0.90–186.05),*** LMR,NLR,and HPR are good metrics to follow the prognosis of the ***_(D)and pPLT_(S)perform just as well as the former,while the use of RPR and PLR with the course of the disease is not *** detection of the abnormal changes in pPLT_(D),pPLT_(S),LMR,NLR,or HPR may alert the practicing oncologist for further therapy decisions in a timely manner.

关键词： Personalized platelet count Lymphocyte-to-monocyte ratio Neutrophil-to-lymphocyte ratio Hemoglobin-to-platelet ratio Platelet-to-lymphocyte ratio Colorectal neoplasms

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High plasma CD40 ligand level is associated with more advanced stages and worse prognosis in colorectal cancer

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World Journal of Clinical Cases 2022年第13期10卷 4084-4096页

作者： Zoltan Herold magdolna Herold Gyorgy Herczeg Agnes Fodor Attila Marcell Szasz magdolna dank Aniko Somogyi Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest H-1083Hungary Department of Internal Medicine and Hematology Semmelweis UniversityBudapest H-1088Hungar Department of General Surgery Szent Imre University Teaching HospitalBudapest H-1115Hungary

BACKGROUND Colorectal cancer(CRC)is often associated with elevated platelet count(>400×10^(9)/L),known as *** role of CD40 ligand(CD40L),a member of the tumor necrosis factor family,is controversial in *** CD40L is higher in CRC,but its relationship with disease staging and local and distant metastasis is not *** most of the circulating CD40L is produced by platelets,no previous study investigated its relationship with CRC-related *** To investigate the role of CD40L to predict the outcome of CRC and its relation to *** A total of 106 CRC patients and 50 age and sex-matched control subjects were enrolled for the *** data including comorbidities and histopathological data were *** measurements were performed at the time of CRC diagnosis and 1.5 mo and at least 6 mo after the surgical removal of the *** CD40L and thrombopoietin were measured via enzyme-linked immunosorbent assay,while plasma interleukin-6 was measured via electrochemiluminescence *** follow-ups were terminated on January 31,*** Plasma CD40L of CRC patients was tendentiously higher,while platelet count(P=0.0479),interleukin-6(P=0.0002),and thrombopoietin(P=0.0024)levels were significantly higher as opposed to the control *** of the 106 CRC patients(11.3%)had *** higher CD40L was found in the presence of distant metastases(P=0.0055)and/or thrombocytosis(P=0.0294).A connection was found between CD40L and platelet count(P=0.0045),interleukin-6(P=0.0130),and thrombocytosis(P=0.0155).CD40L was constant with the course of CRC,and all baseline differences persisted throughout the whole *** pre-and postoperative elevated platelet count,CD40L,and interleukin-6 level were associated with poor overall and disease-specific survival of *** negative effect of CD40L and interleukin-6 on patient survival remained even after the stra

关键词： CD40 ligand Colorectal neoplasms Interleukin-6 Thrombocytosis Thrombopoietin

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Prolonged hyperthermic intraperitoneal chemotherapy duration with 90 minutes cisplatin might increase overall survival in gastric cancer patients with peritoneal metastases

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World Journal of Gastroenterology 2023年第18期29卷 2850-2863页

作者： Heinrich Steinhoff Miklos Acs Sebastian Blaj magdolna dank magdolna Herold Zoltan Herold Jonas Herzberg Patricia Sanchez-Velazquez Tim Strate Attila Marcell Szasz Pompiliu Piso Department of General and Visceral Surgery Hospital Barmherzige BrüderRegensburg 93049Germany Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest 1083Hungary Department of Internal Medicine and Hematology Semmelweis UniversityBudapest 1088Hungary Department of Surgery Krankenhaus Reinbek St.Adolf-StiftReinbek 21465Germany Department of General Surgery Hospital del MarBarcelona 08003Spain

