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Short- and medium-term reproducibility of gastric emptying of a solid meal determined by a low dose of ^(13)C-octanoic acid and nondispersive isotope-selective infrared spectrometry

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World Journal of Gastroenterology 2006年第8期12卷 1243-1248页

作者： Anna Kasicka-Jonderko magdalena kami■ska Krzysztof Jonderko Olga Setera Barbara Blo■ska-Fajfrowska Department of Basic Biomedical Science.School of Pharmacy Medical University of SilesiaSosnowiecPoland Department of Basic Biomedical Science.School of Pharmacy Medical University of SilesiaSosnowiecPoland Department of PhysiologyInstitute of Occupational Medicine and Environmental HealthSosnowiecPoland

瞄准：在一个简单重复的措施学习协议的框架以内评估固体的基于测试的测量分阶段执行胃的倒空的修改 13C 呼吸(GE ) 的重制度。方法：12 个健康题目(6 女性和 6 男性，意味着年龄 24.9+/-0.7 年) 被招募经历三相同 GE 考试。在六个题目... 详细信息

瞄准：在一个简单重复的措施学习协议的框架以内评估固体的基于测试的测量分阶段执行胃的倒空的修改 13C 呼吸(GE ) 的重制度。方法：12 个健康题目(6 女性和 6 男性，意味着年龄 24.9+/-0.7 年) 被招募经历三相同 GE 考试。在六个题目，开始的二考试被执行 2 d 分开，并且第三个会议从第二个在 19.5 d (范围 18-20 d ) 的中部的间隔被执行。在六个题目，开始的二大小被拆开 20 d (中部，范围：17-23 d ) ，而第三个会议发生了在第二以后的 2 d。在稳固的饭(378 千卡) 的吸入以后收集在前并且在六个小时期间的吐气的空气的探针用 75 microL (68 mg ) 标记 13C-octanoic 酸，与非散的同位素选择的红外线的分光术 NDIRS 仪器为 13CO2 丰富被测量。结果：为配对的考试考虑变化的系数， GE 测量的短期的重制度比中期的稍微然而并非显著地好：7.7% 和 11.2% 为迟滞期(T 落后) ， 7.3% 和 10.9% 为倒空时间(T1/2 ) 的胃的一半。在在在 12 配对的考试的 P=0.05 水平可检测的 GE 参数的最少的差别是为 T 落后的 9.6 和 15.6 min，为由到三星期的时间的一两个 two-day 的 T1/2 的 11.6 和 19.7 min 分别地豁开。结论：呼吸的便宜修正测试包含 13C-octanoic 酸和 NDIRS 的更低的剂量，显示固体的胃的倒空的测量的好短期、中期的重制度，以及敏感。

关键词：胃排空同位素红外线光谱测定技术呼吸实验

Methyltransferase-like 3(METTL3)inhibition potentiates anti-tumor immunity:a novel strategy for improving anti-PD1 therapy

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Signal Transduction and Targeted Therapy 2024年第1期9卷 10-11页

作者： Anna Brichkina Roman Suezov magdalena Huber Institute of Systems Immunology Member of the German Center for Lung Research(DZL)Philipps University of Marburg35043 MarburgGermany

In a recent article published in Cancer Discovery,Guirguis et *** that enzymatic inhibitors of the m6 A methyltransferase METTL3 induced a formation of immunostimulatory doublestranded mRNAs(dsRNAs)in cancer cells,which triggered a profound tumor-cell-intrinsic interferon response leading to an enhanced antigen presentation and thereby increased killing of tumor cells by cytotoxic CD8+*** inhibition of METTL3 synergized with anti-PD1 immunotherapy,highlighting its potential for improving cancer treatment.

关键词： PD1 immunity

Financial and non-financial determinants of the indebtedness of hospitals:the case of Poland

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Journal of Management Analytics 2024年第1期11卷 26-44页

作者： Katarzyna Miszczyńska Elżbieta Antczak Department of Banking Faculty of Economics and SociologyUniversity of LodzLodzPoland Department of Spatial Econometrics Faculty of Economics and SociologyUniversity of LodzLodzPoland

The performance of Polish healthcare is still far from satisfactory,which is connected with growing indebtedness that adversely affects not only the development of healthcare but also the quality of medical services *** turn,the financial situation of hospitals depends on various indicators and the relationship between *** paper investigates the determinants of healthcare sector functioning in the context of hospitals’financial situation(dependent variable measured by total debt ratio).321 individual public units were examined between years 2007–*** specifically,the fixed effects panel data model in question measures and evaluates the impact of economic,regional,institutional,and social factors in determining the dependent *** study confirmed dependencies between financial and non-financial ratios along with their impact on the financial condition of studied *** management implications of our study lay the groundwork for the improvement of efficient resource management for public hospitals.

