High plasma CD40 ligand level is associated with more advanced stages and worse prognosis in colorectal cancer
作者机构：Division of OncologyDepartment of Internal Medicine and OncologySemmelweis UniversityBudapest H-1083Hungary Department of Internal Medicine and HematologySemmelweis UniversityBudapest H-1088Hungar Department of General SurgerySzent Imre University Teaching HospitalBudapest H-1115Hungary
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2022年第10卷第13期
页 面：4084-4096页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the National Research,Development and Innovation Office,No.K-116128 the New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research,Development and Innovation Fund,No.UNKP-20-4-I
主 题：CD40 ligand Colorectal neoplasms Interleukin-6 Thrombocytosis Thrombopoietin
摘 要：BACKGROUND Colorectal cancer(CRC)is often associated with elevated platelet count(400×10^(9)/L),known as *** role of CD40 ligand(CD40L),a member of the tumor necrosis factor family,is controversial in *** CD40L is higher in CRC,but its relationship with disease staging and local and distant metastasis is not *** most of the circulating CD40L is produced by platelets,no previous study investigated its relationship with CRC-related *** To investigate the role of CD40L to predict the outcome of CRC and its relation to *** A total of 106 CRC patients and 50 age and sex-matched control subjects were enrolled for the *** data including comorbidities and histopathological data were *** measurements were performed at the time of CRC diagnosis and 1.5 mo and at least 6 mo after the surgical removal of the *** CD40L and thrombopoietin were measured via enzyme-linked immunosorbent assay,while plasma interleukin-6 was measured via electrochemiluminescence *** follow-ups were terminated on January 31,*** Plasma CD40L of CRC patients was tendentiously higher,while platelet count(P=0.0479),interleukin-6(P=0.0002),and thrombopoietin(P=0.0024)levels were significantly higher as opposed to the control *** of the 106 CRC patients(11.3%)had *** higher CD40L was found in the presence of distant metastases(P=0.0055)and/or thrombocytosis(P=0.0294).A connection was found between CD40L and platelet count(P=0.0045),interleukin-6(P=0.0130),and thrombocytosis(P=0.0155).CD40L was constant with the course of CRC,and all baseline differences persisted throughout the whole *** pre-and postoperative elevated platelet count,CD40L,and interleukin-6 level were associated with poor overall and disease-specific survival of *** negative effect of CD40L and interleukin-6 on patient survival remained even after the stra
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