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Co-delivery of PArP and PI3K inhibitors by nanoscale metal-organic frameworks for enhanced tumor chemoradiation

Nano research 2019年第12期12卷 3003-3017页

作者： Megan J.Neufeld Allison N.Duross madeleine r.landry Hayden Winter Andrea M.Goforth Conroy Sun Department of Pharmaceutical Sciences College of PharmacyOregon State UniversityPortlandOregon 97201USA Department of Chemistry Portland State University1719 SW 10th AvePortlandOregon 97201USA Department of radiation Medicine Oregon Health&Science University3181 S.W.Sam Jackson Park RdPortlandOregon 97239USA

Due to their complementary activity,the use of DNA damage repair(DDr)inhibitors during radiotherapy(rT)has yielded promising ***,this approach is often hindered by toxicity and poor in vivo stability of the DDr in *** scale metal-organic frameworks(nMOFs)represent an emerging class of crystalline materials which exhibit advantageous properties over traditional nanomaterials and demonstrate great potential in ***,a unique,synergistic treatment strategy for enhancing the therapeutic efficacy of rT vianMOF-mediated drug delivery and rT enhancement was evaluated.A nMOF containing the high-Zelement Hf and the ligand 1,4-dicarboxybenzene(Hf-BDC)was synthesized and loaded with the two DDr inhibitor drugs,talazoparib and buparlisib(TB@Hf-BDC-PEG).TB@Hf-BDC-PEGaugmented rT by increasing reactive oxygen species generation and thus DNA damage of which repair was inhibited *** enhancement was demonstrated in vivo where the combination of concurrent radiation with in travenous TB@Hf-BDC-PEG administration resulted in improved tumor control and increased ***,no apparent toxicity was observed with nMOF treatment,supporting its potential as an attractive candidate over traditional nano *** work provides the first report of nMOFs employed to enhance thetherapeutic response to rT through DDr inhibitor delivery and physical radiation dose enhancement.

关键词： nano scale metal-organic frameworks chemoradiotherapy DNA damage repair inhibitors drug delivery radiation dose enhancement

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Ubiquitination-mediated regulation of receptorlike kinases in symbiosis and immunity

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Molecular Plant 2024年第9期17卷 1335-1337页

作者： David landry and Benoit Lefebvre Laboratory of Plant-Microbe-Environment Interactions(LIPME) Universite de ToulouseINRAECNRS31326Castanet-TolosanFrance

receptor-like kinases(rLKs)are plasma membrane(PM)proteins that monitor the extracellular environment and regulate various processes such as biotic *** motif(LysM)rLKs are a specific class of rLKs involved in the recognition of chitin-derived molecules produced by microorganisms(Buendia et al.,2018).Notably,the LysM-rLK heterocomplex LjNFr1/LjNFr5 recognizes lipochitooligosaccharides(LCOs,also called Nod factors)leading to root nodule symbiosis(rNS)in Lotus japonicus,whereas the heterocomplexes AtLYK5/AtCErK1 and OsCEBIP/OsCErK1 recognize chitooligosaccharides(COs)leading to defense responses in Arabidopsis thaliana and rice,respectively(Buendia et al.,2018).These receptors function as *** ligand binding activates the intracellular kinase activity of LjNFr1,AtCErK1,and OsCErK1,which mediate phosphorylation-dependent signaling cascades.

关键词： extracellular immunity kinases

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Insight into the Origin of Iron Ore Based on Elemental Contents of Magnetite and Whole-rock Geochemistry:A Case of the Bipindi Banded Iron Formations,Nyong Complex,SW Cameroon

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Journal of Earth Science 2024年第1期35卷 16-28页

作者： landry Soh Tamehe Huan Li Sylvestre Ganno Zuxing Chen Yanick Brice Lemdjou Safiyanu Muhammad Elatikpo School of Geosciences and Info-Physics Central South UniversityChangsha 410083China Department of Earth Sciences University of Yaounde IYaounde 3412Cameroon Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Department of Geology Ahmadu Bello University ZariaZaria 810107Nigeria

The Bipindi iron ore district is located in the central section of the Nyong Complex at the northwestern margin of the Congo Craton in Southwest *** iron district contains numerous iron mineralization hosted by the Mewongo,Bibole,Kouambo,and Zambi banded iron formations(BIFs).These BIFs contain magnetite as the main iron ore mineral associated with pyrite,and gangue minerals are quartz with minor chlorite and *** origin of iron ore from these BIFs was investigated using a combination of in-situ magnetite and whole-rock *** studied BIF ore samples have a narrow range of TFe between 30.90 wt.%and 43.20 wt.%,indicating a low-grade *** geochemical signatures of magnetite such as low contents of base metals(e.g.,Cu,Co,V,and Zn)and low Co/Zn ratiosrothermal *** with the geochemical features of these BIFs,e.g.,high Fe/Ti and Fe/Al ratios(mean>600 and>75,respectively),we suggest that magnetite was derived from a mixture of seawater and~0.1%low-temperature hydrothermal fluids in an oxidizing ***,low-temperature hydrothermal and later metamorphic fluids were necessary for the transformation of the protolith Nyong Complex BIFs to iron ore.

