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Strategies that regulate LSD1 for novel therapeutics

Acta Pharmaceutica Sinica B 2024年第4期14卷 1494-1507页

作者： meng Li mengge Dai bing Cheng Shaotong Li Enhui Guo Junwei Fu Ting ma bin Yu School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450000China Pingyuan Laboratory State Key Laboratory of Antiviral DrugsHenan Normal UniversityXinxiang 453007China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Histone methylation plays crucial roles in regulating chromatin structure and gene transcrip-tion in epigenetic ***-specific demethylase 1(LSD1),the first identified histone de-methylase,is universally overexpressed in various ***1 dysregulation is closely associated with cancer,viral infections,and neurodegenerative diseases,etc.,making it a promising therapeutic *** LSD1 inhibitors and two small-molecule degraders(UM171 and BEA-17)have entered the clinical ***1 can remove methyl groups from histone 3 at lysine 4 or lysine 9(H3K4 or H3K9),resulting in either transcription repression or *** the roles of LSD1 in transcrip-tional regulation are well-established,studies have revealed that LSDl can also be dynamically regulated by other *** example,the expression or activity of LSD1 can be regulated by many proteins that form transcriptional corepressor complexes with ***,some post-transcriptional modifica-tions and cellular metabolites can also regulate LSD1 expression or its demethylase ***,in this review,we will systematically summarize how proteins involved in the transcriptional corepressor complex,various post-translational modifications,and metabolites act as regulatory factors for LSD1 ac-tivity.

关键词： LSD1 regulation Transcription repression Transcription activation the Corepressor complex Post-transcriptional modifications Metabolites

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Experimental study on the feasibility of alternative materials for tilting pad thrust bearings operating in transition to mixed friction

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Friction 2024年第4期12卷 812-822页

作者： michałWASILCZUK michałWODTKE Faculty of Mechanical Engineering and Ship Technology Gdańsk University of TechnologyGdańsk 80-233Poland

In hydrodynamic bearings traditional bearing alloys:Babbitts and bronzes are most frequently *** sliding layers are sometimes applied as a valuable *** diamond-like carbon(DLC)coatings,which are also considered for certain applications may show some advantages,as *** material selection is of secondary importance in a full film lubrication regime it becomes important in mixed friction conditions,which is crucial for bearings with frequent starts and *** research aimed at studying the performance of fluid film bearings in the specific operating regime,including the transition to mixed friction,is described in the *** tests were carried out on four tilting pad bearings of different material compositions:Steel/bronze,DLC/steel,steel/polyether ether ketone(PEEK),and steel/*** tests comprised stopping under load and reproduction of the Stribeck curve by decreasing rotational speed to very low values,and observing the changes of friction force during the transition to mixed friction *** of the transition conditions and other results showed clear differences between the tested bearings,illustrating the feasibility of less popular material compositions for bearings operating in specific *** specifically,the DLC/steel bearing was demonstrating superior performance,*** friction,transition to mixed friction occurring at higher load,and more stable performance at start-stop regime over the other tested bearings.

关键词： tilting pad thrust bearing experimental research start-stop regime polyether ether ketone(PEEK) diamond-like carbon(DLC)coating metallic bearing alloys

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Unified numerical predictor-corrector guidance based on characteristic model

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中国空间科学技术(中英文) 2024年第4期44卷 40-49页

作者： meng bin ZHANG Hangning ZHAO Yunbo Beijing Institute of Control Engineering National Key Laboratory of Space Intelligent Control University of Science and Technology of China

