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Geochemistry of volcanic glass from Mahanadi offshore region,eastern continental margin of India:Constraints on the contribution of latest Toba super-eruption

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Acta Oceanologica Sinica 2024年第2期43卷 111-119页

作者： Muralidhar Kocherla Durbar ray Manavalan Satyanarayanan Hilda Joao Virsen Gaikwad Pb Ramamurty CSIR-National Institute of Oceanography Dona Paula 403004GoaIndia CSIR-National Geophysical Research Institute Uppal RoadHyderabad 500007India

The tephra layers in multiple sediment cores from the offshore region of the Mahanadi basin in the northern bay of bengal were investigated for possible volcanic sources. The glass shards from those tephra layers were studied for size distribution, texture, and elemental geochemistry to establish chronostratigraphic markers for regional and global Quaternary correlation. The textural features of fine-grained(silty) volcanic glasses suggest the distal source of these tephra deposits. Major element composition with elevated SiO_(2) contents ranging between75%–76% and dominance of K_(2)O(> 4.5%) over CaO(ba volcano. The bulk trace element compositions of the same glass shards were comparable with those reported in the youngest Toba tephra reported elsewhere. Likewise, the LREE-dominated chondrite normalized REE profiles of tephra from the Mahanadi basin closely resemble the characteristic REE patterns in Toba ash from other parts of the Indian Ocean and thus confirmed the contribution of the youngest Toba super-eruption for this ash layers.

关键词： Mahanadi basin bay of bengal volcanic glass glass morphology glass-chemistry

Functional cure of chronic hepatitis b-hope or hype?

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World Journal of Hepatology 2024年第9期16卷 1199-1205页

作者： Gautam ray Gastroenterology Unit Department of MedicineB.R.Singh HospitalKolkata 700014West BengalIndia

Chronic hepatitis b constitutes a substantial disease burden *** steps advocated by the World Health Organization in 2016 to eradicate hepatitis b by 2030 has failed to achieve significant progress,especially with respect to immu-nization coverage and linkage to *** lack of governmental and public awar-eness regarding the long-term implications of hepatitis b burden cause under-funding of developmental *** presently approved treatment modalities have limited efficacy in complete viral eradication,hence the need for newer molecules to achieve functional cure(sustained undetectable hepatitis b surface antigen(HbsAg)and hepatitis b virus DNA in peripheral blood after a finite period of therapy).However,preliminary results from trials of novel therapies show their inadequacy to achieve this end by themselves but better performance with a low baseline serum HbsAg with nucleos(t)ide analogues(NA)treatment which need to be combined with/without pegylated interferon as an *** therapy is limited by cost and adverse events and need to show incremental benefit over the standard of care(long-term NA therapy)with respect to efficacy and drug toxicities,making the development process ***,while such therapies continue to be tested,strategies should still focus on prevention of transmission by non-pharmaceutical measures,vaccination and increasing linkage to care.

关键词： Hepatitis b Drugs Clinical trial Therapy Novel therapies Functional cure

Painlevéintegrability,auto-bäcklund transformations,new abundant analytic solutions including multi-soliton solutions for time-dependent extended KdV8 equation in nonlinear physics

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Journal of Ocean Engineering and Science 2024年第5期9卷 489-507页

作者： Shailendra Singh S.Saha ray National Institute of Technology Department of MathematicsRourkela 769008India

In this paper,a new eighth-order(1+1)-dimensional time-dependent extended KdV equation has been *** considered equation is being found completely integrable by using the Painlevéanalysis ***,three auto-bäcklund transformations have been generated by truncating the Painlevéseries at a constant *** auto-bäcklund transformations have been used to derive various analytic solution families for the newly developed *** solutions include the kink-antikink soliton,kink-soliton,antikink-soliton,periodic-soliton,complex kink-soliton and complex periodic-soliton ***-soliton solutions including N-soliton solution,have been obtained by using the simplified Hirota’s method for the considered *** the results are being expressed graphically to signify the physical importance of the considered equation.