关键词： banded iron formations iron ore geochemistry Congo Craton trace element composition LA-ICP-MS

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法国传教士文献所见康熙年间带往中国的器具

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故宫博物院院刊 2024年第4期 18-26,142页

作者： [法]蓝莉法国社会科学高等研究学院近现代中国研究中心

法国传教士档案中,有清康熙时期(1662-1722)关于安菲特里特号(Amphitrite)航行之前被带到或发送到中国物品的数据。安菲特利特号是第一艘到达中国的法国船,分别于1698年和1701年停靠在广州。为了尽可能准确地识别所提供的物品,本文研究... 详细信息

法国传教士档案中,有清康熙时期(1662-1722)关于安菲特里特号(Amphitrite)航行之前被带到或发送到中国物品的数据。安菲特利特号是第一艘到达中国的法国船,分别于1698年和1701年停靠在广州。为了尽可能准确地识别所提供的物品,本文研究了耶稣会神父洪若(1643-1710)从中国寄给法国的一系列信件,信件列出了可能有利于建立传教士的艺术和科学物品的清单,并注意到发明者、供货商和制造者的签名,说明中法间这种科学和艺术创新的氛围是互动的。

关键词：传教士康熙时代礼品巴黎皇家科学院

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喀麦隆西南部Mamelles条带状铁建造元素地球化学特征

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海洋科学 2024年第7期48卷 47-56页

作者： SOH TAMEHE landry GANNO Sylvestre 陈祖兴 rOSIÈrE Carlos Alberto 中国有色桂林矿产地质研究院有限公司广西桂林541004 Department of Earth Sciences University of Yaounde I812 YaoundeCameroon 中国科学院海洋研究所山东青岛266071 Department of Geology Universidade Federal de Minas Gerais31270-901 Belo HorizonteMinas GeraisBrazil

Mamelles铁矿床位于喀麦隆南部刚果克拉通西北缘,距离克里比地区东南方向约20km。该矿床由大规模、高品位磁铁矿矿体组成,赋存于Nyong杂岩体的条带状铁建造(BIF)中。该矿床中的BIF与角闪岩和片麻岩相伴生。在详细的野外调查基础上,我们... 详细信息

Mamelles铁矿床位于喀麦隆南部刚果克拉通西北缘,距离克里比地区东南方向约20km。该矿床由大规模、高品位磁铁矿矿体组成,赋存于Nyong杂岩体的条带状铁建造(BIF)中。该矿床中的BIF与角闪岩和片麻岩相伴生。在详细的野外调查基础上,我们获取了BIF的全岩地球化学数据,并用以约束它们的物质来源和沉积环境。弱正铕(Eu)异常(δEu=2.14~3.55)表明高温热液流体对MamellesBIF的贡献是通过海底火山岩蚀变作用的方式,并有少量碎屑物质输入。正铈(Ce)异常的缺失表明,这些BIF可能沉积在缺氧的深海环境中,如火山弧或弧后盆地深水区。

关键词：刚果克拉通喀麦隆 Mamelles铁矿条带状铁建造地球化学

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“不同人工耳蜗电极电学特性研究”摘译

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听力学及言语疾病杂志 2024年

作者：陈慧琴周道民 Swaddiwudhipong N Jiang C landry TG 全省智能康复与神经电子转化重点实验室

跨阻抗矩阵(trans-impedance matrix,TIM)是指刺激电流在人工耳蜗(CI)电极上所产生的电压场强比率。该电压场强作用于螺旋神经节细胞激发神经冲动而产生听力。在耳蜗模型中对所有CI电极重复构建TIM曲线,所有电路都是公共接地的,即除了...

跨阻抗矩阵(trans-impedance matrix,TIM)是指刺激电流在人工耳蜗(CI)电极上所产生的电压场强比率。该电压场强作用于螺旋神经节细胞激发神经冲动而产生听力。在耳蜗模型中对所有CI电极重复构建TIM曲线,所有电路都是公共接地的,即除了被刺激的电极外,所有CI电极都用作公共回路电极。本实验在相对恒定的体外测试条件下,在耳蜗模型中测量了四种不同设计的CI电极刺激产生的TIM,并研究了CI电极在耳蜗模型中取向对TIM的影响。

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results of an Eight Year Long Practice of Saline Bipolar Transurethral resection of Prostate

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Open Journal of Urology 2024年第4期14卷 189-196页

