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Spatial and Temporal Variation of Particulate Matter (PM10 and PM2.5) and Its Health Effects during the Haze Event in Malaysia

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Journal of Atmospheric Science Research 2023年第4期6卷 26-47页

作者： Afiqah Ma’amor Norazian Mohamed Noor Izzati Amani Mohd Jafri Nur Alis Addiena Ahmad Zia Ul Saufie Nor Azrita Amin madalina boboc Gyorgy Deak Faculty of Civil Engineering&Technology Universiti Malaysia PerlisJejawiArauPerlis02600Malaysia Sustainable Environment Research Group(SERG) Centre of Excellence Geopolymer and Technology(CEGeoGTech)JejawiArauPerlis02600Malaysia Faculty of Computer and Mathematical Sciences Universiti Teknologi Mara(UiTM)Shah Alam40450Malaysia Institute of Engineering Mathematics Universiti Malaysia PerlisPauh Putra CampusArauPerlis02600Malaysia National Institute for Research and Development in Environmental Protection INCDPM Splaiul Independentei 294Bucharest060031Romania

This study aims to assess and compare levels of particulate matter(PM10 and PM2.5)in urban and industrial areas in Malaysia during haze episodes,which typically occur in the south west monsoon *** high concentrations of atmospheric particles are mainly due to pollution from neighbouring *** PM concentrations were analysed for urban and industrial areas including Alor Setar,Tasek,Shah Alam,Klang,Bandaraya Melaka,Larkin,Balok Baru,and Kuala Terengganu in 2018 and *** analysis employed spatiotemporal to examine how PM levels were *** data summary revealed that PM levels in all study areas were right-skewed,indicating the occurrence of high particulate *** peaks in PM concentrations during haze events were consistently observed between June and October,encompassing the south west monsoon and inter-monsoon *** study on acute respiratory illnesses primarily focused on *** revealed that Klang had the highest mean number of inpatient cases for acute exacerbation of bronchial asthma(AEBA)and acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with values of 260.500 and 185.170,***,for outpatient cases of AEBA and AECOPD,Klang had the highest average values of 41.67 and 14.00,*** Alam and Sungai Buloh did not show a significant increase in cases during periods of biomass *** statistical analysis concluded that higher concentrations of PM were associated with increased hospital admissions,particularly from June to September,as shown in the bar *** episodes were associated with more healthcare utilization due to haze-related respiratory illnesses,seen in higher inpatient and outpatient visits(p<0.05).However,seasonal variability had minimal impact on healthcare *** findings offer a comprehensive assessment of PM levels during historic haze episodes,providing valuable insights for authorities to develop policies and guidelines fo

关键词： Haze Particulate matter(PM10 and PM2.5) AEBA and AECOPD Spatial variability

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Diabetes and skin cancers: Risk factors, molecular mechanisms and impact on prognosis

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World Journal of Clinical Cases 2022年第31期10卷 11214-11225页

作者： Elena-Codruta Dobrică madalina Laura Banciu Vincent Kipkorir Mohammad Amin Khazeei Tabari Madeleine Jemima Cox L V Simhachalam Kutikuppala Mihnea-Alexandru Găman Doctoral School University of Medicine and Pharmacy of CraiovaCraiova 200349Romania Department of Dermatology "Elias"University Emergency HospitalBucharest 011461Romania Department of Human Anatomy University of NairobiCollege of Health SciencesNairobi 00100Kenya USERN Office Mazandaran University of Medical SciencesSari 48175-866Iran University of New South Wales University of New South WalesSydney 2052Australia Dr NTR University of Health Sciences VijayawadaAndhra Pradesh 520008India Faculty of Medicine "Carol Davila"University of Medicine and PharmacyBucharest 050474Romania

Diabetes and skin cancers have emerged as threats to public health ***,their association has been less intensively *** this narrative review,we explore the common risk factors,molecular mechanisms,and prognosis of the association between cutaneous malignancies and ***,oxidative stress,low-grade chronic inflammation,genetic,lifestyle,and environmental factors partially explain the crosstalk between skin cancers and this metabolic *** addition,diabetes and its related complications may interfere with the appropriate management of cutaneous *** medication seems to exert an antineoplastic effect,however,future large,observation studies with a prospective design are needed to clarify its impact on the risk of malignancy in *** for diabetes in skin cancers,as well as close follow-up for the development of cutaneous malignancies in subjects suffering from diabetes,is warranted.

