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Wild Nutrition’s Food-Grown® Magnesium Supplementation Increases Sleep Quality and Sleep Duration and Reduces Stress in a Healthy Adult population: A Double-Blind, Randomised, placebo-Controlled Study

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Food and Nutrition Sciences 2024年第7期15卷 509-523页

作者： David Briskey Jane Erickson Chelsie Smith Amanda rao School of Human Movement and Nutrition Sciences University of Queensland Brisbane Australia RDC Clinical Brisbane Australia

Background: Magnesium, an essential mineral crucial for various bodily functions, has been shown to positively influence sleep patterns. This study aimed to evaluate the efficacy of Food-Grown® magnesium in enhancing sleep quality and duration, as well as overall well-being. Methods: Eighty participants were randomly assigned to receive either 80 mg of Food-Grown® magnesium or a placebo (microcrystalline cellulose) daily for 8 weeks. participants completed questionnaires assessing sleep quality, daytime drowsiness, quality of life, anxiety, and stress levels. Additionally, participants maintained daily sleep diaries and wore wrist-worn actigraphy devices. The primary outcome measured was the change in sleep quality and duration. Results: Seventy-one participants fulfilled all study requirements (35 in the active group and 36 in the placebo group). Magnesium supplementation significantly improved reported sleep quality, with the active group showing a 32% increase compared to 16% in the placebo group (p = 0.034). Moreover, magnesium supplementation led to a decrease in reported stress scores at week 8 compared to the placebo group (3.7 ± 2.6 vs. 5.5 ± 3.1, respectively). Both the magnesium and placebo groups exhibited significant increases in reported sleep duration and reductions in time to fall asleep, sleep disturbance, sleep latency, sleep medication usage, and total pittsburgh Sleep Quality Index score at week 8 compared to baseline. Conclusion: Magnesium supplementation notably enhanced sleep quality and reduced stress levels compared to the placebo group. These findings highlight the potential of magnesium as a beneficial supplement for improving sleep quality and overall well-being.

关键词： Magnesium Sleep Quality Sleep Duration Stress Food-Grown

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Analysis of Influencing Factors on Fruit Consumption of Urban and Rural Residents in Beijing

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Asian Agricultural Research 2024年第6期16卷 1-4,10页

作者： Zihao WANG rao CHEN Weimin YANG College of Economics and Management Beijing University of AgricultureBeijing 102206China Beijing Research Center of Rural Revitalization Beijing 102206China Department of Basic Education Beijing University of AgricultureBeijing 102206China

In light of the rapid expansion of China s economy,there has been a notable shift in the consumption patterns of urban and rural *** is evident in the increased consumption of agricultural products,with fruit consumption representing a particularly pronounced *** 2023 Beijing Consumption Statistics indicate that demand for fruit is increasing,accompanied by heightened competition for quality and *** paper is based on research that examines the current situation of fruit consumption among urban and rural residents in *** results indicate that when urban and rural residents in Beijing purchase fruits,price is the most significant factor influencing fruit ***,appearance,and variety are also considered to be important influencing factors,while the influence of factors such as fruit type,consumption pattern,and fruit brand is relatively minor.

关键词： Urban and rural residents of Beijing Fruit consumption Influencing factor Consumption behavior

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Immunology reshapes neuroscience,and neuroscience reshapes immunology

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Fundamental Research 2024年第2期4卷 199-200页

作者： Bo peng Yanxia rao Yun Wang Shumin Duan Hai Qi Jing Yang Hongliang Zhang Department of Neurosurgery Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain ScienceMOE Innovative Center for New Drug Development of Immune Inflammatory DiseasesFudan UniversityShanghai 200040China Department of Laboratory Animal Science MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Neuroscience Research Institute and Department of Neurobiology School of Basic Medical SciencesKey Laboratory for NeuroscienceMinistry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100083China pKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Faculty of Medicine and pharmaceutical Sciences Zhejiang UniversityHangzhou 310014China School of Medicine Tsinghua UniversityBeijing 100084China IDG/McGovern Institute for Brain Research Center for Life SciencesSchool of Life SciencesPeking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China Department of Life Sciences National Natural Science Foundation of ChinaBeijing 100085China

As a result of evolution,our body has evolved into a sophisticated system in which various tissues and organs cooperate in a highly orchestrated *** tissues or organs operate in *** brain serves as the command center of our body and is relatively isolated from the peripheral system due to the presence of the blood-brain barrier(BBB).This barrier prevents direct and extensive interaction between blood cells,plasma molecules,and brain cells,contributing to the longstanding perception of the brain as an“immune-privileged”***,neuroscientists and immunologists historically conducted separate research with minimal overlap between these two ***,this perspective has undergone reconsideration over the past few decades.

