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OPCAB (Off Pump Coronary Artery Bypass) for Kawasaki Disease

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Surgical Science 2018年第9期9卷 287-292页

作者： Murali P. Vettath madhu ravisankar Kannan Arunachalam Veluchamy Nitin Gangadharan Cardiovascular and Thoracic Centre MEITRA Hospital Kozhikode India Department of Cardiovascular and Thoracic Surgery MEITRA Hospital Kozhikode India

We hereby report a case of Kawasaki disease in a 32 year old male, with giant aneurysm of both coronary arteries and severe LV (left ventricular) dysfunction who underwent OPCAB (off pump coronary artery bypass grafting) two years ago. He presented with acute myocardial infarction of his anterior wall of left ventricle. He was stabilised with medical management and was taken up for surgery when his enzymes became normal. His LV function had improved over the time and now has a good ejection fraction.

关键词： Coronary Artery Disease Coronary Artery Aneurysm Kawasaki Disease OPCAB (Off Pump Coronary Artery Bypass)

Development of SIMS (Simple Indigenous Metallic Stabilizer) for OPCAB

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World Journal of Cardiovascular Diseases 2019年第5期9卷 324-330页

作者： Murali P. Vettath Kannan Arunachalam Venkatachalam Nitin Gangadharan madhu ravisankar Smera Koroth Gopalakrishnan Raman Meitra Hospital Kozhikode India

Development of a simple, reusable stabilizer for beating heart surgery has been long overdue. Every time a disposable stabilizer is used and discarded, we add to the carbon footprint we leave behind. We had been working on developing such a stabilizer, and had finally come up with a simple indigenous (reusable) metallic stabilizer (SIMS). We have used it for over 600 consecutive off pump coronary artery bypass (OPCAB) with excellent results. The anatomy of the stabilizer is described here along with a comparison of this stabilizer with the commercially available one.

关键词： SIMS OPCAB

Colorimetric Sensor for Detection of Tabun Mimic Diethyl Cyanophosphonate

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Journal of Analysis and Testing 2024年第3期8卷 374-384页

作者： madhu Bala Dheeraj Pandey Nikita Patel Sheetal Yadav Abha Sharma Department of Medicinal Chemistry National Institute of Pharmaceutical Education and Research RaebareliTransit Campus

Herein,a colorimetric chemosensor （probe 7） was designed and synthesized for sensing diethyl cyanophosphonate （DCNP）,a Tabun nerve agent *** sensitive,selective,fast response and photostable probe 7 in dimethylsulfoxide （DMSO）responded to DCNP at low concentrations with visual naked eye color change from pink to pale yellow and displayed unresponsive behaviour against various interferences except for copper ions,which can be di?erentiated by adding ethylene diamine where the yellow color persisted in the case of DCNP but turned to pink in the case of copper ***,the yellow aqueous solution of probe 7 at pH 10 and 12 turned colorless against the response of *** limit of detection（LOD） of probe 7 was found to be 50 nmol/L in an aqueous basic solution at pH 10 for the detection of *** formation of the cyclized product was elucidated by1H and31P NMR nuclear magnetic resonance (1H NMR,31P NMR),Fourier transform infrared spectroscopy （FTIR）,and high-resolution mass spectrometry （HRMS） ***?lter paper and silica plate loaded with probe 7 were fabricated for real-time and on-site detection of DCNP.

关键词： Chemosensor Colorimetric Fluorescence Tabun mimic

Cr-induced fusion reactions to synthesize superheavy elements

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Nuclear Science and Techniques 2024年第5期35卷 122-130页

作者： S.madhu H.C.Manjunatha N.Sowmya B.M.Rajesh L.Seenappa R.S.Susheela Department of Physics R V College of EngineeringBangalore 560074India Visvesvaraya Technological University BelagaviKarnataka 590018India Department of Physics Government First Grade CollegeSrinivasapurKarnataka 563135India Department of Physics Government First Grade CollegeDevanahallyKarnataka 562110India Department of Physics Government First Grade CollegeMulbagalKarnataka 563131India Department of Physics Government First Grade collegeNanjangudOoty RoadMysore 571301India

We investigated ^(50,52-54)Cr-induced fusion reactions for the synthesis of the superheavy element in the 104≤Z≤122 *** cross sections produced in this investigation using ^(54)Cr projectiles were compared with those obtained in prior *** estimated cross sections from this analysis are consistent with the findings of prior *** the current study,the predicted cross section was found to be 42fb at 236 MeV for ^(53)Cr+^(243)Am,23.2 fb at 236 MeV for ^(54)Cr+^(247)Cm,95.6 fb at 240 MeV for ^(53)Cr+248Bk,and 1.33 fb at 242 MeV for ^(53)Cr+***,these projected cross sections with excitation energy and beam energy will be useful in future Cr-induced fusion reaction investigations.

