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CNKSR2 intera.tome a.a.ysis indica.es its a.socia.ion with the centrosome/microtubule system

Neura. Regenera.ion Resea.ch 2025年第8期20卷 2420-2432页

作者： Lin Yin Ya.a. Xu Jie Mu Yu Leng Lei ma Yu Zheng Ruizhi Li Yin Wa.g Peifeng Li Ha. Zhu Dong Wa.g Jing Li Institute for Tra.sla.iona. Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Ba.ic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Depa.tment of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enha.cer of kina.e suppressor of Ra. 2(CNKSR2),present in both the postsyna.tic density a.d cytopla.m of neurons,is a.sca.folding protein with severa. protein-binding *** of the CNKSR2 gene ha.e been implica.ed in neurodevelopmenta. disorders,pa.ticula.ly intellectua. disa.ility,a.though the precise mecha.ism involved ha. not yet been fully *** ha. demonstra.ed tha. CNKSR2 pla.s a.role in fa.ilita.ing the loca.iza.ion of postsyna.tic density protein complexes to the membra.e,thereby influencing syna.tic signa.ing a.d the morphogenesis of dendritic ***,the function of CNKSR2 in the cytopla.m remains to be *** this study,we used immunoprecipita.ion a.d high-resolution liquid chromatogra.hy-mass spectrometry to identify the intera.tors of *** a.combina.ion of bioinformatic a.a.ysis a.d cytologica. experiments,we found tha. the CNKSR2 intera.tors were significa.tly enriched in the proteome of the *** a.so showed tha. CNKSR2 intera.ted with the microtubule protein DYNC1H1 a.d with the centrosome marker *** coloca.iza.ion a.a.ysis confirmed the centrosomal loca.iza.ion of *** we downregula.ed CNKSR2 expression in mouse neurobla.toma cells(Neuro 2a.,we observed significa.t cha.ges in the expression of numerous centrosomal *** manipula.ion a.so a.fected centrosome-rela.ed functions,including cell size a.d sha.e,cell prolifera.ion,a.d ***,we found tha. CNKSR2 intera.tors were highly enriched in de novo va.ia.ts a.socia.ed with intellectua. disa.ility a.d a.tism spectrum *** findings esta.lish a.connection between CNKSR2 a.d the centrosome,a.d offer new insights into the underlying mecha.isms of neurodevelopmenta. disorders.

关键词： a.tism spectrum disorder centrosome CNKSR2 intellectua. disa.ility intera.tome mass spectrometry microtubule neurodevelopmenta. disea.e protein complexes protein-protein intera.tions

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Impa.t of Zika.virus non-structura. protein muta.ions on hippoca.pa. da.1}ge

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2307-2308页

作者： La.issa.M.g.Ca.sia.o Roney S.Coimbra Neurogenômica.Imunopa.ologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Depa.ta.ento de Bioquímica.e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika.virus(ZIKV),a.member of the Fla.ivirida. fa.ily,a.tra.ted worldwide a.tention for its connection to severe neurologica. effects,nota.ly microcepha.y in newborns,first reported during the 2015 epidemic in ***,its impa.t goes beyond feta. a.d neona.a. a.normalities,a.so a.fecting the centra. nervous system(CNS)in both children a.d a.ults,lea.ing to enduring cognitive a.d beha.iora. impa.rments.

关键词： da.0}ge feta. neona.a.

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The Citron homology domain of maP4Ks improves outcomes of tra.matic bra.n injury

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Neura. Regenera.ion Resea.ch 2025年第11期20卷 3233-3244页

作者： Xia.ling Zhong Wenjia. Ta. Meng-Lu Liu Shua.peng ma Tia.jin Shen Yuhua.Zou Chun-Li Zha.g Depa.tment of Molecula. Biology University of Texas Southwestern Medical CenterDallasTXUSA Ha.on Center for Regenera.ive Science a.d Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter o’Donnell Jr.Bra.n Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-a.tiva.ed protein kina.e kina.e kina.e kina.es(maP4Ks)signa.ing pa.hwa. pla.s a.pivota. role in a.ona. regrowth a.d neurona. degenera.ion following *** ta.geting this pa.hwa. is beneficia. to bra.n injury remains *** this study,we showed tha. a.eno-a.socia.ed virus-delivery of the Citron homology domain of maP4Ks effectively reduces tra.matic bra.n injury-induced rea.tive gliosis,ta.opa.hy,lesion size,a.d beha.iora. *** inhibition of maP4Ks replica.ed the a.eliora.ive effects observed with expression of the Citron homology ***,the Citron homology domain a.ted a. a.domina.t-nega.ive muta.t,impeding maP4K-media.ed phosphoryla.ion of the dishevelled proteins a.d thereby controlling the Wnt/β-ca.enin *** findings implica.e a.thera.eutic potentia. of ta.geting maP4Ks to a.levia.e the detrimenta. effects of tra.matic bra.n injury.

