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A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

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Bone Research 2024年第1期12卷 227-239页

作者： Yong Li Zhengwen Cai Wenjuan ma Long Bai en Luo Yunfeng Lin State Key Laboratory of oral Diseases&National Center for Stomatology&National Clinical Research Center for oral Diseases West China Hospital of StomatologySichuan UniversityChengduSichuan 610041PR China Department of oral and maxillofacial Surgery Affiliated Stomatological HospitalSouthwest Medical UniversityLuzhouSichuan 646000PR China Sichuan provincial engineering Research Center of oral Biomaterials ChengduSichuan 610041China

Diabetic osteoporosis(DoP)is a significant complication that poses continuous threat to the bone health of patients with diabetes;however,currently,there are no effective treatment *** patients with diabetes,the increased levels of ferroptosis affect the osteogenic commitment and differentiation of bone mesenchymal stem cells(BMSCs),leading to significant skeletal *** address this issue,we aimed to target ferroptosis and propose a novel therapeutic approach for the treatment of *** synthesized ferroptosis-suppressing nanoparticles,which could deliver curcumin,a natural compound,to the bone marrow using tetrahedral framework nucleic acid(tFNA).This delivery system demonstrated excellent curcumin bioavailability and stability,as well as synergistic properties with *** in vitro and in vivo experiments revealed that nanoparticles could enhance mitochondrial function by activating the nuclear factor E2-related factor 2(NRF2)/glutathione peroxidase 4(GPX4)pathway,inhibiting ferroptosis,promoting the osteogenic differentiation of BMSCs in the diabetic microenvironment,reducing trabecular loss,and increasing bone *** findings suggest that curcumin-containing DNA tetrahedron-based ferroptosissuppressing nanoparticles have a promising potential for the treatment of DoP and other ferroptosis-related diseases.

关键词： curcumin osteoporosis diabetic

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Effect of resistance training volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females:Systematic review and meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2024年第2期13卷 145-159页

作者： Paulo ricardo prado Nunes Pamela Castro-e-Souza Anselmo Alves de oliveira Bruno de Freitas Camilo Gislaine Cristina-Souza Lucio marques Vieira-Souza marcelo Augusto da Silva Carneiro Department of Body and Human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil University Center of Planalto de Araxa(UNiaRAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exercise and Nutrition Research Group(GPen) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Sciences and Physical Exercise Study and Research Group(GEPCEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgraduate program in Physical Education Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older ***:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and *** controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(CG) were *** reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) *** body and abdominal adiposity,blood lipids,glucose,and C-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%CI) were used for ***:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were *** groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to ***,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared to ***:Compared to CG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.

关键词： C-reactive protein Fat mass Lipid profile Menopause Strength training

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Achieving high strength and rapid degradation in Mg-Gd-Ni alloys by regulating LPSo phase morphology combined with extrusion

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Journal of magnesium and Alloys 2024年第6期12卷 2312-2326页

作者： Kai ma Jingfeng Wang Yinhong Peng Chaoneng dai Yuanlang Pan Ye Wang danqian Wang Jinxing Wang Yanlong ma Fusheng Pan College of materials Science and engineering Chongqing UniversityChongqing 400044PR China National engineering Research Center for magnesium Alloys Chongqing 400044PR China College of Chemistry and Chemical engineering Chongqing UniversityChongqing 401331PR China College of materials Science and engineering Chongqing University of TechnologyChongqing 400054PR China

In this study,Mg-13.2Gd-4.3Ni alloys containing continuous bulk-shaped long-period stacking ordered(LPSo),lamellar LPSo,and a small amount of eutectic phase were prepared,and the evolution of microstructure at different extrusion temperatures and its influence on mechanical and degradation properties as well as corrosion mechanism were *** before extrusion can effectively promote the precipitation of lamellar LPSo in ***400 with higher volume fraction of non-DRXed grains exhibited higher strength,which was mainly due to strong texture,high dislocation density,and high volume fraction of lamellar *** EX420 with higher volume fraction of DRXed grains showed higher degradation rate,which was mainly due to the higher density of grain *** EX400 exhibited excellent comprehensive properties with tensile yield strength(TYS)of 334 MPa,ultimate tensile strength(UTS)of 484 MPa and elongation(EL)of 7.4%,ultimate compressive strength(UCS)of 638 MPa and compressive yield strength(CYS)of 443 MPa,degradation rate of 86.1 mg/cm^(2)/h at 93℃in 3 wt.%KCl solution.

