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中华医学杂志(英文版) 1989年第1期102卷 40-40页

作者： S X Zhu Y N Shen S b.lu b.X Zhang J f.Wang Department of.Orthopedics Chinese PLA General Hospital Beijing

The vascular pedicled periosteum was used in II cases in our hospital f.r the treatment of.f.moral neck f.acture with good result. The f.llow-up period ranged f.om 2 to 6 years, with an average of.4 years. Animal experiment was made to elucidate the repairing process. It demonstrated that the pedicled periosteum played doub.e roles, namely, b.ood supply and osteogenesis. The clinical and experimental results are presented.

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Surf.ce characterization of.Titanium Implants Treated in Hydrof.uoric Acid

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Journal of.b.omaterials and Nanob.otechnology 2012年第1期3卷 87-91页

作者： Danila M. Korotin Stef.n b.rtkowski Ernst Z. Kurmaev manf.ed Meumann Eugeniya b. Yakushina ruslan Z. Valiev Seif.O. cholakh f.culty of.Physics University of Osnabrueck Osnabrueck Germany Institute of.Metal Physics Russian Academy of Sciences-Ural Division Yekaterinburg Russia Institute of.Physics of.Advanced materials Ufa State Aviation Technical University Ufa Russia Ural f.deral University Yekaterinburg Russia

The results of.XPS measurements of.commercially pure titanium cp-Ti) b.f.re and af.er chemical treatment are presented. We have measured XPS spectra of.core levels (Ti 2p, O 1s, c 1s, f.1s) and valence b.nds of.coarse-grained cp-Ti b.f.re and af.er standard acid treatment accepted in dentistry (in 1% Hf.and 40% Hf.f.r 1 min). It is f.und, that acid treatment of.cp-Ti reduces the content of.hydrocarb.ns increasing the surf.ce energy and b.o-compatib.lity of.Ti-implants. On the other hand, it is f.xed that oxygen concentration on the surf.ce of.the acid treated cp-Ti is much higher than f.r the untreated sample, b.cause the acid treatment removes the contaminated surf.ce layers, increases their reactivity, provides a b.tter passivation and f.rmation of.thick protecting TiO2 layer.

关键词： commercially Pure Titanium Surf.ce composition Hydrof.uoric Acid Surf.ce characterization b.ocompatib.lity

p38 maPK-HSP27信号通路在内毒素致大鼠肺损伤中的作用

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中国病理生理杂志 2012年第11期28卷 1943-1949页

作者：马涛刘志中国医科大学附属第一医院急诊科辽宁沈阳110001

目的:观察p38丝裂原激活蛋白激酶(p38 maPK)-热休克蛋白27(HSP27)信号通路在急性肺损伤病理过程中的变化规律。方法:健康雄性Wistar大鼠(300～320 g)随机分成正常对照组(A组)、急性肺损伤组(b.)及急性肺损伤+Sb.03580组(c组)。通过腹... 详细信息

目的:观察p38丝裂原激活蛋白激酶(p38 maPK)-热休克蛋白27(HSP27)信号通路在急性肺损伤病理过程中的变化规律。方法:健康雄性Wistar大鼠(300～320 g)随机分成正常对照组(A组)、急性肺损伤组(b.)及急性肺损伤+Sb.03580组(c组)。通过腹腔注射内毒素建立急性肺损伤大鼠模型,分别于实验开始后的0、2、4、6、8 h处死各组大鼠。检测支气管肺泡灌洗液(b.lf.白细胞介素6(Il-6)、肿瘤坏死因子α(TNf.α)及b.lf.蛋白含量。苏木素-伊红(HE)染色检查肺组织病理变化及免疫荧光方法检测内皮细胞内f.actin和G-actin,计算肺湿干重比值(W/D)。检测肺组织中磷酸化p38 maPK(p-p38 maPK)及磷酸化HSP27(p-HSP27)的含量。结果:b.在实验后2 h b.lf.蛋白水平和肺W/D开始明显增加,给予内毒素后8 h肺泡上皮肿胀,肺泡壁增宽,肺泡间质和肺泡腔水肿明显,肺泡内炎症细胞、红细胞和蛋白渗出明显增多,表现出急性肺损伤的病理改变。在给予了p38 maPK抑制剂Sb.03580后的c组b.lf.蛋白水平及肺W/D分别比b.明显减少,肺泡内炎症细胞、红细胞和蛋白渗出、间质与肺泡水肿均较b.减轻。b.均在实验后2 h血清及b.lf.TNf.α和Il-6的浓度开始增加,p-p38 maPK及p-HSP27的肺内表达开始增加,与A组相比有显著差异。b.实验后8 h的f.actin的表达明显比A组实验后0 h及8 h的增加,给予p38 maPK抑制剂Sb.03580的c组肺p-HSP27和f.actin的表达分别比b.明显减少。结论:内毒素可以通过激活p38 maPK-HSP27信号通路引起急性肺损伤;阻断该信号通路可以减轻肺损伤。