BACKGROUND Advanced gastric cancer with synchronous peritoneal metastases(GC-PM)is associated with a poor *** cytoreductive surgery with hyperthermic intraperitoneal chemotherapy(CRS-HIPEC)is a promising approach,only a limited number of Western studies *** To investigate the clinicopathological outcomes of patients who underwent CRSHIPEC for *** A retrospective analysis of patients with GC-PM was *** patients were seen at the Department of General and Visceral Surgery,Hospital Barmherzige Brüder,Regensburg,Germany between January 2011 and July 2021 and underwent *** laboratory results,the use of neoadjuvant trastuzumab,and the details of CRS-HIPEC,including peritoneal carcinomatosis index,completeness of cytoreduction,and surgical procedures were ***-specific(DSS),and overall survival(OS)of patients were *** A total of 73 patients were included in the *** treated with neoadjuvant trastuzumab(n=5)showed longer DSS(P=0.0482).Higher white blood cell counts(DSS:P=0.0433)and carcinoembryonic antigen levels(OS and DSS:P<0.01),and lower hemoglobin(OS and DSS:P<0.05)and serum total protein(OS:P=0.0368)levels were associated with shorter *** HIPEC duration was associated with more advantageous median survival times[60-min(n=59):12.86 mo;90-min(n=14):27.30 mo],but without statistical *** obtain additional data from this observation,further separation of the study population was ***,propensity score-matched patient pairs(n=14 in each group)were *** different DSS was found between patient pairs(hazard ratio=0.2843;95%confidence interval:0.1119-0.7222;P=0.0082).Second,those patients who were treated with trastuzumab and/or had human epidermal growth factor receptor 2 positivity(median survival:12.68 mo vs 24.02 mo),or had to undergo the procedure before 2016(median survival:12.68 mo vs 27.30 mo;P=0.0493)were removed from the orig

关键词： Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Peritoneal metastasis Stomach neoplasms Gastric cancer

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Evidence based tools to improve efficiency of currently administered oncotherapies for tumors of the hepatopancreatobiliary system

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 1109-1120页

作者： Zoltan Herold A Marcell Szasz magdolna dank Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest H-1083Hungary

Hepatopancreatobiliary tumors are challenging to treat,and the advanced or metastatic forms have a very low 5-year survival *** drug combinations have been tested,and new therapeutic approaches have been introduced in the last decades,including radiofrequency and heat based *** is the artificial heating of tumors by various biophysical methods that may possess immunostimulant,tumoricidal,and chemoradiotherapy sensitizer *** whole-body and regional hyperthermia studies have been conducted since the 1980s after the introduction of deep-seated tumor hyperthermia *** of the effects of hyperthermia in hepatocellular and pancreatic cancer are known from several *** in biliary cancers is a less investigated *** local and overall responses to treatment,increased progression-free and overall survival,and improved laboratory and quality-of-life results are associated with hyperthermia in all three tumor *** the evolution of chemotherapeutic agents and the introduction of newer techniques,the combination of adjuvant hyperthermia with those therapies is advantageous and has not been associated with an increase in alarming adverse ***,despite the many positive effects of hyperthermia,its use is still only known at the experimental level,and its concomitant utilization in routine cancer treatment is not certain because of the lack of thorough clinical studies.

关键词： Hyperthermia induced Carcinoma hepatocellular Cholangiocarcinoma Gallbladder neoplasms Pancreatic neoplasms

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New therapeutic approaches for type 1 diabetes:Disease-modifying therapies

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World Journal of Diabetes 2022年第10期13卷 835-850页

作者： Geza Nagy Tekla Evelin Szekely Aniko Somogyi magdolna Herold Zoltan Herold Department of Internal Medicine and Hematology Semmelweis UniversityBudapest H-1088Hungary Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest H-1083Hungary

It has been 100 years since the first successful clinical use of insulin, yet it remains the only treatment option for type 1 diabetes mellitus(T1DM) patients. Advances in diabetes care, such as insulin analogue therapies and new devices, including continuous glucose monitoring with continuous subcutaneous insulin infusion have improved the quality of life of patients but have no impact on the pathogenesis of the disease. They do not eliminate long-term complications and require several lifestyle sacrifices. A more ideal future therapy for T1DM, instead of supplementing the insufficient hormone production(a consequence of β-cell destruction), would also aim to stop or slow down the destructive autoimmune process. The discovery of the autoimmune nature of type 1 diabetes mellitus has presented several targets by which disease progression may be altered. The goal of disease-modifying therapies is to target autoimmune mechanisms and prevent β-cell destruction. T1DM patients with better β-cell function have better glycemic control, reduced incidence of long-term complications and hypoglycemic episodes. Unfortunately, at the time symptomatic T1DM is diagnosed, most of the insulin secreting β cells are usually lost. Therefore, to maximize the salvageable β-cell mass by disease-modifying therapies, detecting autoimmune markers in an early, optimally presymptomatic phase of T1DM is of great importance. Diseasemodifying therapies, such as immuno-and regenerative therapies are expected to take a relevant place in diabetology. The aim of this article was to provide a brief insight into the pathogenesis and course of T1DM and present the current state of disease-modifying therapeutic interventions that may impact future diabetes treatment.

