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Ma.nutrition a.fects qua.ity of life in ga.troenterology pa.ients

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World Journa. of Ga.troenterology 2006年第21期12卷 3380-3385页

作者： Kristina.Norma. Henriette Kirchner herbert Lochs Ma.thia. Pirlich Klinik mil Schwerpunkt Ga.troenterologie Hepa.ologie und Endokrinologie Charité-Universit(a|¨)tsmedizin Berlin Campus MitteGermany

a.M： To investiga.e the a.socia.ion between ma.nutrition a.d qua.ity of life in pa.ients with benign ga.trointestina. ***： Two hundred pa.ients （104 wellnourished a.d 96 ma.nourished） were a.sessed a.cording to the Subjective Globa. a.sessment, a.thropometric mea.urements a.d bioelectrica. impeda.ce a.a.ysis. Qua.ity of life wa. determined with the va.ida.ed Medica. Outcomes Study 36-item Short-Form Genera. Hea.th Survey （SF 36）. Muscle function wa. a.sessed by ha.d grip strength a.d pea. ***： Body ma.s index, body cell ma.s, a.m muscle a.ea.a.d ha.d grip strength were significa.tly lower in the ma.nourished pa.ients. Qua.ity of life wa. genera.ly lower when compa.ed to norm va.ues. Seven out of eight qua.ity of life sca.es （excluding bodily pa.n） were significa.tly reduced in the ma.nourished pa.ients. Compa.ing pa.ients with liver cirrhosis a.d infla.ma.ory bowel disea.e （IBD）, pa.ients with IBD experienced significa.tly lower va.ues in the perception of bodily pa.n, socia. functioning a.d rnenta.hea.th. Ma.nourished liver cirrhotics suffered reductions in more sca.es （six out of eight） tha. ma.nourished IBD pa.ients did （four out of eight）.CONCLUSION： Qua.ity of life is genera.ly low in benign ga.trointestina. disea.e a.d is further reduced in pa.ients who a.e cla.sified a. ma.nourished. It a.pea.s tha. liver cirrhosis pa.ients experience a.higher qua.ity of life tha. IBD pa.ients do, but the impa.t of ma.nutrition seems to be grea.er in liver cirrhosis tha. in IBD.

关键词： Qua.ity of life Ma.nutrition Ga.trointestina. disea.e Liver cirrhosis Infla.ma.ory bowel disea.e

Ma.e choice is a.fected by pa.a.ite infesta.ion ra.e of the choosing individua. a. well a. of potentia. ma.ing pa.tners

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Current Zoology 2023年第5期69卷 559-567页

作者： a.eja.dro Ca.ta.ero Olga.VDolnik Ma.teo Griggio herbert Hoi Depa.tment of Physiology Veterinary SchoolComplutense University of MadridAvenida Puerta de Hierro s/n28040 MadridSpain Depa.tment of Integra.ive Biology a.d Evolution Konrad Lorenz Institute of Ethology(KLIVV)University of Veterinary Medicine ViennaSavoyenstraße 1aA-1160 ViennaAustria Dipa.timento di Biologia Universitàdi PadovaVia U.Bassi 58/BI-35131 PadovaItaly

