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Cellular & Molecular Immunology 2013年第5期10卷 403-412页

作者： Hao Wang Chi ma Yanlai Lu Xu Ji Yongsheng Pang Fang Hua Lianxian Cui Denian ba Wei He Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and School of Basic Medicine Peking UnionMedical College State Key Laboratory of Medical Molecular Biology Beijing China

The 2009 H 1N 1 influenza pandemic demonstrated the significance of a global health threat to human beings. Although pandemic H 1N 1 vaccines have been rapidly developed, passive serotherapy may offer superior immediate protection against infections in children, the elderly and immune-compromised patients during an influenza pandemic. Here, we applied a novel strategy based on Epstein-barr virus （EBV）-immortalized peripheral blood memory B cells to screen high viral neutralizing monoclonal antibodies （mabs） from individuals vaccinated with the 2009 pandemic H1N1 vaccine PANFLU.1. Through a massive screen of 13 090 immortalized memory B-cell clones from three selected vaccinees, seven mabs were identified with both high viral neutralizing capacities and hemagglutination inhibition （HAl） activities against the 2009 pandemic H 1N 1 viruses. These mabs may have important clinical implications for passive serotherapy treatments of infected patients with severe respiratory syndrome, especially children, the elderly and immunodeficient individuals. Our successful strategy for generating high-affinity mabs from EBV-immortalized peripheral blood memory B ceils may also be applicable to other infectious or autoimmune diseases.

关键词： Epstein-barr virus hemagglutinin memory B cells neutralizing monoclonal antibody 2009 pandemicinfluenza HIN1 virus

不同类型学业压力对不同年级高中生执行功能子成分的影响

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心理学报 2025年第1期57卷 18-35页

作者：马超汪彦云付军军赵鑫甘肃省行为与心理健康重点实验室西北师范大学心理学院兰州730070

选取985名高一~高三年级的学生,采用相关分析和结构方程模型等方法考察了学业压力4个子维度在不同年级高中生各执行功能成分中的作用。结果发现,随着高中生年级的升高,父母压力和教师压力对各执行功能成分的负向预测作用逐渐增强,社交... 详细信息

选取985名高一~高三年级的学生,采用相关分析和结构方程模型等方法考察了学业压力4个子维度在不同年级高中生各执行功能成分中的作用。结果发现,随着高中生年级的升高,父母压力和教师压力对各执行功能成分的负向预测作用逐渐增强,社交压力对各执行功能成分的负向预测作用逐渐减弱。相比之下,自我压力对高中生的干扰抑制、反应抑制和注意转换能力均显示出了正向预测作用,并随年级的升高而增强。这表明,不同类型学业压力对各执行功能成分的预测作用存在差异,并将随高中生年级的升高而发生变化。本研究所产生的结论对于教育工作者有效制定高中生学业压力应对策略具有重要的启示意义。

关键词：执行功能学业压力高中生结构方程模型

Sonographic appearance of anal cushions of hemorrhoids

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World Journal of Gastroenterology 2017年第20期23卷 3664-3674页

作者： Adilijiang Aimaiti ma Mu Ti Jiang A ba bai Ke Re Irshat Ibrahim Hui Chen maimaitituerxun Tuerdi mayinuer Department of Anorectal Surgery Second Affiliated HospitalXinjiang Medical University Department of Anorectal Surgery First Affiliated HospitalXinjiang Medical University Department of General Surgery First People's Hospital of Kashi Area

AIM to evaluate the diagnostic value of different sonographic methods in hemorrhoids. METHODS Forty-two healthy volunteers and sixty-two patients with grades I -IV. hemorrhoids received two different sonographic examinations from January 2013 to January 2016 at the First and Second Hospitals of Xinjiang Medical University in a prospective way. We analyzed the ultrasonographic findings of these participants and evaluated the outcomes. Resected grades. and. hemorrhoid tissues were pathologically examined. The concordance of ultrasonographic results with pathology results was assessed with the Cohen's kappa coefficient. RESULTS All healthy volunteers and all patients had no particular complications related to sonography. There were no statistically significant differences between the participants regarding age (P = 0.5919), gender (P = 0.4183), and persistent symptoms (P > 0.8692). All healthy control participants had no special findings. However, 30 patients with hemorrhoids showed blood signals around the dentate line on ultrasonography. When grades I and II hemorrhoids were analyzed, there were no significant differences between transrectal ultrasound (TRUS), transperianal ultrasound (TPUS), and transvaginal ultrasound (TVUS) (P > 0.05). Grades III and IV hemorrhoids revealed blood flow with different directions which could be observed as a 'mosaic pattern'. In patients with grades III and IV hemorrhoids, the number of patients with 'mosaic pattern' as revealed by TRUS, TPUS and TVUS was 22, 12, and 4, respectively. Patients with grades III and IV disease presented with a pathologically abnormal cushion which usually appeared as a 'mosaic pattern' in TPUS and an arteriovenous fistula in pathology. Subepithelial vessels of resected grades III and IV hemorrhoid tissues were manifested by obvious structural impairment and retrograde and ruptured changes of internal elastic lamina. Some parts of the Trietz's muscle showed hypertrophy and distortion. Arteriovenous fistul