Aerocapture is one of the key technologies for low-cost transportation, with high demands of autonomy, accuracy, and robustness of guidance and control, due to its high reliability requirements for only one chance of trying.A unified numerical predictor-corrector guidance method based on characteristic models for aerocapture is *** numerical predictor-corrector guidance method is used to achieve autonomy and high accuracy, and the characteristic model control method is introduced to achieve *** the same time, by transforming path constraints, characteristic model equations including apogee deviation and altitude differentiation are *** on the characteristic model equations, a unified guidance law which can satisfy path constraints and guidance objectives simultaneously is *** guidance problems, guidance deviation is not directly obtained from the output of the dynamics at present, but is calculated through integral and algebraic ***, the method of directly discretizing differential equations cannot be used to establish characteristic models, which brings great difficulty to characteristic modeling.A method for characteristic modeling of guidance problems is proposed, and convergence analysis of the proposed guidance law is also ***, a joint numerical simulation of guidance and control considering navigation deviation and various uncertainties is conducted to verify the effectiveness of the proposed *** proposed unified method can be extended to general aerodynamic entry guidance designs, providing theoretical and methodological support for them.

关键词： aerocapture characteristic model convergence path constraint unified numerical predictor-corrector guidance

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Deciphering and integrating invariants for neural operator learning with various physical mechanisms

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National Science Review 2024年第4期11卷 111-122页

作者： Rui Zhang Qi meng Zhi-Ming ma Academy of mathematics and Systems Science Chinese Academy of Sciences(CAS) Microsoft Research

Neural operators have been explored as surrogate models for simulating physical systems to overcome the limitations of traditional partial differential equation(PDE) solvers. However, most existing operator learning methods assume that the data originate from a single physical mechanism, limiting their applicability and performance in more realistic scenarios. To this end, we propose the physical invariant attention neural operator(PIANO) to decipher and integrate the physical invariants for operator learning from the PDE series with various physical mechanisms. PIANO employs self-supervised learning to extract physical knowledge and attention mechanisms to integrate them into dynamic convolutional *** to existing techniques, PIANO can reduce the relative error by 13.6%–82.2% on PDE forecasting tasks across varying coefficients, forces or boundary conditions. Additionally, varied downstream tasks reveal that the PI embeddings deciphered by PIANO align well with the underlying invariants in the PDE systems, verifying the physical significance of PIANO.

关键词： neural operator PDE solver contrastive learning physical invariants

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Churning loss characteristics of a wet three-phase high-speed reluctance motor

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第3期25卷 251-267页

作者： Zhenzhou ZHANG Mingzhu DAI Chenchen ZHANG Yi CHEN bin meng College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China

With the increasing requirements of electro-hydrostatic actuators(EHAs)for power,volume,and pressure,there is a growing tendency in the industry to combine the motor and pump to form a so-called'motor pump'to improve the *** this paper,a novel structure for a wet three-phase high-speed reluctance motor pump is proposed,which can further improve integration by removing the dynamic seal on the pump shaft,thereby avoiding the problems of dynamic seal wear and oil leakage and improving heat dissipation under high-speed working ***,after the motor is wetted,the churning loss caused by immersion of the rotor in the oil causes additional fluid resistance *** on fundamental fluid mechanics,an analytical model of the churning torque of a wet motor was *** verify the accuracy of the analytical model,a simulation model of churning loss was established based on computational fluid dynamics(CFD),and the churning torque and flow field state were ***,an experimental prototype was designed and manufactured,and a test bench for churning loss was *** oil churning torque was measured at different speeds and *** results from the analytical,simulation,and experimental models agreed *** experimental results validated the analytical model and CFD *** research provides a practical method for calculating the churning loss and serves as guidance for future optimization of churning loss reduction.

关键词： Motor pump Wet motor Churning loss Analytical model Computational fluid dynamics(CFD)

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Enhanced piezoelectric performance of Cr/Ta non-equivalent co-doped Bi_(4)Ti_(3)O_(12)-based high-temperature piezoceramics

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Journal of Advanced Ceramics 2024年第3期13卷 263-271页

作者： Xuanyu Chen Ziqi ma bin Li Yejing Dai School of materials Sun Yat-sen UniversityShenzhen 518107China

