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A Review about Thermal Comfort in Aircraft

Journal of Thermal Science 2019年第2期28卷 169-183页

作者： FAN juli ZHOU Qiongyao Nanjing University of Aeronautics and Astronautics

Thermal comfort is an important factor which affects both work efficiency and life quality. On the basis of satisfying the normal life of the crew and reliable work of equipment, the thermal comfort is increasingly pursued through the design of the environmental control system of modern craft. Thus, a comprehensive survey of the thermal comfort in the cockpit is carried out. First of all, factors affecting the thermal comfort in aircraft cabin are summarized, including low relative humidity, mean radiant temperature, colored light, human metabolic rate and gender, among which the first three factors are environmental factors and the other two are human factors. Although noise is not a factor affecting thermal comfort, it is an important factor in the overall satisfaction of the aircraft cabin environment. Then the thermal comfort prediction models are introduced, including thermal comfort models suitable for steady state uniform environment and thermal comfort models suitable for transient non-uniform environment. Then the limitations of the typical thermal comfort models applied to aircraft are discussed. Since the concept of thermal adaptation has been gradually accepted in recent years, many field studies on thermal adaptation have been carried out. Therefore, the adaptive thermal comfort models are summarized and analyzed systematically in this paper. At present, mixing ventilation(MV) system is widely used in most commercial aircraft. However, the air quality under the MV system is very poor, and contaminants cannot be effectively eliminated. So a noticeable shift is the design of ventilation system for cabin drawing lessons from the surface buildings. Currently, the most interesting question is that whether the traditional mixing ventilation(MV) system in an aircraft can be replaced by or combined with displacement ventilation(DV) system without decreasing thermal comfort. A reduction of energy consumption is a valuable gain. Additionally, various seat persona

关键词： aircraft thermal comfort energy efficient ventilation system numerical simulation

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Nuclear cGAS: sequestration and beyond

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Protein & Cell 2022年第2期13卷 90-101页

作者： juli Bai Feng Liu Departments of Pharmacology University of Texas Health at San AntonioSan AntonioTXUSA National Clinical Research Center for Metabolic Diseases Metabolic Syndrome Research CenterKey Laboratory of Diabetes ImmunologyMinistry of Educationand Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangsha 410011China

The cyclic GMP-AMP(cGAMP)synthase(cGAS)has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STING-dependent signaling *** the past several years,a growing body of evidence has revealed that cGAS is also localized in the nucleus where it is associated with distinct nuclear substructures such as nucleosomes,DNA replication forks,the double-stranded breaks,and centromeres,suggesting that cGAS may have other functions in addition to its role in DNA ***,while the innate immune function of cGAS is well established,the non-canonical nuclear function of cGAS remains poorly ***,we review our current understanding of the complex nature of nuclear cGAS and point to open questions on the novel roles and the mechanisms of action of this protein as a key regulator of cell nuclear function,beyond its well-established role in dsDNA sensing and innate immune response.

关键词： cGAS STING innate immunity nuclear translocation DNA damage repair micronuclei

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu Leng Lei ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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The Citron homology domain of maP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-Lu Liu Shuaipeng ma Tianjin Shen Yuhua Zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(maP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of maP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of maP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding maP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting maP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

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Multiplexing metal grating coupler based on MIM structure

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Optoelectronics Letters 2025年

作者： LIU Yang LIU Fei ma Yunxia ZHANG Ailing Engineering Research Center of Communication Devices and Technology， Ministry of Education， Tianjin Key Laboratory of Film Electronic and Communication Devices， School of Integrated Circuit Science and Engineering， Tianjin University of Technology

We propose and numerically investigate a multiplexing metal grating coupler based on metal/insulator/metal （MIM） structure. The coupler consists of gold grating/silicon/gold layers， which combines with MIM waveguide， concurrently achieving path multiplexing and wavelength multiplexing through TMnmodes coupling. In visible light band， TM waves are coupled to the upper surface of gold plate， and the coupling efficiency reaches maximum of 31.67% at wavelength of 736 nm. In near infrared and mid infrared bands， TM waves are coupled into MIM waveguide， and the coupling efficiency reaches maximum of 53.57% at wavelength of 2550 nm. There can be four modes of TM0， TM1， TM2and TM3simultaneously in MIM waveguide， which are excited at different wavelengths. The preparation process of the structure designed in this article is simple， with dimensions at the micrometer level， easy to be integrated， and can be applied to be integrated optical circuits.

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Steel surface defect detection based on lightweight YOLOv7

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Optoelectronics Letters 2025年

作者： Shi Tao Wu Rongxin Zhu Wenxu ma Qingliang School of Electrical Engineering and Automation， Tianjin University of Technology North China University of Science and Technology， College of Electrical Engineering Guangzhou Institute of Measurement and Testing Technology

Aiming at the problems of low detection efficiency and difficult positioning of traditional steel surface defect detection methods， a lightweight steel surface defect detection model based on YOLOv7 is proposed. First， a CSS Block module is proposed， which uses more lightweight operations to obtain redundant information in the feature map， reduces the amount of computation， and effectively improves the detection speed. Secondly， the improved SPPCSPC structure is adopted to ensure that the model can also pay attention to the defect location information while predicting the defect category information， obtain richer defect features. In addition， the convolution operation in the original model is simplified， which significantly reduces the size of the model and helps to improve the detection speed. Finally， using EIOU Loss to focus on high-quality Anchors， speed up convergence and improve positioning accuracy. Experiments were carried out on the NEU-DET steel surface defect dataset. Compared with the original YOLOv7 model， the number of parameters of this model was reduced by 40%， the FPS reached 112， and the average accuracy reached 79.1%.， the detection accuracy and speed have been improved， which can meet the needs of steel surface defect detection.