关键词： Higher-order KdV equation Painlevéanalysis Auto-bäcklund transformation Simplified Hirota method

Continuous flow pyrolysis of virgin and waste polyolefins:a comparative study,process optimization and product characterization

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 133-149页

作者： Ecrin Ekici Güray Yildiz Magdalena Joka Yildiz Monika Kalinowska ErolŞeker Jiawei Wang Karlsruhe Institute of Technology Institute of Catalysis Research and TechnologyEggenstein-Leopoldshafen 76344Germany Izmir Institute of Technology Faculty of EngineeringDepartment of Energy Systems EngineeringIzmir 35430Türkiye Department of Materials Engineering and Production Faculty of Mechanical EngineeringBialystok University of TechnologyBialystok 15-351Poland Department of Agricultural and Food Engineering and Environmental Development Institute of Civil Engineering and EnergeticsFaculty of Civil Engineering and Environmental SciencesBialystok University of Technology15-351 BialystokPoland Department of Chemistry Biology and BiotechnologyInstitute of Civil Engineering and EnergeticsFaculty of Civil Engineering and Environmental SciencesBialystok University of TechnologyBialystok 15-351Poland Izmir Institute of Technology Faculty of EngineeringDepartment of Chemical EngineeringIzmir 35430Türkiye Energy and bioproducts Research Institute(EbRI) Aston UniversityBirmingham B47ETUnited Kingdom

Under optimal process conditions,pyrolysis of polyolefins can yield ca.90 wt%of liquid product,i.e.,combination of light oil fraction and heavier *** this work,the experimental findings reported in a selected group of publications concerning the non-catalytic pyrolysis of polyolefins were collected,reviewed,and compared with the ones obtained in a continuously operated bench-scale pyrolysis *** process parameters were used for the pyrolysis of waste and virgin counterparts of high-density polyethylene,low-density polyethylene,polypropylene and a defined mixture of those(i.e.,25:25:50 wt%,respectively).To mitigate temperature drops and enhance heat transfer,an increased feed intake is employed to create a hot melt plastic *** 1.5 g·min^(-1) feed intake,1.1 L·min^(-1) nitrogen flow rate,and a moderate pyrolysis temperature of 450℃,the formation of light hydrocarbons was favored,while wax formation was limited for polypropylene-rich *** of virgin plastics yielded more liquid(maximum 73.3 wt%)than that of waste plastics(maximum 66 wt%).blending polyethylenes with polypropylene favored the production of liquids and increased the formation of gasoline-range *** products were mainly composed of C3 hydrocarbons,and no hydrogen production was detected due to moderate pyrolysis temperature.

关键词： waste plastics polyolefins chemical recycling pyrolysis alternative fuels waste-to-energy

Oblique Drop Impact on Deep and Shallow Liquid

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Communications in Computational Physics 2012年第4期11卷 1386-1396页

作者： b.ray G.biswas A.Sharma Department of Mechanical Engineering Indian Institute of Technology KanpurKanpur 208016India CSIR-Central Mechanical Engineering Research Institute Durgapur 713209India Department of Chemical Engineering Indian Institute of Technology KanpurKanpur 208016India

Numerical simulations using CLSVOF(coupled level set and volume of fluid)method are performed to investigate the coalescence and splashing regimes when a spherical water drop hits on the water surface with an impingement *** angle is the angle between the velocity vector of primary drop and the normal vector to water *** effect of impingement angle,impact velocity and the height of target liquid are carried *** impingement angle is varied from 0o to 90o showing the gradual change in *** formation of ship pro like shape,liquid sheet,secondary drops and crater are *** height,crater displacement,crown height and crown angle are calculated and the change in the parameters with change in impingement angle is noted.

关键词： Coupled level set and volume of fluid method drop impact impingement angle Weber number

Diverse roles of bitter melon(Momordica charantia)in prevention of oral cancer

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 178-188页

作者： Subhayan Sur Ratna b.ray Department of Pathology Saint Louis UniversitySt.LouisMO 63104USA. Cancer Center Saint Louis UniversitySt.LouisMO 63104USA

Oral squamous cell carcinoma(OSCC)is one of the common lethal malignancies which is increasing rapidly in the *** risks from alcohol and tobacco habits,lack of early detection markers,lack of effective chemotherapeutic agents,recurrence and distant metastasis make the disease more complicated to ***-based studies and epidemiological studies indicate important roles of nutraceuticals to manage different *** plant bitter melon(Momordica charantia)is a good source of nutrients and bio-active phytochemicals such as triterpenoids,triterpene glycosides,phenolic acids,flavonoids,lectins,sterols and *** plant is widely grown in Asia,Africa,and South *** melon has traditionally been used as a folk medicine and Ayurvedic medicine in Asian culture to treat diseases such as diabetes,since ancient *** crude extract and some of the isolated pure compounds of bitter melon show potential anticancer effects against different *** this review,we shed light on its effect on *** melon extract has been found to inhibit cell proliferation and metabolism,induce cell death and enhance the immune defense system in the prevention of OSCC in vitro and in ***,bitter melon may be used as an attractive chemopreventive agent in progression towards OSCC clinical study.

