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Allergic and nonallergic rhinitis in children: The role of nasal cytology

Open Journal of Pediatrics 2013年第2期3卷 133-138页

作者： Maria Cristina Provero Alberto Macchi Sara Antognazza maddalena marinoni Luigi Nespoli Department of Clinical and Experimental Medicine University of Insubria c/o Ospedale Filippo del Ponte Varese Italy Otorhinolaringology Clinic University of Insubria Varese AICNA c/o Ospedale di Circolo Varese Italy

Nasal cytology is a diagnostic tool currently used in rhinology to study either allergic and vasomotor rhinological disorders or infectious and inflammatory rhinitis. Over the past few years nasal cytology has been rarely used in pediatrics, nevertheless its clinical and scientific applications seem to be very promising. The advantages of this technique are different: the ease of performance, the noninvasiveness allowing repetition and the low cost. We evaluated 100 children, from 2 to 15 years old, referred to our outpatient service for allergic children for suspected allergic rhinitis (AR). After skin prick test (SPT) or Radio Allergo Sorbent Test (RAST), 59/100 subjects were classified as affected by AR, while 8 children refused to be tested. According to ARIA guidelines, the 59 children with AR (4 - 15 years old) were divided in 56 with persistent AR and 3 with an intermittent form. Nine out of 59 children with AR had a significant number of neutrophils and eosinophils at the nasal cytology, documenting the presence of “minimal persistent inflammation”. Eleven out of 59 AR patients showed a positive swab for bacteria. Children with nonallergic rhinitis (NAR) were 33/100 (2 - 15 years old). After nasal cytology, 17/33 children were classified as NARES (nonallergic rhinitis with eosinophils), including one X-linked agammaglobulinemia (XLA) child, 1/33 as NARESMA (nonallergic rhinitis with eosinophils and mast cell) and another 1/33 as NARMA (nonallergic rhinitis with mast cell). In conclusion, nasal cytology allowed us to correctly classify children with NAR and to better assess the condition of children with AR.

关键词： Allergic Rhinitis Children Nasal Cytology Nonallergic Rhinitis X-Linked Agammaglobulinemia

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Galvanic Skin Response—Extinction Biofeedback Training for Psychogenic Abdominal Pain: A Validation Protocol

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Journal of Biosciences and Medicines 2024年第5期12卷 190-201页

作者： maddalena Castelletti Enrico Berné Erasmo Dionigio Carlo Castagnoli Alberto Montagna Giorgio Tonon Magenta Medical Center Milan Italy Castagnoli Medical Center Garlasco Italy GEA Soluzioni Turin Italy

Abdominal and pelvic pain of psychogenic origin is a widespread, disabling, difficult to identify, and often inadequately treated medical condition. This condition is often associated with poor quality of life due to high pain interference with daily activities. Cognitive behavioral psychological therapy and neuromodulation with biofeedback are validated therapies for the treatment of this condition. Aim of the present research work is the validation of a therapeutic protocol that involves the use of both techniques in combination. 20 patients diagnosed with psychogenic abdominal pain, of both sexes, aged between 18 and 60 years who had not benefited from pharmacological therapies were enrolled. 10 patients were randomly assigned to the control group (psychological treatment only), another 10 patients were assigned to the study group (neuromodulation with biofeedback-Galvanic skin response-extinction in combination with psychological therapy). For both groups, the pain score, interference of pain with daily living activities, pain relief, and the share of anxiety associated with the pain condition were evaluated (pre- and post-treatment). The patients who underwent the combined treatment achieved statistically significant better scores than patients in the control group, respectively −4.9 ± 0.9 vs −1.0 ± 0.4 for Pain;−5.1 ± 1.1 vs −0.9 ± 0.3 for Interference with life;−7.2 ± 3.7 vs −2.2 ± 2.1 for HAMA;4.6 ± 1.2 vs 1.1 ± 0.6 for Relief.

关键词： Chronic Abdominal and Pelvic Psychogenic Pain (PAP) Biofeedback Training Pain Management Galvanic Skin Response (GSR)

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Literature review on earthen vernacular heritage: contributions to a referential framework

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Built Heritage 2022年第2期6卷 43-54页

作者： Gilberto Carlos Telma Ribeiro maddalena Achenza Cristina Cruz Ferreira de Oliveira Humberto Varum Gallaecia Architecture and Multimedia Department UPT-Portucalense UniversityR.Dr.António Bernardino de Almeida 5414200-072 PortoPortugal Department of Civil Engineering Environment and ArchitecureCagliari University09123 CagliariItaly CONSTRUCT-LESE Polytechnic Institute of SetúbalBarreiro School of TechnologyRua Américo da Silva Marinho2839-001 LavradioPortugal Faculty of Engineering Civil Engineering DepartmentCONSTRUCT-LESEUniversity of PortoRua Dr.Roberto Frias4200-465 PortoPortugal

