检索结果-南通市图书馆

Peripheral memory T cells specific for Arginase-1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第8期16卷 718-719页

作者： Evelina Martinenaite Shamaila Munir Ahmad Inge Marie Svane mads hald andersen Center for Cancer Immune Therapy(CCIT) Copenhagen University HospitalHerlevDenmark Department of Immunology and Microbiology University of CopenhagenCopenhagenDenmark

Increased arginase-1(Arg-1)activity is one of the common mechanisms of immune inhibition in patients with ***-1 is an enzyme catalyzing the first step in L-arginine metabolism and is expressed by various immunosuppressive myeloid cells as well as by cancer ***-1-associated deprivation of L-arginine downregulates the expression of the T cell receptorζchain and decreases cytokine production and proliferation of activated T cells.

关键词： metabolism Arg cytokine

Characterization of TGFβ-specific CD4+T cells through the modulation of TGFβexpression in malignant myeloid cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第11期18卷 2575-2577页

作者： Rasmus Erik Johansson Mortensen Morten Orebo Holmström mads hald andersen National Center for Cancer Immune Therapy Department of OncologyCopenhagen University HospitalHerlevDenmark Institute for Immunology and Microbiology Copenhagen UniversityCopenhagenDenmark

Transforming growth factor beta(TGFβ)is a pleiotropic cytokine with functions related to angiogenesis,tumor suppression,and immune tolerance[1].TGFβis involved in tumor immune escape and is a target for cancer immune therapy[1].We have reported that healthy donors and cancer patients harbor CD8^(+)cytotoxic T lymphocytes(CTLs)that are specific to TGFβ-derived epitopes and that these CD8^(+)CTLs kill malignant myeloid cells in a TGFβ-dependent manner[2].

关键词： TGFβ malignant myeloid

Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第2期18卷 415-426页

作者： Morten Orebo Holmström Rasmus Erik Johansson Mortensen Angelos Michail Pavlidis Evelina Martinenaite Stine Emilie Weis-Banke Mia Aaboe-Jørgensen Simone Kloch Bendtsen Özcan Met Ayako Wakatsuki Pedersen Marco Donia Inge Marie Svane mads hald andersen Department of Oncology National Center for Cancer Immune TherapyCopenhagen University HospitalHerlevDenmark IO Biotech ApS CopenhagenDenmark Institute for Immunology and Microbiology Copenhagen UniversityCopenhagenDenmark

Transforming growth factor-beta(TGFβ)is a highly potent immunosuppressive *** TGFβis a tumor suppressor in early/premalignant cancer lesions,the cytokine has several tumor-promoting effects in advanced cancer;abrogation of the antitumor immune response is one of the most important tumor-promoting *** several immunoregulatory mechanisms have recently been shown to be targets of specific T cells,we hypothesized that TGFβis targeted by naturally occurring specific T cells and thus could be a potential target for immunomodulatory cancer ***,we tested healthy donor and cancer patient T cells for spontaneous T-cell responses specifically targeting 3820-mer epitopes derived from TGFβ*** identified numerous CD4^(+)and CD8^(+)T-cell responses against several epitopes in TGFβ.Additionally,several ex vivo responses were *** enriching specific T cells from different donors,we produced highly specific cultures specific to several TGFβ-derived *** CD8^(+)T-cell clones specific for both a 20-mer epitope and a 9-mer HLA-A2 restricted killed epitope peptide were pulsed in HLA-A2+target cells and killed the HLA-A2+cancer cell lines THP-1 and ***,stimulation of THP-1 cancer cells with cytokines that increased TGFβexpression increased the fraction of killed *** conclusion,we have shown that healthy donors and cancer patients harbor CD4^(+)and CD8^(+)T cells specific for TGFβ-derived epitopes and that cytotoxic T cells with specificity toward TGFβ-derived epitopes are able to recognize and kill cancer cell lines in a TGFβ-dependent manner.

关键词： Immune regulation TGFbeta cancer T cells adaptive immunity

Understanding the effects of structured self-assessment in directed,self-regulated simulation-based training of mastoidectomy:A mixed methods study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2020年第4期15卷 117-123页

作者： Steven Arild Wuyts andersen Martin Frendø mads Guldager mads Sølvsten Sørensen Department of OtorhinolaryngologydHead&Neck Surgery RigshospitaletBlegdamsvej 9DK-2100CopenhagenDenmark The Simulation Centre at Rigshospitalet Copenhagen Academy for Medical Education and Simulation(CAMES)Centre for HRthe Capital Region of Denmark.RigshospitaletAfsnit 5404Blegdamsvej 9DK-2100CopenhagenDenmark

