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Deficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology

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World Journal of Gastroenterology 2006年第24期12卷 3901-3905页

作者： martin Bortlík Ivana Vítková martina Pape(z|ˇ)ová Milada Kohoutová Ale(s|ˇ) Novotn(y|') Stanislav Adamec Petra Chalupná Milan Luká(s|ˇ) Gastroenterology Center 4th Internal Department General Faculty Hospital1st School of MedicineCharles UniversityPragueCzech Republic Department of Pathology General Faculty Hospital 1st School of MedicineCharles UniversityPragueCzech Republic Institute for Biology and Medical Genetics General Faculty Hospital 1st School of MedicineCharles UniversityPragueCzech Republic

AIM： To evaluate the frequency of the loss of the Adenomatous Polyposis Coil （APC） protein and to compare the APC status with the characteristics of colorectal adenomas. METHODS： Immunohistochemical analysis of the APC protein was performed on 118 adenomas and the results were compared with parameters of malignant potential, location of adenomas, macroscopic appearance and age of the patients. RESULTS： A complete loss of the APC protein was found in 28 （24%） adenomas, while 90 （76%） were APC positive. The mean size of adenomas was 13.5± 14.2 mm （95% CI 10.5-16.5） in APC-positive, and 13.8 ±15.5 mm （95% CI 7.8-19.8） in APC-negative adenomas （P = 0.364）. Statistical analysis revealed no difference between APC-positive and negative adenomas as to the histological type （P = 0.327） and grade of dysplasia （P =0.494）. We found that even advanced adenomas did not differ in their APC status from the non-advanced tumors （P = 0.414）. Finally, no difference was found when the location （P = 0.157）, macroscopic appearance （P = 0.571） and age of patients （P = 0.438） were analysed and compared between both APC positive and negative adenomas. CONCLUSION： Most adenomas expressed full-length APC protein, suggesting that protein expression is not a reliable marker for assessment of APC gene mutation. Complete loss of APC protein did not influence morphology, location, or appearance of adenomas, nor was it affected by the patient＇s age.

关键词： Adenomatous Polyposis Coli protein Adeno-ma Immunohistochemistry Histology

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Gadolinium-doped mesoporous tungsten oxides:Rational synthesis,gas sensing performance,and mechanism investigation

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Nano Research 2023年第5期16卷 7527-7536页

作者： Yanyan Li Keyu Chen Yan Liu Junhao ma Yaozu Liao Haitao Yang Jinsheng Cheng Qin Yue Kaiping Yuan Yuan Ren Yidong Zou Yonghui Deng Department of Chemistry Department of Gastroenterology and HepatologyZhongshan HospitalZhangjiang Fudan International Innovation CenterState Key Laboratory of Molecular Engineering of PolymersiChEMShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China State Key Laboratory for Modification of Chemical Fibers and Polymer materials Donghua UniversityShanghai 201620China School of materials Science and Engineering Nanchang Hangkong UniversityNanchang 330063China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610051China Frontier Institute of Chip and System Fudan UniversityShanghai 200433China Henry-Fork School of Food Sciences Shaoguan UniversityShaoguan 512005China

As a typical family of volatile toxic compounds,benzene derivatives are massive emission in industrial production and the automobile field,causing serious threat to human and *** reliable and convenient detection of low concentration benzene derivatives based on intelligent gas sensor is urgent and of great significance for environmental ***,through heteroatomic doping engineering,rare-earth gadolinium(Gd)doped mesoporous WO_(3)with uniform mesopores(15.7–18.1 nm),tunable high specific surface area(52–55 m^(2)·g^(−1)),customized crystalline pore walls,was designed and utilized to fabricate highly sensitive gas sensors toward benzene derivatives,such as *** to the high-density oxygen vacancies(ov)and significantly increased defects(W^(5+))produced by Gd atoms doping into the lattice of WO_(3)octahedron,Gd-doped mesoporous WO_(3)exhibited excellent ethylbenzene sensing performance,including high response(237 vs.50 ppm),rapid response–recovery dynamic(13 s/25 s vs.50 ppm),extremely low theoretical detection limit of 24 *** in-situ diffuse reflectance infrared Fourier transform and gas chromatograph-mass spectrometry results revealed the gas sensing process underwent a catalytic oxidation conversion of ethylbenzene into alcohol species,benzaldehyde,acetophenone,and carboxylate species along with the resistance change of the Gd-doped mesoporous WO_(3)based ***,a portable smart gas sensing module was fabricated and demonstrated for real-time detecting ethylbenzene,which provided new ideas to design heteroatom doped mesoporous materials for intelligent sensors.

