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Data.driven analysis reveals prognostic genes and immunological targets in human sepsis-associated acute kidney injury

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World Journal of Emergency Medicine 2024年第2期15卷 91-97页

作者： Qing Zhao Jinfu ma Jianguo Xiao Zhe Feng Hui Liu department of Diagnosis and Treatment of Cadres the First Medical CenterChinese PLA General HospitalBeijing 100853China Intensive Care Unit the 305th Hospital of Chinese PLABeijing 100032China department of Critical Care Medicine the First Medical CenterChinese PLA General HospitalBeijing 100853China Nephrology department the First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND:The molecular mechanism of sepsis-associated acute kidney injury(SA-AKI)is *** analyzed co-differentially expressed genes(co-deGs)to elucidate the underlying mechanism and intervention targets of ***:The microarray datasets GSE65682,GSE30718,and GSE174220 were downloaded from the Gene Expression Omnibus(GEO)*** identified the co-deGs and constructed a gene co-expression network to screen the hub *** analyzed immune correlations and disease correlations and performed functional annotation of the hub *** also performed single-cell and microenvironment analyses and investigated the enrichment pathways and the main transcription ***,we conducted a correlation analysis to evaluate the role of the hub ***:Interleukin 32(IL32)was identified as the hub gene in SA-AKI,and the main enriched signaling pathways were associated with hemopoiesis,cellular response to cytokine stimulus,inflammatory response,and regulation of kidney ***,IL32 was significantly associated with mortality in SA-AKI ***,macrophages,T cells,and NK cells were closely related to IL32 and were involved in the immune microenvironment in SA-AKI ***32 expression increased significantly in the kidney of septic ***-like receptor 2(TLR2)was significantly and negatively correlated with ***:IL32 is the key gene involved in SA-AKI and is significantly associated with ***2 and relevant immune cells are closely related to key genes.

关键词： Sepsis Acute kidney injury Interleukin 32 Toll-like receptor 2 Bioinformatics analysis

Causal role of immune cells in obstructive sleep apnea hypopnea syndrome:Mendelian randomization study

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World Journal of Clinical Cases 2024年第7期12卷 1227-1234页

作者： Huang-Hong Zhao Zhen ma Dong-Sheng Guan department of Encephalopathy Henan Provincial Hospital of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina department of Personnel The First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina department of Neurology Henan Provincial Hospital of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina

BACKGROUND despite being one of the most prevalent sleep disorders,obstructive sleep apnea hypoventilation syndrome(OSAHS)has limited information on its immunologic *** immunological underpinnings of certain major psychiatric diseases have been uncovered in recent years thanks to the extensive use of genome-wide association studies(GWAS)and genotyping techniques using highdensity genetic markers(e.g.,SNP or CNVs).But this tactic hasn't yet been applied to *** a Mendelian randomization analysis,we analyzed the causal link between immune cells and the illness in order to comprehend the immunological bases of *** To investigate the immune cells'association with OSAHS via genetic methods,guiding future clinical *** A comprehensive two-sample mendelian randomization study was conducted to investigate the causal relationship between immune cell characteristics and *** statistics for each immune cell feature were obtained from the GWAS *** on 731 immune cell properties,such as morphologic parameters,median fluorescence intensity,absolute cellular,and relative cellular,was compiled using publicly available genetic *** results'robustness,heterogeneity,and horizontal pleiotropy were confirmed using extensive sensitivity *** Following false discovery rate(Fdr)correction,no statistically significant effect of OSAHS on immunophenotypes was ***,two lymphocyte subsets were found to have a significant association with the risk of OSAHS:Basophil%CD33dim HLa.dr-CD66b-(OR=1.03,95%CI=1.01-1.03,P<0.001);CD38 on IgD+CD24-B cell(OR=1.04,95%CI=1.02-1.04,P=0.019).CONCLUSION This study shows a strong link between immune cells and OSAHS through a gene approach,thus offering direction for potential future medical research.