关键词： organs overlap contributing

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Effect of β-Glucan (Angel Yeast) Compared to a placebo on Cold and Flu Incidence and Symptoms in an Adult population—A Double Blind, Randomised Controlled Trial

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Food and Nutrition Sciences 2024年第6期15卷 484-497页

作者： David Briskey Haibo Zhang Zhixian Chen Amanda rao RDC Clinical Brisbane Australia School of Health Science and Engineering Shanghai Engineering Research Center of Food Microbiology University of Shanghai for Science and Technology Shanghai China The Hubei provincial Key Laboratory of Yeast Function Angel Yeast Co. Ltd. Yichang China

Background: 1-3, 1-6 β-glucan derived from Baker’s yeast (Saccharomyces cerevisiae) has been widely studied for its immune stimulatory capabilities and safety. previous studies found β-glucan to have efficacy at reducing incidence of URTIs as well as being a low risk for negative side effects. The current study aimed to examine the effects of yeast β-glucan (Angel Yeast) on cold and flu incidences and symptoms in healthy adults. Methods: Two hundred and thirty-one males and females aged 18 to 65 years old supplemented with either β-glucan or a placebo for 3-months. participants completed a general health questionnaire every 4 weeks and in addition, if participants experienced any cold or flu symptoms, these were recorded daily (along with severity) until resolved or up to 2 weeks. Results: Supplementation with β-glucan reduced the self-reported severity of sore throats and improved sleep quality compared to the placebo group. Conclusions: Yeast β-glucan supplementation appears to be able to help reduce certain symptoms experienced during a cold or flu episode and is safe and well tolerated.

关键词： Beta-Glucan Cold Flu Baker’s Yeast

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倾斜椭球凹陷阵列湍流强化传热实验与数值分析

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推进技术 2024年第4期45卷 144-152页

作者：许超张鹏饶宇上海交通大学机械与动力工程学院上海200240

为了提高涡轮叶片内部通道对流传热性能,本文基于瞬态液晶热像技术分别针对矩形通道表面排布的球形凹陷和斜椭球凹陷阵列的传热和压力损失特性进行了实验研究。在雷诺数为1×10^(4)~6×10^(4)内,与基准球形凹陷相比,平行排布和V形排布... 详细信息

为了提高涡轮叶片内部通道对流传热性能,本文基于瞬态液晶热像技术分别针对矩形通道表面排布的球形凹陷和斜椭球凹陷阵列的传热和压力损失特性进行了实验研究。在雷诺数为1×10^(4)~6×10^(4)内,与基准球形凹陷相比,平行排布和V形排布的斜椭球凹陷总体传热分别增强了23.8%~33.8%和104%~121%,V形排布的斜椭球凹陷综合传热性能显著提高了25%~68.3%。通过数值模拟发现,平行排布的斜椭球凹陷虽然可以诱发更强烈的二次流,但是平行的排布方式使下游凹陷受到来自上游凹陷升温后的流体冲刷,因此限制了传热的进一步增强。V形排布的斜椭球凹陷通过诱发大尺度的纵向涡对将来自主流的冷流体输运至壁面,冷流体直接冲击壁面并与近壁流体剪切,极大地增强了对流传热。

关键词：涡轮叶片冷却斜椭球凹陷传热瞬态液晶热像实验流动结构

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明清诗歌叙事传统之因变及研治策略

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苏州大学学报（哲学社会科学版） 2024年第4期45卷 132-141页

作者：饶龙隼四川大学中国俗文化研究所四川成都610207

明清诗歌叙事传统之确立,绝非独立突兀地自成一体;而是经历长期的蓄势发展,并以元代诗歌叙事为前导。正是在因承早前的基础上,才有所拓展并现若干新变。其拓展与新变固然重要,但并非诗歌叙事之主导;主导明清时期诗歌叙事的,还是诗歌叙... 详细信息

明清诗歌叙事传统之确立,绝非独立突兀地自成一体;而是经历长期的蓄势发展,并以元代诗歌叙事为前导。正是在因承早前的基础上,才有所拓展并现若干新变。其拓展与新变固然重要,但并非诗歌叙事之主导;主导明清时期诗歌叙事的,还是诗歌叙事传统之因承。在因承的基础上拓充,在新变的驱动下互渗,拓充与互渗,才是其主线。故明清诗歌叙事传统之因承新变,主要表征为体制拓充与功能互渗。尽管学界期待对之作定量分析,但在目前条件下暂时难以落实;针对明清诗歌叙事传统因承新变的研治策略,还应落实为定性分析、特征描述和变量追踪。

