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Spontaneous mutations and mutational responses to penicillin treatment in the bacterial pathogen Streptococcus pneumoniae D39

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marine Life Science & Technology 2024年第3期6卷 198-211页

作者： Wanyue Jiang Tongtong Lin Jiao Pan Caitlyn eRivera Clayton Tincher Yaohai Wang Yu Zhang Xiang Gao Yan Wang Ho‑Ching T.Tsui ma.colm e.winkler Michael Lynch Hongan Long Institute of evolution and marine Biodiversity KLMMEOcean University of ChinaQingdao 266003China Laboratory for marine Biology and Biotechnology Laoshan LaboratoryQingdao 266237China Department of Biology Indiana UniversityBloomingtonIN 47405USA School of mathematics Science Ocean University of ChinaQingdao 266000China State Key Laboratory of Microbial Technology Microbial Technology InstituteSchool of Life ScienceShandong UniversityQingdao 266237China Biodesign Center for Mechanisms of evolution Arizona State UniversityTempeAZ 85281USA

Bacteria with functional DNA repair systems are expected to have low mutation rates due to strong natural selection for genomic ***,our study of the wild-type Streptococcus pneumoniae D39,a pathogen responsible for many common diseases,revealed a high spontaneous mutation rate of 0.02 per genome per cell division in mutation-accumulation(ma)*** rate is orders of magnitude higher than that of other non-mutator bacteria and is characterized by a high mutation bias in the A/T *** high mutation rate may have resulted from a reduction in the overall efficiency of selection,conferred by the tiny effective population size in *** line with this,*** D39 also exhibited the lowest DNA mismatch-repair(MMR)efficiency among *** with the antibiotic penicillin did not elevate the mutation rate,as penicillin did not induce DNA damage and *** lacks a stress response *** findings suggested that the ma results are applicable to within-host scenarios and provide insights into pathogen evolution.

关键词： Neutral evolution Mutation spectrum Antibiotics DNA mismatch repair Oxidative damage repair

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General Solutions of First-Order Algebraic ODes in Simple Constant extensions

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系统科学与复杂性学报:英文版 2023年第4期36卷 1769-1788页

作者： MITTeRAMSKOGLeR Johann Josef winkler Franz Research Institute for Symbolic Computation(RISC) Johannes Kepler Universität LinzA-4040 LinzAustria

If a first-order algebraic ODe is defined over a certain differential field,then the most elementary solution class,in which one can hope to find a general solution,is given by the adjunction of a single arbitrary constant to this *** of this type give rise to a particular kind of generic point—a rational parametrization—of an algebraic curve which is associated in a natural way to the ODe’s defining *** for the opposite direction,we show that a suitable rational parametrization of the associated curve can be extended to a general solution of the ODe if and only if one can find a certain automorphism of the solution *** automorphisms are determined by linear rational functions,i.e.,Möbius *** properties of rational parametrizations,in combination with the particular shape of such automorphisms,lead to a number of necessary conditions on the existence of general solutions in this solution ***,the desired linear rational function can be determined by solving a comparatively simple differential system over the ODe’s field of *** results hold for arbitrary differential fields of characteristic zero.

关键词： Algebraic curve algebraic differential equation general solution Möbius transformation rational parametrization

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大肠杆菌生产的重组尿激酶的纯化及其特性

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中国生物工程杂志 1987年第6期 39-48页

作者： marjorie e.winkler ,牛思敏

由大肠杆菌生产的重组尿激酶的高低分子量两种形式均已经重新折叠和提纯。对该蛋白质的低分子量形式作了比活性,氨基酸组成,氨基末端分析,羧基末端分析,胰蛋白酶图谱,抗体滴定,和色谱行为等特性描述。对高分子量形式作了比活性和色谱行... 详细信息

由大肠杆菌生产的重组尿激酶的高低分子量两种形式均已经重新折叠和提纯。对该蛋白质的低分子量形式作了比活性,氨基酸组成,氨基末端分析,羧基末端分析,胰蛋白酶图谱,抗体滴定,和色谱行为等特性描述。对高分子量形式作了比活性和色谱行为等特性描述。除缺少连接了天冬酰氨302碳水化合物外,在被试验的各个方面,重组尿激酶和天然尿激酶几乎完全相同。结果表明,由于大肠杆菌生产的可适当折叠,天然尿激酶上连接的碳水化合物在酶的催化活性中不起作用。

关键词：尿激酶天然蛋白酶血纤维蛋白大肠杆菌大肠埃希氏菌埃希氏杆菌属二硫化物多硫化物

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Collembola communities and soil conditions in forest plantations established in an intensively managed agricultural area

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Journal of Forestry Research 2021年第5期32卷 1819-1832页

作者： István Harta Barbara Simon Szergej Vinogradov Dániel winkler Institute of environmental Science Szent István UniversityGödöllőHungary Institute of Methodology Szent István UniversityGödöllőHungary Institute of Wildlife management and Vertebrate Zoology University of SopronSopronHungary