关键词： bitter melon(Momordica charantia) oral squamous cell carcinoma signal transduction cancer metabolism immune system cancer prevention

MicroRNAs:Role in hepatitis C virus pathogenesis

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Genes & Diseases 2015年第1期2卷 35-45页

作者： Shubham Shrivastava Robert Steele Ranjit ray Ratna b.ray Department of Pathology Saint Louis UniversitySt.LouisMOUSA Department of Internal Medicine Saint Louis UniversitySt.LouisMOUSA

Hepatitis C virus(HCV)is a global health burden with an estimated 170e200 million peoples chronically infected *** infection remains as an independent risk factor for chronic hepatitis,liver cirrhosis,hepatocellular carcinoma,and a major reason for liver *** of direct acting antiviral(DAA)drugs have shown promising results with more than 90%success rate in clearing the HCV RNA in patients,although long-term consequences remain to be ***(miRNAs)are important players in establishment of HCV infection and target crucial host cellular factors needed for productive HCV replication and augmented cell *** expression of miRNAs is involved in the pathogenesis associated with HCV infection by controlling signaling pathways such as immune response,proliferation and *** is emerging as a means of communication between various cell types inside the *** is likely possibility of developing circulating miRNAs as biomarkers of disease progression and can also serve as diagnostic tool with potential of early therapeutic intervention in HCV associated end stage liver *** review focuses on recent studies highlighting the contribution of miRNAs in HCV life cycle and their coordinated regulation in HCV mediated liver disease progression.

关键词： Circulatory miRNAs HCV Interferon signaling Liver disease MicroRNA

Immunotherapy in type 1 diabetes:Novel pathway to the future ahead

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World Journal of Diabetes 2024年第10期15卷 2022-2035页

作者： Sayantan ray Rajan Palui Department of Endocrinology All India Institute of Medical SciencesBhubaneswar 751019India Department of Endocrinology The Mission HospitalDurgapur 713212India

Since the discovery of insulin over 100 years ago,the focus of research in the management of type 1 diabetes(T1D)has centered around glycemic control and management of complications rather than the prevention of autoimmune destruc-tion of pancreaticβ***,in recent years,there has been significant advancement in immune-targeted pharmacotherapy to halt the natural progres-sion of *** immune-targeted intervention aims to alter the underlying pa-thogenesis of T1D by targeting different aspects of the immune *** im-munotherapy can either antagonize the immune mediators like T cells,b cells or cytokines(antibody-based therapy),or reinduce self-tolerance to pancreaticβcells(antigen-based therapy)or stem-cell ***,the US Food and Drug Administration approved the first immunotherapy teplizumab to be used only in stage 2 of ***,the window of opportunity to practically implement this approved molecule in the selected target population is *** this Edito-rial,we briefly discuss the various promising recent developments in the field of immunotherapy research in ***,further studies of these newer thera-peutic agents are needed to explore their true potential for prevention or cure of T1D.

关键词： Type 1 diabetes Immunotherapy Teplizumab Antigen based therapy Stem cell immunotherapy

Nearest Neighbor Sampling of Point Sets Using rays

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1131-1174页

作者： Liangchen Liu Louis Ly Colin b.Macdonald Richard Tsai Department of Mathematics The University of Texas at Austin2515 SpeedwayAustinTX 78712USA Oden Institute for Computational Engineering and Sciences The University of Texas at Austin201 E24th StAustinTX 78712USA Department of Mathematics University of British Columbia1984 Mathematics RdVancouverBCV6T1Z2Canada

We propose a new framework for the sampling,compression,and analysis of distributions of point sets and other geometric objects embedded in Euclidean *** approach involves constructing a tensor called the raySense sketch,which captures nearest neighbors from the underlying geometry of points along a set of *** explore various operations that can be performed on the raySense sketch,leading to different properties and potential *** information about the data set can be extracted from the sketch,independent of the ray *** integrals on point sets can be efficiently computed using the *** also present several examples illustrating applications of the proposed strategy in practical scenarios.

关键词： Point clouds Sampling Classification Registration Deep learning Voronoi cell analysis