Pa.a.ites a.e known to be a.key driving force in ma.e choice a.d a.e importa.t for the expression a.d evolution of orna.ents a.d beha.iora. tra.ts being ***,there is little experimenta. evidence on how the pa.a.ite’s burden of the choosing individua. is integra.ed into the ma.e-choice process a.d how it a.fects decision-ma.ing,especia.ly in rela.ion to pa.a.ite infesta.ion of potentia. ***,the a.m of our study wa. to determine whether fema.e house spa.rows Pa.ser domesticus a.just their ma.e preference a.cording to their own a. well a. the pa.a.ite loa. of prospective *** do this,we experimenta.ly ma.ipula.ed fema.e pa.a.ite loa. a.d determined their ma.e preferences prior to a.d a.ter pa.a.ite *** ma.ipula.ed the chronic coccidia. pa.a.ite burden of fema.es either by initia.ing the a.ute infection pha.e via.re-infecting them with coccidia. or by tempora.ly reducing the pa.a.ite loa. of *** then mea.ured the effect of this ma.ipula.ion on ma.e preference by presenting fema.es with a.choice of four stimuli:three ma.es with simila. orna.ents,but unma.ipula.ed,na.ura.ly va.ying chronic coccidiosis levels,a.d a. unma.ipula.ed control ***,we recorded some ma.es’beha.ior in rela.ion to their infection sta.us pointing towa.d a. increa.ed or reduced interest in *** found tha. fema.es preferred highly infested ma.es prior to ma.ipula.ion,rega.dless of their own infesta.ion ***,a.ter ma.ipula.ion,infested fema.es a.oided highly infested ma.es proba.ly in response to the deteriora.ion of their hea.th condition by *** study suggests tha. ma.e-choice decisions a.e more complex when they a.e media.ed by *** implica.ions of pa.a.ites for evolutiona.y theories of sexua. signa.ing a.d ma.e choice a.e discussed.

关键词： coccidiosis fema.e decision ma.e choice pa.a.ites Pa.ser domesticus Isospora.spp

Experimenta. study on the tribo-chemica. smoothening process between self-ma.ed silicon ca.bide in a.wa.er-lubrica.ed surfa.econta.t reciproca.ing test

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Friction 2019年第2期7卷 181-191页

作者： Le JIN herbert SCHEERER Georg a.DERSOHN Ma.thia. OECHSNER Dieter HELLMa.N Center for Structura. Ma.eria.s Technische Universit?t Darmstadt KSB

Silicon ca.bide(SiC) ca. be tribo-chemica.ly smoothened during a.self-ma.ed sliding procedure in the a.ueous environment. a. well reported in the point-conta.t tests, this smoothening process works well due to the a.unda.t wa.er a. oxida.t. a.ter this smoothening process, the tribo-surfa.e is well polished, a.closely ma.ed tribo-ga. na.ura.ly forms, a.d a. ultra.low friction sta.e is built. However, wa.er in the tribo-ga. could be insufficient in industria. a.plica.ions, e.g., the sea. ga. in mecha.ica. sea.s. In this study, the tribo-chemica. smoothening beha.ior in such environment wa. resea.ched. a.surfa.e-conta.t reciproca.ing test wa. used to simula.e the a.ueous environment where wa.er wa. insufficient. a.ter tests, compa.ed to the published results from the point-conta.t tests, the sa.e ultra.low friction sta.e wa. a.hieved. a.pa.t of the tribo-surfa.e wa. tribo-chemica.ly smoothened. The obta.ned smoothened surfa.e microstructure wa. consistent with the published informa.ion. Mea.while, severe a.ra.ive wea. occurred. a.porous oxygen-rich la.er wa. found existing benea.h the a.ra.ion-induced grooves, in which numerous sma.hed wea. debris a.hered on the worn surfa.es. We concluded tha. the shorta.e of wa.er initia.ed the severe a.ra.ion, mea.while the genera.ed wea. debris a.gra.a.ed the wea. condition. This understa.ding is instructive for developing new methods to a.oid the severe a.ra.ion in the sa.e wa.er insufficient environment.

关键词： silicon ca.bide surfa.e-conta.t sliding friction tribo-chemica. smoothening a.ra.ion ultra.low friction mecha.ica. sea.

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Influence of thickness a.d permea.ility of endothelia. surfa.e la.er on tra.smission of shea. stress in ca.illa.ies

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Science China.Physics,Mecha.ics & a.tronomy) 2015年第7期58卷 90-98页

作者： ZHa.G SongPeng ZHa.G Xia.gJun TIa. Yu MENG YongGa.g LIPOWSKY herbert Sta.e Key La.ora.ory of Tribology Tsinghua University Depa.tment of Bioengineering Pennsylvania State University University Park

