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Efficacy of Huangma Ding or autologous platelet-rich gel for the diabetic lower extremity arterial disease patients with foot ulcers

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World Journal of Diabetes 2024年第5期15卷 923-934页

作者： Xue-Qin Wang Dan-lan Pu Wei-Ling Leng Xiao-Tian Lei Jiang Juan Zou la Ding Yao Jia-Zhuang Xi Li Jian Teng Miao Qi-Nan Wu Endocrinology Department The People’s Hospital of Yubei District of Chongqing CityChongqing 401120China Department of Endocrinology Chongqing Yubei District People’s HospitalChongqing 400030China Endocrinology Department The First Affiliated Hospital of the Army Medical UniversityChongqing 400038China Endocrinology and Nephrology Department Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer HospitalChongqing 400016China Department of Endocrinology Dazu Hospital of Chongqing Medical UniversityThe People’s Hospital of DazuChongqing 402360China

BACKGROUND Diabetes foot is one of the most serious complications of diabetes and an important cause of death and disability,traditional treatment has poor efficacy and there is an urgent need to develop a practical treatment *** To investigate whether Huangma Ding or autologous platelet-rich gel(APG)treatment would benefit diabetic lower extremity arterial disease(LEAD)patients with foot *** A total of 155 diabetic LEAD patients with foot ulcers were enrolled and divided into three groups:Group A(62 patients;basal treatment),Group B(38 patients;basal treatment and APG),and Group C(55 patients;basal treatment and Huangma Ding).All patients underwent routine follow-up visits for six *** follow-up,we calculated the changes in all variables from baseline and determined the differences between groups and the relationships between *** The infection status of the three groups before treatment was the ***(PCT)improved after APG and Huangma Ding treatment more than after traditional treatment and was significantly greater in Group C than in Group *** regression analysis revealed that PCT was positively correlated with total amputation,primary amputation,and minor amputation *** ankle-brachial pressure and the transcutaneous oxygen pressure in Groups B and C were greater than those in Group *** major amputation rate,minor amputation rate,and total amputation times in Groups B and C were lower than those in Group *** Our research indicated that diabetic foot ulcers(DFUs)lead to major amputation,minor amputation,and total amputation through local infection and poor microcirculation and *** Ding and APG were effective attreating *** clinical efficacy of Huangma Ding was better than that of autologous platelet gel,which may be related to the better control of local infection by Huangma *** finding suggested that in patients with DFUs combined with coinfection,controll

关键词： Diabetic foot ulcer Huangma Ding Autologous platelet-rich gel Ankle-brachial index Transcutaneous oxygen partial pressure

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新时代中小学国际理解教育课程的内涵目标、现实境遇与建设路径

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教育理论与实践 2024年第2期44卷 16-20页

作者：罗腊梅重庆第二师范学院国际学院重庆400065

加强中小学国际理解教育课程建设是提升新时代青少年国际理解素养、培育人类社会未来发展向度具有命运共同体意识社会公民的重要路径。而科学厘清和合理辨析内涵目标是建设新时代中小学国际理解教育课程的前提,主要表现为立足中华优秀... 详细信息

加强中小学国际理解教育课程建设是提升新时代青少年国际理解素养、培育人类社会未来发展向度具有命运共同体意识社会公民的重要路径。而科学厘清和合理辨析内涵目标是建设新时代中小学国际理解教育课程的前提,主要表现为立足中华优秀传统文化认同的理论基础,树立人类命运共同体意识的愿景目标,破解人类可持续发展困境的行动取向。但是其建设过程中却面临着课程认识偏差、课程目标失衡、课程融合乏力、课程评价滞后等现实困境。为此,应从这四个维度逐一破解,精准定位新时代中小学国际理解教育课程建设,为其构建有益的建设路径。

关键词：新时代中小学国际理解教育课程课程认识课程目标课程融合课程评价

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基于转录组学探讨滋肾清肝方改善2型糖尿病糖、脂代谢的作用机制

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中国实验方剂学杂志 2024年第8期30卷 109-117页

作者：王景存田春雨张帆喇孝瑾吴范武朱亮马雷雷华北理工大学河北唐山063210 河北省中西医结合防治糖尿病及其并发症重点实验室河北唐山063210 唐山市中药药理重点实验室河北唐山063210

目的:基于网络药理学及转录组学探讨滋肾清肝方(ZSQGF)改善2型糖尿病(T2DM)模型大鼠糖、脂代谢的作用机制。方法:基于网络药理学分析ZSQGF与T2DM的差异基因,进行基因本体(GO)富集分析与京都基因与基因组百科全书(KEGG)通路富集分析,并... 详细信息