关键词： mesoporous materials semiconductor metal oxides gadolinium doping gas sensor benzene derivatives

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最优速度模型与元胞自动机模型的比较研究

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物理学报 2010年第2期59卷 832-841页

作者：贾宁马寿峰天津大学管理学院系统工程研究所天津300072

用解析分析与数值仿真的手段研究了一种典型的车辆跟驰模型(ov模型)与元胞自动机模型(NS模型)之间的区别与联系.首先通过对模型规则的分析,证明了确定NS模型是ov模型的一种离散形式.随后针对两模型更复杂的具体形式,通过数值仿真的手段... 详细信息

用解析分析与数值仿真的手段研究了一种典型的车辆跟驰模型(ov模型)与元胞自动机模型(NS模型)之间的区别与联系.首先通过对模型规则的分析,证明了确定NS模型是ov模型的一种离散形式.随后针对两模型更复杂的具体形式,通过数值仿真的手段进行了模型的密度-流量关系与模型在开放边界下的动态特性的研究.实验结果表明,从现象来看,ov模型与NS模型具有非常近似的性质,但两种模型的机制不相同,并且各自具有不能相互替代的优势.为交通流模型的使用和改进提供了参考.

关键词：最优速度模型元胞自动机模型基本图时空斑图

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P2RX1对浆液性卵巢癌患者的预后判断价值及其在免疫浸润机制中的作用

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癌变．畸变．突变 2024年第3期36卷 208-218页

作者：宋珍明于运亮杨金梅刘坤盖婵婵马春宇锦州医科大学基础医学院辽宁锦州121001 滨州医学院烟台附属医院检验科山东烟台264100

目的:探讨嘌呤能受体X1(P2RX1)与浆液性卵巢癌(ov)患者的临床病理指标及肿瘤微环境免疫细胞浸润的关系,为ov免疫治疗提供新的线索。方法:以ov患者的血清和卵巢癌组织为研究对象,分别以健康成年人和非癌症患者为对照,采用免疫组织化学(I... 详细信息

目的:探讨嘌呤能受体X1(P2RX1)与浆液性卵巢癌(ov)患者的临床病理指标及肿瘤微环境免疫细胞浸润的关系,为ov免疫治疗提供新的线索。方法:以ov患者的血清和卵巢癌组织为研究对象,分别以健康成年人和非癌症患者为对照,采用免疫组织化学(IHC)、逆转录荧光定量PCR(RT-qPCR)、酶联免疫吸附试验(ELISA)及生物信息学方法研究ov中P2RX1的表达模式。利用TCGA数据库分析P2RX1 mRNA的表达水平与ov患者不同临床病理指标的相关性;筛选差异基因,分析ov中P2RX1参与的信号通路及其生物学功能;分析P2RX1与免疫细胞浸润丰度、肿瘤免疫相关基因、免疫检查点等的相关性。结果:IHC检测结果显示,P2RX1主要表达于正常卵巢上皮中;RT-qPCR检测结果显示,与非癌组织相比,P2RX1 mRNA在ov中低表达(Pov患者血清中低表达(Pov患者总生存期较长,预后较好(Pov患者的肿瘤纯度和年龄有关(Pov患者其差异表达基因主要富集于免疫细胞分化、发育等生物学进程。P2RX1与ov中TGFB1、SLAMF7、CD27等多个免疫检查点有关。P2RX1与B细胞标记包括CD79A、CD79B、CD19明显正相关(均为r>0.4,Pov中P2RX1的低表达与患者预后不良有关,P2RX1可能参与ov肿瘤微环境免疫细胞浸润、分化等进程。

关键词：嘌呤能受体X1 浆液性卵巢癌预后免疫治疗

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New insights into the mechanism of reactive adsorption desulfurization on Ni/ZnO catalysts:Theoretical evidence showing the existence of interfacial sulfur transfer pathway and the essential role of hydrogen

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Petroleum Science 2023年第5期20卷 3240-3250页

作者： Hou-Yu Zhu Nai-You Shi Dong-Yuan Liu Rui Li Jing-Gang Yu Qi-Tang ma Tu-Ya Li Hao Ren Yuan Pan Yun-Qi Liu Wen-Yue Guo School of materials Science and Engineering China University of Petroleum(East China)Qingdao266580ShandongChina State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao266580ShandongChina