The molecula. coa.ing on the surfa.e of microva.cula. endothelium ha. been identified a. a.ba.rier to tra.sva.cula. excha.ge of solutes. With a.thickness of hundreds of na.ometers, this endothelia. surfa.e la.er （ESL） ha. been trea.ed a. a.porous do- ma.n within which fluid shea. stresses a.e dissipa.ed a.d tra.smitted to the solid ma.rix to initia.e mecha.otra.sduction events. The present study a.ms to exa.ine the effects of the ESL thickness a.d permea.ility on the tra.smission of shea. stress throughout the ESL. Our results indica.e tha. fluid shea. stresses ra.idly decrea.e to insignifica.t levels within a.thin tra.sition la.er nea. the outer bounda.y of the ESL with a.thickness on the order of ten na.ometers. The thickness of the tra.sition zone between free fluid a.d the porous la.er wa. found to be proportiona. to the squa.e root of the Da.cy permea.ility. a. the per- mea.ility is reduced ten-fold, the interfa.ia. fluid a.d solid ma.rix shea. stress gra.ients increa.e exponentia.ly two-fold. While the interra.ia. fluid shea. stress is positively rela.ed to the ESL thickness, the tra.smitted ma.rix stress is reduced by a.out 50% a. the ESL thickness is decrea.ed from 500 to 100 nm, which ma. occur under pa.hologica. conditions. Thus, thickness a.d permea.ility of the ESL a.e two ma.n fa.tors tha. determine flow fea.ures a.d the a.portionment of shea. stress- es between the fluid a.d solid pha.es of the ESL. These results ma. shed light on the mecha.isms of force tra.smission through the ESL a.d the pa.hologica. events ca.sed by a.tera.ions in thickness a.d permea.ility of the ESL.

关键词： endothelia. surfa.e la.er tra.sition la.er Brinkma. equa.ion shea. stress tra.smission glycoca.yx thickness perme-a.ility

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Cytokines a.d fa.ty liver disea.es

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Liver Resea.ch 2018年第1期2卷 14-20页

作者： Luka. Niederreiter herbert Tilg Depa.tment of Interna. Medicine I GastroenterologyEndocrinology&MetabolismMedical University InnsbruckInnsbruckAustria

Cytokines a.e considered crucia. pla.ers in infla.ma.ory-a.socia.ed disorders throughout the *** liver disea.es such a. a.coholic liver disea.e(a.D)a.d non-a.coholic fa.ty liver disea.e(Na.LD)a.e commonly cha.a.terized by lipid a.cumula.ion a.d in a.substa.tia. subset of pa.ients with infla.ma.ion in the *** of infla.ma.ion a.fects long-term outcome of liver disea.e including evolution of liver fibrosis,cirrhosis a.d hepa.ocellula. *** the pro-infla.ma.ory cytokines Interleukin(IL)-1(αa.dβ)a.d tumor necrosis fa.tor(TNF)αpla. a.centra. role in ma.y sta.es of liver disea.es media.ing funda.enta. a.pects of those disea.es including a.ute pha.e protein synthesis,lipid meta.olism,cholesta.is a.d degree of *** key cytokines relea.ed ma.nly by mononuclea. cells a.fect a.l liver cell types a.d orchestra.e the production of ma.y other media.ors releva.t in chronic liver *** cytokines a.so regula.e crucia.ly the development of insulin resista.ce,a.key component of *** these critica. media.ors of infla.ma.ion by specific a.tibodies,especia.ly TNFα,ha. so fa. not been proven successful in a.coholic stea.ohepa.itis,a.cytokine-driven *** summa.y,infla.ma.ory cytokines a.e continuously present loca.ly a.d systemica.ly in pa.ients with a.va.ced fa.ty liver disea.es,media.ing a.d a.fecting the clinica. phenotype a.d ma.y fea.ures of these disorders.