目的:基于网络药理学及转录组学探讨滋肾清肝方(ZSQGF)改善2型糖尿病(T2DM)模型大鼠糖、脂代谢的作用机制。方法:基于网络药理学分析ZSQGF与T2DM的差异基因,进行基因本体(GO)富集分析与京都基因与基因组百科全书(KEGG)通路富集分析,并通过分子对接分析对接能,验证成分与靶点结合。通过高脂喂养及注射链脲佐菌素的方法建立T2DM大鼠模型,并随机分为正常组、模型组、二甲双胍组(二甲双胍72 mg·kg^(-1))和ZSQGF高、中、低剂量组(分别折合生药量4.8、2.4、1.2 g·kg^(-1)的药液);监测大鼠的生活状态;检测大鼠血清总胆固醇(TC)、总甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)含量;对肝脏组织进行苏木素-伊红(HE)染色和油红O染色;通过肝脏转录组学分析差异基因、进行GO与KEGG富集分析,绘制蛋白质-蛋白质相互作用(PPI)网络图筛选核心靶点;结合网络药理学与转录组学分析结果进行蛋白通路验证,通过蛋白免疫印迹法(Western blot)检测肝脏核转录因子-κB(NF-κB)、基质金属蛋白酶(MMP-1、MMP-9)的蛋白表达量,通过实时荧光定量聚合酶链式反应(realtime PCR)验证B细胞淋巴瘤(Bcl)-2修正因子(BMF)、还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶4(NOX4)、脂肪酸合酶(FASN)的mRNA表达,通过免疫荧光染色检测MMP-1、MMP-9在肝脏的表达情况。结果:转录组学与网络药理学分析ZSQGF可能通过糖脂代谢通路、炎症通路作用于糖脂代谢、保护肝脏。实验证明给药8周后大鼠体质量、血糖、血清指标、病理染色结果均有改善,Western blot结果表明ZSQGF组肝脏NF-κB、MMP-1、MMP-9蛋白相对表达量降低,real-time PCR结果表明ZSQGF高剂量组BMF、NOX4、FASN转录表达降低,免疫荧光结果ZSQGF组肝脏MMP-1、MMP-9蛋白表达量降低。结论:ZSQGF可以抑制FASN的表达、减少脂质合成,并通过调节NF-κB信号通路改善糖脂代谢。

关键词：滋肾清肝方 2型糖尿病糖脂代谢网络药理学转录组学

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基于结构方程模型的大兴安岭北部天然林林下草本物种多样性驱动力分析

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西北林学院学报 2024年第2期39卷 13-20页

作者：王子瑞妙文豪呼日查高明龙刘磊李岩付宇萨如拉内蒙古农业大学林学院内蒙古呼和浩特010019 内蒙古农业大学农学院内蒙古呼和浩特010019 北京林业大学生态与自然保护学院北京100083

林下草本层植物在森林群落结构稳定性的调节和生态功能的发挥上具有非常重要的作用,是森林生态系统不可或缺的组成部分。以大兴安岭北部天然林为研究对象,运用结构方程模型探究气候、土壤和林分空间结构等环境因子对林下草本物种多样性... 详细信息

林下草本层植物在森林群落结构稳定性的调节和生态功能的发挥上具有非常重要的作用,是森林生态系统不可或缺的组成部分。以大兴安岭北部天然林为研究对象,运用结构方程模型探究气候、土壤和林分空间结构等环境因子对林下草本物种多样性的相对重要性,并探讨影响因子之间存在的复杂关系对林下草本物种多样性的影响机理。结果表明,从整体上来看,气候、土壤和林分空间结构对林下草本物种多样性均有较强的影响作用,其中气候的影响强度最大,土壤次之,林分空间结构的影响作用最小。从中介效应上来看,气候变化会导致土壤和林分空间结构发生变化,进而影响林下草本物种多样性,除此之外,还发现林分空间结构的改变,也会导致土壤性质发生变化,进而影响林下草本物种多样性。从影响系数上来看,影响林下草本物种多样性的驱动因子因各影响因素的不同而存在差异,年均降水、有机碳含量、混交度是分别表征气候因子、土壤因子、林分空间结构影响林下草本物种多样性的主导因子。在大兴安岭林区开展林下草本物种多样性保护及修复工作时,可适当调整混交度,维持合理的林分结构,并综合考虑改善土壤养分的森林经营方案。

关键词：草本物种多样性结构方程模型驱动力分析林分空间结构大兴安岭北部

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雪宝顶白钨矿的谱学特征及主微量元素分析

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光谱学与光谱分析 2024年第6期44卷 1689-1696页