关键词： Hemorrhoids Anal cushion Transperianal Transrectal Transvaginal Sonography

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锂电池中串扰行为的研究进展

聊城大学学报（自然科学版） 2025年第1期38卷 34-42页

作者：马君中国科学院青岛生物能源与过程研究所、青岛储能产业技术研究院山东青岛266101 山东能源研究院山东青岛266101 青岛新能源山东省实验室山东青岛266101

高安全和高能量密度的锂电池是加快能源转型的重要支撑技术。但是锂电池存在电、化、力和热失效行为,导致电池容量损失、寿命下降和安全性降低,严重阻碍了高能量密度和高安全锂电池的发展。本文从正极与负极协同作用的视角,阐述了锂电... 详细信息

高安全和高能量密度的锂电池是加快能源转型的重要支撑技术。但是锂电池存在电、化、力和热失效行为,导致电池容量损失、寿命下降和安全性降低,严重阻碍了高能量密度和高安全锂电池的发展。本文从正极与负极协同作用的视角,阐述了锂电池中电/化/力/热串扰行为的最新研究进展及相应的解决策略,对比分析了使用电解液的常规锂电池与使用固态电解质的全固态锂电池在电/化/力/热串扰失效行为方面的相似之处与不同之处,并且总结了电/化/力耦合串扰行为的新观点,展望了进一步深刻认识并解决锂电池电/化/力/热耦合串扰行为的重要研究方向。

关键词：锂电池全固态正极负极串扰

38CrSi合金钢表面纳米化中渗碳体相的细化分析

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材料热处理学报 2009年第4期30卷 120-123页

作者：马世宁巴德玛装甲兵工程学院装备再制造工程系北京100072

利用表面机械加工法在具有回火索氏体组织的38CrSi合金钢表面制备了纳米结构层,利用X射线衍射和透射电镜等分析技术,对距表面不同深度处渗碳体相的微观结构特征及物相组成进行研究,分析38CrSi合金钢表面纳米化过程中渗碳体相的细化过程... 详细信息

利用表面机械加工法在具有回火索氏体组织的38CrSi合金钢表面制备了纳米结构层,利用X射线衍射和透射电镜等分析技术,对距表面不同深度处渗碳体相的微观结构特征及物相组成进行研究,分析38CrSi合金钢表面纳米化过程中渗碳体相的细化过程。结果表明,铁素体基体细化过程中,渗碳体颗粒在切变力作用下形成细小颗粒的同时还发生了溶解。在应变量和应变速度较高的最表面,渗碳体颗粒溶解较严重,分析表明高密度位错产生的高界面能、应力集中以及能量波动是使得渗碳体颗粒发生切变和溶解主要原因。

关键词： 38CrSi合金钢表面纳米化渗碳体相细化机理

不同运动模式影响心肌梗死致心力衰竭大鼠骨骼肌重塑的机制

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中国组织工程研究 2025年第2期29卷 221-230页

作者：付常喜何瑞波马刚朱政马文超徐州工程学院体育学院江苏省徐州市221008 中国人民武装警察部队后勤学院卫生勤务系天津市300309

背景:急性心肌梗死可引起心脏重塑和心力衰竭,同时导致骨骼肌病变,影响患者生活质量。运动疗法是心力衰竭患者的重要康复手段,然而最佳运动处方尚未明确。目的:对比不同运动模式(有氧运动、抗阻运动)对急性心肌梗死诱导心力衰竭模型大... 详细信息

背景:急性心肌梗死可引起心脏重塑和心力衰竭,同时导致骨骼肌病变,影响患者生活质量。运动疗法是心力衰竭患者的重要康复手段,然而最佳运动处方尚未明确。目的:对比不同运动模式(有氧运动、抗阻运动)对急性心肌梗死诱导心力衰竭模型大鼠骨骼肌重塑的影响,探讨其可能的作用机制,为优化运动康复方案提供依据。方法:48只SD大鼠随机分为假手术组、心肌梗死组、有氧运动组和抗阻运动组。利用冠状动脉结扎术进行心力衰竭模型制作,3个月后有氧运动组和抗阻运动组进行12周相应运动模式干预,假手术组和心肌梗死组于鼠笼内安静饲养。实验后,利用递增负荷跑台运动实验和爬梯实验分别测定大鼠最高跑速和最大负重,超声心动图评估心脏结构与功能;分离出心脏,分别行苏木精-伊红染色和天狼星红染色观察心脏重塑情况;分离出腓肠肌,行ATP酶染色观察肌纤维类型和细胞横截面积改变,二氢乙锭法评估活性氧水平,酶联免疫吸附法测定丙二醛含量以及抗氧化酶活性,免疫印迹法测定泛素-蛋白酶体系统蛋白表达量,双重免疫荧光染色检测活化的卫星细胞数(Pax7^(+)/MyoD^(+))。结果与结论:①运动能力:与假手术组比较,心肌梗死组最高跑速和最大负重下降(P0.05)。③骨骼肌重塑:与假手术组比较,心肌梗死组腓肠肌质量、腓肠肌质量指数、细胞横截面积、超氧化物歧化酶活性、谷胱甘肽过氧化物酶活性、活化的卫星细胞数量下降(PmaFbx蛋白表达量上调(PmaFbx蛋白表达量降低(P<0.05);与有氧运动组比较,抗阻运动组腓肠肌质量、腓肠肌质量指数、细胞横截面积、活性氧水平、丙二醛含量、活化的卫星细胞数量升高(P<0.05),超氧化物歧化酶活性、谷胱甘肽过氧化物酶活性下调(P<0.05)。结果表明:有氧运动和抗阻运动均可提升心力衰竭大鼠的运动能力,其机制与减轻氧化应激、抑制泛素-蛋白酶体系统活性以及激活卫星细胞进而改善骨骼肌重塑有关。有氧运动对于改善骨骼肌氧化应激作用更佳,而抗阻运动促进骨骼肌再生方面效果更为显著。