关键词：诗歌叙事叙事传统因承新变研治策略

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phytochemicals of Aloe barbadensis miller as potential Inhibitors of Uropathogenic Escherichia coli for Urinary Tract Infection Therapy: An in Silico Approach

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Open Journal of Biophysics 2024年第2期14卷 99-120页

作者： Mikidadi Salehe Gurisha pulapa Venkata Kanaka rao Laxmikanth Cherupally Department of physics College of Natural and Mathematical Sciences University of Dodoma Dodoma Tanzania

Urinary tract infections (UTIs) are common infections caused by normal skin or rectum bacteria that get into the urethra and infect the urinary tract. Although the infection can affect various parts of the tract, bladder infections are the most prevalent kind. Uropathogenic Escherichia Coli (UpEC) is the most common pathogen associated with UTI development. Therefore, inhibiting the UpEC protein target (pDB ID: 8BVD) appears to be a promising therapeutic strategy. Therefore, in this study, molecular docking and dynamics were conducted to examine the antibacterial activity of Aloe barbadensis miller against UpEC bacteria. The Aloe barbadensis miller natural compounds licochalcone A, palmidin B and palmidin C were downloaded from pubChem with amoxicillin, which was used as a control drug and studied against the target molecule. The potential parameters examined were the docking scores, absorption, distribution, metabolism, excretion, toxicity (ADMET), bioavailability, root mean square deviation (RMSD), root mean square fluctuation (RMSF), hydrogen bonding, radius of gyration, and potential energy of the system. Docking scores showed that all ligands demonstrated an admirable candidature as an inhibitor to 8BVD molecule, and the score hierarchy is licochalcone A (-6.4 kcal/mol), palmidin C (-6.1 kcal/mol), palmidin B (-6.0 kcal/mol), and amoxicillin (-5.9 kcal/mol). All ligands appeared to have good drug-like properties and oral bioavailability. Molecular dynamic studies showed that all ligands exhibited an excellent nominee as inhibitors in their vicinity at 20 ns. However, there is a relatively high fluctuation of palmidin B compared with other compounds, which seems to be more stable. This work suggests that the selected phytoconstituents could be used as inhibitors of the 8BVD protein in the fight against UTIs. However, further investigation on the clinical and experimental validation of UTI treatment’s specific mechanisms and effects is still welcomed.

关键词： Uropathogenic Escherichia Coli phytochemicals Molecular Docking Ligand Hydrogen Bond

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A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization

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Acta pharmaceutica Sinica B 2024年第7期14卷 3232-3250页

作者： ping Yu Tanwei Gu Yueyang rao Weimin Liang Xi Zhang Huanguo Jiang Jindi Lu Jianglian She Jianmin Guo Wei Yang Yonghong Liu Yingfeng Tu Lan Tang Xuefeng Zhou Guangdong provincial Key Laboratory of New Drug Screening Guangdong-Hong Kong-Macao Joint Laboratory for New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China NMpA Key Laboratory for Research and Evaluation of Drug Metabolism School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Lewwin pharmaceutical Research Institute Co. Ltd.Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and ResearchGuangdong Engineering Research Center for Innovative Drug Evaluation and ResearchGuangzhou 510990China

Insufficient therapeutic strategies for acute kidney injury(AKI)necessitate precision therapy targeting its *** study reveals the new mechanism of the marine-derived anti-AKI agent,piericidin glycoside S14,targeting peroxiredoxin 1(pRDX1).By binding to Cys83 of pRDX1 and augmenting its peroxidase activity,S14 alleviates kidney injury efficiently in prdx1-overexpression(prdx1-OE)***,S14 also increases pRDX1 nuclear translocation and directly activates the Nrf2/HO-1/NQO1 pathway to inhibit ROS *** to the limited druggability of S14 with low bioavailability(2.6%)and poor renal distribution,a pH-sensitive kidney-targeting dodecanaminechitosan nanoparticle system is constructed to load S14 for precise treatment of AKI.L-Serine conjugation to chitosan imparts specificity to kidney injury molecule-1(Kim-1)-overexpressed *** developed S14-nanodrug exhibits higher therapeutic efficiency by improving the in vivo behavior of S14 *** encapsulation with micelles,the AUC_(0-t),half-life time,and renal distribution of S14 increase 2.5-,1.8-,and 3.1-fold,*** main factors contributing to the improved druggability of S14 nanodrugs include the lower metabolic elimination rate and UDpglycosyltransferase(UGT)-mediated *** summary,this study identifies a new therapeutic target for the marine-derived anti-AKI agent while enhancing its ADME properties and druggability through nanotechnology,thereby driving advancements in marine drug development for AKI.