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machine Learning-Based Radio Access Technology Selection in the Internet of Moving Things

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China Communications 2021年第7期18卷 13-24页

作者： Ramon Sanchez-iborra Luis Bernal-Escobedo Jose Santa Dept.Engineering and Applied Techniques University Centre of Defence at the Spanish Air Force Academy30729 San JavierSpain Dept.Information and Communication Engineering University of Murcia30100 MurciaSpain Dept.of Electronics Computing Technology and ProjectsTechnical University of Cartagena30202 CartagenaSpain

The Internet of Moving Things(IoMT)takes a step further with respect to traditional static IoT *** this line,the integration of new eco-friendly mobility devices such as scooters or bicycles within the Cooperative-Intelligent Transportation Systems(C-ITS)and smart city ecosystems is crucial to provide novel *** this end,a range of communication technologies is available,such as cellular,vehicular WiFi or Low-Power Wide-Area Network(LPWAN);however,none of them can fully cover energy consumption and Quality of Service(QoS)***,we propose a Decision Support System(DSS),based on supervised machine Learning(ML)classification,for selecting the most adequate transmission interface to send a certain message in a multi-Radio Access Technology(RAT)set *** ML algorithms have been explored taking into account computing and energy constraints of IoMT enddevices and traffic ***,a real implementation of a decision tree-based DSS for micro-controller units is presented and *** attained results demonstrate the validity of the proposal,saving energy in communication tasks as well as satisfying QoS requirements of certain urgent *** footprint of the real implementation on an Arduino Uno is 444 bytes and it can be executed in around 50µs.

关键词： internet of moving things multi-RAT CITS classification personal mobility

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mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第01期 329-336页

作者： Yuzhu Li Yumeng Gao Feng Tian Yu Wang Yuan Yao Shaoliang Lin Xiang ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton

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Science China Life Sciences 2025年

作者： Yanlong Li Yinuo Fu Yaoyao Li Rui Zhang Jing Yang Huanhuan ma Ling Min Xianlong Zhang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University

High temperature (HT) stress causes male sterility,leading to reduced upland cotton ***,we identified a key gene,Casein Kinase I (GhCKI),that negatively regulates male fertility in upland cotton under ***,conventional genetic manipulations of GhCKI would result in male sterility,hindering its utilization in breeding ***,we engineered quantitative variation for anther thermotolerance-related traits in upland cotton by creating weak promoter alleles of GhCKI genes,using CRISPR/Cas9 and CRISPR/Cpf1genome ***,we screened and identified two new upland cotton plant lines exhibiting a HT-tolerant phenotype with edited GhCKI promoters,and characterized their corresponding heat-tolerant allelic *** research revealed that the primary reason for the HT tolerance of the GhCKI promoter editing mutants is that the trans-acting factors GhMYB73 and GhMYB4,which positively regulate GhCKI expression under HT,failed to bind and activate the expression of ***,our study not only provides a rapid strategy to generate new beneficial alleles but also offers novel germplasm resources and molecular insights for crop HT tolerance breeding.

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数字普惠金融的农户增收效应与作用机制——基于陕西省9市18县的调查数据

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西北农林科技大学学报（社会科学版） 2025年第1期25卷 101-110页

作者：马红刚西安交通大学经济与金融学院西安710049

拓展农民增收致富渠道是完善城乡融合发展体制机制的关键环节,也是中国实现共同富裕的核心目标。基于陕西省9市18县(区)3658份农户微观调研数据,运用逻辑回归模型与中介效应模型,分析了数字普惠金融对农户家庭收入的影响及其作用机制。... 详细信息

拓展农民增收致富渠道是完善城乡融合发展体制机制的关键环节,也是中国实现共同富裕的核心目标。基于陕西省9市18县(区)3658份农户微观调研数据,运用逻辑回归模型与中介效应模型,分析了数字普惠金融对农户家庭收入的影响及其作用机制。研究表明,数字普惠金融对农户家庭收入具有显著的正向影响,数字普惠金融发展水平越高的县域,农户的家庭收入水平越高,特别是在数字普惠金融的使用深度、覆盖广度与数字化程度方面,影响尤为显著。进一步探讨作用机制后发现,缓解家庭金融约束、促进信息对称与扩大农业经营规模是数字普惠金融促进农户增收的主要途径。此外,数字普惠金融的增收效应存在异质性,农村居民的金融素养与金融市场参与度越高,数字普惠金融对农户家庭收入的正向影响越显著。

关键词：数字普惠金融农户增收信息获取农业经营规模信贷约束

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