关键词：心肌梗死心力衰竭运动心脏骨骼肌重塑

恶劣综采工况条件下的采煤机摇臂散热设计研究

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煤矿机械 2025年第1期46卷 35-37页

作者：马兰上海创力集团股份有限公司上海201706

简述了在采煤机设计过程中对恶劣综采工况中工作倾角较大、煤岩硬度较硬、截割功率大且结构紧凑限制条件下的摇臂热功率的计算,分析了该工况中摇臂简化为复杂齿轮箱思路下的热功率计算、散热途径和热平衡点,提出了摇臂内部结构改进及增... 详细信息

简述了在采煤机设计过程中对恶劣综采工况中工作倾角较大、煤岩硬度较硬、截割功率大且结构紧凑限制条件下的摇臂热功率的计算,分析了该工况中摇臂简化为复杂齿轮箱思路下的热功率计算、散热途径和热平衡点,提出了摇臂内部结构改进及增加外置冷却装置的散热设计方案,并验证了满载试验条件下摇臂截割热平衡温度不超过90℃的方案可行性。

关键词：大功率大倾角采煤机摇臂紧凑结构热功率热平衡

maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for Lithium Metal battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi Sun Zelong Gong Tao Zhang Jiafeng Li Xianli Zhu Ruixiao Zhu Lingxu Wang Leyuan ma Xuehui Li Miaofa Yuan Zhiwei Zhang Luyuan Zhang Zhao Qian Longwei Yin Rajeev Ahuja Chengxiang Wang Key Laboratory for Liquid‑Solid Structural Evolution and Processing of materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFma)monomers with flame-retardant triethyl phosphate(TEP)solvents and LiTFSI–LiDFOB dual lithium *** is strongly anchored to PTFma matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of Li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes Li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The Li|SGPE|Li cell presents highly reversible Li stripping/plating performance for over 1000 h at 0.1 ma cm^(−2),and 4.2 V LiCoO_(2)|SGPE|Li battery delivers high average specific capacity>120 mah g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with Li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface Li metal battery

凡纳滨对虾肌质钙结合蛋白纯化鉴定、理化特性及抗原表位分析

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食品科学 2025年第2期46卷 30-37页

作者：陈伟周军君陈雅纯贾英民马爱进北京工商大学食品与健康学院北京100048

以凡纳滨对虾(Penaeus vannamei)为原料,分离纯化和鉴定过敏原肌质钙结合蛋白(sarcoplasmiccalcium-binding protein,SCP),对其理化性质(免疫活性、热稳定性、pH值稳定性及消化稳定性)、二级结构和抗原表位进行研究。结果表明:采用蛋白... 详细信息

以凡纳滨对虾(Penaeus vannamei)为原料,分离纯化和鉴定过敏原肌质钙结合蛋白(sarcoplasmiccalcium-binding protein,SCP),对其理化性质(免疫活性、热稳定性、pH值稳定性及消化稳定性)、二级结构和抗原表位进行研究。结果表明:采用蛋白粗提、硫酸铵分级沉淀、阴离子交换层析等步骤纯化得到的蛋白分子质量为21.6 kDa,经鉴定,该蛋白为凡纳滨对虾SCP,肽段覆盖率达93.26%。凡纳滨对虾SCP具有较强的免疫活性,在热处理温度≥65℃和强酸强碱条件下免疫活性减弱;SCP对肠液消化具有较强的稳定性,而对胃液消化稳定性较差。凡纳滨对虾SCP的二级结构中α-螺旋、β-折叠、β-转角和无规卷曲的相对含量分别为26%、16.9%、17.5%、39.6%。利用生物信息学工具结合免疫学技术最终预测识别出8条凡纳滨对虾SCP抗原表位。

关键词：凡纳滨对虾肌质钙结合蛋白稳定性抗原表位