Objective:Self-directed training represents a challenge in simulation-based training as low cognitive effort can occur when learners overrate their own level of *** study aims to explore the mechanisms underlying the positive effects of a structured self-assessment intervention during simulation-based training of ***:A prospective,educational cohort study of a novice training program consisting of directed,self-regulated learning with distributed practice(5x3 procedures)in a virtual reality temporal bone *** intervention consisted of structured self-assessment after each procedure using a rating form supported by small ***-structured telephone interviews upon completion of training were conducted with 13 out of 15 *** were analysed using directed content analysis and triangulated with quantitative data on secondary task reaction time for cognitive load estimation and participants’self-assessment ***:Six major themes were identified in the interviews:goal-directed behaviour,use of learning supports for scaffolding of the training,cognitive engagement,motivation from self-assessment,selfassessment bias,and feedback on self-assessment(validation).Participants seemed to self-regulate their learning by forming individual sub-goals and strategies within the overall goal of the *** scaffolded their learning through the available learning ***,structured self-assessment was reported to increase the participants’cognitive engagement,which was further supported by a quantitative increase in cognitive ***:Structured self-assessment in simulation-based surgical training of mastoidectomy seems to promote cognitive engagement and motivation in the learning task and to facilitate self-regulated learning.

关键词： Temporal bone surgery Structured self-assessment Directed Self-regulated learning Virtual reality surgical simulation Technical skills training Simulation-based training

Diagnosing heart failure in centenarians

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2019年第1期16卷 1-11页

作者： Signe Hoi Rasmussen Karen andersen-Ranberg Jordi Sanchez Dahl mads Nybo Bernard Jeune Kaare Christensen Sabine Gill Danish Aging Research Center Department of Public HealthUniversity of Southern DenmarkOdenseDenmark Department of Geriatrics Odense University HospitalOdenseDenmark Department of Cardiology Odense University HospitalOdenseDenmark Department of Clinical Biochemistry and Pharmacology Odense University'HospitalOdenseDenmark Max-Planck Odense Center on the Biodemography of Aging University of Southern DenmarkOdenseDenmark

Background As a consequence of the demographic development with increasing proportion of older people,the prevalence of heart failure(HF)is expected to rise with considerable economic and societal ***,knowledge on cardiac structure and function among population-based samples of the exceptional old is *** Population-based study of all persons(no exclusion criteria)living in the western part of Denmark and turning 100 years in the year ***-home face-to-face interviews were conducted,and echocardiography and blood sampling for plasma Brain Natriuretic Peptide(BNP)were offered to those who were able to give *** Out of 303 eligible,238(79%)participated,of which 125(53%)accepted *** ventricular(LV)dysfunction was present in 68(54%)of the participants of whom less than half had HF *** hypertension was present in 31(42%)with no correlation to LV *** well-known association between increased level of BNP and the prevalence of LV dysfunction could not be *** This in-home echocardiographic study shows that more than half of the participants had LV dysfunction,although mostly *** was no association between heart failure symptoms and LV ***,BNP seems to have lost its biomarker potential to rule out heart failure in *** to the latter,and the questionable symptom validity among centenarians,the current criteria to diagnose HF might be less valid in a centenarian population than in younger olds.

关键词： Brain Natriuretic Peptide Centenarian Heart failure In-home echocardiography Left ventricular dysfunction

Central Retinal Microperimetry by Scanning Laser Ophthalmoscopy in Chiasmal Patients with Visual Inattention Temporally at Monocular Visual Acuity Testing

在线全文

学校读者我要写书评

暂无评论

Open Journal of Ophthalmology 2017年第1期7卷 44-50页

作者： Hans C. Fledelius mads Nis V. andersen Rigshospitalet University Eye Department Copenhagen Demark

Background: In a previous study, a specific visual behaviour was described in four chiasmal patients. It manifested as inattention/ignorance within the temporal visual space (“visual blocking”) at monocular visual acuity testing. Moreover, in 3 out of the 4, the process of reading a text appeared cognitively impaired. Methods: As a supplement to conventional visual field testing, the present analysis focus was on microperimetry by Scanning Laser Ophthalmocopy (SLO). Our aim was to identify the perceptual retinal counterparts to the temporally located visual field defects as caused by the visual pathway lesion on a chiasmal level, possibly also to indicate the apparently ineffective saccadic movements underlying that only part of the line on the chart could be given. Results and Conclusions: The central retinal areas with lacking recognition by SLO testing were given by black rectangles expressing scotomatous points;they clustered in a zone extending nasally from the fixation area, as expected. The methodology further depicted an orderly fixation in two cases, and only minor deviation in two. Fixation saccades thus were considered by and large within normal and with only exceptional outlier points recorded. All considered, the shortcomings of the perceptual mechanisms underlying the lateralised visual inattention as observed in the four patients have remained without a satisfactory explanation.

