检索结果-南通市图书馆

Effect of tumor necrosis factor-alpha in rats with hepatic ischemia-reperfusion injury

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2008年第3期7卷 296-299页

作者： ma, mao ma, Zhen-Hua Xian Jiaotong Univ Sch Med Dept Geriatr Surg Affiliated Hosp 1 Xian 710061 Peoples R China Xian Jiaotong Univ Sch Med Dept Hepatobiliary Surg Affiliated Hosp 1 Xian 710061 Peoples R China

BACKGROUND: With the development of hepatic surgery, especially liver transplantation, the pathophysiological processes of hepatic ischemia-reperfusion (I/R) injury have gained special attention. Controlling I/R injury has become one of the most important factors for successful liver transplantation. This study a.med to investigate the effects of tumor necrosis factor-alpha (TNF-alpha) in rats with hepatic I/R injury and promote the recognition of I/R injury in the liver. METHODS: Thirty-two Sprague-Dawley rats were randomly divided into 2 groups. Rats in the sham-operated (SO) group served as controls. Rats in the hepatic ischemia-reperfusion (I/R) group underwent reperfusion after 30 minutes of liver ischemia. Rats were sacrificed at 1, 6 and 12 hours. The expression of TNF-alpha mRNA in the liver was measured by RT-PCR. Histological changes in the liver were assessed. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum were measured. RESULTS: The expression of TNF-alpha mRNA in the SO group was decreased compared with that in the I/R group (Pmatory reaction. TNF-alpha production in the liver triggers hepatic I/R injury through a cascade.

关键词： liver ischemia-reperfusion injury tumor necrosis factor-alpha inflammatory reaction

Studies on Different Hydrolysis Procedures for Drugs of Abuse in Hair

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1999年第3期10卷 239-242页

作者： ma, C Zhou, TH Chinese Acad med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union med Coll Beijing 100050 Peoples R China

Different hydrolysis and extraction procedures have been studied for the determination of drugs of abuse in hair samples. The results showed that acid and enzymatic hydrolysis gave high extraction recoveries for 6-monoacetylmorphine, morphine, codeine and heroin. Enzymatic hydrolysis was more expensive. After alkaline hydrolysis, 6-monoacetylmorphine, a unique proof of heroin abuse, could not be detected and after methanolic extraction, the extract was dirty and the obtained chromatogram showed an interfering background. It is concluded that acid hydrolysis is the extraction method of choice.

关键词： drugs of abuse hydrolysis hair

Carbon‑Based Electrodes for Advanced Zinc‑Air Batteries:Oxygen‑Catalytic Site Regulation and Nanostructure Design

在线全文

学校读者我要写书评

暂无评论

Electrochemical Energy Reviews 2023年第1期6卷 532-572页

作者： Wenjie shao Rui Yan Mi Zhou Lang ma Christina Roth Tian ma Sujiao Cao Chong Cheng Bo Yin Shuang Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065SichuanChina College of Biomass Science and Engineering Sichuan UniversityChengdu 610065SichuanChina Department of Ultrasound West China HospitalSichuan UniversityChengdu 610041SichuanChina Electrochemical Process Engineering Engineering SciencesUniversity of BayreuthUniversitätsstr.3095447 BayreuthGermany med-X Center for materials Sichuan UniversityChengdu 610065SichuanChina Functional materials Department of ChemistryTechnische Universität BerlinHardenbergstraße 4010623 BerlinGermany

Zn-air batteries are highly attractive for direct chemical-to-electrical energy conversion and for solving the energy crisis and environmental *** efficient oxygen electrodes has been considered one of the most critical steps in the development of advanced Zn-air batteries because of the sluggish kinetics of the oxygen reduction reaction and the oxygen evolution *** recent years,nanostructured carbon-based electrodes with large surface areas,efficient oxygen-catalytic centers,and hierarchically porous matrices have provided significant opportunities to optimize the performance of the oxygen electrodes in both primary and rechargeable Zn-air *** this review,we provide a comprehensive summary of the reported nanostructured carbon-based electrodes for advanced Zn-air batteries in terms of tailoring the oxygen-catalytic sites and designing carbon *** versatile synthetic strategies,characterization methods,and in-depth understanding of the relationships between the oxygen-catalytic sites/nanostructures and the oxygen electrode performance are systematically ***,we also briefly outline recent progress in engineering flexible and high-power Zn-air ***,a thorough discussion of current primary challenges and future perspectives on the rational design of nanostructured carbon-based oxygen electrodes is given,thus providing inspiration for the future prosperity of fast-kinetic and efficient Zn-air batteries in a broad range of energy fields.