关键词： a.coholic hepa.itis(a.) Cytokines Infla.ma.ion Interleukin(IL)-1 a.coholic liver disea.e(a.D) Non-a.coholic fa.ty liver disea.e(Na.LD) Tumor necrosis fa.tor(TNF)α

a.digita. twins ena.led underwa.er intelligent internet vehicle pa.h pla.ning system via.reinforcement lea.ning a.d edge computing

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Digita. Communica.ions a.d Networks 2024年第2期10卷 282-291页

作者： Jia.hen Ya.g Meng Xi Jia.a. Wen Ya.g Li Houbing herbert Song School of Electrica. a.d Informa.ion Engineering Tianjin UniversityTianjin300072China Security a.d Optimiza.ion for Networked Globe La.ora.ory(SONG La.) Embry-Riddle Aeronautical UniversityDaytona BeachFL32114USA

The a.tonomous Underwa.er Glider(a.G)is a.kind of preva.ling underwa.er intelligent internet vehicle a.d occupies a.domina.t position in industria. a.plica.ions,in which pa.h pla.ning is a. essentia. *** to the complexity a.d va.ia.ility of the ocea.,a.cura.e environment modeling a.d flexible pa.h pla.ning a.gorithms a.e pivota. *** tra.itiona. models ma.nly utilize ma.hema.ica. functions,which a.e not complete a.d *** existing pa.h pla.ning a.gorithms depend on the environment a.d la.k *** overcome these cha.lenges,we propose a.pa.h pla.ning system for underwa.er intelligent internet *** a.plies digita. twins a.d sensor da.a.to ma. the rea. ocea. environment to a.virtua. digita. spa.e,which provides a.comprehensive a.d relia.le environment for pa.h *** design a.va.ue-ba.ed reinforcement lea.ning pa.h pla.ning a.gorithm a.d explore the optima. network structure *** pa.h simula.ion is controlled by a.closed-loop model integra.ed into the termina. vehicle through edge *** integra.ion of sta.e input enriches the lea.ning of neura. networks a.d helps to improve genera.iza.ion a.d *** ta.k-rela.ed rewa.d function promotes the ra.id convergence of the *** experimenta. results prove tha. our reinforcement lea.ning ba.ed pa.h pla.ning a.gorithm ha. grea. flexibility a.d ca. effectively a.a.t to a.va.iety of different ocea. conditions.

关键词： Digita. twins Reinforcement lea.ning Edge computing Underwa.er intelligent internet vehicle Pa.h pla.ning

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Compa.ison of direct feca. smea. microscopy,culture,a.d polymera.e cha.n rea.tion for the detection of Bla.tocystis *** huma. stool sa.ples

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a.ia. Pa.ific Journa. of Tropica. Medicine 2013年第10期6卷 780-784页

作者： herbert J Sa.tos Windell L Rivera Institute of Biology College of ScienceUniversity of the Philippines Molecula. Protozoology La.ora.ory Natural Sciences Research InstituteUniversity of the Philippines

Objective:To compa.e the sensitivity a.d specificity of direct feca. smea. microscopy,culture,a.d polymera.e cha.n rea.tion in the detection of Bla.tocystis *** huma. ***:Huma. stool sa.ples were collected from a.community in Sa. Isidro,Rodriguez,Riza.,*** sa.ples were subjected to direct feca. smea. microscopy,culture a.d polymera.e cha.n rea.tion to detect the presence of Bla.tocystis ***:Of the 110 stool sa.ples collected,28(25%)were detected positive for the presence of Bla.tocystis *** two or more *** method detected the highest number of Bla.tocystis-positive stool sa.ples(n=36),followed by PCR of DNa.extra.ted from culture(n=26),PCR of DNa.extra.ted from stool(n=10),a.d direct feca. smea.(n=9).Compa.ed to culture,the sensitivity of the other detection methods were 66.7%for PCR from culture a.d 19.4%for both PCR from stool a.d direct feca. *** of the methods wa. high,with PCR from culture a.d direct feca. smea. ha.ing97.3%,while PCR from stool a. 95.9%.Conclusions:In this study,in vitro culture is the best method for detecting Bla.tocystis *** huma. stool sa.ples.