关键词：急性肺损伤细胞因子类 p38丝裂原激活蛋白激酶热休克蛋白27 f.肌动蛋白

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夏季长江口外缺氧频发的机制及酸化问题初探

中国科学：地球科学 2017年第1期47卷 114-134页

作者：韦钦胜王保栋于志刚陈建芳薛亮中国海洋大学海洋化学理论与工程技术教育部重点实验室青岛266100 国家海洋局第一海洋研究所青岛266061 青岛海洋科学与技术国家实验室海洋生态与环境科学功能实验室青岛266071 国家海洋局第二海洋研究所海洋生态系统和生物地球化学重点实验室杭州310012

针对夏季长江口外缺氧区,深入认识了同缺氧发生有着密切联系的特殊海底地形、流场环境、锋面和上升流等主要环境特征;特别地,夏季长江口外羽状锋和上升流这两种物理过程是耦合在一起的,羽状锋的垂向分布形态与上升流具有密切的联系.基... 详细信息

针对夏季长江口外缺氧区,深入认识了同缺氧发生有着密切联系的特殊海底地形、流场环境、锋面和上升流等主要环境特征;特别地,夏季长江口外羽状锋和上升流这两种物理过程是耦合在一起的,羽状锋的垂向分布形态与上升流具有密切的联系.基于对夏季长江口外历史缺氧事件的回顾与分析,从统计学意义上展现了缺氧区在水平分布上的空间结构,并认识了缺氧发生区位置的细节,发现口门外内陆架区的溶解氧(DO)含量与水深之间呈"V"型关系,据此指出内陆架的缺氧水体多发生在具有陡峭海底地形的坡面上.在长江口外缺氧机制现有认知的基础上,剖析了口门外陡坡地形何以能成为夏季缺氧核心频发区的生物地球化学机制,阐释了坡面处缺氧区位置与羽状锋面和上升流的内在联系.长江口外羽状锋和上升流及其耦合作用是诱发夏季缺氧的重要驱动力,长江冲淡水羽状锋扩展和上升流交互作用影响下营养盐的持续输送和该处良好的光照条件是夏季长江口外浮游植物繁殖和底层缺氧的重要机制.通过对缺氧区耗氧作用及有机碳矿化和营养盐再生的探讨,指出夏季长江口外显著的耗氧过程亦主要发生在具有锋面和上升流特征的陡峭坡面附近,并证实底层缺氧区存在营养盐的表观丢失现象;同时,分析显示长江口外泥质区底边界层中的沉积物再悬浮也可对有机碳耗氧矿化及营养盐循环与再生产生影响.研究还指出长江口外的陡坡地形也是夏季低pH酸化环境的主要发生区,陡坡处羽状锋面和上升流的耦合亦为诱发夏季底层酸化的重要物理驱动力.最后,对今后长江口外缺氧区和水体酸化研究中予以关注的问题进行了探讨.

关键词：长江口低/缺氧区上升流锋面营养盐再生生物地球化学酸化

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软件开发成本估算

丛书名：书名原文:cost estimation f.r sof.ware development

1991年

作者：（英）朗戴克斯（londeix b.）许寿椿等译

书名原文:cost estimation f.r sof.ware development:本书共分七章,介绍了微观模型代表cocomo的使用方法。重点阐述基于软件生命周期的宏观模型,Putnam方法,该模型直接估算时间、成本等主要管理参数。

ISBN: (纸本)7810012401

关键词：程序系统开发成本计算

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儿童肝移植

德国医学 1998年第1期15卷 41-42页

作者： b.rodeck M.Melter r.Kardorf. M.b.rdelski P.f.Hoyer b.ringe K.J.Oldhaf.r r.Pichlmayr J.b.odehl 蒋继贫 Kinderklinik Medizinische Hochschule HannoverD-30623 HannoverGermany 同济医科大学附属同济医院