关键词： Zn-air batteries Carbon nanostructures Electrocatalysts Oxygen-catalytic catalysts ORR OER

Meridian-like character of reflex electromyogram activity in longissimus dorsi muscles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2001年第1期46卷 57-62页

作者： Chao ma Zheng Zheng Yikuan Xie Chinese Acad med Sci Peking Union Med Coll Inst Basic Med Sci Beijing 100005 Peoples R China

We studied the temporal and spacial character of the electromyogram (EMG) evoked by acupuncture in long-issimus dorsi (LD) muscles of rat, and evaluated the effect of needling direction or local blockade on EMG propagation. When certain sites on LD muscle were acupunctured, asynchronous EMG could be activated not only at the acupunctured point, but also within the muscle region supplied by the adjacent 2-3 vertebral segments. The EMG evoked by stimulation on the borderline of aponeurosis and muscle venter was larger in amplitude than those on the other sites in the same vertebral segment. When the distance from the recorded site to stimulated site increased, the EMG amplitude decreased, and its latency prolonged. Acupuncture in an oblique direction toward rostral or caudal side of the muscle enhanced the EMG amplitude in the same direction. EMG activity was weakened and its propagation was blocked by local injection of procaine. These results indicated that the character of EMG propagation evoked by

关键词： longissimus dorsi muscle reflex electromyogram activity acupuncture needle-feeling propagation.

Genetic identification, pathogenicity and patulin production of Penicillium species from apple blue mold in China

在线全文

学校读者我要写书评

暂无评论

FOOD QUALITY AND SAFETY 2024年第8期8卷 414-426页

作者： Shen, Youming ma, Wenyu ma, Ning Li, Mengyao Zhang, Jianyi Xu, Guofeng Chinese Acad Agr Sci Qual Inspect & Test Ctr Fruit Nursery Stocks Minist Agr & Rural Affairs Xingcheng Res Inst PomolMinist Agr & Rural AffairsLab Qual Xingcheng Peoples R China Agr Univ Hebei Coll Vet Med Baoding Peoples R China Chinese Acad Agr Sci Minist Agr & Rural Affairs Xingcheng Qual Inspect & Test Ctr Fruit & Nursery Stocks Res Inst Pomol 98 Xinghai South St Xingcheng 125100 Peoples R China

Objectives Blue mold is a common postharvest disease that leads to severe rot and patulin (PAT) contamination in fruits, which is a key factor endangering the storage and quality of apple products. However, the Penicillium species from apple blue mold in China and their pathogenicity and PAT production ability have not been well *** and Methods In this study, 62 strains of pathogenic Penicillium species were isolated from blue mold apples collected from different regions of China. The ITS, BenA, and CaM genes were sequenced for molecular *** Penicillium strains were identified as three species, 57 P. expansum, 3 P. crustosum, and 2 P. polonicum. Twelve variants of the ITS sequence, 61 variants of BenA and 67 variants of CiaM genes were identified between Penicillium species. Fungal morphology was observed on potato dextrose agar (PDA). After 10 d of cultivation, P. expansum cultures were detected with PAT concentrations ranging from 457.98 to 1333.85 mg/kg, and two P. polonicum strains were 6.02 mg/kg and 6.30 mg/kg. The three P. crustosum strains could not produce PAT on PDA. In apple inoculation, P. expansum strains showed significantly faster infection rates than P. crustosum and P. polonicum strains. All P. expansum strains can produce PAT during infection, and the concentrations in the rot apple tissues were 2.31-88.67 mg/kg. The P. crustosum and P. polonicum strains could not produce PAT during *** This study provides data and information regarding the morphology, virulence and PAT production of Penicillium pathogens that will improve the understanding of apple blue mold and postharvest disease control.

关键词： malus domestica blue mold Penicillium expansum single nucleotide polymorphism mycotoxins

STUDIES ON THE SYNTHESIS OF NOVEL ISONUCLEOSIDE FROM D-GLUCOSE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1995年第8期6卷 655-656页

作者： Yu, HW ma, LT Zhang, LH Beijing med Univ Sch Pharmaceut Sci Beijing 100083 Peoples R China

A novel isonucleoside, 2,5-anhydro-4-(adenine-9-yl-)-L-iditol was synthesized from D-glucose through 9 steps.