As well known in the petroleum industry and academia,Ni/ZnO catalysts have excellent desulfurization ***,the sulfur transfer mechanism of reactive adsorption desulfurization(RADS)that occurs on Ni/ZnO catalysts remains ***,a periodic Ni nanorod supported on ZnO slab was built to represent the Ni/ZnO system,and density functional theory calculations were performed to study the sulfur transfer process and the role of H_(2)within the *** results elucidate that the direct solid-state diffusion of S from Ni to interfacial oxygen vacancies(ov)is more favorable than the hydrogenation of S to SH/H_(2)S on Ni and the subsequent H_(2)S desorption,and accordingly,H_(2)O is produced on Ni rather than on *** initio thermodynamics analysis shows that the hydrogen atmosphere applied in preparing Ni/ZnO catalysts greatly promotes the O_(v)formation on ZnO surface,which accounts for the presence of interfacial O_(v)in freshly prepared *** RADS condition,hydrogenation of interfacial O atoms to form O-H groups facilitates the reverse spillover of these lattice O atoms from ZnO to Ni,accompanied with the interfacial O_(v)*** contrast to the classic S transfer mechanism via H_(2)S,the present work clearly demonstrates that the interfacial S transfer is a feasible reaction pathway in the RADS *** importantly,the existence of interfacial O_(v)is an essential prerequisite for this interfacial S diffusion,and H_(2)plays a key role in facilitating the O_(v)formation.

关键词： Reactive adsorption desulfurization Ni/ZnO Interface Sulfur transfer Density functional theory

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Energy-Efficient Jammer Selection Approach for QoS Provisioning in Distributed Wireless Cooperative Networks

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China Communications 2012年第7期9卷 90-98页

作者： ma Yue Wang Li Ke Tenghui Zhang Yong Song Mei Wang Xiaojun School of Computer Science Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China Dublin City University DublinIreland

Abstract：Aiming at achieving better Quality of Service （QoS） provisioning in distributed wireless cooperative networks, a novel energy efficient jammer selection approach is proposed in this pa per. We employ Secrecy Capacity （SC） to charac terize the security of transmission. In order to ac curately describe the timevarying characteristic, related channels are modeled as FiniteState M ark ov Channels （FSMCs）. The remaining energy of candidate node is considered in a similar way.

关键词： wireless cooperative network jammer selection secrecy capacity energy balance

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Ag nanoparticles deposited on oxygen-vacancy-containing BiVO_4 for enhanced near-infrared photocatalytic activity

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Chinese Journal of Catalysis 2018年第1期39卷 128-137页

作者： Chunjing Shi Xiaoli Dong Xiuying Wang Hongchao ma Xiufang Zhang School of Light Industry and Chemical Engineering Dalian Polytechnic University Dalian 116034 Liaoning China

This study investigates the photodegradation of the organic dye rhodamine B by Ag‐nanoparticlecontaining BiVO4catalysts under different irradiation *** catalysts consist of Ag nanoparticles deposited on oxygen‐vacancy‐containing *** morphology of the BiVO4is olive shaped,and it has a uniform size *** BiVO4possesses a high oxygen vacancy density,and the resulting Ag nanoparticle‐BiVO4catalyst exhibits higher photocatalytic activity than *** RhB degradation by the Ag nanoparticle‐BiVO4catalyst is99%after100min of simulated solar ***4containing oxygen vacancies as a rationally designed support extends the catalyst response into the near‐infrared region,and facilitates the trapping and transfer of plasmonic hot *** enhanced photocatalytic efficiency is attributed to charge transfer from the BiVO4to Ag nanoparticles,and surface plasmon resonance of the Ag *** insights into electron‐hole separation and charge transfer may arouse interest in solar‐driven wastewater treatment and water splitting.?2018,Dalian Institute of Chemical Physics,Chinese Academy of *** by Elsevier *** rights reserved.