关键词： Type 1 diabetes Mesenchymal stem cell Immunotherapy Islet cells Autoimmunity Regenerative medicine

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EXPERIMENTAL AND COMPUTED GEOMETRIES:SHOULD THEY BE THE SAME?

EXPERIMENTAL AND COMPUTED GEOMETRIES:SHOULD THEY BE THE SAME...

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Sixteenth Congress of the International Union of Crystallography

作者： Istvan Hargittai magdolna Hargittai Institute of General and Analytical Chemistry Technical University of BudapestH-1521 Budapest Structural Chemistry Research Group of the Hungarian Academy of Sciences at Eotvos University Pf.117H-143 BudapestHungary

＜正＞Experimental structural parameters determined by different physical techniques are often compared in the literature with each other and with computed structures without allowing for the difference in their physical *** enhanced accuracy of both the experimental and state-of-the-art computational structure determinations,the question of their compatibility becomes increasingly *** involving cryslallographic data have to take account of the consequences of intcrmolecular interactions as *** such comparisons are

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MULTIPLE SCLEROSIS AFTER HEPATITIS B VACCINATION IN A 16-YEAR-OLD PATIENT

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Chinese Medical Journal 2006年第1期119卷 77-79页

作者： DANIELLA TERNEY SáNDOR BENICZKY PéTER BARSI ISTVáN KONDáKOR JóZSEF PERéNYI BéLA FALUDI magdolna SZAPPER LáSZLó VéCSEI DEPARTMENT OF NEUROLOGY ALBERT SZENT-GYRGYI MEDICAL AND PHARMACEUTICAL CENTRE UNIVERSITY OF SZEGED P.O. BOX 427 H-6701 SZEGED HUNGARY DEPARTMENT OF RADIOLOGY OPNI HüVSVLGYI úT 116 H-1021 BUDAPEST HUNGARY DEPARTMENT OF NEUROLOGY UNIVERSITY OF PéCS RéT U. 2 H-7623 PéCS HUNGARY DEPARTMENT OF NEUROLOGY OPNI HüVSVLGYI úT 116 H-1021 BUDAPEST HUNGARY NEUROLOGY RESEARCH GROUP OF THE HUNGARIAN ACADEMY OF SCIENCES AND UNIVERSITY OF SZEGED SEMMELWEIS U. 6 H-6725 SZEGED HUNGARY

Since the first description of multiple sclerosis （MS）, it has been known that relapse of the disease may be triggered by febrile infections. Although the prevention of febrile illness is therefore clearly advantageous for those with MS there is considerable controversy as to whether vaccine should be administered to such individuals. A further subject of debate is the possibility that vaccination （against influenza,

关键词： hepatitis B vaccination encephalomyelitis multiple sclerosis

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L78部分氨基酸残基对SERCA1a钙转运功能的影响

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生物化学与生物物理进展 2014年第8期41卷 796-803页

作者：王国丽 DAIHO Takashi YAMASAKI Kazuo dank0 Stefania 王彪宿文辉 SUZUKI Hiroshi 中国医科大学生物化学与分子生物学教研室沈阳110001 Department of Biochemistry Asahikawa Medical UniversityAsahikawa 078-8501Japan

跨肌浆网膜的钙离子ATP酶SERCA1a可在水解ATP的同时逆浓度梯度从胞浆转运钙离子入肌浆网,引发收缩的骨骼肌细胞舒张.目前对SERCA1a结构与功能的研究,要领先于对其他P型离子转运ATP酶的研究.为了解SERCA1a跨膜螺旋M7与M8膜内侧连接部Link... 详细信息