关键词： polish healthcare system hospitals’financial situation debt ratio panel data analysis

Modeling the effect of stand and site characteristics on the probability of mistletoe infestation in Scots pine stands using remote sensing data

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Forest Ecosystems 2024年第3期11卷 296-306页

作者： Luiza Tymińska-Czabańska Piotr Janiec Pawel Hawrylo Jacek Slopek Anna Zielonka Pawel Netzel Daniel Janczyk Jaroslaw Socha Department of Forest Resources Management Faculty of ForestryUniversity of Agriculture in KrakowAl.29 Listopada 46Krakow31-425Poland Forest Management and Geodesy Bureau Ul.Lesnikow 2105-090Sekocin StaryPoland Department of Geoinformatics and Cartography Institute of Geography and Regional DevelopmentFaculty of Earth Sciences and Environmental ManagementUniversity of WroclawPl.Uniwersytecki 1WroclawPoland Institute of Geography and Spatial Management Faculty of Geography&GeologyJagiellonian University in KrakowUl.Gronostajowa 730-387Poland Torun Regional Directorate of State Forests Ul.Adama Mickiewicza 987-100TorunPoland

Over the past decade,the presence of mistletoe(Viscum album ***)in Scots pine stands has increased in many European *** the factors that influence the occurrence of mistletoe in stands is key to making appropriate forest management decisions to limit damage and prevent the spread of mistletoe in the ***,the main objective of this study was to determine the probability of mistletoe occurrence in Scots pine stands in relation to stand-related endogenous factors such as age,top height,and stand density,as well as topographic and edaphic *** used unmanned aerial vehicle(UAV)imagery from 2,247 stands to detect mistletoe in Scots pine stands,while majority stand and site characteristics were calculated from airborne laser scanning(ALS)*** on stand age and site type from the State Forest database were also *** found that mistletoe infestation in Scots pine stands is influenced by stand and site *** documented that the densest,tallest,and oldest stands were more susceptible to mistletoe *** type and specific microsite conditions associated with topography were also important factors driving mistletoe *** addition,climatic water balance was a significant factor in increasing the probability of mistletoe occurrence,which is important in the context of predicted temperature increases associated with climate *** results are important for better understanding patterns of mistletoe infestation and ecosystem functioning under climate *** an era of climate change and technological development,the use of remote sensing methods to determine the risk of mistletoe infestation can be a very useful tool for managing forest ecosystems to maintain forest sustainability and prevent forest disturbance.

关键词： Generalized additive models Tree infestation Mistletoe occurrence ALS UAV Scots pine

Anthropogenic noise interacts with the predation risk assessment in a free-ranging bird

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Current Zoology 2024年第3期70卷 277-283页

作者： Piotr Matyjasiak Patrycja Chacińska and Piotr Książka Institute of Biological Sciences Cardinal Stefan Wyszyński University in WarsawWóycickiego 1/3PL-01-815 WarsawPoland Department of Environmental Acoustics Institute of Environmental Protection—National Research InstituteKolektorska 4PL-01-692 WarsawPoland

Anthropogenic noise can affect a number of behavioral,physiological,and ecological aspects of animals from major taxonomic groups,raising serious conservation *** example,noise pollution impacts communicative behavior and perception of signals,movements and distribution,as well as predator–prey interactions,such as hunting success or predator detection and predation risk *** have carried out an experimental playback study,in which we investigated whether exposure to anthropogenic noise(sound of a tractor)distracts free-ranging barn swallows Hirundo rustica from paying attention to an approaching human“predator”(the“cognitive distraction”hypothesis),or whether noise leads to increased responsiveness to this“predator”(the“increased threat”hypothesis).The subjects were male barn swallows attending their breeding territories during the time when the females were *** found that barn swallow males initiated fight at signifcantly greater distances to the approaching human“predator”in the noise treatment than during the quiet control *** results suggest that anthropogenic noise causes increased vigilance and reactivity rather than a distraction,enabling birds to avoid the“predator”more *** further discuss the mechanism behind the increased alertness in response to noise and contrast the“increased threat”mechanism,usually tested in previous studies,with an alternative“cognitive sensitization”mechanism.