关键词： Microperimetry Laser Ophthalmoscope Monocular Visual Acuity Testing Optic Chiasm

Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir Anne Skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell mads Christian andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

美国临床生化科学院检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物的应用

在线全文

学校读者我要写书评

暂无评论

临床检验杂志 2012年第2期30卷 116-160页

作者：鄢盛恺 Ulf-Hkan Stenman Rolf Lamerz Leendert H.Looijenga Nils Brünner Michael J.Duffy Caj Haglund mads Holten-andersen Hans JФrgen Nielsen Francisco J.Esteva Nadia Harbeck Daniel F.Hayes Rafael Molina Daniel W.Chan Robert C.Bast Jr Ie-Ming Shih Lori J.Sokoll Gyrgy Slétormos 刘洋梁红艳姜晓峰田亚平薛丽林文涛顾兵潘世扬沈文梅郑磊李江卫生部中日友好医院检验科北京100029 北京豪迈生物工程有限公司北京100028

经美国临床生化科学院(NCAB)授权,由鄢盛恺教授组织学者、专家翻译审定2009年NCAB检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的应用单行本(Catharine ***教授和Eleftherios ***-dis教授编辑)。该指南包含第1至6... 详细信息

经美国临床生化科学院(NCAB)授权,由鄢盛恺教授组织学者、专家翻译审定2009年NCAB检验医学实践指南:睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的应用单行本(Catharine ***教授和Eleftherios ***-dis教授编辑)。该指南包含第1至6章共6部分内容,参加指南制订的专家阵容强大,分别从临床及检验角度对睾丸、前列腺、结直肠、乳腺及卵巢癌中肿瘤标志物的检测与临床应用方面的问题进行了详细阐述与说明,是目前国内外在肿瘤实验诊断方面的纲领性应用文件。不仅适合广大检验人员、临床医护人员学习使用,也非常适合相关仪器试剂生产厂商研发应用。本指南由刘洋、薛丽、林文涛、李江、梁红艳、顾兵、潘世扬、郑磊等翻译,姜晓峰、沈文梅、田亚平、鄢盛恺审校,最后由鄢盛恺统稿审定。本指南的翻译出版,不仅有助于我国检验人员和医护人员合理的检测和应用睾丸、前列腺、结直肠、乳腺及卵巢癌肿瘤标志物,对我国检验医学指南的编写与应用也有一定的借鉴作用。本刊特在本期刊发,以飨广大读者。

关键词：肿瘤标志物临床应用实践指南检验医学临床生化前列腺结直肠卵巢癌

在线全文

学校读者我要写书评

暂无评论

阿梅格尔巴克/哥本山

城市环境设计 2019年第2期 172-183页

作者： Nanna Gyldholm M?ller Alberto Cumerlato Aleksander Wadas Alexander Codda Alexander Ejsing Alexandra Gustafsson Alina Tamosiunaite Armor Gutierrez Anders Hjortn?s Andreas Klok Pedersen Annette Jensen Ariel Wallner Ask andersen Balaj IIulian Blake Smith Borko Nikolic Brygida Zawadzka Buster Christensen Chris Falla Chris Zhongtian Yuan Daniel Selensky Dennis Rasmussen Espen Vik Finn N?rkj?r Franck Fdida Gonzalo Castro Gül Ertekin George Abraham Helen Chen Henrick Poulsen Henrik R?mer Kania Horia Spirescu Jakob Ohm Laursen Jelena Vucic Jeppe Ecklon Ji-young Yoon Jing Xu Joanna Jakubowska Johanna Nenander Kamilla Heskje Katarzyna Siedlecka Krzysztof Marciszewski Laura W?tte Liang Wang Lise Jessen Long Zuo Maciej Zawadzki mads Enggaard Stidsen Marcelina Kolasinska Marcos Bano Maren Allen Mathias Bank Matti N?rgaard Michael andersen Narisara Ladawal Schr?der Niklas A. Rasch Nynne madsen ?ssur Nols? Pero Vukovic Richard Howis Ryohei Koike Se Hyeon Kim Simon Masson Sunming Lee Toni Mateu Xing Xiong Zoltan David Kalaszi Rasmus Hjortshoj 陈子钰

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新... 详细信息

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新。我们提出了一种新型的垃圾焚烧发电厂,这种工厂能产生经济、环保和社会效益。我们不将阿梅格尔巴克/哥本山视为一个孤立的对象,而是调动起建筑的

关键词：巴克本山