关键词： Obstructive sleep apnea hypopnea syndrome Immunity Causal inference MR analysis Sensitivity

Entangled photon pair generation in an integrated SiC platform

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Light(Science & Applications) 2024年第6期13卷 1041-1046页

作者： Anouar Rahmouni Ruixuan Wang Jingwei Li Xiao Tang Thomas Gerrits Oliver Slattery Qing Li Lijun ma National Institute of Standards and Technology 100 Bureau DrGaithersburgMD20899USA department of Electrical and Computer Engineering Carnegie Mellon UniversityPittsburghPA15213USA

Entanglement plays a vital role in quantum information *** to its unique material properties,silicon carbide recently emerged as a promising candidate for the scalable implementation of advanced quantum information processing *** date,however,only entanglement of nuclear spins has been reported in silicon carbide,while an entangled photon source,whether it is based on bulk or chip-scale technologies,has remained ***,we report the demonstration of an entangled photon source in an integrated silicon carbide platform for the first ***,strongly correlated photon pairs are efficiently generated at the telecom C-band wavelength through implementing spontaneous four-wave mixing in a compact microring resonator in the 4H-silicon-carbide-on-insulator *** maximum coincidence-to-accidental ratio exceeds 600 at a pump power of 0.17 mW,corresponding to a pair generation rate of(9±1)×103 pairs/***-time entanglement is created and verified for such signal-idler photon pairs,with the two-photon interference fringes exhibiting a visibility larger than 99%.The heralded single-photon properties are also measured,with the heralded g(2)(0)on the order of 10−3,demonstrating the SiC platform as a prospective fully integrated,complementary metal-oxide-semiconductor compatible single-photon source for quantum applications.

关键词： quantum coincidence mixing

dental-derived stem cells in tissue engineering:the role of biomaterials and host response

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Regenerative Biomaterials 2024年第1期3卷 17-26页

作者： Weihao Yuan Luiza de Almeida Queiroz Ferreira Bo Yu Sahar Ansari Alireza Moshaverinia Weintraub Center for Reconstructive Biotechnology Section of ProsthodonticsSchool of DentistryUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA department of Restorative dentistry School of DentistryUniversidade Federal de Minas GeraisBelo HorizonteMinas GeraisBrazil Section of Restorative dentistry School of DentistryUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA department of Bioengineering Henry Samueli School of Engineering and Applied SciencesUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA

dental-derived stem cells(DSCs)are attractive cell sources due to their easy access,superior growth capacity and low *** can respond to multiple extracellular matrix signals,which provide biophysical and biochemical cues to regulate the fate of residing ***,the direct transplantation of DSCs suffers from poor proliferation and differentiation toward functional cells and low survival rates due to local ***,elegant advances in the design of novel biomaterials have been made to give promise to the use of biomimetic biomaterials to regulate various cell behaviors,including proliferation,differentiation and *** could be tailored with multiple functionalities,e.g.,*** is an emerging need to summarize recent advances in engineered biomaterials-mediated delivery and therapy of DSCs and their potential ***,we outlined the design of biomaterials for supporting DSCs and the host response to the transplantation.

关键词： dental-derived stem cells biomaterials host response tissue engineering

Using CONTAM to design ventilation strategy of negative pressure isolation ward considering different height of door gaps

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Energy and Built Environment 2024年第1期5卷 32-45页

作者： Mingyao ma Changsheng Cao Yukun Xu Zhijian Liu Lingjie Zeng Chengquan Zhang Jun Gao School of Mechanical Engineering Tongji UniversityShanghai 200092China department of Power Engineering North China Electric Power UniversityBaodingHebei 071003China College of Civil Engineering Tongji UniversityShanghai 200092China

Infectious disease departments in hospitals require pressure gradient to create unidirectional airflow to prevent the spread of contaminants,typically by creating active air infiltration through the difference between supply and exhaust air *** door gap is the channel of air flow between rooms,so its height has an important influence on the pressure difference and infiltration air volume of the *** is still a lack of research on setting reasonable ventilation strategies according to the different heights of door gaps at different positions in the *** this study,model of a set of isolation wards was established and analyzed using the multi-zone simulation software CONTAM,and the ventilation strategies with different heights of door gaps were applied to the actual infection diseases *** results show that in a building with ventilation system divided by functional area,the difference in the height of the door gaps requires different active infiltration air *** fluctuations in the medical and patient corridors are greater than in other *** significance of this study is to understand the active infiltration of air to guide the design and operation of ventilation systems in infectious disease hospitals or building remodeled to isolate close contacts of COVID-19 *** is also instructive for the design of pressure gradients in clean workshops,biological laboratories,and other similar buildings.