关键词： anthropogenic noise barn Swallow cognitive distraction flight initiation distance Hirundo rustica predation risk assessment

Continuous flow pyrolysis of virgin and waste polyolefins:a comparative study,process optimization and product characterization

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 133-149页

作者： Ecrin Ekici Güray Yildiz magdalena Joka Yildiz Monika Kalinowska ErolŞeker Jiawei Wang Karlsruhe Institute of Technology Institute of Catalysis Research and TechnologyEggenstein-Leopoldshafen 76344Germany Izmir Institute of Technology Faculty of EngineeringDepartment of Energy Systems EngineeringIzmir 35430Türkiye Department of Materials Engineering and Production Faculty of Mechanical EngineeringBialystok University of TechnologyBialystok 15-351Poland Department of Agricultural and Food Engineering and Environmental Development Institute of Civil Engineering and EnergeticsFaculty of Civil Engineering and Environmental SciencesBialystok University of Technology15-351 BialystokPoland Department of Chemistry Biology and BiotechnologyInstitute of Civil Engineering and EnergeticsFaculty of Civil Engineering and Environmental SciencesBialystok University of TechnologyBialystok 15-351Poland Izmir Institute of Technology Faculty of EngineeringDepartment of Chemical EngineeringIzmir 35430Türkiye Energy and Bioproducts Research Institute(EBRI) Aston UniversityBirmingham B47ETUnited Kingdom

Under optimal process conditions,pyrolysis of polyolefins can yield ca.90 wt%of liquid product,i.e.,combination of light oil fraction and heavier *** this work,the experimental findings reported in a selected group of publications concerning the non-catalytic pyrolysis of polyolefins were collected,reviewed,and compared with the ones obtained in a continuously operated bench-scale pyrolysis *** process parameters were used for the pyrolysis of waste and virgin counterparts of high-density polyethylene,low-density polyethylene,polypropylene and a defined mixture of those(i.e.,25:25:50 wt%,respectively).To mitigate temperature drops and enhance heat transfer,an increased feed intake is employed to create a hot melt plastic *** 1.5 g·min^(-1) feed intake,1.1 L·min^(-1) nitrogen flow rate,and a moderate pyrolysis temperature of 450℃,the formation of light hydrocarbons was favored,while wax formation was limited for polypropylene-rich *** of virgin plastics yielded more liquid(maximum 73.3 wt%)than that of waste plastics(maximum 66 wt%).Blending polyethylenes with polypropylene favored the production of liquids and increased the formation of gasoline-range *** products were mainly composed of C3 hydrocarbons,and no hydrogen production was detected due to moderate pyrolysis temperature.

关键词： waste plastics polyolefins chemical recycling pyrolysis alternative fuels waste-to-energy

A dual-beam piezo-magneto-elastic wake-induced vibration energy harvesting system for high-performance wind energy harvesting

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Science China(Technological Sciences) 2024年第1期67卷 221-239页

作者： MA XiaoQing ZHANG Hang MARGIELEWICZ Jerzy GĄska Damian WOLSZCZAK Piotr LITAK Grzegorz ZHOU ShengXi School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute in Shenzhen Northwestern Polytechnical UniversityShenzhen 518057China Faculty of Transport and Aviation Engineering Silesian University of TechnologyKrasińskiego 8Katowice 40-019Poland Department of Automation Lublin University of TechnologyNadbystrzycka 36Lublin 20-618Poland

Wind-induced vibration energy harvesting has a great potential for utilizing wind energy to supply power for low-powered *** improve the working performance of energy harvesters effectively,a suitable structural design is *** paper proposes a dual-beam piezo-magneto-elastic wake-induced vibration energy harvesting system to enhance the functional performance of aeroelastic energy harvesters in environments with variable wind *** system contains two piezoelectric beams coupled by magnets(forming upstream and downstream energy harvesters),and each beam is attached with a foam cylinder.A corresponding dynamic model is provided,and output characteristics are obtained at different wind *** and experimental verification indicate that both upstream and downstream energy harvesters can realize efficient energy *** the wind speed exceeds a certain critical value,the amplitudes of the system’s displacement and voltage are *** wind speed threshold value is approximately 1.25 m/*** the wind speed and magnet spacing are 10.2 m/s and 20 mm,respectively,the output power of the system reaches 4.9×10^(−4)***,the wind speed threshold value of the proposed system can be adjusted by an equivalent nonlinear restoring force.