作者： Sossa Jean Mangoue Moube Ariane landry Yevi Dodji Inès Magloire Hodonou Fred Avakoudjo Déjinnin Josué Georges Centre National Hospitalier Universitaire Hubert Koutoucou Maga Cotonou Benin

Background: Open prostatectomy has long been the only prostatic bladder outlet obstruction’s surgery available in Benin. It is prone to postoperative bleeding and infections and is not suitable for prostate cancer-induced bladder outlet obstruction. Objective: To evaluate the first results of endoscopic surgery of prostatic bladder outlet obstruction in our environment. Patients and Method: We conducted an observational study of saline bipolar transurethral resection of prostate (B-TUrP) at the former Military Teaching Hospital of Cotonou. We retrospectively collected the data from patients’ medical records from November 17, 2014, to September 7, 2022. We used Excel 2019 to make a descriptive analysis of the data. results: Saline B-TUrP was performed in 60 consecutive patients. Their mean age was 69.1 years (range: 48-85). The procedure was indicated in 22 (36.7%), 32 (53.3%), 3 (5%), and 3 (5%) patients, respectively for acute urinary retention, chronic urinary retention, obstructive renal failure, and unresponsiveness to alpha-blockers. 35 patients (58.3%) had prostate cancer (PCa). 25 patients (41.7) had benign prostate hyperplasia (BPH). No patient got a blood transfusion. The duration of postoperative hospitalization was 3 days (88.3%) to 5 days (11.7%). 5 patients (8.3%), i.e., 3 BPH and 2 prostate cancer patients got preoperative urinary tract infection. The causative bacteria were Escherichia coli in 3 patients (60%), Klebsiella pneumoniae in 2 patients (40%), and multi-resistant Acinetobacter as a metachronous infection to Escherichia coli in 1 patient (20%). All the infections were associated with indwelling Foley catheter. 7 patients (11.7%), i.e., 3 BPH and 4 prostate cancer patients, got a second resection to recover full spontaneous micturition. Prostate size was available in the medical record of 21 BPH patients and 15 prostate cancer patients. Prostate size ranged from 22 to 123 g with a mean value of 61.1 g in BPH patients, and from 34 to 180 g with

关键词： Saline B-TUrP BPH Prostate Cancer

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Phytochemical Characterization and Evaluation of the Antibacterial Activity of Leaf Extracts of Mitragyna inermis (Willd.) O. Ktze on the in Vitro Growth of Clinical Strains Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa Involved in Gastro Enteritis

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Journal of Biosciences and Medicines 2024年第6期12卷 101-113页

作者： Monon Kone Youssouf Zanga Traore Tidiane Kamagate Ahmont landry Claude Kablan Abdoulaye Toure Karamoko Ouattara Adama Coulibaly Department of Biochemistry-Genetics Training and Research Unit Biological Sciences Peleforo Gon Coulibaly University Korhogo Cte dIvoire Department of Mathematics-Physics-Chemistry Training and Research Unit Biological Sciences Peleforo Gon Coulibaly University Korhogo Cte dIvoire Department of Biology and Health Training and Research Unit of Bioscience University of Flix Houphout-Boigny Abidjan Ivory Coast Department of Microbiology and Molecular Biology Training and Research Unit of Agriculture Fisheries Resources and Agro-Industry University of San Pedro San Pedro Cte dIvoire

Gastroenteritis constitutes a group of diarrheal diseases of infectious origin, responsible for absenteeism from work, morbidity and mortality, especially among aged people. This study aimed to evaluate the antibacterial activity of Mitragyna inermis extracts on the in vitro growth of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa involved in gastroenteritis. Phytochemical screening was carried out using two distinct methods. The detection of phytochemical compounds by tube coloring and chromatography on a thin layer of silica gel. The sensitivity of organisms was evaluated by the agar well method. The dilution method in liquid medium coupled with spreading on Mueller Hinton agar helped determine the CMB/MIC activity ratios. The investigations show that the extract has the best extraction yield (75.86% ± 0.20%) compared to the aqueous macerated (61.8% ± 0.08%) and decocted (66.6% ± 0.12%). These extracts contain several phytochemical compounds such as flavonoids, polyphenols, tannins, alkaloids, saponosides, coumarins and sterols and terpenes. These substances are endowed with biological activities and could be at the origin of antibacterial activity observed with M. inermis extracts. The analysis of antibacterial activity showed that the germs are sensitive to the extracts with inhibition diameters ranging from 8.30 ± 0.53 to 17.87 ± 0.58 mm. The ethanolic extract was the most active with diameters varying from 15.07 ± 0.62 to 17.87 ± 0.58 mm on all the germs tested. E. coli and S. aureus were the most sensitive germs to the extracts. P. aeruginosa was the least sensitive germ. Activity reports indicate that the extracts exert bactericidal activity on E. coli and S. aureus but bacteriostatic activity on P. aeruginosa. These results justify the use of M. inermis leaves in a traditional environment to treat gastroenteritis.