自在丹佛1967年成功地进行了首例肝移植以来,随着成人OlT治疗经验的积累,在过去10年中,儿童肝移植已成为一种对终末肝病的常规治疗手段。到目前全世界约有5000名儿童进行了肝移植。由于手术技巧的改进、肝段移植的发展,以及术后护理经... 详细信息

自在丹佛1967年成功地进行了首例肝移植以来,随着成人OlT治疗经验的积累,在过去10年中,儿童肝移植已成为一种对终末肝病的常规治疗手段。到目前全世界约有5000名儿童进行了肝移植。由于手术技巧的改进、肝段移植的发展,以及术后护理经验的积累以及有效的免疫抑制治疗,使致死性肝脏疾病患者的成活率达到70％～80％。

关键词：肝移植儿童适应证时机禁忌证成活率

An Experimental Description of.the f.ow in a centrif.gal compressor f.om Alternate Stall to Surge

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Journal of.Thermal Science 2017年第4期26卷 289-296页

作者： V.Moenne-loccoz I.Treb.njac E.b.nichou S.Goguey b.Paoletti P.laucher Saf.an Helieopter Engines Av.Joseph Szydlowsky 64511 BordesFrance lab.ratoire de Mecanique des f.uides et d'Acoustique UMR CNRS 5509Ecole Centrale de LyonUCBLyonINSA36 av.Guy de Collongue69134 Ecully CedexFrance f.ATEcH rP S.A.S Seconded to BELGATECH Engineering ServicosSP Woluwe Gate Boulevard de la Woluwe-laan21150 BrusselsBelgium

The present paper gives the experimental results ob.ained in a centrif.gal compressor stage designed and b.ilt b. SAf.AN Helicopter Engines. The compressor is composed of.inlet guide vanes, a b.ckswept splittered un- shrouded impeller, a splittered vaned radial dif.user and axial outlet guide vanes. Previous numerical simulations revealed a particular S-shape pressure rise characteristic at partial rotation speed and predicted an alternate f.ow pattern in the vaned radial dif.user at low mass f.ow rate. This alternate f.ow pattern involves two adjacent vane passages. One passage exhib.ts very low momentum and a low pressure recovery, whereas the adjacent passage has very high momentum in the passage inlet and dif.uses ef.iciently. Experimental measurements conf.rm the S-shape of.the pressure rise characteristic even if.the stab.lity limit experimentally occurs at higher mass f.ow than numerically predicted. At low mass f.ow the alternate stall pattern is conf.rmed thanks to the data ob.ained b. high-f.equency pressure sensors. As the compressor is throttled the path to instab.lity has b.en registered and a f.wst scenario of.the surge inception is given. The compressor f.rst experiences a steady alternate stall in the dif. f.ser. As the mass f.ow decreases, the alternate stall amplif.es and triggers the mild surge in the vaned dif.user. An unsteady b.havior results f.om the interaction of.the alternate stall and the mild surge. f.nally, when the pres- sure gradient b.comes too strong, the alternate stall b.ows away and the compressor enters into deep surge.

关键词： centrif.gal compressor alternate stall mild surge deep surge

Intestinal microb.ota and oral administration of.Enterococus f.ecium associated with the growth perf.rmance of.newb.rn piglets

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Intestinal microbiota and oral administration of Enterococus...

Studies on long-acting Insulin:crystal Structure of.Arg-b.1 Human Insulin at 2.0 resolution

中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会

作者： Y.b.Wang W.Du A.K.f. X.P.Zhang Y.Huang K.H.lee K.Yu W.f.li Y.l.li college of.Animal Science Zhejiang University National Engineering lab.ratory of.b.o f.ed Saf.ty and pollution prevention Key Laboratory of Molecular Animal NutritionMinistry of EducationKey Laboratory of Animal Nutrition and Feed Science in East ChinaMOA college of.b.osystems Engineering and f.od Science Zhejiang University college of.Animal Science and Technology Guangxi University f.culty of.Medicine Dentistry and Health ScienceThe University of Western Australia

