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modeling Microstructural Evolution under the Influence of Thermosolutal Convection during Ingot Solidification Process

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Journal of materials Science & Technology 2003年第z1期19卷 20-22页

作者： Qiang li Chunli mo Dianzhong li Bainian Qian Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

A model combined both macroscopic transport and microstructural evolution is applied to describe the influence of thermosolutal convection on microstructural evolution during the solidification process. Firstly, the volume average method and Simpler algorithm are used to solve the macroscopic transport equation. Then the calculated results are incorporated into the cellular automaton (ca) model to simulate the microstructural evolution. Using this model, a simple casting ingot is applied to simulate microstructural evolution. Through the simulation, it is found that the thermosolutal convection has a strong influence on the redistribution of temperature field and solute field, which influence the solidification microstructural evolution.

关键词： modeling, Thermosolutal convection, ca, Microstructural evolution

In-situ TEM study on the evolution of dislocation loops and bubbles in CeO_(2)during Kr^(+)single-beam and Kr^(+)-H_(2)^(+)dual-beam synergetic irradiation

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Journal of materials Science & Technology 2022年第28期123卷 49-59页

作者： Ziqi cao Guang Ran Zhen Wang Yipeng li Xiaoyong Wu Lu Wu Xiuyin Huang Huajun mo College of Energy Xiamen UniversityXiamen 361102China The First Sub-Institute Nuclear Power Institute of ChinaChengdu 610041China Fujian Provincial Nuclear Energy Engineering Technology Research Center Xiamen 361102China

CeO_(2)is widely used as the nonradioactive surrogate fuel of UO_(2)when studying the irradiation performance of UO_(2).The evolution and characteristics of dislocation loops and bubbles in CeO_(2)foils were studied by in-situ transmission electron microscopy(TEM)observation during 400 ke V Kr^(+)&30 ke V H_(2)^(+)dual-beam synergetic irradiation and 400 ke V Kr^(+)single-beam irradiation at 1073 *** rotation of the habit plane of dislocation loops induced by above ion irradiation was found in the CeO_(2)for the first time,such as from[211]to[311]and then to[100].The rafted loops were first observed under Kr^(+)&H_(2)^(+)dual-beam synergetic irradiation,which not only had similar[111]direction,but also belonged to perfect dislocation loops(PDLs).The rafted loops were formed not only by the growth of loops that absorbed irradiation defects,but also by the combination of ***,this phenomenon of loop rafting was not obvious during Kr single-beam *** was first found that Kr^(+)irradiation induced the change of Burgers vectors of *** absorption of large PDLs to small PDLs was also *** average size and areal number density of dislocation loops and gas bubbles as a function of irradiation dose were constructed,which showed that the addition of H_(2)^(+)obviously affected the characteristics of dislocation loops and gas bubbles and the swelling of CeO_(2).

关键词： Nuclear Fuel Cerium dioxide In-situ TEM Irradiation Dislocation Bubbles

Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening

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Journal of molecular Cell Biology 2020年第8期12卷 630-643页

作者： Yuhong Du Xingnan li Qiankun Niu Xiulei mo Min Qui Tingxuan ma calvin J.Kuo Haian Fu Department of Pharmacology and Chemical Biology and Emory Chemical Biology Discovery Center Emory University School of MedicineAtlantaGAUSA Department of Medicine Division of HematologyStanford University School of MedicineStanfordCAUSA

The recent advent of robust methods to grow human tissues as 3D organoids allows us to recapitulate the 3D architecture of tumors in an in vitro setting and offers a new orthogonal approach for drug ***,organoid culturing with extracellular matrix to support 3D architecture has been challenging for high-throughput screening(HTS)-based drug discovery due to technical *** genetically engineered human colon organoids as a model system,here we report our effort to miniaturize such 3D organoid culture with extracellular matrix support in high-density plates to enable *** first established organoid culturing in a 384-well plate format and validated its application in a cell viability HTS assay by screening a 2036-compound *** further miniaturized the 3D organoid culturing in a 1536-well ultra-HTS format and demonstrated its robust performance for large-scale primary compound *** miniaturized organoid culturing method may be adapted to other types of *** leveraging the power of 3D organoid culture in a high-density plate format,we provide a physiologically relevant screening platform to model tumors to accelerate organoid-based research and drug discovery.