关键词： Mg-Gd-Ni alloys LPSo Mechanical properties Degradation rate

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The g-factor measurement as an ultimate test for nuclear chirality

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Frontiers of physics 2024年第3期19卷 1-10页

作者： Ernest Grodner Michał Kowalczyk Julian Srebrny Leszek próchniak Chrystian Droste Jan Kownacki maciej Kisieliński Krzysztof Starosta Takeshi Koike National Centre for Nuclear Research 05-540ŚwierkPoland Heavy Ion Laboratory University of WarsawPasteura 5a02-093 WarsawPoland Faculty of Physics University of WarsawPasteura 502-093 WarsawPoland Simon Fraser University 8888 University Drive BurnabyB.C.Canada V5A 1S6 Department of Physics Tohoku UniversitySendaiMiyagi 980-8577Japan

We present results of a series of experiments aimed at finding the most direct fingerprints of a phenomenon of nuclear chirality. These experiments brought a detailed knowledge of the so called partner bands in 132La, 128Cs and 126Cs including absolute values of E2 and M1 transition probabilities obtained through the DSA (Doppler Shift Attenuation) method. Considering the indirect character of observables such as energies and transition rates we proposed measurement of the g-factor of a chosen state as a direct, ultimate test of chirality. our experiment on the bandhead of partner bands in 128Cs showed feasibility of this approach. Measured value of the g-factor which suggests non-chiral character of this state leads to another puzzle in the chirality studies — how the chirality emerges with increasing spin of levels along a partner band.

关键词： nuclear chirality electromagnetic transitions electromagnetic moments level lifetimes

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The prediction of projectile-target intersection for moving tank based on adaptive robust constraint-following control and interval uncertainty analysis

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Defence Technology（防务技术） 2024年第1期31卷 351-363页

作者： Cong Li Xiuye Wang Yuze ma Fengjie Xu Guolai Yang The School of Mechanical engineering Nanjing University of Science and TechnologyNanjing290014PR China Inner Mongolia North Heavy Industries Co. Ltd.Baotou014033PR China Nanjing Chenguang Group Co. Ltd.Nanjing210006PR China

To improve the hit probability of tank at high speed,a prediction method of projectile-target intersection based on adaptive robust constraint-following control and interval uncertainty analysis is *** method proposed provides a novel way to predict the impact point of projectile for moving ***,bidirectional stability constraints and stability constraint-following error are constructed using the Udwadia-Kalaba theory,and an adaptive robust constraint-following controller is designed considering ***,the exterior ballistic ordinary differential equation with uncertainties is integrated into the controller,and the pointing control of stability system is extended to the impact-point control of ***,based on the interval uncertainty analysis method combining Chebyshev polynomial expansion and affine arithmetic,a prediction method of projectile-target intersection is ***,the co-simulation experiment is performed by establishing the multi-body system dynamic model of tank and mathematical model of control *** results demonstrate that the prediction method of projectile-target intersection based on uncertainty analysis can effectively decrease the uncertainties of system,improve the prediction accuracy,and increase the hit *** adaptive robust constraint-following control can effectively restrain the uncertainties caused by road excitation and model error.

