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Relationship between retinopathy and cirrhosis

World Journal of Gastroenterology 2005年第14期11卷 2193-2196页

作者： Colakoglu Onder Taskiran Bengur Dayi Selcuk Sozmen Bulent Unsal Belkis maden ahmet Pasa Eser Aslan S. Leyla Clinics of Gastroenterology Izmir Ataturk Teaching and Research Hospital IzmirTurkey 3rd Clinics of Internal Medicine Izmir Ataturk Teaching and Research Hospital Izmir Turkey Clinics of Ophthalmology Izmir Ataturk Teaching and Research Hospital IzmirTurkey 3rd Clinics of Internal Medicine Izmir Ataturk Teaching and Research Hospital IzmirTurkey Clinics of Ophthalmology 9th September University Hospital IzmirTurkey

AIM: To evaluate ophthalmic disorders with special attention to retinopathy in cirrhotic patients. Vitamin A deficiency-related ophthalmopathy, xerophthalmia, and color blindness may be documented in cirrhosis due to various etiologies. Retinopathy is an obscure feature of cirrhosis. METHODS: Thirty-two cirrhotic patients, who were followed up by Clinics of Gastroenterology, Izmir Ataturk Teaching and Research Hospital, were enrolled to the study. Associated systemic diseases such as diabetes mellitus and hypertension were excluded. Thirty-two healthy volunteers took part as the control subjects. All participants had ophthalmologic examination in the same hospital. RESULTS: Five (15.6%) of the cirrhotic subjects had soft exudate in the retina. None of the control subjects had retinopathy (P＜0.05). Intraocular pressure (IOP) measured for both eyes were also significantly lower in the cirrhotics (P＜0.05 vs P = 0.01). There were no statistically significant differences between the two groups in terms of other ophthalmic pathologies. The ophthalmic findings did not show up any differences according to the etiology of cirrhosis. CONCLUSION: Soft exudates may develop in cirrhotic patients probably due to loss of synthetic function of liver and hemodynamic effects of portal hypertension. Retinopathy must be sought in cirrhosis because of its severe morbidity.

关键词： Cirrhosis Portal hypertension Retinopathy

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The relation between differential leukocyte count, neutrophil to lymphocyte ratio and the presence and severity of coronary artery disease

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Open Journal of Internal Medicine 2012年第3期2卷 163-169页

作者： Hatice Selcuk Lale Dinc Mehmet Timur Selcuk Orhan maden ahmet Temizhan Cardiology Department Turkiye Yuksek Ihtisas Hospital Ankara Turkey

Objectives: Total leukocyte count, a marker of inflammation has long been reported to be related with coronary artery disease (CAD). Recently, differenttial leukocyte count and elevated neutrophil to lymphocyte ratio (N/L) has been shown to indicate an increased long-term risk of mortality in patients with stable CAD, myocardial infarction and undergoing cardiovascular surgery. Thses studies offer incremental prognostic value to total leukocyte count. We sought to determine the relationship between the leukocyte subtypes and N/L ratio and the presence and extent of CAD. Study design: The study consisted of 107 patients [70 (65.4%) men, 37 (34.6%) women, mean age 59.5 ± 10.6 years] referred to coronary angiography with suspected CAD. The subjects were classified into two groups according to the presence of significant CAD and the extent of CAD was determined by the Gensini method. Results: The lymphocyte count was found to be lower (2031 ± 741 cells/μL vs 2392 ± 611 cells/μL, p: 0.010) and the N/L ratio was found to be higher in patients with CAD (2.86 ± 1.57 vs 2.04 ± 1.01, p p: 0.005]. Conclusion: Our findings reveal that N/L ratio, a simple marker which can be derived from a routine complete blood count test was significantly and independently related to presence and severity of coronary atherosclerosis.

关键词： Leukocyte Neutrophil Lymphocyte Coronary Artery Disease Lymphocyte Ratio

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