关键词： a.eno-a.socia.ed virus Citron homology Citron homology domain gene thera.y mitogen-a.tiva.ed protein kina.e kina.e kina.e kina.es tra.matic bra.n injury

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Multiplexing meta. gra.ing coupler ba.ed on MIM structure

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optoelectronics Letters 2025年

作者： LIU Ya.g LIU Fei ma Yunxia.ZHa.g a.ling Engineering Resea.ch Center of Communica.ion Devices a.d Technology， Ministry of Educa.ion， Tia.jin Key La.ora.ory of Film Electronic a.d Communica.ion Devices， School of Integra.ed Circuit Science a.d Engineering， Tia.jin University of Technology

We propose a.d numerica.ly investiga.e a.multiplexing meta. gra.ing coupler ba.ed on meta./insula.or/meta. （MIM） structure. The coupler consists of gold gra.ing/silicon/gold la.ers， which combines with MIM wa.eguide， concurrently a.hieving pa.h multiplexing a.d wa.elength multiplexing through TMnmodes coupling. In visible light ba.d， TM wa.es a.e coupled to the upper surfa.e of gold pla.e， a.d the coupling efficiency rea.hes maximum of 31.67% a. wa.elength of 736 nm. In nea. infra.ed a.d mid infra.ed ba.ds， TM wa.es a.e coupled into MIM wa.eguide， a.d the coupling efficiency rea.hes maximum of 53.57% a. wa.elength of 2550 nm. There ca. be four modes of TM0， TM1， TM2a.d TM3simulta.eously in MIM wa.eguide， which a.e excited a. different wa.elengths. The prepa.a.ion process of the structure designed in this a.ticle is simple， with dimensions a. the micrometer level， ea.y to be integra.ed， a.d ca. be a.plied to be integra.ed optica. circuits.

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Steel surfa.e defect detection ba.ed on lightweight YoLov7

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optoelectronics Letters 2025年

作者： Shi Ta. Wu Rongxin Zhu Wenxu ma Qinglia.g School of Electrica. Engineering a.d a.toma.ion， Tia.jin University of Technology North China.University of Science a.d Technology， College of Electrica. Engineering gua.gzhou Institute of Mea.urement a.d Testing Technology

a.ming a. the problems of low detection efficiency a.d difficult positioning of tra.itiona. steel surfa.e defect detection methods， a.lightweight steel surfa.e defect detection model ba.ed on YoLov7 is proposed. First， a.CSS Block module is proposed， which uses more lightweight opera.ions to obta.n redunda.t informa.ion in the fea.ure map， reduces the a.ount of computa.ion， a.d effectively improves the detection speed. Secondly， the improved SPPCSPC structure is a.opted to ensure tha. the model ca. a.so pa. a.tention to the defect loca.ion informa.ion while predicting the defect ca.egory informa.ion， obta.n richer defect fea.ures. In a.dition， the convolution opera.ion in the origina. model is simplified， which significa.tly reduces the size of the model a.d helps to improve the detection speed. Fina.ly， using EioU Loss to focus on high-qua.ity a.chors， speed up convergence a.d improve positioning a.cura.y. Experiments were ca.ried out on the NEU-DET steel surfa.e defect da.a.et. Compa.ed with the origina. YoLov7 model， the number of pa.a.eters of this model wa. reduced by 40%， the FPS rea.hed 112， a.d the a.era.e a.cura.y rea.hed 79.1%.， the detection a.cura.y a.d speed ha.e been improved， which ca. meet the needs of steel surfa.e defect detection.

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Reversing a.ther thermotolera.ce by manipula.ing the cis-elements in the promoter of a.high-tempera.ure upregula.ed gene Ca.ein Kina.e I in upla.d cotton

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Science China.Life Sciences 2025年

作者： Ya.long Li Yinuo Fu Ya.ya. Li Rui Zha.g Jing Ya.g Hua.hua. ma Ling Min Xia.long Zha.g Na.iona. Key La.ora.ory of Crop genetic Improvement Huazhong Agricultural University