关键词： Phytochemical Characterization Antibacterial Activity Mitragyna inermis Gastro Enteritis

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Influence of Continental Atmospheric Forcing on the Decadal Variability of the West African Monsoon

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Atmospheric and Climate Sciences 2024年第1期14卷 1-28页

作者： Adjoua Moïse landry Famien Sandrine Djakouré Bi Tra Jean Claude Youan Serge Janicot Abé Delfin Ochou Arona Diedhiou Département des Sciences et Techniques Université Alassane Ouattara de Bouaké Bouaké C&#244te d’Ivoire LASMES-UFr SSMT Université Félix Houphou&#235t Boigny d’Abidjan Abidjan C&#244te d’Ivoire LSS-UFr SSMT Université Félix Houphou&#235t Boigny d’Abidjan Abidjan C&#244te d’Ivoire Laboratoire d’Océanographie et du Climat: Expérimentations et Approches Numériques Sorbonne Université IRD CNRS MNHN Paris France Université Grenoble Alpes IRD CNRS Grenoble INP IGE Grenoble France UFHB-IrD Joint International Laboratory of research on NEXUS Climate Water Energy and Agriculture and Development of Cli-mate Services African Centre of Excellence CCBAD (Climate Change Biodiversity and Sustainable Agriculture) Université Félix Houphou&#235t-Boigny Abidjan C&#244te D’Ivoire

The West African Monsoon (WAM) is characterized by strong decadal and multi-decadal variability and the impacts can be catastrophic for the local populations. One of the factors put forward to explain this variability involves the role of atmospheric dynamics, linked in particular to the Saharan Heat Low (SHL). This article addresses this question by comparing the sets of preindustrial control and historical simulation data from climate models carried out in the framework of the CMIP5 project and observations data over the 20th century. Through multivariate statistical analyses, it was established that decadal modes of ocean variability and decadal variability of Saharan atmospheric dynamics significantly influence decadal variability of monsoon precipitation. These results also suggest the existence of external anthropogenic forcing, which is superimposed on the decadal natural variability inducing an intensification of the signal in the historical simulations compared to preindustrial control simulations. We have also shown that decadal rainfall variability in the Sahel, once the influence of oceanic modes has been eliminated, appears to be driven mainly by the activity of the Arabian Heat Low (AHL) in the central Sahel, and by the structure of the meridional temperature gradient over the inter-tropical Atlantic in the western Sahel.

关键词： Influence of Continental Atmospheric Forcing on the Decadal Variability of the West African Monsoon

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Assessment of the Drafting Quality of request Forms Submitted to the Malaria and Parasitology Units at the Institut Pasteur de Cote d’Ivoire

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Journal of Biosciences and Medicines 2024年第5期12卷 330-339页

作者： Yao Serge-Stéphane Ako Ako Bérenger Aristide Sylvain Beourou Ouattara Yacouba N’Guessan Tiacoh landry N’Dri Kouadio Thierry-Borel Toure André Offianan Malaria Unit Institut Pasteur de Cote d&#8217Ivoire Abidjan Cote d&#8217Ivoire Parasitology Unit Institut Pasteur de Cote d&#8217Ivoire Abidjan Cote d&#8217Ivoire

Biological tests provide information on the medical analysis requested by both the patient and the prescriber. It is a communication link between the prescriber and the laboratory staff. The lack of some information on request forms not only affects the drafting quality of the test and patient care, but could also make thousands of data produced by healthcare centers unusable. The aim of this study was to assess the drafting quality of request forms submitted to the Malaria and Parasitology Units at the Institut Pasteur de Côte d’Ivoire. Methods: It was a descriptive cross-sectional study to assess the drafting quality of request forms of various prescribers received at the Institut Pasteur de Côte d’Ivoire. This study was conducted at the Malaria and Parasitology Units, department of Parasitology and Mycology (Institut Pasteur de Côte d’Ivoire), from 6th December 2020 to 6th December 2021. The information on each request forms was recorded on a data collection form designed for this purpose. Each data collection form corresponds to a request forms and each test to a patient. results: Out of a total of 1990 request forms received, the patient’s age and sex were missing on 18% and 26.8% of the tests respectively. More than half (51.80%) of request forms did not indicate the patient’s place of residence. Clinical information was not provided on 45.90% of the tests. Prescribers omitting their signatures were 51%, stamps were 50.3% and contacts were 71.2%. Only 5.4% of request forms were of good drafting quality. Providing all the required information on the forms could facilitate the use and analysis of data and samples.

关键词： Laboratory Quality request Forms Information

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