关键词： Diabetes Skin cancers Squamous cell carcinoma Melanoma Basocellular carcicoma

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Ten-year multicentric retrospective analysis regarding postoperative complications and impact of comorbidities in hemorrhoidal surgery with literature review

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World Journal of Clinical Cases 2023年第2期11卷 366-384页

作者： Cosmin Moldovan Elena Rusu Daniel Cochior madalina Elena Toba Horia Mocanu Razvan Adam Mirela Rimbu Adrian Ghenea Florin Savulescu Daniela Godoroja Florin Botea Department of Medical Surgical Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Witting Clinical HospitalBucharest 010243Romania Department of Preclinic Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Sanador Clinical HospitalBucharest 010991Romania Department of General Surgery Monza Clinical HospitalBucharest 021967Romania Department of Ear Nose and ThroatIlfov County Clinical Emergency HospitalBucharest 022104Romania Department of Orthopedics and Traumatology Elias Emergency University HospitalBucharest 011461Romania Medical Doctoral School Titu Maiorescu University of BucharestBucharest 040317Romania Department of Coloproctology MedLife SA Băneasa HyperclinicBucharest 013693Romania nd Department of Surgery Carol Davila Central Military Emergency University HospitalBucharest 010242Romania Department of Anesthesia Ponderas Academic HospitalBucharest 014142Romania Florin Botea 2nd Department of SurgeryFundeni Clinical InstituteBucharest 022328Romania

BACKGROUND Hemorrhoidal disease(HD)is considered a low-severity pathology by both general population and physicians,but the lengthy conservative therapy and postoperative complications suggest *** To assess the effectiveness of different treatment options,both conservative and surgical,in contrast with some preexisting *** We conducted a retrospective,10-yearlong study between January 2011 and December 2021 in two surgical centers,a private and a state-owned *** compared the efficacy and safety of several treatment options,such as open hemorrhoidectomy,stapled hemorrhoidopexy,rubber band ligation and infrared coagulation in terms of complication rates and types and their correlation with different preexisting comorbidities such as inflammatory bowel disease(IBD),use of anticoagulant medication(AM)and liver *** also conducted a 20-years long PubMed research(1.263 articles)for relevant *** Our study recorded 10940 patients with HD,10241 with conservative and 699 with surgical *** of these,the male-to-female ratio of 1.3,and a peak in age distribution between 59 and 68 years old(32%of patients).For the entire study,we recorded a 90%incidence of immediate pain,immediate bleeding in 1.5%(11 cases),delayed bleeding in 1.0%(7 cases),and 0.6%surgical site *** retention was also present,with 0.2%of patients,anal stricture in 1%and fecal incontinence for 0.5%of patients(4 cases).We recorded no severe complications such as Fournier`s gangrene or rectovaginal *** accounted for 6%of the patients,with ulcerative colitis in 12%and Chron`s disease in 10.5%.6.6%of the patients had AM,determining 4%immediate and 2%delayed bleeding,in surgically treated *** Our study determined that most common complications(pain,urinary retention,bleeding,and stricture)are correlated with each surgical technique and pre-existing comorbidities.