关键词： Fusion cross sections Compound nucleus formation probability Survival probability Evaporation residue cross sections

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Prediction of Geopolymer Concrete Compressive Strength Using Convolutional Neural Networks

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1455-1486页

作者： Kolli Ramujee Pooja Sadula Golla madhu Sandeep Kautish Abdulaziz S.Almazyad Guojiang Xiong Ali Wagdy Mohamed Department of Civil Engineering VNR Vignana Jyothi Institute of Engineering and TechnologyHyderabadTelangana500090India Department of Information Technology VNR Vignana Jyothi Institute of Engineering and TechnologyHyderabadTelangana500090India Department of Computer Science LBEF Campus(Asia Pacific University of Technology&InnovationMalaysia)Kathmandu44600Nepal Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Guizhou Key Laboratory of Intelligent Technology in Power System College of Electrical EngineeringGuizhou UniversityGuiyang550025China Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied Science Research Center Applied Science Private UniversityAmmanJordan

Geopolymer concrete emerges as a promising avenue for sustainable development and offers an effective solution to environmental *** attributes as a non-toxic,low-carbon,and economical substitute for conventional cement concrete,coupled with its elevated compressive strength and reduced shrinkage properties,position it as a pivotal material for diverse applications spanning from architectural structures to transportation *** this context,this study sets out the task of using machine learning(ML)algorithms to increase the accuracy and interpretability of predicting the compressive strength of geopolymer concrete in the civil engineering *** achieve this goal,a new approach using convolutional neural networks(CNNs)has been *** study focuses on creating a comprehensive dataset consisting of compositional and strength parameters of 162 geopolymer concrete mixes,all containing Class F fly *** selection of optimal input parameters is guided by two distinct *** first criterion leverages insights garnered from previous research on the influence of individual features on compressive *** second criterion scrutinizes the impact of these features within the model’s predictive *** to enhancing the CNN model’s performance is the meticulous determination of the optimal *** a systematic trial-and-error process,the study ascertains the ideal number of epochs for data division and the optimal value of k for k-fold cross-validation—a technique vital to the model’s *** model’s predictive prowess is rigorously assessed via a suite of performance metrics and comprehensive score ***,the model’s adaptability is gauged by integrating a secondary dataset into its predictive framework,facilitating a comparative evaluation against conventional prediction *** unravel the intricacies of the CNN model’s learning trajectory,a loss plot is deployed to elucidate its learning rat

关键词： Class F fly ash compressive strength geopolymer concrete prediction deep learning convolutional neural network

Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

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Oncology Research 2024年第1期32卷 19-47页

作者： ABHISHEK WAHI MAMTA BISHNOI NEHA RAINA MEGHNA AMRITA SINGH PIYUSH VERMA PIYUSH KUMAR GUPTA GINPREET KAUR HARDEEP SINGH TULI madhu GUPTA Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical Sciences Gurugram UniversityHaryana122003India Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-Sciences and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is a leading cause of death globally,with limited treatment options and several *** agents often result in toxicity which long-term conventional *** are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the *** phytoconstituents act in several ways and deliver optimum effectiveness against ***,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and *** presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective *** holds significant potential for future advancements in cancer ***,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in ***,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo ***,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers Nanotechnology Clinical development

Hot deformation behavior and processing maps of Ti-15Al-12Nb alloy

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Rare Metals 2022年第7期41卷 2316-2323页

作者： Ravindranadh Bobbili Vemuri madhu Defense Metallurgical Research Laboratory Hyderabad 500058India