关键词： Acute kidney injury piericidin glycoside peroxiredoxin 1 Nanodrug Kim-1 targeted ADME Marine drug Druggability

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Hierarchical V_(3)S_(4)/C nanofibers with fast kinetics for superior alkali metal batteries

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Rare Metals 2024年第4期43卷 1836-1844页

作者： Li Chen Zhi-Xin rao Zhi Chen Zhao-Hui Wu Shuai Yang Zhi-Jun Feng Hui-Yong Yang Fan-Yan Zeng Xi-Bao Li Jin-Yang Hu Jun-Tong Huang School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang330063China School of Aeronautical Manufacturing Engineering Nanchang Hangkong UniversityNanchang330063China

Owing to the numerous benefits,including low cost and great theoretical capacity,V3S4 has been a research hotspot for Li^(+)/Na^(+)/K^(+) ***,the V_(3)S_(4) electrode with long cycling stability and high specific capacities continues to pose significant *** this work,vacuum vulcanization is combined with electrospinning to synthesize V_(3)S_(4)/C composite nanofibers(V_(3)S_(4)@CNF).

关键词： composite fibers kinetics

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Cretaceous integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1229-1289页

作者： Dangpeng XI Guobiao LI Shijun JIANG Xin rao Tian JIANG Tianyang WANG Zuohuan QIN Yasu WANG Jianzhong JIA Muhammad KAMRAN Zhongye SHI Yuyang WU panxi WANG Lixin SUN Qinggao ZENG Xiaoqiao WAN State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China College of Oceanography Hohai UniversityNanjing 213200China Key Laboratory of palaeobiology and petroleum Stratigraphy Nanjing Institute of Geology and PaleontologyChinese Academy of SciencesNanjing 210008China State Key Laboratory of Tibetan plateau Earth System Environmentand Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China China National Offshore Oil Corporation Limited Beijing 100028China Shanghai Science and Technology Museum Shanghai 200120China Xizang Bureau of Geological and Mineral Exploration and Development Lhasa 850000China Tianjin Geological Survey Center of China Geological Survey Tianjin 300170China

The Cretaceous period is a vital time interval in deciphering the evolutionary history of the Neo-Tethys Ocean and the convergence of different plates and blocks across the Qinghai-Tibetan plateau.A detailed stratigraphic framework and paleogeographic patterns are the basis for understanding the evolution of the Neo-Tethys Ocean and the formation of the QinghaiTibetan ***,the Cretaceous stratigraphy,biota,paleogeography,and major geological events in the Qinghai-Tibetan plateau are analyzed to establish an integrative stratigraphic framework,reconstruct the paleogeography during the Cretaceous period,and decode the history of the major geological *** Cretaceous rocks of the Qinghai-Tibetan plateau and its surrounding area are predominantly marine deposits,with a small amount of interbedded marine-terrestrial and terrestrial *** Indus-Yarlung Tsangpo Suture Zone was responsible for the deposition of deep marine sediments dominated by ophiolite suites and radiolarian *** the south,the Tethys Himalayas and Indus Basin received marine sediments of varying depths and lithology;to the north,the Xigaze and Ladakh forearc basins are also filled with marine *** Lhasa Block,Karakorum Block,western Tarim Basin,and West Burma block consist of shallow marine,interbedded marine-terrestrial,and terrestrial *** Qiangtang Basin and other areas are dominated by terrestrial *** Cretaceous strata of the Qinghai-Tibetan plateau and its surrounding areas are widely distributed and diversified,with abundant foraminifera,calcareous nannofossils,radiolarians,ammonites,bivalves,and *** the basis of integrated lithostratigraphic,biostratigraphic,geochronologic,and chemostratigraphic analyses,we proposed herein a comprehensive stratigraphic framework for the Cretaceous period of the eastern *** analyzing the Cretaceous biota of different biogeographic zones from eastern Neo-Tethys and its surrounding a

关键词： Qinghai-Tibetan plateau Tethys Cretaceous Stratigraphy Biota paleogeography

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