作者：曹沁元史淼马世玉河北地质大学地球科学学院河北石家庄050031 河北地质大学宝石与材料学院河北石家庄050031 河北省岩石矿物材料绿色开发重点实验室河北石家庄050031 硅酸盐固废资源化利用河北省工程研究中心河北石家庄050031

白钨矿是一种稀有宝石,具粒状、块状构造,颜色为白-浅黄色,油脂光泽,荧光性明显。四川平武雪宝顶白钨矿矿床为围岩蚀变较弱的脉状热液巨晶宝石级矿床,产出白钨矿颜色饱和度较高,具完美晶型且色泽纯正,与绿柱石、锡石和白云母共生。该研... 详细信息

白钨矿是一种稀有宝石,具粒状、块状构造,颜色为白-浅黄色,油脂光泽,荧光性明显。四川平武雪宝顶白钨矿矿床为围岩蚀变较弱的脉状热液巨晶宝石级矿床,产出白钨矿颜色饱和度较高,具完美晶型且色泽纯正,与绿柱石、锡石和白云母共生。该研究选取雪宝顶近无色-橘黄色调白钨矿为研究对象,使用X射线粉晶衍射(XRD)、傅里叶变换红外光谱分析仪、紫外-可见分光光度计、激光拉曼光谱仪、电子探针、激光剥蚀电感耦合等离子体质谱仪(la-ICP-MS)的综合分析,结合矿物学、谱学与主微量元素特征,确定近无色-橘黄色调白钨矿的矿物成分、晶体结构、特征鉴别谱带、致色离子以及主微量、稀土等化学组分含量,探讨白钨矿稀土元素含量与颜色成因关系,为雪宝顶近无色-橘黄色调白钨矿提供诊断性鉴别依据。研究结果表明,白钨矿结晶程度较好,化学成分均匀,无明显间断,矿物成分含量相对集中,共生矿物多为白云母和伊利石。样品具典型的白钨矿红外特征峰440、809和870 cm^(-1)及与Ca_(2+)有关的448 cm^(-1)特征峰,谱峰显示色调越深者吸收度越高;拉曼特征峰909 cm^(-1)和Ca—O晶格振动峰207 cm^(-1),随色调加深强度加深;紫外吸收峰表现为橙黄区强吸收,尖峰在383、570、584和804 nm附近,近无色调者仅具383 nm尖峰,黄色调较浅者近紫外区Fe^(3+)吸收度较低,黄色调较深者蓝紫区Fe^(3+)强吸收且其橘黄色调由Nd^(3+)所致;白钨矿化学组分WO_(3)和CaO质量比接近甚至超过理想值,近无色者含量相对集中;微量元素中Fe元素与色调呈正相关,黄色调越深者,含量越高;稀土总量变化范围大,轻稀土更为富集,具明显的Eu负异常,Ce异常不明显。浅黄色调受微量元素Si、Fe元素及Fe^(3+)的d—d电子跃迁影响,黄色调受微量元素Mn、Fe元素及Fe^(3+)的电子跃迁所致,橘黄色调受稀土Nd和Sm元素影响较大。

关键词：雪宝顶白钨矿近无色-橘黄色调谱学特征原位微区主微量元素特征

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Quality-adjusted life years and surgical waiting list:Systematic review of the literature

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1155-1164页

作者： Roberto de la Plaza Llamas Lorena Ortega Azor marina Hernández Yuste Ludovica Gorini Raquel Aránzazu latorre-Fragua Daniel Alejandro Díaz Candelas Farah Al Shwely Abduljabar Ignacio Antonio Gemio del rey Department of General and Digestive Surgery Hospital Universitario de GuadalajaraGuadalajara 19002Spain Department of Surgery Medical and Social SciencesFaculty of Medicine and Health SciencesUniversity of AlcaláAlcaláde Henares 28871MadridSpain