The challenges of a changing climate have directed greater attention to afforestation,but the effects of afforestation on soil fertility and soil biota have not been fully *** explore changes in the soil conditions in two 20-year-old forest plantations established in formerly intensively fertilized plots of agricultural land,we focused on the current developmental state of the sites that received the most fertilizer and evaluated soil properties and Collembola(springtails)*** oak(Quercus petraea)and black locust(Robinia pseudoacacia)that had been planted in the afforestation sites were assessed for differences between plantations of native and invasive *** adjacent reference associations,including forests and open habitats,were also analyzed and *** showed that the soils in the two afforested sites were similar in their properties and Collembola communities to those of the control cultivated forests,but differed from each other in pH,calcium,phosphorus,and ammonium *** available potassium and phosphorus contents in the soil of the sessile oak plantation were still high,while the soil organic matter content was adequate(SOM>2.0%)in both *** richness of Collembola ranged from 18 in the cultivated arable land to 43 in the relict *** a few species typical for forests(e.g.,Neanura muscorum,Isotomiella minor,entomobrya muscorum)were detected in the young plantations,while species characteristic of open habitats(e.g.,Protaphorura campata,Lepidocyrtus cyaneus)occurred as *** more individuals and species of Collembola were present in the soil of young plantations than in arable fields,their community diversities were significantly lower compared to the control forest *** community diversity differed significantly also between the two plantation types(with native and non-native tree species).Mean abundance in the afforested sites was about 2.5 times higher than in the cultiv

关键词： Afforestation Diversity Fertilizers Soil fauna Soil properties Springtails

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Stochastic Runge-Kutta–Munthe-Kaas Methods in the Modelling of Perturbed Rigid Bodies

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Advances in Applied mathematics and Mechanics 2022年第2期14卷 528-538页

作者： Michelle Muniz matthias ehrhardt Michael Günther Renate.winkler Institute of mathematical Modelling Analysis and Computational Mathematics(IMACM)Applied Mathematics and Numerical AnalysisBergische Universität WuppertalGaußstraße 2042119 WuppertalGermany

In this paper we present how nonlinear stochastic Itˆo differential equations arising in the modelling of perturbed rigid bodies can be solved numerically in such a way that the solution evolves on the correct *** this end,we formulate an approach based on Runge-Kutta–Munthe-Kaas(RKMK)schemes for ordinary differ-ential equations on ***,we provide a proof of the mean-square convergence of this stochastic version of the RKMK schemes applied to the rigid body problem and illustrate the effectiveness of our proposed schemes by demonstrating the structure preservation of the stochastic RKMK schemes in contrast to the stochastic Runge-Kutta methods.

关键词： Stochastic Runge-Kutta method Runge-Kutta–Munthe-Kaas scheme nonlinear Itˆo SDes rigid body problem

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Local buckling of thin plate on tensionless elastic foundations under interactive uniaxial compression and shear

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Theoretical & Applied Mechanics Letters 2018年第2期8卷 75-82页

作者： Iianghui Dong Xing ma Yan Zhuge Julie e.Mills School of Natural and Built environments University of South AustraliaAdelaideSA 5095Australia

This paper uses a mathematical method to develop an analytical solution to the local buckling behaviour of long rectangular plates resting on tensionless elastic winkler foundations and under combined uniform longitudinal uniaxial compressive and uniform in-plane shear loads. Fitted formulas are derived for plates with clamped edges and simplified supported edges. Two examples are given to demonstrate the application of the current method： one is a plate on tensionless spring foundations and the other is the contact between the steel sheet and elastic solid foundation. Finite element （Fe） analysis is also conducted to validate the analytical results. Good agreement is obtained between the current method and Fe analysis.

关键词： Buckling coefficient Contact buckling winkler foundation Interaction curve Finite element analysis

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热解碳涂层的烧蚀行为

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新型炭材料 1993年第1期9卷 44-45页

作者： e. winkler 宋怀河

研究涂复热解碳(PC)的石墨材料的氧化侵蚀作用,对其实际应用十分重要,然而至今为止,对这样腐蚀的研究进行得还很不够。一般地说,多晶石墨的氧化速度与其孔隙度、织态结构及石墨化程度紧密相关。随着石墨化程度的提高,由O_2和CO_2引起的... 详细信息

研究涂复热解碳(PC)的石墨材料的氧化侵蚀作用,对其实际应用十分重要,然而至今为止,对这样腐蚀的研究进行得还很不够。一般地说,多晶石墨的氧化速度与其孔隙度、织态结构及石墨化程度紧密相关。随着石墨化程度的提高,由O_2和CO_2引起的氧化反应的速度相应降低。在氧化反应过程中,氧化剂首先对晶体的棱状边缘进行作用。900℃左右温度时。

关键词：热解碳涂层石墨材料烧蚀

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The innate immune system in Parkinson's disease:a novel target promoting endogenous neuroregeneration

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Neural Regeneration Research 2015年第5期10卷 704-706页