关键词： Retrospective Hemorrhoidal Postoperative Complications Comorbidities

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A Comparative Study of the Ghost Literary Motif in Snow in Midsummer by Guan Hanqing and Hamlet by Shakespeare

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Journal of Foreign Languages and Cultures 2021年第1期5卷 125-134,155页

作者： Cristina-madalina Dinu University of Bucharest

In classical Chinese literature,employing the literary motif of the ghost represents both the writers'desire to escape the pattern of didactic literature promoted by Confucianism and their attempt to revolt against the rigidity of the Confucian dogma that is far too entrenched in reality and inhibits their *** during the Yuan Dynasty(1279-1368)by Guan Hanqing(1225-1302),Snow in Midsummer presents the injustice of Dou'E who dies for a crime she did not commit,with the girl returning to the world of the living in the form of a ghost to obtain her *** motif of the vengeful ghost also appears in Shakespeare's(1564-1616)play,*** this essay,I will investigate comparatively the dramatic aesthetics through which the spirits are outlined in the two plays,the comedy used by Guan Hanqing and Shakespeare,respectively,in the scenes of the appearance of spirits,and last but not least,the religious substratum contained in the symbolism of these *** a contrastive analysis of the dramaturgical and aesthetic construction of the two spirits in these plays,I argue that,despite their belonging to two different cultural spaces,both authors question through the supernatural the moral values of the societies in which they lived.

关键词： Snow in Midsummer Hamlet ghost Guan Hanqing Shakespeare Shakespearean theater zaju theater

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Progress in Natural Science:Materials International 2015年第2期25卷 122-130页

作者： Valentina Mitran madalina Georgiana Albu Eugeniu Vasile Anisoara Cimpean Marieta Costache University of Bucharest Faculty of Biology Department of Biochemistry and Molecular Biology INCDTP – Division Leather and Footwear Research Institute Collagen Department 3. University Politehnica of Bucharest Advanced Polymer Materials Group

This paper aims at demonstrating the biocompatibility of recently developed 3D hydrogel scaffolds containing the same amount of collagen(COLL) and variable concentrations of sericin(SS) in order to find the most suitable formula for adipose tissue engineering(ATE) *** scaffolds were obtained by COLL crosslinking with glutaraldehyde followed by freeze-drying and, subsequently, seeded with 3T3-L1 preadipocytes. Scanning electron microscopy studies revealed the scaffolds’ architecture and cellular colonization. Also, in vitro biocompatibility of the developed scaffolds was evaluated by LDH and MTT assays and Live/Dead analysis of 3T3-L1 preadipocyte populating these 3D *** best results in terms of cell survival and proliferation status were obtained in the case of the hybrid COLL scaffold containing 40% SS(COLL–SS4). Furthermore, the biological performance of the analyzed COLL-based hydrogels at 5- and 8- days post-seeding was found to decrease as follows: COLL–SS4 4 COLL–SS2 4 COLL 4 COLL–SS6. Consequently, our study highlights that hybrid scaffolds obtained by the addition of variable concentrations of SS to a constant COLL composition positively influences the behavior of 3T3-L1 cells with the exception of the COLL–SS6 matrix(60% SS). Altogether, the data obtained recommend SS as a component of COLL-based hydrogels providing them with features that may be useful in ATE applications.

关键词： Sericin–collagen scaffold Preadipocyte Proliferation Morphology Tissue engineering

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Boundary Conditions for Limited Area Models Based on the Shallow Water Equations

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Communications in Computational Physics 2013年第8期14卷 664-702页

作者： Arthur Bousquet madalina Petcu Ming-Cheng Shiue Roger Temam Joseph Tribbia The Institute for Scientific Computing and Applied Mathematics Indiana UniversityBloomingtonIN 47405USA Laboratoire de Mathematiques et Applications UMR 6086Universite de PoitiersFrance The Institute of Mathematics of the Romanian Academy BucharestRomania Department of Applied Mathematics National Chiao Tung UniversityHsinchuTaiwan National Center for Atmospheric Research BoulderColoradoUSA.

A new set of boundary conditions has been derived by rigorousmethods for the shallow water equations in a limited *** aim of this article is to present these boundary conditions and to report on numerical simulations which have been performed using these boundary *** new boundary conditions which are mildly dissipative let the waves move freely inside and outside the *** problems considered include a one-dimensional shallow water system with two layers of fluids and a two-dimensional inviscid shallow water system in a rectangle.