In this study,(Cr_(1/3)/Ta_(2/3))non-equivalent co-doped Bi_(4)Ti_(3)O_(12)(BIT)ceramics were prepared to solve the problem that high piezoelectric performance,high Curie temperature,and high-temperature resistivity could not be achieved simultaneously in BIT-based ceramics.A series of Bi_(4)Ti_(3-x)(Cr_(1/3)Ta_(2/3))_(x)O_(12)(x=0-0.04)ceramics were synthesized by the solid-state reaction *** phase structure,microstructure,piezoelectric performance,and conductive mechanism of the samples were systematically *** B-site non-equivalent co-doping strategy combining high-valence Ta^(5+)and low-valence Cr^(3+)significantly enhances electrical properties due to a decrease in oxygen vacancy ***_(4)Ti_(2.97)(Cr_(1/3)Ta_(2/3))_(0.03)O_(12)ceramics exhibit a high piezoelectric coefficient(d_(33)=26 pC·N^(-1))and a high Curie temperature(TC=687℃).Moreover,the significantly increased resistivity(ρ=2.8×10^(6)Ω·cm at 500℃)and good piezoelectric stability up to 600℃are also obtained for this *** the results demonstrate that Cr/Ta co-doped BIT-based ceramics have great potential to be applied in high-temperature piezoelectric applications.

关键词： high temperature piezoelectricity co-doped Bi_(4)Ti_(3)O_(12)(BIT)

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The main strategies for soil pollution apportionment:A review of the numerical methods

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Journal of Environmental Sciences 2024年第2期136卷 95-109页

作者： bin Shi Jing meng TieyuWang Qianqian Li Qifan Zhang Guijin Su Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Guangdong Provincial Key Laboratory of marine Disaster Prediction and Prevention Shantou UniversityShantou 515063China

Nowadays,a large number of compounds with different physical and chemical properties have been determined in *** behaviors and source identification of pollutants in soil are the foundation of soil pollution *** and quantitative analysis of potential pollution sources are the prerequisites for its prevention and *** efforts have made to develop methods for identifying the sources of soil *** efforts have involved the measurement of source and receptor parameters and the analysis of their relationships via numerical statistics *** have comprehensively reviewed the progress made in the development of source apportionment methodologies to date and present our *** numerical methods,such as spatial geostatistics analysis,receptor models,and machine learning methods are addressed in *** most cases,however,the effectiveness of any single approach for source apportionment remains *** multiple methods to address soil quality problems can reduce uncertainty about the sources of soil *** review also constructively highlights the key strategies of combining mathematical models with the assessment of chemical profiles to provide more accurate source *** review intends to provide a comprehensive summary of source apportionment methodologies to help promote further development.

关键词： Soil pollutants Source attribution Methodologies Chemical profiles mathematical models

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One-step construction of strongly coupled Co_(3)V_(2)O_(8)/Co_(3)O_(4)/MXene heterostructure via in-situ Co-F bonds for high performance all-solid-state asymmetric supercapacitors

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Rare Metals 2024年第2期43卷 682-691页

作者： Ji Zhou bin-bin Liu Hu Zheng Wen-Qing ma Qian Li Cai-Xia Xu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongSchool of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China

Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) composite was easily synthesized via one-step succinct-operated hydrothermal *** interconnected Co_(3)V_(2)O_(8)/Co_(3)O_(4) nanowires network can in-situ grow and anchor on the surface of Ti_(3)C_(2)T_(x) via the strong Co-F bonds and contribute tremendously to depress Ti_(3)C_(2)T_(x) *** from the synergistically interplayed effect among the multiple interfaces and high conductivity of Ti_(3)C_(2)T_(x) as well as outstanding stability of the as-designed nanostructure,the optimum Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x)electrode reaches a commendable specific capacitance(up to 3800 mF·cm^(−2)),great rate capability(80%capacitance retention after 20-times current increasing),and preeminent cycling stability(95.4%/85.5%retention at 7000th/20,000th cycle).Moreover,the all-solid-state asymmetric supercapacitor based on Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) and active carbon can deliver a high energy density of 84.0μWh·cm^(−2) at the power energy of 3.2 mW·cm^(−2),and excellent cycling durability with 87.0%of initial capacitance retention upon 20,000 *** work provides a practicable pathway to tailor MXene-based composites for high-performance supercapacitor.