BACKGROUND The quality-adjusted life year(QALY)is a metric that is increasingly used today in the field of health economics to evaluate the value of different medical treatments and *** waiting lists(SWLs)represent a pressing problem in public *** QALY measure has rarely been used in the context of *** would be interesting to know how many QALYs are lost by patients on *** To investigate the relationship between QALYs and SWLs in a systematic review of the scientific *** The study was conducted in accordance with the Preferred reporting Items for Systematic reviews and Meta-Analyses *** unlimited search was carried out in PubMed,updated on January 19,*** on the following variables were investigated and analyzed:Specialty,country of study,procedure under study,scale used to measure QALYs,the use of a theoretical or real-life model,objectives of the study and items measured,the economic value assigned to the QALY in the country in question,and the results and conclusions *** Forty-eight articles were selected for the *** data were found regarding QALYs lost on *** specialties in which QALYs were studied the most in relation to the waiting list were urology and general surgery,with 15 articles *** country in which the most studies of QALYs were carried out was the United States(n=21),followed by the United Kingdom(n=9)and Canada(n=7).The most studied procedure was organ transplantation(n=39),including 15 kidney,14 liver,5 heart,4 lung,and 1 ***(n=4),cataract surgery(n=2),bariatric surgery(n=1),mosaicplasty(n=1),and septoplasty(n=1)completed the surgical interventions ***-nine of the models used were theoretical(the most frequently applied being the markov model,n=34),and nine were *** survey used to measure quality of life in 11 articles was the European Quality of Life-5 dimensions,but in 32 articles the survey was not specified.T

关键词： Quality-adjusted life year Waitlist Quality of life Surgery Systematic review

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Carbocysteine as Adjuvant Therapy in Acute respiratory Tract Infections in Patients without Underlying Chronic Conditions: Systematic review and Meta-Analysis

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Open Journal of respiratory Diseases 2024年第2期14卷 39-50页

作者： Myriam Calle Rubio Olga de la Serna Blazquez José Luis R. martin manuel Ruiz Cuetos Pulmonology Department Hospital Clínico San Carlos Madrid Spain Department of Medicine School of Medicine Universidad Complutense de Madrid Madrid Spain Instituto de Investigacion Sanitaria del Hospital Clínico San Carlos (IdISSC) Madrid Spain Pediatric Pulmonology Unit Pediatrics Department Hospital Universitario La Paz Madrid Spain Simplifying research Institute Layos Spain Medical department in ITF research Pharma S.L.U. Alcobendas Spain

Objective: This study aims to systematically examine the existing evidence regarding the clinical benefits of carbocysteine as an adjunctive treatment in acute bronchopulmonary and otorhinological processes. Design: Systematic review and meta-analysis. Data sources: An electronic search was conducted across PubMed, Cochrane Library, ***, and the European Clinical Trial register, with the search dated to may 2023. Bibliographic references from other literature reviews and meta-analyses were also reviewed. The search was limited to randomized clinical trials published in any language and year. It was completed by cross-checking the references of the located articles. Methods: Inclusion criteria covered studies assessing systemic or inhaled carbocysteine, regardless of dosing regimen. Concomitant medication use was acceptable if balanced between intervention and control groups. Authors independently extracted data, resolving disagreements through consensus. Methodological quality assessment relied on critical reading of each study. Dichotomous variables were analyzed using odds ratio (OR), and a final effect size was calculated. Statistical significance was established when confidence intervals did not cross the neutral value. Heterogeneity was assessed via the X2 test and I2 index. results: Out of 318 initially identified studies, 4 met inclusion criteria. The meta-analysis for poor general condition yielded an OR of 0.45 in favor of intervention, p = 0.013, with non-significant heterogeneity. Cough events showed a percentage of 15.8% for carbocysteine vs. 27.2% for placebo. On the seventh day, expectoration rates were 18.37% for carbocysteinevs 33.3% for placebo. Conclusions: The observed clinical benefits align with carbocysteine’s mucoactive and muco-regulatory properties, complemented by anti-inflammatory and antioxidant actions. Carbocysteine stands out among mucolytic agents. In the context of persistent infectious diseases,

关键词： Acute respiratory Infections Carbocystenine Systematic review Meta-Analysis

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添加蒲公英对苜蓿青贮品质及抗氧化活性的影响

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草业科学 2024年第9期41卷 2155-2163页

作者：马成艳周小栋马小婧黄帅宁夏大学林业与草业学院宁夏银川750021

将药用蒲公英(Taraxacum officinale)分别以0(对照组,CK)、2%、4%、6%和8%添加至苜蓿(Medicago sativa)中进行青贮,每组4个重复,发酵60 d后测定青贮营养成分、发酵品质及抗氧化活性。结果表明,与CK相比,在营养品质上,4%组的干物质(DM)... 详细信息