The state of the art of earthen architecture and vernacular built heritage comprises a complex set of issues that range from fundamental problematic recognition to anthropological and cultural studies and,more recently,to technological and experimental *** paper addresses the development of the feld,following the milestones of the international literature and pursuing a refective-theory approach within a historical *** aims to explore the main contributions that have enhanced vernacular heritage and earthen architecture as specifc domains,from pioneering public awareness essays to institutional expertise ***,in addition to the literature review process,this paper considers the recent corpus of recommendations from conservation management reference institutions,the updating of the operative problematic of earthen vernacular built heritage,and the relevance of local community involvement in facing increasing challenges.

关键词： Vernacular heritage Earthen architecture Conservation

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Productive and physiological implications of top-dress addition of branched-chain amino acids and arginine on lactating sows and offspring

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1080-1101页

作者： Diana Luise Federico Correa Claudio Stefanelli Aude Simongiovanni Tristan Chalvon-Demersay maddalena Zini Luciano Fusco Paolo Bosi Paolo Trevisi Department of Agricultural and Food Sciences University of Bologna40127 BolognaItaly Department for Life Quality Studies Alma Mater StudiorumUniversity of Bologna47921 RiminiItaly Metex Noovistago 32 Rue Guersant75017 ParisFrance Department of Biomedical and Neuromotor Sciences Alma Mater StudiorumUniversity of Bologna40126 BolognaItaly Freelancer Reggio nell’EmiliaItaly.

Background Branched-chain amino acids(BCAAs),including L-leucine(L-Leu),L-isoleucine(L-Ile),L-valine(L-Val),and L-arginine(L-Arg),play a crucial role in mammary gland development,secretion of milk and regulation of the catabolic state and immune response of lactating ***,it has recently been suggested that free amino acids(AAs)can also act as microbial *** study aimed at evaluating whether the supplementation of lactating sows with BCAAs(9,4.5 and 9 g/d/sow of L-Val,L-Ile and L-Leu,respectively)and/or L-Arg(22.5 g/d/sow),above the estimated nutritional requirement,could influence the physiological and immunological parameters,microbial profile,colostrum and milk composition and performance of sows and their *** At d 41,piglets born from the sows supplemented with the AAs were heavier(P=0.03).The BCAAs increased glucose and prolactin(P<0.05)in the sows’serum at d 27,tended to increase immunoglobulin A(IgA)and IgM in the colostrum(P=0.06),increased the IgA(P=0.004)in the milk at d 20 and tended to increase lymphocyte%in the sows’blood at d 27(P=0.07).Furthermore,the BCAAs tended to reduce the Chao1 and Shannon microbial indices(P<0.10)in the sows’*** BCAA group was discriminated by Prevotellaceae_UCG-004,Erysipelatoclostridiaceae UCG-004,the Rikenellaceae_RC9_gut_group and *** reduced piglet mortality pre-(d 7,d 14)and post-weaning(d 41)(P<0.05).Furthermore,Arg increased the IgM in the sow serum at d 10(P=0.05),glucose and prolactin(P<0.05)in the sow serum at d 27 and the monocyte percentage in the piglet blood at d 27(P=0.025)and their jejunal expression of NFKB2(P=0.035)while it reduced the expression of GPX-2(P=0.024).The faecal microbiota of the sows in Arg group was discriminated by *** combination of BCAAs and Arg tended to increase spermine at d 27(P=0.099),tended to increase the Igs(IgA and IgG,P<0.10)at d 20 in the milk,favoured the faecal colonisation of Oscillospiraceae UCG

关键词： Microbiota Post-weaning mortality Prolactin Sows diet

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Validation of LPD Scale for the Assessment of Pressure Ulcer at Home

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Open Journal of Nursing 2023年第5期13卷 267-282页

作者： Renzo Zanotti maddalena Segala Anna Bovo Dpartment of Medicine-DIMED University of Padova Padova Italy Az ULSS 5 Polesana Rovigo Italy

Objectives: This study was designed to test and validate the new LPD scale in a home care setting. The specific objectives are to validate the LPD scale for subjects cared for at home;and to compare LPD to the Braden scale for internal validity. Method: This multicenter, cross-sectional study was conducted in the domestic environment of subjects cared for Home Care services from North to South of Italy. Data collection lasted 8 months, between June 2018 and September 2020, and consisted of the simultaneous compilation of the new LPD, and the Braden scale. Home Care Expert nurses could interface with the recruited subjects and/or caregivers. The parameters considered to validate the new scale were sensitivity (Se), specificity (Sp), positive predictive values (PPV), odds ratio (OR), and the area under the receiver operating characteristic (ROC) curve. Results: Of the 679 recruited subjects, 63.2% were women, and more than 50% did not have a pressure ulcer. 48.2% of the sample aged over 85 years old;69% was affected by multiple disease, and 76.6% took a lot of drugs. 91.6% of the subjects were affected by a partial or total functional dependency. Around 50% of subjects presented double incontinence, and 43% were conscious and collaborated. 85.4% of subjects lived in a healthy environment. The predictive validity parameters showed: Se 77.25%, Sp 84.04%, PPV 91.37%, and the area under the curve (AUC) 0.88% with a confidence interval (CI) 95%. These values mean a moderately accuracy of the test. Conclusions: The new LPD scale has demonstrated a good capacity for identifying the subjects at risk of pressure ulcer and had a better discriminatory power rather than Braden scale.