关键词： human colon organoids KRAS^G12D 3D culture 384-well plate high-throughput screening(HTS) 1536-well plate ultra-HTS(uHTS)

Attribution analysis and multi-scenario prediction of NDVI drivers in the Xilin Gol grassland,China

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Journal of Arid Land 2022年第9期14卷 941-961页

作者： XU Mengran ZHANG Jing li Zhenghai mo Yu College of Enoironment and Bioresources Dalian Minzu UniversityDalian 116600China

Grassland degradation is influenced by climate change and human activities,and has become a major obstacle for the development of arid and semi-arid areas,posing a series of environmental and socio-economic *** in-depth understanding of the inner relations among grassland vegetation dynamics,climate change,and human activities is therefore greatly significant for understanding the variation in regional environmental conditions and predicting future developmental *** on moDIS(moderate resolution imaging spectroradiometer)NDVI(normalized difference vegetation index)data from 2000 to 2020,our objective is to investigate the spatiotemporal changes of NDVI in the Xilin Gol grassland,Inner mongolia Autonomous Region,*** with 12 natural factors and human activity factors in the same period,the dominant driving factors and their interactions were identified by using the geographic detector model,and multiple scenarios were also simulated to forecast the possible paths of future NDVI changes in this *** results showed that:(1)in the past 21 a,vegetation cover in the Xilin Gol grassland exhibited an overall increasing trend,and the vegetation restoration(84.53%)area surpassed vegetation degradation area(7.43%);(2)precipitation,wind velocity,and livestock number were the dominant factors affecting NDVI(the explanatory power of these factors exceeded 0.4).The interaction between average annual wind velocity and average annual precipitation,and between average annual precipitation and livestock number greatly affected NDVI changes(the explanatory power of these factors exceeded 0.7).moreover,the impact of climate change on NDVI was more significant than human activities;and(3)scenario analysis indicated that NDVI in the Xinlin Gol grassland increased under the scenarios of reduced wind velocity,increased precipitation,and ecological *** contrast,vegetation coverage restoration in this area was significantly reduced under the scenarios o

关键词： normalized difference vegetation index(NDVI) grassland degradation geographical detector Cellular Automat(ca)–markov model Xilin Gol grassland

Learning to synthesize:robust phase retrieval at low photon counts

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light(Science & Applications) 2020年第1期9卷 1657-1672页

作者： mo Deng Shuai li Alexandre Goy Iksung Kang George Barbastathis Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMA 02139USA Sensebrain Technology limited LLC 2550 N 1st StreetSuite 300San JoseCA 95131USA Omnisens SA Riond Bosson 31110 MorgesVDSwitzerland Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Singapore-MIT Alliance for Research and Technology(SmaRT)Centre Singapore 117543Singapore

The quality of inverse problem solutions obtained through deep learning is limited by the nature of the priors learned from examples presented during the training *** in the case of quantitative phase retrieval,spatial frequencies that are underrepresented in the training database,most often at the high band,tend to be suppressed in the *** hoc solutions have been proposed,such as pre-amplifying the high spatial frequencies in the examples;however,while that strategy improves the resolution,it also leads to high-frequency artefacts,as well as low-frequency distortions in the ***,we present a new approach that learns separately how to handle the two frequency bands,low and high,and learns how to synthesize these two bands into full-band *** show that this“learning to synthesize”(LS)method yields phase reconstructions of high spatial resolution and without artefacts and that it is resilient to high-noise conditions,e.g.,in the case of very low photon *** addition to the problem of quantitative phase retrieval,the LS method is applicable,in principle,to any inverse problem where the forward operator treats different frequency bands unevenly,i.e.,is ill-posed.