将药用蒲公英(Taraxacum officinale)分别以0(对照组,CK)、2%、4%、6%和8%添加至苜蓿(Medicago sativa)中进行青贮,每组4个重复,发酵60 d后测定青贮营养成分、发酵品质及抗氧化活性。结果表明,与CK相比,在营养品质上,4%组的干物质(DM)和粗脂肪(EE)含量显著增加(Pla)含量和乳酸菌(laB)数量均显著增加,分别为4.85%和7.19 lg(cfu·g^(−1)),且氨态氮(NH_(3)-N)含量显著降低,为2.46%。抗氧化活性上,8%组类黄酮含量显著增加,为1.37%,4%、6%和8%组的总酚和总多糖含量及谷胱甘肽过氧化物酶(GSH-Px)活性均显著提高,6%组青贮的超氧化物歧化酶(SOD)活性显著提高,为241.37 U·mg^(−1),2%和6%组青贮的1,1-二苯基-2-三硝基苯肼(DPPH)清除率均显著提高,且均在90.00%以上;2%、4%和8%组青贮的总抗氧化能力(T-AOC)均显著提高,分别为0.51、0.60和0.43 mmol·L^(−1)。主成分分析和综合得分排名表现为6%组>4%组>2%组>8%组>CK。综上所述,蒲公英添加量为6.0%时对苜蓿青贮的营养品质、发酵品质和抗氧化活性效果最好。

关键词：苜蓿蒲公英营养品质发酵品质抗氧化活性黄酮多糖

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A compact multi-pixel superconducting nanowire single-photon detector array supporting gigabit space-to-ground communications

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Light(Science & Applications) 2024年第2期13卷 254-266页

作者： Hao Hao Qing-Yuan Zhao Yang-Hui Huang Jie Deng Fan Yang Sai-Ying Ru Zhen Liu Chao Wan Hao Liu Zhi-Jian Li Hua-Bing Wang Xue-Cou Tu la-Bao Zhang Xiao-Qing Jia Xing-Long Wu Jian Chen Lin Kang Pei-Heng Wu research Institute of Superconductor Electronics(riSE) School of Electronic Science and EngineeringNanjing UniversityNanjingJiangsu 210023China Purple Mountain laboratories NanjingJiangsu 211111China Hefei National laboratory HefeiAnhui 230088China National laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210023China

Classical and quantum space-to-ground communications necessitate highly sensitive receivers capable of extracting information from modulated photons to extend the communication distance from near-earth orbits to deep space *** achieve gigabit data rates while mitigating strong background noise photons and beam drift in a highly attenuated free-space channel,a comprehensive design of a multi-functional detector is *** this study,we present an innovative compact multi-pixel superconducting nanowire single-photon detector array that integrates near-unity detection efficiency(91.6%),high photon counting rate(1.61 Gcps),large dynamic range for resolving different photon numbers(1-24),and four-quadrant position sensing function all within one ***,we have constructed a communication testbed to validate the advantages offered by such an *** 8-PPM(pulse position modulation)format communication experiments,we have achieved an impressive maximum data rate of 1.5 Gbps,demonstrating sensitivities surpassing previous benchmarks at respective *** incorporating photon number information into error correction codes,the receiver can tolerate maximum background noise levels equivalent to 0.8 photons/slot at a data rate of 120 Mbps—showcasing a great potential for daylight operation ***,preliminary beam tracking tests were conducted through open-loop scanning techniques,which revealed clear quantitative dependence indicating sensitivity variations based on beam *** on the device characterizations and communication results,we anticipate that this device architecture,along with its corresponding signal processing and coding techniques,will be applicable in future space-to-ground communication tasks.

关键词： photon supporting correction

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风级对船舶主推进柴油机加速特性的影响

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哈尔滨工程大学学报 2024年第7期45卷 1330-1337页

作者：李兵权丁宇向拉随从标哈尔滨工程大学动力与能源工程学院黑龙江哈尔滨150001

为了研究船舶主推进柴油机在风浪海况下的加速特性,本文以一艘超大型油轮智能示范船为研究对象,利用模块化方法建立了柴油机、推进系统、船舶三自由度运动和风浪干扰综合模型,分别利用柴油机台架实验和实船试航数据对模型进行了验证。... 详细信息

为了研究船舶主推进柴油机在风浪海况下的加速特性,本文以一艘超大型油轮智能示范船为研究对象,利用模块化方法建立了柴油机、推进系统、船舶三自由度运动和风浪干扰综合模型,分别利用柴油机台架实验和实船试航数据对模型进行了验证。通过模拟不同风级下柴油机的加速过程,计算出不同风级下船舶主推进柴油机的运行极限,揭示风浪对推进系统加速性能的影响规律。研究结果表明:随着风级的增加,柴油机加速过程功率裕度越来越小,且风力为8、9、10级时,安全运行极限为:57.4 r/min&18866 kW、51 r/min&14910 kW、48 r/min&13560 kW;风级大小主要影响加速过程增压器效率,对增压器安全性影响较小。本文研究结果可用于指导船舶航行安全设计。

关键词：柴油机船舶推进系统恶劣海况船舶试航试验风级主机加速风浪干扰柴油机运行边界

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