关键词： Boundary conditions finite volumes shallow water

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Primary rhabdomyosarcoma: An extremely rare and aggressive variant of male breast cancer

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World Journal of Clinical Cases 2020年第19期8卷 4466-4474页

作者： Catalin Bogdan Satala Ioan Jung Tivadar Jr Bara Patricia Simu Iunius Simu madalina Vlad Rita Szodorai Simona Gurzu Department of Pathology Clinical County Emergency HospitalTirgu Mures 540139Romania Department of Pathology George Emil Palade University of MedicinePharmacySciences and TechnologyTargu Mures 530149Romania Department of Surgery Clinical County Emergency HospitalTargu Mures 540136Romania Department of Radiology George Emil Palade University of MedicinePharmacySciences and TechnologyTargu Mures 530149Romania Department of Pathology Clinical County Emergency HospitalTargu Mures 540136Romania Department of Pathology George Emil Palade University of MedicinePharmacyScience and TechnologyTargu Mures 530149Romania Research Center(CCAMF) University of MedicinePharmacySciences and TechnologyTargu Mures 540139Romania

BACKGROUND Rhabdomyosarcoma(RMS)of the breast,a mesenchymal neoplasm with skeletal muscle differentiation,is an extremely rare tumour in males,with less than 30 cases published in English-language *** report on the first case of a male breast RMS,with an unusual ectomesenchymal/neuroectodermal *** SUMMARY A 55-year-old,previously healthy male,underwent a radical left mastectomy for an ulcerated tumour mass,occupying the breast and left anterior thoracic *** biopsy specimen indicated the presence of a tumour with neural origins,namely a peripheral neuroectodermal tumour(PNET).The surgical specimens identified two *** rhabdomyosarcomatous component(over 70%)was represented by large pleomorphic cells with positivity for desmin,sarcomeric actin and *** PNET-like ectomesenchymal component,which was admixed with the RMS cells,and was also revealed during the preoperative biopsy,consisted of small cells which expressed neurofilament,neuron specific enolase and *** microscopic examination,along with the immunohistochemical profile,allowed the diagnosis of an RMS,with unusual ectomesenchymal *** patient refused the postoperative oncologic therapy and died three months after *** In patients with RMS of the breast,the PNET-like ectomesenchymal component increases the diagnosis difficulty,especially in biopsy *** differentiation can be immunohistochemically proven and might highlight the possible development of high-grade sarcoma of the breast from remnants of the embryological ectodermal layer.

关键词： Mammary gland Rhabdomyosarcoma Ectomesenchymoma Male Case report CD99

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EU Regulation of Land-Based Plastic Pollution Under the International Legal Framework——Analysing the Approach to Plastic Packaging Waste

EU Regulation of Land-Based Plastic Pollution Under the Inte...

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作者： madalina Merlusca 上海财经大学

学位级别：硕士

塑料产品对于我们的日常使用来说简易又便利,但是它们对人体健康和环境所造成的负面影响也不容忽视。如今,塑料废料的负面影响和效应已广为人知,并已成为欧洲乃至全球范围内备受媒体和学术研究关注的主题。我们目前在海洋中发现的许多... 详细信息