关键词： synthesize bands phase

Mineral Chemistry and Crystallization Conditions of the Late Cretaceous mamba Pluton from the Eastern Gangdese, Southern Tibetan Plateau

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Journal of Earth Science 2016年第4期27卷 545-570页

作者： Xiaowei li Xuanxue mo mark Scheltens Qi Guan State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of Geosciences School of Earth and Space Sciences Peking University College of Resources Hebei GEO University

The Late Cretaceous mamba granodiorite belongs to a part of the Mesozoic Gangdese continental magmatic belt. No quantitative mineralogical study has been made hitherto, and hence the depth at which it formed is poorly constrained. Here we present mineralogical data for the mamba pluton, including host rocks and their mafic microgranular enclaves（MMEs）, to provide insights into their overall crystallization conditions and information about magma mixing. All amphiboles in the mamba pluton are calcic, with ~B（ca＋Na）〉1.5, and Si=6.81-7.42 apfu for the host rocks and Si=6.77-7.35 apfu for the MMEs. The paramount cation substitutions in amphibole include edenite type and tschermakite type. Biotites both in the host rocks and the MMEs collectively have high Mg O（13.19 wt.%-13.03 wt.%） contents, but define a narrow range of Al apfu（atoms per formula unit） variations（2.44-2.57）. The oxygen fugacity estimates are based on the biotite compositions cluster around the NNO buffer. The calculated pressure ranges from 1.2 to 2.1 kbar according to the aluminum-in-hornblende barometer. The computed pressure varies from 0.9 to 1.3 kbar based on the aluminum-in-biotite barometer which corresponds to an average depth of ca. 3.9 km. Besides, the estimates of crystallization pressures vary from 0.8 to 1.4 kbar based on the amphibole barometer proposed by Ridolfi et al.（2010）, which can be equivalent to the depths ranging from 3.1 to 5.2 km. The MMEs have plagioclase oscillatory zonings and quartz aggregates, probably indicating the presence of magma mixing. Besides, core-to-rim element variations（Rb, Sr, Ba, and P） for the K-feldspar megacrysts serve as robust evidence to support magma mixing and crystal fractionation. This indicates the significance of the magma mixing that contributes to the formation of K-feldspar megacryst zonings in the mamba pluton.

关键词： mamba pluton Gangdese terrane MMEs K-feldspar megacrysts magma mixing P-Tconditions oxygen fugacity in-situ trace element.

Characterization of summer PM_(2.5) aerosols from four forest areas in Sichuan,SW China

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Particuology 2015年第3期13卷 94-103页

作者： Hengqin mo li li Wei Lai Min Zhao Jinguo Pu Yi Zhou Shihuai Deng Rural Environment Protection Engineering & Technology Center of Sichuan Province College of Resources and EnvironmentSichuan Agricultural University Meishan Environmental monitoring Center

Aerosol samples were collected over 24 and 12 h to represent day/night aerosol characteristics in forest areas at Ya＇an Baima Spring Scenic Area （BM）, Panzhihua Cycas National Nature Reserve （PZ）, Gongga mountain National Nature Reserve （GG）, and Wolong National Nature Reserve （WL）, during the summers of 2010-2012. mass and chemical component concentrations, including organic carbon, elemental car- bon, and inorganic ions （F , C1 , NO2-, NO3-, SO42-, C2042-, PO43-, K＋, Na＋, ca2＋, Mg2＋, and NH4＋）, of PM2.5 aerosols were measured. The average PM2.5 concentrations for 24 h were 72.42, 104.89, 20.55, and 29.19 p,g/m3 at BM, PZ, GG, and WL, respectively. Organic matter accounted for 38.0-49.3%, while ele- mental carbon accounted for 2.0-5.7% of PM2.s mass. The sum concentrations of 5042-, NH4＋, and NO3- accounted for 23.0%, 17.4%, 22.1%, and 30.5% of PM2.s mass at BM, PZ, GG, and WL, respectively. Soil dust was also an important source of PM2.s, accounting for 6.3%, 17.0%, 10.4%, and 19.1% of PM2.s mass at BM, PZ, GG, and WL, respectively. These reconstructed masses accounted for 75.9-102.0% of PM2.5 mass from the four forest areas of SW China.