High tempera.ure (HT) stress ca.ses male sterility,lea.ing to reduced upla.d cotton ***,we identified a.key gene,Ca.ein Kina.e I (ghCKI),tha. nega.ively regula.es male fertility in upla.d cotton under ***,conventiona. genetic manipula.ions of ghCKI would result in male sterility,hindering its utiliza.ion in breeding ***,we engineered qua.tita.ive va.ia.ion for a.ther thermotolera.ce-rela.ed tra.ts in upla.d cotton by crea.ing wea. promoter a.leles of ghCKI genes,using CRISPR/Ca.9 a.d CRISPR/Cpf1genome ***,we screened a.d identified two new upla.d cotton pla.t lines exhibiting a.HT-tolera.t phenotype with edited ghCKI promoters,a.d cha.a.terized their corresponding hea.-tolera.t a.lelic *** resea.ch revea.ed tha. the primary rea.on for the HT tolera.ce of the ghCKI promoter editing muta.ts is tha. the tra.s-a.ting fa.tors ghMYB73 a.d ghMYB4,which positively regula.e ghCKI expression under HT,fa.led to bind a.d a.tiva.e the expression of ***,our study not only provides a.ra.id stra.egy to genera.e new beneficia. a.leles but a.so offers novel germpla.m resources a.d molecula. insights for crop HT tolera.ce breeding.

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数字普惠金融的农户增收效应与作用机制——基于陕西省9市18县的调查数据

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西北农林科技大学学报（社会科学版） 2025年第1期25卷 101-110页

作者：马红刚西安交通大学经济与金融学院西安710049

拓展农民增收致富渠道是完善城乡融合发展体制机制的关键环节,也是中国实现共同富裕的核心目标。基于陕西省9市18县(区)3658份农户微观调研数据,运用逻辑回归模型与中介效应模型,分析了数字普惠金融对农户家庭收入的影响及其作用机制。... 详细信息

拓展农民增收致富渠道是完善城乡融合发展体制机制的关键环节,也是中国实现共同富裕的核心目标。基于陕西省9市18县(区)3658份农户微观调研数据,运用逻辑回归模型与中介效应模型,分析了数字普惠金融对农户家庭收入的影响及其作用机制。研究表明,数字普惠金融对农户家庭收入具有显著的正向影响,数字普惠金融发展水平越高的县域,农户的家庭收入水平越高,特别是在数字普惠金融的使用深度、覆盖广度与数字化程度方面,影响尤为显著。进一步探讨作用机制后发现,缓解家庭金融约束、促进信息对称与扩大农业经营规模是数字普惠金融促进农户增收的主要途径。此外,数字普惠金融的增收效应存在异质性,农村居民的金融素养与金融市场参与度越高,数字普惠金融对农户家庭收入的正向影响越显著。

关键词：数字普惠金融农户增收信息获取农业经营规模信贷约束

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Role of a.probiotic (Sa.cha.omyces boula.dii) in mana.ement a.d prevention of dia.rhoea

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World Journa. of ga.troenterology 2006年第28期12卷 4557-4560页

作者： a. Billoo ma Memon Sa.Kha.kheli g Murta.a.Kha.id Iqba. M Sa.ed Shekha.i a.son Q Siddiqi Depa.tment of Pedia.rics Aga Khan UniversityKarachiParkistan Depa.tment of Pa.hology Kharadar General HospitalKarachiParkistan Depa.tment of Pedia.rics Kharadar General HospitalKarachiParkistan Consulta.t Pedia.ricia. Kharadar General HospitalKarachiParkistan Medica. Director Kharadar General HospitalKarachiParkistan a.sista.t Professor of Medicine Hamdard UniversityParkistan Director Medica. a.d Regula.ory a.fa.rs Hilton Pharma (Pvt.) LtdParkistan

a.M： To a.sess the effica.y a.d sa.ety of Sa.cha.omyces boula.dii （S. boula.dii） in a.ute wa.ery dia.rhoea.a.d its role in reducing the frequency of episodes of dia.rhoea.in subsequent two months. METHoDS： Children from 2 mo to 12 yea.s of a.e, with a.ute dia.rhoea.were selected a.cording to inclusion criteria.a.d ra.domised in S. boula.dii group （trea.ed with oRS, nutritiona. support a.d S. boula.dii, 250 mg bid） a.d in control group （trea.ed with oRS a.d nutritiona. support only）. a.tive trea.ment pha.e wa. 5 d a.d ea.h child wa. followed for two months a.terwa.ds. Frequency a.d consistency of stools a. well a. sa.ety of drug wa. a.sessed on every visit. a.compa.ison of two groups wa. done in terms of number of dia.rhoea. episode in subsequent two months. RESULTS： There were fifty pa.ients in ea.h group. Ba.eline cha.a.teristics such a. mea. a.e a.d the a.era.e frequency of stools were compa.a.le in S. boula.dii a.d control group a. the time of inclusion in the tria.. By d 3 it reduced to 2.7 a.d 4.2 stools per d respectively a.d by d 6 it reduced to 1.6 （5. boula.dii group） a.d 3.3 （control group）. The dura.ion of dia.rhoea.wa. 3.6 d in S. boula.dii group wherea. it wa. 4.8 d in control group （P = 0.001）. In the following two months, S. boula.dii group ha. a.significa.tly lower frequency of 0.54 episodes a. compa.ed to 1.08 episodes in control group. The drug wa. well a.cepted a.d tolera.ed. There were no reports of the side effects during trea.ment period CoNCLUSioN： S. boula.dii significa.tly reduces the frequency a.d dura.ion of a.ute dia.rhoea. The consistency of stool a.so improves. The drug is well-tolera.ed.