关键词： Tank stability control Constraint-following Adaptive robust control Uncertainty analysis prediction of projectile-target intersection

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progress of proximity Sensors for Potential Applications in Electronic Skins

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Transactions of Tianjin University 2024年第1期30卷 40-62页

作者： Runnan Zou Yanhong Tong Jiayi Liu Jing Sun da Xian Qingxin Tang Center for Advanced optoelectronic Functional materials Research Key Lab of UV-Emitting Materials and Technology of Ministry of EducationNortheast Normal UniversityChangchun 130024China

Recently,electronic skins and fl exible wearable devices have been developed for widespread applications in medical monitoring,artifi cial intelligence,human–machine interaction,and artifi cial *** proximity sensors can accurately perceive external objects without contact,introducing a new way to achieve an ultrasensitive perception of *** article reviews the progress of fl exible capacitive proximity sensors,fl exible triboelectric proximity sensors,and fl exible gate-enhanced proximity sensors,focusing on their applications in the electronic skin fi ***,their working mechanism,materials,preparation methods,and research progress are discussed in ***,we summarize the future challenges in developing fl exible proximity sensors.

关键词： Capacitive proximity sensors Triboelectric proximity sensors Gate-enhanced proximity sensors Flexible wearable devices Electronic skins

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A self-centering and stiffness-controlled MEMS accelerometer

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Microsystems & Nanoengineering 2024年第1期10卷 27-40页

作者： Yiming Jin Zhipeng ma Ziyi Ye Mingkang Li Xudong Zheng Zhonghe Jin School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310013China Key Laboratory of Micro/Nano-Satellite Research of Zhejiang province Hangzhou 310007PR China

This paper presents a high-performance MEMS accelerometer with a DC/AC electrostatic stiffness tuning capability based on double-sided parallel plates(DSPPs).DC and AC electrostatic tuning enable the adjustment of the effective stiffness and the calibration of the geometric offset of the proof mass,respectively.A dynamical model of the proposed accelerometer was developed considering both DC/AC electrostatic tuning and the temperature *** on the dynamical model,a self-centering closed loop is proposed for pulling the reference position of the forceto-rebalance(FTR)to the geometric center of *** self-centering accelerometer operates at the optimal reference position by eliminating the temperature drift of the readout circuit and nulling the net electrostatic tuning *** stiffness closed-loop is also incorporated to prevent the pull-in instability of the tuned low-stiffness accelerometer under a dramatic temperature ***-time adjustments of the reference position and the DC tuning voltage are utilized to compensate for the residue temperature drift of the proposed *** a result,a novel controlling approach composed of a self-centering closed loop,stiffness-closed loop,and temperature drift compensation is achieved for the accelerometer,realizing a temperature drift coefficient(TDC)of approximately 7μg/℃ and an Allan bias instability of less than 1μg.

关键词： stiffness electrostatic centering

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Flexible wearable sensors:An emerging platform for monitoring of bacterial infection in skin wounds

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engineered Regeneration 2024年第2期5卷 186-198页

作者： Hao Meng Weicheng Zhong Kui ma Jianlong Su Liqian ma Yaying Hao Yufeng Jiang Xi Liu Xiaobing Fu Cuiping Zhang Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical CollegeBeijing 100048PR China PLA Key Laboratory of Tissue Repair and Regenerative Medicine Beijing 100048PR China Beijing Key Research Laboratory of Skin Injury Repair and RegenerationBeijing 100048PR China Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048PR China College of Graduate Tianjin Medical UniversityTianjin300070PR China Department of Tissue Regeneration and Wound Repair PLA General HospitalBeijingPR China

Persistent inflammatory responses often occur when bacteria and other microorganisms frequently invade and colonize open wounds and eventually result in the formation of chronic ***,achieving real-time detection of invasive bacteria accurately and promptly is essential for efficient wound management and accelerat-ing the healing ***,flexible wearable sensors have garnered significant attention,especially those designed for monitoring real-time biophysical or biochemical signals in wound sites in a minimally invasive *** provide more precise and continuous monitoring data,making them as emerging tools for clinical *** this review,we first discuss the species and community distribution of different types of bacteria in chronic ***,we introduce currently developed techniques for detecting bacteria at wound ***-lowing that,we discuss the recent progress and unresolved issues of various flexible wearable sensors in detecting bacteria at wound *** believe that this review can provide meaningful guidance for the development of flexible wearable sensors for bacteria detection.