塑料产品对于我们的日常使用来说简易又便利,但是它们对人体健康和环境所造成的负面影响也不容忽视。如今,塑料废料的负面影响和效应已广为人知,并已成为欧洲乃至全球范围内备受媒体和学术研究关注的主题。我们目前在海洋中发现的许多塑料垃圾均来自陆地。自二十一世纪初以来,全世界生产出了相当于整个二十世纪的塑料,科学家观察到的警告信号,越来越多地要求政客、跨国企业、律师和政策制定者提出化解危机的举措。有必要指出,当前的国际和区域框架为全球塑料生命周期的治理提供了一种碎片化的方法。尽管存在许多与海洋塑料垃圾有关的文书,但尚无主要侧重于消除塑料污染的国际协议。尽管全球塑料制品的年产量持续攀升,但没有任何一项国际文书涉及塑料从生产到消费,再到处理阶段的整个生命周期。在联合国环境大会第三次会议的背景下,已经发布并提出了处理海洋垃圾的三种备选方法。已有专门的文献强调了重新考虑和改善复杂塑料价值链功能的必要性,这需要所有主要参与者(从塑料生产商到回收商、零售商和消费者)作出巨大的努力并加强合作。它还需要创新和共同的愿景来推动资本朝着正确的方向运行。本文的问题意识源于经济生活中完全剔除塑料制品的愿望不具有现实意义。监管部门需要识别不同类型的塑料,并确保使用过的塑料产品被引导至适当的路径进行再利用、回收或处理。本文概述了包装塑料垃圾带来的问题,并阐述了它们对环境的影响。讨论了扩大生产者责任原则的作用,并提供了一些强化生产者责任的建议。当前用于治理塑料污染的全球架构无法应对塑料污染的挑战。治理分散在各个辖区,部门和产品线中。各国之间几乎没有政策协调,国际机构的作用仅停留在会谈层面。国家与各地区之间存在政策不协调,存有漏洞和执行力不强的问题。标准不一致,在世界许多地方普遍存在系统性违法行为。这种自下而上的临时治理方式,可以在全球范围内减少某些形式的塑料污染,特别是塑料食品袋和微珠产品。面对日益增多的塑料废物,整个欧盟尤其是许多欧洲国家的政府,目前正在修订可用于解决该问题的政策选择。为减轻塑料废物造成的压力,可以使用的一种工具是扩大生产者责任计划。它被视为是支持实施欧洲废物等级体系的主要废物管理政策工具之一。它的应用可能有助于促进含有塑料的废物流的收集和回收。事实证明,欧盟引领着未来塑料的变革,但仍一些问题亟待发现和解决。新的《欧盟塑料战略》的目标有望在处理塑料污染方面发生重大变化。同样,国际参与将是推动欧洲境外变革的必要条件,这需要国际承诺。《循环经济计划》由四个单独的立法提案构成,修订了六个不同的欧盟废物指令,即《废物框架指令》、《填埋区指令》、《包装及包装废物指示》、《电池指示》、《电子废物WEEE指示》及《报废车辆指示》。除了《包装和包装废物指令修订法》是在内部市场法律基础下批准的外,对这些废物指令的每项修订法都是在环境法律基础下提出和通过的。作为《欧洲循环经济中塑料战略》的一部分,提出了针对海洋塑料污染问题的其他立法,包括关于减少某些塑料产品对环境影响的指令。本文的主要目的是对当前欧盟针对塑料包装废料的法律方法进行详尽的研究分析,特别关注《包装和包装废料指令》和欧盟的《塑料战略》。此外,这项分析将在国际法规的背景下进行,以便确定当前的国际和区域框架为塑料生命周期的全球治理提供有效的方法。它着眼于政府,企业和个人如何应对塑料污染这一重要因素。特别关注塑料包装的新兴用途以及由此产生的废物。海洋环境中塑料污染的增加与强化废物管理和回收的趋势相对应。包装作为一种产品显示出许多区别与其他商品的独特特征:它在形状,尺寸和材料组成方面是一种具有高度差异化的产品类别;它是由大量不同种类的生产者产生的;与其他产品相比,生产和处置之间的时间间隔相对较短;包装的数量,质量和寿命的责任在于包装链中的参与者,包括生产商,填充商和零售商。因此,很难确定包装的最终责任人,也就无法明确包装政策的目标群体。在查明负责人的生产者层面出现了困难。即使可以找到这样一个最终负责任的生产者,也很难将包装(以小单位并从大量来源处置的包装)退还给该生产者。PPW指令在2018年更新了回收目标,以鼓励包装再利用和回收,并防止污染,使其不偏离原始目标。特别是,该指令规定了包装设计、生产和商业化的基本要求使其能够重复使用、回收和再循环,最大程度地减少对环境的影响。塑料包装废料的回收被认为是将其从垃圾填埋场和生物圈中转移出来的一个重要前提,并产生一种公认的高质量次要材料。自从1994年采用PPWD以来,它一直是包装回收和回收率稳步提高的主要驱动力。但是,各国在转运方面的差异导致实施PPWD的方式不同,,EU-28的包装废物管理绩效也存在很大差异。需要PPWD中的法律最低要求,因为国家法律没有为旧包装的EPR计划提供明确的监管框架。在许多情况下,国家立法没有明确赋予国家主管部门控制和执行要求以确保对使用过的包装