The isothermal hot compression tests of Ti-15Al-12Nb alloy under wide range of strain rates(0.01-10.00 s^(-1)and deformation temperatures(950,1000,1050,and 1100℃)were carried out using Gleeble-3500 thermo-simulation machine.A constitutive equation represented as a function of temperature,strain rate and true strain was developed,and the hot deformation appar-ent activation energy is calculated to be about 453 kJ·mol^(-1).By employing dynamic material model(DMM),the processing maps of Ti-15Al-12Nb alloy at various strains were *** efficiency of about 57%for power dissipation is obtained at high temperature and low strain *** to the high power dissipation efficiency and excellent processing ability in dynamic recrystallization(DRX)zone for metal material,the optimum processing conditions are selected as the temperature range of 1050-1100℃and the strain rate range of 0.01-0.10 s^(-1).Using transmission electron microscopy(TEM)studies,it is found that the dislocation density is directly associated with the value of processing *** is observed that when the processing effi-ciency is about 22%,the dislocation density is reasonably *** flow instability region occurs at strain rate of 10.00 s^(-1)with cracks,which should be avoided during hot processing to obtain the required mechanical properties.

关键词： Hot deformation Processing map Ti–15Al–12Nb

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Antioxidant and modulatory role of Chlorophytum borivilianum against arsenic induced testicular impairment

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Journal of Environmental Sciences 2012年第12期24卷 2159-2165页

作者： Garima Sharma madhu Kumar Cell and Molecular Biology Laboratory Department of ZoologyCentre for Advanced studiesUniversity of RajasthanJaipur 302055India

Arsenic has a suppressive influence on spermatogenesis and induces impairment in male reproductive system due to oxidative stress. The present study was aimed to test the arsenic induced toxicity and protection by Chlorophytum borivilianum. The effect of sodium arsenite （4 mg/（kg body weight （bw）.day）） via double distilled water without or with C. borivilianum （800 mg/（kg ***）） was evaluated in Swiss albino mice for 30 days. The radical scavenging activity of the aqueous C. borivilianum root extract was measured using DPPH （1,1-diphenyl-2-picryl hydrayzyl） radical. Qualitative assessment of various cell types in the testis, sperm count and motility, testicular activity of lipid peroxidation （LPO）, reduced glutathione （GSH）, acid and alkaline phosphatase, cholesterol and serum testosterone were monitored. Arsenic treatment showed a significant increase in LPO, acid and alkaline phosphatase, cholesterol and decrease in sperm count, sperm motility, GSH and serum testosterone. Combined treatment showed significant decrease in LPO, acid and alkaline phosphatase, cholesterol and elevation in sperm count, sperm motility, GSH and serum testosterone. Testicular histopathology showed that C. borivilianum had reduced degeneration of germ cell in the seminiferous tubules and loss of sperms induced by arsenic intoxication. The results thus led us to conclude that administration of C. borivilianum root extract is found to be protective against arsenic induced toxicity.

关键词： DPPH radical assay Chlorophytum borivilianum reduced glutathione lipid peroxidation arsenic testosterone

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N-policy for M^(x)/G/1 Unreliable Retrial G-Queue with Preemptive Resume and Multi-services

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Journal of the Operations Research Society of China 2016年第4期4卷 437-459页

作者： Amita Bhagat madhu Jain Department of Applied Sciences The Northcap UniversityGurgaon 122017India Department of Mathematics Indian Institute of Technology RoorkeeRoorkee 247667India

Bulk arrival retrial G-queue with impatient customers and multi-servicessubject to server breakdowns has been analyzed. The system allows the arrival oftwo types of customers: positive customers and negative customers in the *** negative customers make the server fail if they find the server in busy state,whereas positive customers are served if the server is idle otherwise they join thevirtual pool of customers called orbit. The customers from the retrial orbit try theirchance again for the service. The customers have the option of obtaining more than oneservice. Moreover, the customers are impatient and may renege from the system withprobability (1−r ). The server is sent for repair as soon as it breakdowns;after repair,the service process starts again. Also, the server has the provision to initiate the servicewhen there areN customers accumulated in the system. Using supplementary variablestechnique and generating functions, various performance measures like reliabilityindices and long run probabilities have been obtained.

关键词： Retrial queue N-policy vacation Negative customers Reneging Bulk arrival Breakdowns Preemptive resume Multi-services