关键词：

Reversed－Phase　High－Performance　Liquid　　Chromatographic　Determination　of　Drugs　of　Abuse

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1996年第11期7卷 1027-1028页

作者： ma, C Duan, HJ Xu, YQ Zhou, TH CHINESE ACAD med SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA BEIJING UNION med COLL BEIJING 100050PEOPLES R CHINA

A high-performance liquid chromatographic method using uv detection for thedetermination of 10 drugs of abuse is described. The method is sample and sensitive. The linear rangesare 20￣100ng/ml with relative standard ... 详细信息

关键词： Determination Drugs Abuse Chromatographic

Systemic longitudinal immune profiling identifies proliferating Treg cells as predictors of immunotherapy benefit: biomarker analysis from the phase 3 CONTINUUM and DIPPER trials

在线全文

学校读者我要写书评

暂无评论

SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 1-13页

作者： Huang, Sai-Wei Jiang, Wei Xu, sha Zhang, Yuan Du, Juan Wang, Ya-Qin Yang, Kun-Yu Zhang, Ning Liu, Fang Zou, Guo-Rong Jin, Feng Wu, Hai-Jun Zhou, Yang-Ying Zhu, Xiao-Dong Chen, Nian-Yong Xu, Cheng Qiao, Han Liu, Na Sun, Ying ma, Jun Liang, Ye-Lin Liu, Xu Sun Yat Sen Univ Guangdong Prov Clin Res Ctr Canc Guangdong Key Lab Nasopharyngeal Carcinoma Diag & Dept Radiat OncolState Key Lab Oncol South China Guangzhou Peoples R China Sun Yat Sen Univ Guangdong Prov Clin Res Ctr Canc Guangdong Key Lab Nasopharyngeal Carcinoma Diag & Dept Expt ResState Key Lab Oncol South ChinaColl Guangzhou Peoples R China Huazhong Univ Sci & Technol Union Hosp Tongji Med Coll Canc Ctr Wuhan Peoples R China First Peoples Hosp Foshan Dept Radiat Oncol Foshan Peoples R China First Peoples Hosp Foshan Dept Pathol Foshan Peoples R China Panyu Cent Hosp Dept Oncol Guangzhou Peoples R China Guizhou med Univ Affiliated Canc Hosp Dept Oncol Guiyang Peoples R China Cent South Univ Xiangya Hosp Dept Oncol Changsha Peoples R China Guangxi med Univ Affiliated Tumor Hosp Dept Radiat Oncol Nanning Peoples R China Sichuan Univ West China Hosp Canc Ctr Dept Radiat Oncol Chengdu Peoples R China

The identification of predictors for immunotherapy is often hampered by the absence of control groups in many studies, making it difficult to distinguish between prognostic and predictive biomarkers. This study presents biomarker analyses from the phase 3 CONTINUUM trial (NCT03700476), the first to show that adding anti-PD-1 (aPD1) to chemoradiotherapy (CRT) improves event-free survival (EFS) in patients with locoregionally advanced nasopharyngeal carcinoma. A dynamic single-cell atlas was profiled using mass cytometry on peripheral blood mononuclear cell samples from 12 pairs of matched relapsing and non-relapsing patients in the aPD1-CRT arm. Using a supervised representation learning algorithm, we identified a Ki67+ proliferating regulatory T cells (Tregs) population expressing high levels of activated and immunosuppressive molecules including FOXP3, CD38, HLA-DR, CD39, and PD-1, whose abundance correlated with treatment outcome. The frequency of these Ki67+ Tregs was significantly higher at baseline and increased during treatment in patients who relapsed compared to non-relapsers. Further validation through flow cytometry (n = 120) confirmed the predictive value of this Treg subset. Multiplex immunohistochemistry (n = 249) demonstrated that Ki67+ Tregs in tumors could predict immunotherapy benefit, with aPD1 improving EFS only in patients with low baseline levels of Ki67+ Tregs. These findings were further validated in the multicenter phase 3 DIPPER trial (n = 262, NCT03427827) and the phase 3 OAK trial of anti-PD-L1 immunotherapy in NSCLC, underscoring the predictive value of Ki67+ Treg frequency in identifying the beneficiaries of immunotherapy and potentially guiding personalized treatment strategies.

关键词： PD1 immunotherapy proliferating

Role of protective stoma in low anterior resection for rectal cancer:A meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第47期20卷 18031-18037页

作者： Sheng-Wen Wu Cong-Chao ma Yu Yang Department of General surgery The Affiliated Jianhu Hospital of Nantong University Jianhu People’s Hospital

AIM: To provide a comprehensive evaluation of the role of a protective stoma in low anterior resection (LAR) for rectal cancer.

关键词： Protective stoma Low anterior resection Rectal cancer Complication Meta-analysis