跨肌浆网膜的钙离子ATP酶SERCA1a可在水解ATP的同时逆浓度梯度从胞浆转运钙离子入肌浆网,引发收缩的骨骼肌细胞舒张.目前对SERCA1a结构与功能的研究,要领先于对其他P型离子转运ATP酶的研究.为了解SERCA1a跨膜螺旋M7与M8膜内侧连接部Linker78(L78)的功能,我们评估了L78部分氨基酸残基突变对SERCA1a反应循环的影响,发现:除G864A之外的所有突变体均可不同程度地降低钙离子转运速率;G862或P863氨基酸残基的突变导致SERCA1a的ATP酶活性显著降低或丧失,并引起由ATP或无机磷酸Pi生成的磷酸化酶中间体EP量显著减少;A893被P取代对SERCA1a的影响与G862、P863突变相似;与野生型SERCA1a相比,G864A与FMQ873-875单突变体ATP酶活性及EP生成量无明显差别.上述结果表明,M7、M8膜内侧连接部L78不仅与跨膜区钙离子转运过程密切相关,而且L78在GPG862-864处及A893附近的正确转折对胞浆结构域P的磷酸化也具有关键的远距离调控作用,提示L78的结构及柔度对SERCA1a构象正常的周期性变化至关重要.

关键词： P型ATP酶钙离子ATP酶 SERCA 定点诱变反应循环

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Changes of Metabolites and Macro- and Micro-elements in Hungarian Potatoes under Organic and Conventional Farming

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农业科学与技术：B 2016年第2期6卷 83-92页

作者： Rita Tomoskozi-Farkas Nora Adanyi magdolna Gasztonyi-Nagy Maria Berki Viola Horvath Tibor Renkecz Kinga Simon Zoltan Fabulya Zsolt Polgar National Agricultural Research and Innovation Centre Food Science Research Institute Budapest H-1022 Hungary Research Group for Technical Analytical Chemistry Hungarian Academy of Sciences Budapest University of Technology andEconomics Budapest H-1111 Hungary Department of Inorganic and Analytical Chemistry Budapest University of Technology and Economics Budapest H-1111Hungary Department of Engineering University of Szeged Szeged H-6720 Hungary Potato Research Centre University ofPannonia Keszthely H-8360 Hungary

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高敏的异位性体质患者嗜碱性粒细胞CD63表达分析:慢性自身免疫性荨麻疹的一种实用的方法

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 19-20页

作者： Gyimesi E. Sipka S. dankó K. 刘超 3rd Department of Medicine Medical and Health Sciences Centre University of Debrecen M'oricz Zs. u. 22 H-4004 Debrecen Hungary Dr.

Background: The autoimmune subclass of chronic idiopathic urticaria (CU) has been characterized by the occurrence of biologically relevant IgG antibodies against the IgE molecule or the αchain of the high-affinity Fc receptor (FcRIα) on basophils and mast cells. These antibodies are usually detected by autologous serum skin testing and confirmed by histamine release studies, immunoblotting, or enzyme-linked immunosorbent assay, but not always. Objectives: To detect autoantibodies to the FcRIαin sera of CU patients by a modified serum-induced basophil activation testmeasured by flowcytometry (FCM) and to evaluate the relationship between the in vitro functional test, the autologous serum skin test (ASST), and the serum levels of IgE, eosinophil cationic protein (ECP) and antithyroid antibodies. Methods: Sera of 30 patients with CU and 26 patients with systemic autoimmune diseases (systemic lupus erythematosus, dermatomyositis) were tested for CD63 activation marker expression on basophils by FCM. Leucocytes from two highly sensitized atopic donors (DA1. DA2) and one non-atopic donor (DNA) were incubated with patients’sera and double-labelled with anti-IgE and anti-CD63 antibodies. Subsequently, the percentage of CD63-expressing basophils was determined by using FCM. In all CU patients an ASST was carried out and the serum IgE, and ECP levels and antithyroid antibodies were evaluated. Results: Twelve patients had a positive ASST and 14 patients a positive CD63 expression assay. There was a strong correlation between the ASST and CD63 assay. Sera from patients with systemic autoimmune diseases did not raise positive CD63 expression on basophils. There was a moderate negative correlation between the occurrence of atopic serum markers (IgE, ECP) and the ability of sera to induce CD63 expression on basophil cells of DA2 (P < 0.05). The female sex was preponderant and antithyroid antibodies were more frequent. Conclusions: Our new technical observation demonstrates that ba

关键词： CD63 异位性体质血清皮肤试验嗜碱性粒细胞甲状腺抗体阳离子蛋白自身免疫性疾病双重标记免疫印迹系统性红斑狼疮

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