关键词：塑料污染包装废物循环经济法律责任环境保护

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Mechanisms of fibrinolysis resistance and potential targets for thrombolysis in acute ischaemic stroke: lessons from retrieved stroke emboli

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Stroke & Vascular Neurology 2021年第4期6卷 658-667页

作者： Waleed Brinjikji Oana madalina Mereuta Daying Dai David F Kallmes Luis Savastano Yang Liu Shahid M Nimjee Raul G Nogueira Mehdi Abbasi Ramanathan Kadirvel Radiology Mayo ClinicRochesterMinnesotaUSA Neurosurgery Mayo ClinicRochesterMinnesotaUSA Neurosurgery Ohio State University Medical CenterColumbusOhioUSA Neurology Emory University School of MedicineAtlantaGeorgiaUSA

There has been growing interest and insight into the histological composition of retrieved stroke *** of the main focuses of the stroke clot analysis literature has been the implications of clot composition on mechanical thrombectomy ***,the holy grail of clot analysis may not be in the field of clot-device interaction,but rather,in understanding mechanisms of fibrinolysis *** mechanisms underlying the low response to fibrinolytic therapy,even with the newer,more powerful agents,remain poorly *** factors such as embolus size,location and collateral status influence alteplase delivery and recanalisation rates;compositional analyses focused on histological and ultrastructural characteristics offer unique insights into mechanisms of alteplase *** this review,we strive to provide comprehensive review of current knowledge on clot composition and ultrastructural analyses that help explain resistance to fibrinolysis.

关键词： fibrin histological resistance

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Long-Term Clinical Outcome of Patients Using Risperidone Long-Acting Injectable: The Romanian e-STAR Database

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Open Journal of Psychiatry 2015年第2期5卷 153-164页

作者： Ioana Micluţia madalina Vrabie Roxana Ciungu Department of Neurosciences Discipline of Psychiatry“Iuliu Hatieganu”University of Medicine&PharmacyEmergency County Hospital ClujSecond Psychiatric ClinicCluj-NapocaRomania Medical Affairs JanssenDivision of Johnson&Johnson RomaniaBucharestRomania

The objectives of e-STAR Romania (NCT00283517) were to collect clinical outcome data of Romania schizophrenia or schizo-affective disorder patients;prospectively to assess the reasons of treatment initiation, medication usage patterns;to document (long-term) clinical efficacy;and to collect safety data, as well as recording 2-year corresponding retrospective data. In total, 378 eligible subjects were enrolled who were initiated either on risperidone long-acting injectable (RLAI) (290) or on an oral antipsychotic (OA) (88) at baseline as required by the local Summary of the Product Characteristics. Data were collected from per patient both retrospectively and prospectively over a 24-month period at 3-month intervals after starting treatment. The results indicated that subjects suffering from schizophrenia or schizo-affective disorder initiated on RLAI were less likely to be hospitalized within the first 24 months after the initiation of treatment. Moreover, subjects treated with RLAI experienced significant improvements in their illness severity and functioning. Discontinuation rates for RLAI were low and doses were stable throughout the 24 months following the initiation of treatment. In addition, the necessity for supplementary concomitant medication was reduced. Adverse events were reported in 20.3% (RLAI) and 11.4% (OA) of the subjects. In general, patients initiated on RLAI and OA at baseline both clinically improved on all assessed parameters but a larger improvement was observed for patients on RLAI. Incidences of reported AEs during the use of RLAI in a naturalistic setting are comparable with those described in clinical studies;however, the incidence of extrapyramidal signs and weight gain was lower than expected.

关键词： Schizophrenia Registry Risperidone Long-Acting Injectable Hospitalizations Clinical Outcome Safety

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