作者： Johannes CM Schlachetzki Jürgen winkler Department of Molecular Neurology Friedrich-AlexanderUniversity (FAU) erlangen-Nürnberg University Hospital Erlangen

Parkinson＇s disease （PD） is a slowly progressing neuro- degenerative disorder clinically defined by key symptoms like bradykinesia, rigidity, resting tremor, and postural instability. Reduction of dopaminergic terminals in the caudate nucleus and putamen, i.e., the striatum, accom- panied by decreased striatal levels of dopamine, and most likely consecutive degeneration of dopaminergic neurons in the substantia nigra pars compacta （SNpc） are tightly linked to the onset of the motor symptoms. With the etiology of PD largely not yet well defined, there is accu- mulating evidence for increased immune activation in PD. The majority of studies favor a detrimental effect of microglia, the resident innate immune cells of the brain, on PD pathogenesis. In the presence of alpha-synuclein, inflammatory responses elicited by microglia may be initiated by pattern recognition receptors, e.g.,

关键词： SVZ GFAP PD

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莫斯科1987年度汽车维修展览会简介

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国外汽车 1987年第6期 67-67页

作者： e.winkler 史宗庄

1987年4月2日至9日,在莫斯科举行了一次“1987年度汽车维修展览会”,西方国家的参展商占了大多数;在经互会国家中,只有波兰和捷克斯洛伐克展出了全套维修设备,苏联甚至没有派出参展单位。在对轿车进行一般维修工作的举升工具方面,参展... 详细信息

1987年4月2日至9日,在莫斯科举行了一次“1987年度汽车维修展览会”,西方国家的参展商占了大多数;在经互会国家中,只有波兰和捷克斯洛伐克展出了全套维修设备,苏联甚至没有派出参展单位。在对轿车进行一般维修工作的举升工具方面,参展产品以在车下可自由操作的双侧

关键词：轿车汽车客车车桥莫斯科俄罗斯车轮定位波兰车身举升

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Transgenerational bone toxicity in F3 medaka (Oryzias latipes) induced by ancestral benzo[a]pyrene exposure: Cellular and transcriptomic insights

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Journal of environmental Sciences 2023年第5期127卷 336-348页

作者： Jiezhang Mo Miles Teng Wan DorisWai-Ting Au Jingchun Shi Nathan Tam Xian Qin Napo K.M.Cheung Keng Po Lai Christoph winkler Richard Yuen-Chong Kong Frauke Seemann Southern marine Science and engineering Guangdong Laboratory(Guangzhou) Guangzhou 510000China Shenzhen Key Laboratory for the Sustainable Use of marine Biodiversity Research Centre for the Oceans and Human HealthShenzhen Research InstituteCity University of Hong KongShenzhen 518057China State Key Laboratory of marine Pollution and Department of Chemistry City University of Hong KongHong Kong SARChina Laboratory of environmental Pollution and Integrative Omics Guilin Medical UniversityHuan Cheng North 2nd Road 109Guilin 541004China Department of Biological Sciences National University of Singapore119077Singapore Center for Coastal Studies and Department of Life Sciences Texas A&M University-Corpus ChristiCorpus ChristiTexas 78412USA

Benzo[a]pyrene(BaP),a ubiquitous pollutant,raises environmental health concerns due to induction of bone toxicity in the unexposed *** of F0 ancestor medaka(Oryzias latipes)to 1μg/L BaP for 21 days causes reduced vertebral bone thickness in the unexposed F3 male *** reveal the inherited modifications,osteoblast(OB)abundance and molecular signaling pathways of transgenerational BaP-induced bone thinning were *** analysis showed a reduction in OB *** of the miRNA and mRNA transcriptomes revealed the dysregulation of Wnt signaling(frzb/ola-miR-1–3p,sfrp5/ola-miR-96–5p/miR-455–5p)and bone morphogenetic protein(Bmp)signaling(bmp3/ola-miR-96–5p/miR-181b-5p/miR-199a-5p/miR-205–5p/miR-455–5p).Both pathways are major indicators of impaired bone formation,while the altered Rank signaling in osteoclasts(c-fos/miR-205–5p)suggests a potentially augmented bone ***,a typical BaP-responsive pathway,the Nrf2-mediated oxidative stress response(gst/ola-miR-181b-5p/miR-199a-5p/miR-205),was also ***,mRNA levels of epigenetic modification enzymes(e.g.,hdac6,hdac7,kdm5b)were found *** findings indicated that epigenetic factors(e.g.,miRNAs,histone modifications)may directly regulate the expression of genes associated with transgenerational BaP bone toxicity and warrants further *** identified candidate genes and miRNAs may serve as potential biomarkers for BaP-induced bone disease and as indicators of historic exposures in wild fish for conservation purposes.

关键词： Polycyclic aromatic hydrocarbons (PAHs) Transcriptome Impaired bone formation Molecular pathways MicroRNAs Medaka(Oryzias latipes)

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