关键词： Pressure Ulcers Sores Home Care Validation Measurement Scale

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COVID-19 Vaccine Allocation: Modeling Health Outcomes and Equity Implications of Alternative Strategies

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Engineering 2021年第7期7卷 924-935页

作者： maddalena Ferranna Daniel Cadarette David E.Bloom Harvard T.H.Chan School of Public Health BostonMA 02115USA

Given the scarcity of safe and effective COVID-19 vaccines,a chief policy question is how to allocate them among different sociodemographic *** paper evaluates COVID-19 vaccine prioritization strategies proposed to date,focusing on their stated goals;the mechanisms through which the selected allocations affect the course and burden of the pandemic;and the main epidemiological,economic,logistical,and political issues that arise when setting the prioritization *** paper uses a simple,agestratified susceptible–exposed–infectious–recovered model applied to the United States to quantitatively assess the performance of alternative prioritization strategies with respect to avoided deaths,avoided infections,and life-years *** demonstrate that prioritizing essential workers is a viable strategy for reducing the number of cases and years of life lost,while the largest reduction in deaths is achieved by prioritizing older adults in most scenarios,even if the vaccine is effective at blocking viral *** regarding this property and potential delays in dose delivery reinforce the call for prioritizing older ***,we investigate the strength of the equity motive that would support an allocation strategy attaching absolute priority to essential workers for a vaccine that reduces infectionfatality risk.

关键词： Vaccine allocation COVID-19 Equity SEIR model

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Evaluation of the risk factors for severe complications and surgery of intestinal foreign bodies in adults:a single-center experience with 180 cases

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Gastroenterology Report 2022年第1期10卷 420-429页

作者： Tingting Hu Jie Zhang Yang Liu Lifang Chen Wei Cen Wenzhi Wu Qingke Huang Xuecheng Sun Simon Stock maddalena Zippi Vincent Zimmer Zarrin Basharat Wandong Hong Department of Gastroenterology and Hepatology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangP.R.China Department of Otolaryngology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangP.R.China Department of Radiology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangP.R.China The First Clinical College Wenzhou Medical UniversityWenzhouZhejiangP.R.China Department of Surgery World Mate Emergency HospitalBattambangCambodia Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini HospitalRomeItaly Department of Medicine II Saarland University Medical CenterSaarland UniversityHomburgGermany Jamil-ur-Rahman Center for Genome Research Dr.Panjwani Center for Molecular Medicine and Drug ResearchInternational Center for Chemical and Biological SciencesUniversity of KarachiKarachiPakistan

Background Foreign bodies(FBs)lodged in the intestine or causing intestinal complications are uncommon in clinical practice but may pose diagnostic difficulties and prove *** study aimed to evaluate the risk factors for severe complications and surgery to aid clinicians in the diagnosis and management of intestinal *** We performed a retrospective analysis of patients in whom FBs were lodged in the intestine or caused complications from 2010 to 2020 in the First Affiliated Hospital of Wenzhou Medical University(Zhejiang,China).The characteristics of the patients and FBs,symptoms,imaging findings,diagnostics,treatment strategies,and clinical outcomes were ***,the risk factors for complications and surgery were *** In total,180 patients were included in our *** patients(76.1%)were unable to provide a history of *** were the most common FBs(35.6%).The FBs were mainly located in the duodenum(32.8%)and the ileum(27.8%).Surgical removal of FBs was successful in 89(49.4%)patients and endoscopic removal in 54(30.0%)*** with perforations were treated *** located in the jejunum or ileum were more likely to cause severe complications than those located in the *** located in the jejunum,ileum,or sigmoid colon were more likely to undergo surgery,and severe complications were an independent risk factor for *** Intestinal FBs,often localized in angulation,are likely to be misdiagnosed because most patients do not provide a history of FB *** and endoscopic therapy are the most commonly used treatment *** is not mandatory in clinically stable patients with small and contained *** located in the jejunum or ileum are risk factors for both complications and surgery.