关键词： Ti_(3)C_(2)T_(x) Co_(3)V_(2)O_(8)/Co_(3)O_(4) Heterostructure Cathode Supercapacitor

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Bismuth clusters pinned on TiO_(2) porous nanowires boosting charge transfer for CO_(2) photoreduction to CH_(4)

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Nano Research 2024年第3期17卷 1190-1198页

作者： Jiazhi meng Kaiwen Wang Yang Wang Jiangping ma Chaogang Ban Yajie Feng bin Zhang Kai Zhou Liyong Gan Guang Han Danmei Yu Xiaoyuan Zhou College of Physics and Institute of Advanced Interdisciplinary Studies Chongqing UniversityChongqing 401331China School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China College of materials Science and Engineering Chongqing UniversityChongqing 400044China Beijing Key Lab of Microstructure and Properties of Advanced materials Beijing University of TechnologyBeijing 100124China Analytical and Testing Center Chongqing UniversityChongqing 401331China

Artificial photosynthesis in carbon dioxide(CO_(2))conversion into value-added chemicals attracts considerable attention but suffers from the low activity induced by sluggish separation of photogenerated carriers and the kinetic bottleneck-induced unsatisfied ***,we prepare a new-style Bi/TiO_(2) catalyst formed by pinning bismuth clusters on TiO_(2) nanowires through being confined by pores,which exhibits high activity and selectivity towards photocatalytic production of CH_(4) from CO_(2).Boosted charge transfer from TiO_(2) through Bi to the reactants is revealed via in situ X-ray photon spectroscopy and time-resolved photoluminescence(PL).Further,in situ Fourier transform infrared results confirm that Bi/TiO_(2) not only overcomes the multi-electron kinetics challenge of CO_(2) to CH_(4) via boosting charge transfer,but also facilitates proton production and transfer as well as the intermediates*CHO and*CH_(3)O generation,ultimately achieving the tandem catalysis towards *** calculation also underlies that the more favorable reaction step from*CO to*CHO on Bi/TiO_(2) results in CH_(4) production with higher *** work brings new insights into rational design of photocatalysts with high performance and the formation mechanism of CO_(2) to CH_(4) for solar energy storage in future.

关键词： carbon dioxide(CO_(2))photoreduction charge transfer tandem catalysis methanation

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A dual-beam piezo-magneto-elastic wake-induced vibration energy harvesting system for high-performance wind energy harvesting

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Science China(Technological Sciences) 2024年第1期67卷 221-239页

作者： ma XiaoQing ZHANG Hang maRGIELEWICZ Jerzy GĄska Damian WOLSZCZAK Piotr LITAK Grzegorz ZHOU ShengXi School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute in Shenzhen Northwestern Polytechnical UniversityShenzhen 518057China Faculty of Transport and Aviation Engineering Silesian University of TechnologyKrasińskiego 8Katowice 40-019Poland Department of Automation Lublin University of TechnologyNadbystrzycka 36Lublin 20-618Poland

Wind-induced vibration energy harvesting has a great potential for utilizing wind energy to supply power for low-powered *** improve the working performance of energy harvesters effectively,a suitable structural design is *** paper proposes a dual-beam piezo-magneto-elastic wake-induced vibration energy harvesting system to enhance the functional performance of aeroelastic energy harvesters in environments with variable wind *** system contains two piezoelectric beams coupled by magnets(forming upstream and downstream energy harvesters),and each beam is attached with a foam cylinder.A corresponding dynamic model is provided,and output characteristics are obtained at different wind *** and experimental verification indicate that both upstream and downstream energy harvesters can realize efficient energy *** the wind speed exceeds a certain critical value,the amplitudes of the system’s displacement and voltage are *** wind speed threshold value is approximately 1.25 m/*** the wind speed and magnet spacing are 10.2 m/s and 20 mm,respectively,the output power of the system reaches 4.9×10^(−4)***,the wind speed threshold value of the proposed system can be adjusted by an equivalent nonlinear restoring force.

关键词： dual-beam structure piezoelectric energy harvester theoretical model nonlinear dynamics

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