关键词： Flexible wearable sensors Chronic wounds Bacterial infections Real-time detection

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Synthesis and microwave absorption performance of heat-treated RF/Sio_(2)aerogels

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Defence Technology（防务技术） 2024年第4期34卷 177-186页

作者： Xinli Ye Hao Yu Kai Zheng Shan Li Xiaomin ma Bangxiao mao Junxiong Zhang School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072PR China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057PR China Yangtze River Delta Research Institute of Northwestern Polytechnical University Suzhou 215400PR China National Equipment New material&Technology(Jiangsu)Co. LtdSuzhou 215400PR China Beijing Xinfeng Aerospace Equipment Co. LtdBeijing 100854PR China School of Textile and Clothing Nantong UniversityNantong 226019PR China

The well-designed composite with satisfactory electromagnetic microwave absorption at high temperatures remains a serious ***,we fabricated a resorcinol-formaldehyde/silica dioxide composite aerogel(RF/Sio_(2))with a three-dimensional network structure using sol-gel,atmospheric pressure drying technique as well as heat-treated processes to achieve enhanced microwave absorption capabilities in the low frequency *** pristine RF/Sio_(2)aerogel presented a typical micropores structure with a surface area,porous volume,and density of 146.82 m^(2)/g,62.40%,and 0.28 cm^(3)/g,***,the RF/Sio_(2)aerogel showed an effective absorption bandwidth of 3.56 GHz and a minimum reflection loss value of-46.10 d B at 2.25 mm after being heat-treated at 1500°C,while the maximum effective absorption bandwidth was 3.60 GHz at 2.30 *** intricate three-dimensional networks possessed remarkable impedance matching,multiple attenuation mechanisms,interfacial polarization,and dielectric loss,which were attributed to the exceptional ability to absorb electromagnetic *** offered a fresh approach to creating adaptable and effective microwave absorption materials in military defense.

关键词： RF/Sio_(2) Aerogel Heat-treated Microwave absorption

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Experimental research on the launching system of auxiliary charge with filter cartridge structure

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Defence Technology（防务技术） 2024年第1期31卷 41-48页

作者： Zi-Jun Chen Ze He Hong-Hao ma Lu-Qing Wang Zhao-Wu Shen CAS Key Laboratory of Mechanical Behavior and Design of materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefeiAnhui230027PR China State Key Laboratory of Fire Science University of Science and Technology of ChinaHefeiAnhui230026PR China

A launching system with a filter cartridge structure was proposed to improve the muzzle velocity of the *** combustion chamber of the launching system is divided into two fixed chambers,one is located in the breech chamber,and the other is arranged in the *** breech chamber charge was ignited first,and the charges in the auxiliary chambers were ignited by the high-temperature,highpressure combustible gas trailing the *** this way,the combustible gas in the auxiliary chambers could compensate for the pressure drop caused by the movement of the *** proposed device features the advantage of launching a projectile with high muzzle velocity without exceeding the maximum pressure in the *** order to obtain some internal ballistic characteristics of the launch system,some critical structure,such as the length of the filter cartridge auxiliary charge,the combustion degree of the propellant in the chamber,and the length of the barrel,are *** experimental results show that with the increased auxiliary charge length,a pressure plateau or even a secondary peak pressure can be formed,which is less than the peak *** projectile velocity increased by 23.57%,14.64%,and 7.65%when the diaphragm thickness was 0 mm,1 mm,and2 mm,*** muzzle velocity of the projectile can be increased by 13.42%by increasing the length of the *** the same charge condition,with the increase of barrel length,the energy utilization rate of propellant increases by 28.64%.

关键词： Interior ballistics Charge structures Launch system Charge design

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