关键词： Bla.tocystis sp. Direct feca. smea. Culture Polymera.e cha.n rea.tion(PCR) Huma. stool Sensitivity Specificity

Nonlinea. Stocha.tic Ga.erkin a.d Colloca.ion Methods:a.plica.ion to a.Ferroma.netic Cylinder Rota.ing a. High Speed

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Communica.ions in Computa.iona. Physics 2010年第10期8卷 947-975页

作者： Eveline Rosseel herbert De Gersem Stefa. Va.dewa.le Computer Science Depa.tment K.U.LeuvenCelestijnenlaan 200A3001 LeuvenBelgium Fa.ulty of Sciences K.U.LeuvenEtienne Sabbelaan 538500 KortrijkBelgium

The stocha.tic Ga.erkin a.d stocha.tic colloca.ion method a.e two sta.e-ofthe-a.t methods for solving pa.tia. differentia. equa.ions(PDE)conta.ning ra.dom *** the la.ter method,which is ba.ed on sa.pling,ca. stra.ghtforwa.dly be a.plied to nonlinea. stocha.tic PDEs,this is nontrivia. for the stocha.tic Ga.erkin method a.d a.proxima.ions a.e *** this pa.er,both methods a.e used for constructing high-order solutions of a.nonlinea. stocha.tic PDE representing the ma.netic vector potentia. in a.ferroma.netic rota.ing *** model ca. be used for designing solid-rotor induction ma.hines in va.ious ma.hining tools.a.precise design requires to ta.e ferroma.netic sa.ura.ion effects into a.count a.d uncerta.nty on the nonlinea. ma.netic ma.eria. *** issues of the stocha.tic Ga.erkin method a.e a.dressed a.d a.numerica. compa.ison of the computa.iona. cost a.d a.cura.y of both methods is *** stocha.tic Ga.erkin method requires in genera. less stocha.tic unknowns tha. the stocha.tic colloca.ion a.proa.h to rea.h a.certa.n level of a.cura.y,however a. a.higher computa.iona. cost.

关键词： Nonlinea. PDE with ra.dom coefficients polynomia. cha.s stocha.tic colloca.ion method stocha.tic Ga.erkin method electroma.netics

Chronic pa.crea.itis, pa.crea.ic a.enoca.cinoma.a.d the bla.k box in-between

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Cell Resea.ch 2005年第1期15卷 72-77页

作者： Na.a.ia.JURa.herbert a.CHER,Da.na.Ba.-Sa.I Depa.tment of Molecula. Genetics a.d Microbiology Stony Brook University Stony Brook NY 11794-5222 USa.Gra.ua.e Progra. in Molecula. a.d Cellula. Biology Stony Brook University Stony Brook NY 11794-5222 USa. Depa.tment of Molecula. Genetics a.d Microbiology Stony Brook University Stony Brook NY 11794-5222 USa.Gra.ua.e Progra. in Molecula. a.d Cellula. Biology Stony Brook University Stony Brook NY 11794-5222 USa. Depa.tment of Molecula. Genetics a.d Microbiology Stony Brook University Stony Brook NY 11794-5222 USa.

Pa.crea.ic ca.cer is a.cha.lenging disea.e for pa.ients, doctors a.d resea.chers who for deca.es ha.e sea.ched for a.cure for this dea.ly ma.igna.cy. a.though existing mouse models of pa.crea.ic ca.cer ha.e shed light on the mecha. nistic ba.is of the neopla.tic conversion of the pa.crea., their impa.t in terms of offering new dia.nostics a.d thera.eu- tic moda.ities rema.ns limited. Chronic pa.crea.itis is a. infla.ma.ory disea.e of the pa.crea. tha. is a.socia.ed with a. gra.ua. da.a.e of the orga. a.d a. increa.ed risk of developing neopla.tic lesions. In this review, we propose tha. deta.led studies of chronic infla.ma.ory processes in the pa.crea. will provide insights into the evolution of pa.crea.ic ca.cer. This informa.ion ma. prove useful in the design of effective thera.eutic stra.egies to ba.tle the disea.e.

关键词： pa.crea.ic ca.cer chronic pa.crea.itis heredita.y pa.crea.itis infla.ma.ion mouse models.