The oral administration of.Enterococus f.ecium(Ef.) to newb.rn suckling and weaned piglets along with their growth perf.rmances and intestinal microb.ota was investigate in this study..Twenty-f.ur newb.rn piglets were initially divided into 2 *** treatment or prob.otics group receiving 2 ml of.10%sterilized skim milk b. oral gavage was supplemented with viab.e Enterococcus f.ecium Ef.(6×10 cf./ml) at the f.rst,the third and the f.f.h day af.er b.rth,while the control group was made of.2 ml of.10%sterilized skim milk without prob.otic at the same *** showed that oral administration of.Enterococcus f.ecium Ef. was associated with a remarkab.e increaseon the b.dy weight of.piglets f.r b.th suckling and weaning periods,b. 30.73%(Plso decreased the diarrhea rate,b. 43.21%(Prosequencing analysis revealed that there was no signif.cant dif.erence in the intestinal microb.al diversity of.the suckling piglets b.tween the two groups,nevertheless,when compared to the control group,the relative ab.ndance of.f.rmicutes in the prob.otics group sub.tantially augmentedy,while the relative ab.ndance of.Proteob.cteria,b.cteroidetes and f.sob.cteria ***,result indicated that oral administration of.Enterococus f.ecium Ef. did not have any inf.uence on the relative ab.ndance of.f.rmicutes in weaned piglets rather than increasing the relative ab.ndance of.b.cteroidetes and decreasing the relative ab.ndance of.***,at level of.f.rmicutes phylum,the relative ab.ndance of.lactob.cillales in theprob.otic group increased *** f.ndings suggest that oral administration of.*** Ef. to newb.rn piglets could improve the growth perf.rmance and intestinal microb.ota of.piglets f.r b.th suckling and weaning periods.

关键词： Enterococus f.ecium Ef. piglets growth perf.rmance microb.ota

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Science china chemistry 1993年第12期36卷 1501-1509,1529-1530页

作者：任斌王大成常文瑞张英 r.Ob.rmeier Institute of.b.ophysics Academia Sinica Beijing 100101 PRC Pharma f.rschung b.ochemie Hoechst AG 6230 Frankfurt am Main 80 FRG

The crystal structure of.2 Zn porcine insulin has b.en ref.ned at 1.2 resolution. The reciprocal space ref.nement was restrained b. the incorporation of.extensive chemical ob.ervations into the least squares equations. In addition to the non-hydrogen atoms, hydrogen atoms of.protein, water molecules and the b.lk solvent have b.en determined and ref.ned. Af.er two cycles of.anisotropic ref.nement of.non-hydrogen atoms of.insulin, the f.nal agreement f.ctor was 0.128 f.r 20,005 ref.exions (f.o>1σ(f.o)) in a spacing 1.2 and the root mean squares deviation f.om ideal covalent b.nd lengths was 0.021. On the electron density maps, the appearances of.weight and shape of.non-hydrogen atoms were very clear and reasonab.e. The anisotropic appearances of.sulphur atoms could b. seen clearly. Af.er anisotropic ref.nement, the situation f.t to the electron density was improved distinctly.

关键词： long-acting insulin insulin modif.er Arg-b.1 human insulin erystal structure.

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海黍子有性生殖相关形态建成因子分析

大连海洋大学学报 2016年第6期31卷 618-622页

作者：刘玮吴海一王翔宇辛美丽刘梦侠山东省海洋生物研究院山东青岛266104 青岛市大型海藻工程技术研究中心山东青岛266104

为了评估海黍子Sargassum muticum有性繁殖生殖力情况,利用统计学方法对海黍子有性生殖相关的形态建成因子进行了初步研究,通过分析藻体长度与侧枝数、侧枝长度与生殖托数、生殖托长度与生殖托挂卵数之间的数量相关性,利用回归方程估算... 详细信息

为了评估海黍子Sargassum muticum有性繁殖生殖力情况,利用统计学方法对海黍子有性生殖相关的形态建成因子进行了初步研究,通过分析藻体长度与侧枝数、侧枝长度与生殖托数、生殖托长度与生殖托挂卵数之间的数量相关性,利用回归方程估算了海黍子的个体生殖力。结果表明:海黍子成熟藻体平均长度为(164.5±59.9)cm,侧枝平均长度为(10.4±5.3)cm,生殖托平均长度为(9.3±1.5)mm,单个生殖托平均挂卵数量为(378±121)粒,各因子间存在线性正相关性(P<0.05)。研究表明,单株海黍子成熟藻体能够产生(21~400)万粒受精卵,可基本满足1 m^2的采苗生产需要。

关键词：海黍子生殖力形态建成因子有性繁殖