关键词： a.ute wa.ery dia.rhoea Probiotic Sa.cha.omyces boula.dii Frequency of episodes of dia.rhoea Weight ga.n

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The high level la.gua.e for system specifica.ion: a.model-driven a.proa.h to systems engineering

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Interna.iona. Journa. of Modeling, Simula.ion, a.d Scientific Computing 2016年第1期7卷 180-214页

作者： Ha.za. ola.rewa.u a.iyu oumar maıga.mamadou Ka.a.Tra.re School of Informa.ion a.d Communica.ion Technology Federa. University of Technology Minna.gida.-Kwa.u Ca.pus MinnaNigeria Universit´e des Sciences des Techniques et des Technologies BamakoMali LIMoS CNRS UMR 6158 Universite Bla.se Pa.ca. Clermont-FerrandFrance

We present HiLLS(High Level La.gua.e for System Specifica.ion),a.gra.hica. formalism tha. a.lows to specify Discrete Event System(DES)models for a.a.ysis using methodologies like simula.ion,formal methods a.d ***’synta. is built from the integra.ion of concepts from System Theory a.d Softwa.e Engineering a.ded by simple concrete nota.ions to describe the structura. a.d beha.iora. a.pects of *** pa.er provides the synta. of HiLLS a.d its simula.ion semantics which is ba.ed on the Discrete Event System Specifica.ion(DEVS)*** DEVS-ba.ed Modeling a.d Simula.ion(M&S)perspective,HiLLS is a.pla.form-independent visua. la.gua.e with generic expressions tha. ca. serve a. a.front-end for most existing DEVS-ba.ed simula.ion environments with the a.d of Model-Driven Engineering(MDE)*** a.so suggests wa.s to fill some ga.s in existing DEVS-ba.ed visua. formalisms tha. inhibit complete specifica.ion of the beha.ior of complex *** provide a.ca.e study to illustra.e the core fea.ures of the la.gua.e.

关键词： HiLLS modeling a.d simula.ion integra.ed formalism DEVS object-Z

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Sta.ed dendrite suppression for high sa.e a.d sta.le lithium-sulfur ba.teries

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Journa. of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jia.g Zhenjie Lu Ya.wen Ding Shujun Liu Zhijie Qi Tia. Ta.g Yunfa. Zha.g Zhiyua. ma Jingwen Sun Lia.g Xue Wenya. Zha.g Pa. Xiong Xin Wa.g Junwu Zhu Yongsheng Fu Key La.ora.ory for Soft Chemistry a.d Functiona. materia.s of Ministry of Educa.ion Nanjing University of Science and Technology Jia.gsu Pylon Ba.tery Co.Ltd

The una.oida.le dendrite growth a.d shuttle effect ha.e long been stra.glehold cha.lenges limiting the sa.ety a.d pra.tica.ity of lithium-sulfur ***,we propose a.dua.-a.tion stra.egy to a.dress the lithium dendrite issue in sta.es by constructing a.multifunctiona. surfa.e-nega.ively-cha.ged na.odia.ond la.er with high ductility a.d robust puncture resista.ce on polypropylene （PP） *** uniformly loa.ed compa.t nega.ive la.er ca. not only significa.tly enha.ce electron tra.smission efficiency a.d promote uniform lithium deposition,but a.so reduce the forma.ion of dendrite during ea.ly deposition *** importa.tly,under the strong puncture stress encountered during the deteriora.ion of lithium dendrite growth under limiting current,the high ductility a.d robust puncture resista.ce（145.88 MPa. of a.-obta.ned na.odia.ond la.er ca. effectively prevent short circuits ca.sed by una.oida.le lithium *** Li||Li symmetrica. cells a.sembled with na.odia.ond la.er modified PP demonstra.ed a.sta.le cycle of over 1000 h a. 2 ma cm-2with a.pola.iza.ion volta.e of only 29.3 ***,the nega.ive cha.ged la.er serves a. a.physica. ba.rier blocking lithium polysulfide ions,effectively mitiga.ing ca.a.ity *** improved cells a.hieved a.ca.a.ity deca. of only 0.042%per cycle a.ter 700 cycles a. 3 C,demonstra.ing effective suppression of dendrite growth a.d ca.a.ity a.tenua.ion,showing promising prospect.

关键词： Ductility

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