关键词： Door gap height Active infiltration Pressure gradient Multizone model CONTAM Control strategy

An integrated computational method for calculating dynamic thermal bridges of building facades in tropical countries

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Frontiers of Architectural Research 2024年第1期13卷 201-218页

作者： Miktha Farid Alkadri Muhammad Rafif Cahyadi Agung Francesco de Luca Research Cluster of Architectural Sciences and Building Technology Department of ArchitectureFaculty of EngineeringUniversitas IndonesiaDepok 16425Indonesia department of Civil Engineering and Architecture Tallinn University of TechnologyTallinn 19086Estonia

Identifying thermal bridges on building façades has been a great challenge for architects,especially during the conceptual design *** is not only due to the complexity of parameters when calculating thermal bridges,but also lack of feature integration between building energy simulation(BES)tools and the actual building *** example,existing BES tools predominantly calculate thermal bridges only in steady state without considering the temperature dynamic behaviour of building ***,relevant features such as thermal delay,decrement factor,and operative temperature are often neglected,and this can lead to miscalculation of energy *** study then proposes an integrated method to calculate dynamic thermal bridges under transient conditions by incorporating field observations and computational simulations of thermal *** specifically,the proposed method employs several measurement tools such as HOBO data logger to record the actual conditions of indoor and outdoor room temperature and thermal cameras to identify the surface temperature of selected building *** actual datasets are then integrated with the simulation workflow developed in BES *** study ultimately enables architects not only to identify potential thermal bridges on existing building façades but also to support material and geometric exploration in early design phase.

关键词： Thermal bridges Dynamic calculation Thermal delay Cooling load Computational design method

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Eclats de vert

中国与非洲（法文版） 2024年第6期16卷 32-33页

作者： dr CHRISTIAN SEKOMO BIRAME directeur général de l'Agence nationale de recherche et de développement industriels au Rwanda

Au fil des années,le continent africain a importédes véhicules d'occasionàessence et au diesel,souventâgés de plus de 10 *** véhiculesémettent du dioxyde de carbone,un gazàeffet de serre(GES)majeur responsable du changement *** Rwanda,le transport routier represente 13% desémissions de GES du pays,selon I'Autoritéde gestion environnementale du *** tant que continent en développement,I'Afrique continue de polluer l'air,en partie à cause de l'importation de voitures d'occasion en provenance des pays développés.

关键词： des continent les

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Fruitful Transition

ChinAfrica 2024年第6期16卷 32-33页

作者： dr.CHRISTIAN SEKOMO BIRAME National Industrial Research and development Agency Rwanda

Over the years,the African continent has been importing used gasoline and diesel vehicles including ones that are 10 years *** vehicles emit carbon dioxide,which is the leading cause of greenhouse gases(GHGs)that are driving the climate *** Rwanda,for example,road transport contributes to 13 percent of the country’s greenhouse emissions,according to the Rwanda Environment management Authority(REma).Africa as a developing continent continues to pollute air,partly due to the use of second-hand cars from developed countries.

关键词： Authority greenhouse dioxide

Optimal Scheduling Strategy of Source-Load-Storage Based onWind Power Absorption Benefit

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Energy Engineering 2024年第7期121卷 1823-1846页

作者： Jie ma Pengcheng Yue Haozheng Yu Yuqing Zhang Youwen Zhang Cuiping Li Junhui Li Wenwen Qin Yong Guo State Grid Henan Economic Research Institute Zhengzhou450000China Zaozhuang Power Supply Company State Grid Shandong Electric Power CompanyZaozhuang277000China Key Laboratory of Modern Power SystemSimulation and Control&Renewable Energy Technology Ministry of EducationNortheast Electric Power UniversityJilin132012China

In recent years,the proportion of installed wind power in the three north regions where wind power bases are concentrated is increasing,but the peak regulation capacity of the power grid in the three north regions of China is limited,resulting in insufficient local wind power consumption ***,this paper proposes a two-layer optimal scheduling strategy based on wind power consumption benefits to improve the power grid’s wind power consumption *** objective of the uppermodel is tominimize the peak-valley difference of the systemload,which ismainly to optimize the system load by using the demand response resources,and to reduce the peak-valley difference of the system load to improve the peak load regulation capacity of the *** lower scheduling model is aimed at maximizing the system operation benefit,and the scheduling model is selected based on the rolling *** load-side schedulingmodel needs to reallocate the absorbed wind power according to the response speed,absorption benefit,and curtailment penalty cost of the two dr dispatching ***,the measured data of a power grid are simulated by maTLAB,and the results show that:the proposed strategy can improve the power grid’s wind power consumption capacity and get a large wind power consumption benefit.

关键词： Wind power consumption two-layer optimal demand response rolling scheduling wind curtailment penalty