关键词： PM2.5Forest areasmass closureSouthwest China

Ezrin Promotes the Proliferation, Migration, and Invasion of Ovarian cancer Cells

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Biomedical and Environmental Sciences 2021年第2期34卷 139-151页

作者： li mo Juan XIONG Dan HUANG Hao WEN Zhong Yong Department of Obstetrics and Gynecology Nanhai Hospital Affiliated to Southern Medical UniversityFoshan 528200GuangdongChina Department of Hematology Shunde Hospital of Southem Medical University(The First People's Hospital of Shunde)Foshan 528308GuangdongChina

Objective The underlying mechanism of Ezrin in ovarian cancer(OVca) is far from being ***, this study aimed to assess the role of Ezrin in OVca cells(SKOV3 and ca OV3) and investigate the associated molecular *** We performed Western blotting, reverse transcription-quantitative polymerase chain reaction, MTT, cell colony, cell wound healing, transwell migration and invasion, Rho A and Rac active pull down assays, and confocal immunofluorescence experiments to evaluate the functions and molecular mechanisms of Ezrin overexpression or knockdown in the proliferation and metastasis of OVca *** The ectopic expression of Ezrin significantly increased cell proliferation, invasiveness, and epithelial–mesenchymal transition(EMT) in OVca cells. By contrast, the knockdown of endogenous Ezrin prevented OVca cell proliferation, invasiveness, and EMT. Lastly, we observed that Ezrin can positively regulate the active forms of Rho A rather than Rac-1 in OVca cells, thereby promoting robust stress fiber *** Our results indicated that Ezrin regulates OVca cell proliferation and invasiveness by modulating EMT and induces actin stress fiber formation by regulating Rho-GTPase activity, which provides novel insights into the treatment of the OVca.

关键词： Epithelial ovarian cancer Ezrin Proliferation Invasiveness RhoA Stress fiber

motor neuron replacement therapy for amyotrophic lateral sclerosis

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Neural Regeneration Research 2022年第8期17卷 1633-1639页

作者： Bochao liu mo li lingyan Zhang Zhiguo Chen Paul Lu Cell Therapy Center Beijing Institute of GeriatricsXuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric Diseasesand Key Laboratory of Neurodegenerative DiseasesMinistry of EducationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Center of Parkinson’s Disease Beijing Institute for Brain DisordersBeijingChina iXCells Biotechnologies USA Inc.San DiegoCAUSA Amogene Biotech XiamenFujian ProvinceChina Veterans Administration San Diego Healthcare System San DiegoCAUSA Department of Neurosciences University of California-San DiegoLa JollaCAUSA

Amyotrophic lateral sclerosis is a motor neuron degenerative disease that is also known as Lou Gehrig’s disease in the United States,Charcot’s disease in France,and motor neuron disease in the *** loss of motor neurons causes muscle wasting,paralysis,and eventually death,which is commonly related to respiratory failure,within 3-5 years after onset of the *** there are a limited number of drugs approved for amyotrophic lateral sclerosis,they have had little success at treating the associated symptoms,and they cannot reverse the course of motor neuron ***,there is still a lack of effective treatment for this debilitating neurodegenerative *** cell therapy for amyotrophic lateral sclerosis is a very attractive strategy for both basic and clinical researchers,particularly as transplanted stem cells and stem cell-derived neural progenitor/precursor cells can protect endogenous motor neurons and directly replace the lost or dying motor *** cell therapies may also be able to re-establish the motor control of voluntary ***,we review the recent progress in the use of neural stem cells and neural progenitor cells for the treatment of amyotrophic lateral *** focus on MN progenitor cells derived from fetal central nervous system tissue,embryonic stem cells,and induced pluripotent stem *** our recent studies,we found that transplanted human induced pluripotent stem cell-derived motor neuron progenitors survive well,differentiate into motor neurons,and extend axons into the host white matter,not only in the rostrocaudal direction,but also along motor axon tracts towards the ventral roots in the immunodeficient rat spinal ***,the significant motor axonal extension after neural progenitor cell transplantation in amyotrophic lateral sclerosis models demonstrates that motor neuron replacement therapy could be a promising therapeutic strategy for amyotrophic lateral sclerosis,particularly as a variety

关键词： amyotrophic lateral sclerosis motor neuron replacement neural progenitor cells neural stem cells stem cells