关键词： dual-beam structure piezoelectric energy harvester theoretical model nonlinear dynamics

Compact and effective photon-resolved image scanning microscope

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Advanced Photonics 2024年第1期6卷 84-95页

作者： Giorgio Tortarolo Alessandro Zunino Simonluca Piazza Mattia Donato Sabrina Zappone Agnieszka Pierzyńska-Mach Marco Castello Giuseppe Vicidomini Istituto Italiano di Tecnologia Molecular Microscopy and SpectroscopyGenoaItaly Genoa Instruments GenoaItaly University of Genoa Dipartimento di InformaticaBioingegneriaRobotica e Ingegneria dei SistemiGenoaItaly Istituto Italiano di Tecnologia Nanoscopy and NIC@IITGenoaItaly École Polytechnique Fédérale de Lausanne Laboratory of Experimental BiophysicsLausanneSwitzerland

Fluorescence confocal laser-scanning microscopy(LSM)is one of the most popular tools for life science *** popularity is expected to grow thanks to single-photon array detectors tailored for *** detectors offer unique single-photon spatiotemporal information,opening new perspectives for gentle and quantitative superresolution ***,a flawless recording of this information poses significant challenges for the microscope data acquisition(DAQ)*** present a DAQ module based on the digital frequency domain principle,able to record essential spatial and temporal features of *** use this module to extend the capabilities of established imaging techniques based on single-photon avalanche diode(SPAD)array detectors,such as fluorescence lifetime image scanning ***,we use the module to introduce a robust multispecies approach encoding the fluorophore excitation spectra in the time ***,we combine time-resolved stimulated emission depletion microscopy with image scanning microscopy,boosting spatial *** results demonstrate how a conventional fluorescence laser scanning microscope can transform into a simple,information-rich,superresolved imaging system with the simple addition of a SPAD array detector with a tailored data acquisition *** expected a blooming of advanced single-photon imaging techniques,which effectively harness all the sample information encoded in each photon.

关键词： fluorescence lifetime image scanning microscopy digital frequency domain single photon

The Pichia pastoris enzyme production platform:From combinatorial library screening to bench-top fermentation on residual cyanobacterial biomass

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Journal of Bioresources and Bioproducts 2024年第1期9卷 43-57页

作者： Korbinian Sinzinger Ulrike Obst Samed Güner Manuel Döring magdalena Haslbeck Doris Schieder Volker Sieber Chair of Chemistry of Biogenic Resources Campus Straubing for Biotechnology and SustainabilityTechnical University of MunichStraubing 94315Germany Catalysis Research Center Technical University of MunichGarching 85748Germany SynBiofoundry@TUM Technical University of MunichStraubing 94315Germany School of Chemistry and Molecular Biosciences The University of QueenslandSt.Lucia 4072Australia

The demand for industrial enzymes is continually rising,fueled by the growing need to shift towards more sustainable industrial ***,making efficient enzyme production strains and identifying optimal enzyme expression conditions remains a ***,the production of the enzymes themselves comes with unavoidable impacts,e.g.,the need to utilize secondary ***,we take a more holistic view of bioprocess development and report an integrative approach that allows us to rapidly identify improved enzyme expression and secretion conditions and make use of cyanobacterial waste biomass as feed for supporting Pichia pastoris *** demonstrate these capabilities by producing a phytase secreted by *** that is grown on cyanobacterium hydrolysate and buffered glycerol-complex(BMGY)medium,with genetic expression conditions identified by high-throughput screening of a randomized se-cretion *** our best-performing strain is grown in a fed-batch fermentation on BMGY,we reach over 7000 U/mL in three days.

关键词： Protein secretion Phytase Cyanobacterial biomass Fed-batch fermentation Pichia pastoris