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Characterization and Origin of the Miocene Mudawwara-Quwayra Basaltic Dike, Southern Jordan

International Journal of Geosciences 2015年第8期6卷 869-881页

作者： hani Alnawafleh Khaled tarawneh Khalil Ibrahim Khitam Zghoul awad Titi Rami Rawashdeh Khaled Moumani Ahmad masri Faculty of Engineering Al-Hussein Bin Talal University Ma’an Jordan Faculty of Engineering Tafila Technical University Tafila Jordan Faculty of Natural Resources and Environment Hashemite University Zarqa Jordan Geological mapping Division Geology Directorate Natural Resources Authority Amman Jordan

Petrographic, mineralogical and geochemical investigations were carried out on representative?samples from the Mudawwara-Quwayra Dike (MQD) in southernJordan. The MQD intruded Paleozoic and Cretaceous rocks as sub-vertical basaltic plugs, striking NW-SE along a fault zone and extending for more than 100 km. The MQD forms irregularly positive features, and is represented by symmetrical, elliptical, elongated or circular hills. It comprises thin basaltic layers intercalated?with pyroclastics and inclusions of different size and lithology, including limestone, sandstone, phosphate, quartzite, and marble. Petrographically, the rock exhibits phyric, porphyritic, vitrophyric and locally glomerophyritic textures manifested by plagioclase, clinopyroxene and rare?olivine and set in a matrix of plagioclase, pyroxene, brown glass and opaque phases. Clinopyroxene?and olivine phenocyrsts show disequilibrium textures such as reaction/resorbed rims in the?forms of corroded ends. The paragenetic sequence shows that olivine is the first phase to be crystallized and coexisting with pyroxene at sometime, while pyroxene continues crystallization. Plagioclase might have crystallized in contemporaneous later than the pyroxene. The MQD rocks are classified?as basalt and exhibit a narrow range of silica with a unique subalkaline affinity. This is most?probably attributed to assimilation of the abundant siliciclastic inclusions by the ascending magma. Emplacement of the MQD is attributed to regional phase of magmatism in Jordan and Saudi Arabia, which is probably the peripheral extension of a large magmatic event widely exposed in the Red Sea realm.

关键词： Jordan Basalt Dike Miocene Geochemistry

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Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice

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Bone Research 2017年第2期5卷 95-108页

作者： Eric E Beier Tzong-Jen Sheu Emily A Resseguie ma.a.iko ta.a.a.a.hani a.awad Deborah A Cory-Slechta J Edward Puzas Department of Environmental Medicine University of Rochester School of Medicine and Dentistry Rochester NY USA Department of Environmental and Occupational Medicine Rutgers University Piscataway NJ USA and Center for Musculoskeletal Research University of Rochester School of Medicine and Dentistry Rochester NY USA

Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in ***, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone.

关键词： Sclerostin prenatal negative

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Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”

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Bone Research 2019年第3期7卷 225-242页

作者： Elysia A. masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie hani A. awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan Center for Musculoskeletal Research University of Rochester Medical Center Rochester NY USA Department of Biomedical Engineering University of Rochester Medical Center Rochester NY USA Department of Pathology and Laboratory Medicine University of Rochester Medical Center Rochester NY USA Department of Orthopaedics University of Rochester Medical Center Rochester NY USA Department of Microbiology & Immunology University of Rochester Medical Center Rochester NY USA Department of Orthopaedic Surgery Kyoto University Kyoto Japan Department of Orthopaedic Surgery Virginia Commonwealth University Medical Center Richmond VA USA

Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, *** intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure.

关键词： disease caused by soft tissue necrotic tissuel

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华仁杏幼果转录组SSR信息分析及其分子标记开发

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植物遗传资源学报 2018年第5期19卷 987-992页

作者：赵罕高福玲郭欢欢乌云塔娜朱高浦中国林业科学研究院经济林研究开发中心郑州450003 河南省经济林和林木种苗工作站郑州450003 郑州植物园郑州450042

为了解华仁杏微卫星(SSR)分布规律,开发EST-SSR引物,为华仁杏种质资源评价与辅助育种提供有效的鉴定标记。本研究采用生物信息学方法对华仁杏幼果转录组SSR位点的数量、频率、分布特征进行了统计分析;利用转录组数据进行了SSR引物的筛... 详细信息

为了解华仁杏微卫星(SSR)分布规律,开发EST-SSR引物,为华仁杏种质资源评价与辅助育种提供有效的鉴定标记。本研究采用生物信息学方法对华仁杏幼果转录组SSR位点的数量、频率、分布特征进行了统计分析;利用转录组数据进行了SSR引物的筛选和开发,并利用开发出的引物对华仁杏29个无性系进行了多态位点检测和鉴定。结果表明:华仁杏幼果EST-SSR的分布频率为19.21%,重复单元的重复次数分布在5~24次之间,优势重复基序为单核苷酸、2核苷酸、3核苷酸,分别占总SSR的19.81%、46.47%、32.49%。参试的139对引物中有39对引物可扩增出目标序列,其中24对引物可检测出多态性位点,占参试引物总数的17.27%。24对引物在29个华仁杏无性系中共检测出了170个等位基因位点,多态性信息含量(PIC)介于0.33~0.87之间,平均为0.64,其中高多态性引物19条,占多态性引物比例的79.2%。本研究对华仁杏转录组SSR信息进行了分析,并开发出了19对高多态性SSR引物,5对中多态性引物,为华仁杏种质资源评价及分子标记辅助育种提供了基础。

关键词：华仁杏微卫星转录组

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哈尼族与“茶马古道”

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思茅师范高等专科学校学报 2007年第4期23卷 18-22页

作者：敏塔敏吉 <墨江>报社云南墨江654800

以今天普洱市为中心的"茶马古道",是历史上普洱茶走出普洱、走向中原、走向世界、芳香天下的主要通道。而哈尼族则全面参与开拓了这一普洱连接世界的古道。通过考察哈尼族与"茶马古道"的关系,从这一侧面为普洱茶文化的研究提供了依据。

关键词：哈尼族茶马古道文化交流

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