关键词： complication foreign body intestine risk factor surgery

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Ocular ultrasound evaluation of optic nerve sheath diameter in military environments

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Military Medical Research 2019年第3期6卷 272-274页

作者： maddalena De Bernardo Livio Vitiello Palmiro Cornetta Nicola Rosa Department of Medicine Surgery and Dentistry "Scuola Medica Salernitana" University of Salerno

In this letter to the Editor, we would like to comment on the article by Betcher et al., concerning the possibility of teaching military trainees to obtain accurate optic nerve sheath diameter measurements, using a brief didactic and a hands-on training session. In particular, this letter notes the importance of the measurement of optic nerve sheath diameter in detecting the eventual elevated intracranial pressure following traumatic brain injury, highlights several limitations in the use of B-scan for such a purpose and suggests a more accurate evaluation with the standardized A-scan.

关键词： Blooming effect Intracranial pressure Optic nerve sheath diameter

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The role of defects association in structural and transport properties of the Ce_(1-x)(Nd_(0.74)Tm_(0.26))_xO_(2-x/2) system

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Journal of Energy Chemistry 2021年第9期30卷 494-502页

作者： Cristina Artini Sabrina Presto Massimo Viviani Sara Massardo Maria maddalena Carnasciali Lara Gigli Marcella Pani DCCI Department of Chemistry and Industrial ChemistryUniversity of GenovaVia Dodecaneso 3116146 GenovaItaly Institute of Condensed Matter Chemistry and Technologies for Energy National Research CouncilCNR-ICMATEVia De Marini 616149 GenovaItaly Institute of Condensed Matter Chemistry and Technologies for Energy National Research CouncilCNR-ICMATEc/o DICCA-UNIGEVia all’Opera Pia 1516145 GenovaItaly INSTM Genova Research UnitVia Dodecaneso 3116146 GenovaItaly Elettra-Sincrotrone Trieste S.C.p.A. ss 14km 163.534149 BasovizzaTriesteItaly CNR-SPIN Genova Corso Perrone 2416152 GenovaItaly

An experimental investigation of the crystallographic,Raman and transport properties of the Ce_(1-x)(Nd_(0.74)Tm_(0.26))_xO_(2-x/2)(0.1≤x≤0.6) doped ceria system was performed with the aim of setting out correlations between structural features and ionic conductivity of the *** chosen composition ensures that the average size of the Nd^(3+) and Tm^(3+) doping ions coincides with the one of Sm^(3+);even so,the studied system presents larger cell parameters and a wider compositional extent of the CeO_(2)-based solid solution than Sm-doped ***,the occurrence of two different activation energies to ionic conduction below and above ~750 K determines the existence of two distinct conduction *** described experimental results agree with the formation below the threshold temperature of1 V_O2 Tm'_(Ce) trimers,which promote the incorporation of Nd'_(Ce) isolated defects into the CeO_(2)-based solid *** the high temperature range the dissociation of trimers induces the appearance of a lower activation energy;the extrapolation of its value at infinite dilution provides a result in good accordance with the expected binding energy of 1 V_ORE'_(Ce) dimers,pointing at their stability even in the high temperature conduction regime.

关键词： Solid oxide fuel cells RE-doped ceria High resolution X-ray powder diffraction Rietveld refinement μ-Raman spectroscopy Impedance spectroscopy

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Hypertransaminasemia in the course of infection with SARS-CoV-2:Incidence and pathogenetic hypothesis

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World Journal of Clinical Cases 2020年第8期8卷 1385-1390页

作者： maddalena Zippi Sirio Fiorino Giuseppe Occhigrossi Wandong Hong Unit of Gastroenterology and Digestive Endoscopy Sandro Pertini HospitalRome 00157Italy Unit of Internal Medicine Maggiore HospitalLocal Health Unit of BolognaBologna 40133Italy Department of Gastroenterology and Hepatology First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

In patients infected with severe acute respiratory syndrome coronavirus 2,the respiratory symptoms,such as fever,cough and dyspnea,are the most frequent clinical *** patients may also present with less well-defined symptoms like diarrhea,nausea,vomiting and/or abdominal discomfort both at the time of diagnosis and during the clinical *** a few cases,these symptoms may also present before the appearance of respiratory *** penetrate the body,Severe acute respiratory syndrome coronavirus 2 uses ACE2 receptors,which are present not only in respiratory epithelium but also in gastrointestinal mucosa and liver *** several cases,viral RNA is detectable in the stool of patients with coronavirus disease 2019(COVID-19).The liver damage seems to show a multifactorial *** 2%-11%of patients with COVID-19 have known underlying hepatic *** 14%-53%of COVID-19 cases,there is an alteration of the indices of liver cytolysis and is more frequently observed in severe forms of COVID-19,especially during hospitalization.

关键词： Coronavirus COVID-19 Hypertransaminasemia Liver Meta-analysis SARS-CoV-2

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