关键词： Bismuth vanadate Oxygen vacancy Silver nanoparticle Surface plasmon resonance Solar‐driven

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高阶像差及散射光对非球面IOL眼视网膜成像质量的影响

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中华实验眼科杂志 2016年第3期34卷 254-259页

作者：马瑶马忠旭高原孙龙格天津医科大学眼科临床学院天津市眼科医院天津市眼科学与视觉科学重点实验 300020

背景高阶像差和散射光可能会对白内障超声乳化摘出联合非球面IOL植入眼视网膜成像质量造成影响，但目前采用客观方法评估其影响的研究较少。目的客观分析白内障超声乳化摘出联合非球面IOL植入术后的高阶像差及散射光对视网膜成像质量的... 详细信息

背景高阶像差和散射光可能会对白内障超声乳化摘出联合非球面IOL植入眼视网膜成像质量造成影响，但目前采用客观方法评估其影响的研究较少。目的客观分析白内障超声乳化摘出联合非球面IOL植入术后的高阶像差及散射光对视网膜成像质量的影响，并探讨改善白内障术后视觉质量的方法。方法采用系列病例观察研究方法，收集天津市眼科医院2014年2—8月行白内障超声乳化摘出联合非球面IOL植入术3个月的患者53例67眼，利用i-Trace波前像差仪测量术后3个月患者4mm瞳孔下的全眼、角膜及晶状体的总像差、总高阶像差、球差、彗差、三叶草等主要高阶像差的均方根值（RMS），分析全眼像差与角膜像差、晶状体像差的相关性。用视觉质量分析系统OQASⅡ测量非球面IOL植入眼4mm瞳孔下的客观散射指数（OSI）及客观视网膜成像质量指标，包括调制解调函数截止频率（MTFcutoff）、斯特尔比值（SR）及100％、20％、9％对比度下的OQAS值，分析客观视网膜成像质量指标与全眼像差、角膜像差、晶状体像差及OSI的相关性；并分析OSI与全眼像差、角膜像差及晶状体像差的相关性。结果全眼像差与角膜像差、晶状体像差均呈正相关（r=0．255～0．586，均P〈O．05；r=0．582—0．907，均P〈0．01），全眼像差与晶状体像差的相关性更强。客观视网膜成像质量指标与全眼的总像差、总高阶像差及各主要高阶像差均呈负相关（r=-0．247—-0．675，均P〈0．05）；客观视网膜成像质量指标与角膜、晶状体的总像差、总高阶像差及部分主要高阶像差呈负相关（r=-0．245—-0．497，均P〈0．05；r=-0．246—-0．513，均P〈0．05）。客观视网膜成像质量指标与OSI均呈负相关（r=-0．620—-0．781，均P〈0．01）；OSI与全眼、角膜及晶状体的总像差、总高阶像差及部分主要高阶像差均呈正相关（r=0．396—0．727，均P〈O．01；r=0．320—0．522，均P〈0．05；r=0．319—0．598，均P〈0．01）。结论非球面IOL植入眼的高阶像差及散射光可能是术眼客观视网膜成像质量下降的主要影响因素，晶状体高阶像差对全眼高阶像差的影响更大。

关键词：白内障非球面人工晶状体像差散射光视觉质量

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基于Metropolis-Hastings算法的α稳定分布参数估计

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电机与控制学报 2012年第12期16卷 94-98页

作者：马洪斌马岩杨春梅沈锋哈尔滨理工大学机械动力工程学院黑龙江哈尔滨150080 东北林业大学研究生院黑龙江哈尔滨150040 东北林业大学机电工程学院黑龙江哈尔滨150040 哈尔滨工程大学自动化学院黑龙江哈尔滨150001

针对α稳定分布参数估计问题,提出了一种基于MCMC动态模拟的参数估计方法。该方法根据贝叶斯理论建立在α稳定分布层次模型的基础上,利用Metropolis-Hastings抽样方法生成mark-ov链,在贝叶斯框架下将所有待估计参数视为随机变量,利用后... 详细信息

针对α稳定分布参数估计问题,提出了一种基于MCMC动态模拟的参数估计方法。该方法根据贝叶斯理论建立在α稳定分布层次模型的基础上,利用Metropolis-Hastings抽样方法生成mark-ov链,在贝叶斯框架下将所有待估计参数视为随机变量,利用后验分布实现稳定分布参数的同时估计,给出了新方法的迭代更新过程,并推导了接受概率的计算公式。理论分析和仿真结果表明,该方法能准确地估计出α稳定分布的4个参数,实现了任意对称或非对称α稳定分布的参数估计。

关键词： α稳定分布参数估计 MCMC Metropolis-Hastings算法贝叶斯推断

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Landslide mapping and analysis along the China-Pakistan Karakoram Highway based on SBAS-InSAR detection in 2017

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Journal of Mountain Science 2021年第10期18卷 2540-2564页

作者： SU Xiao-jun ZHANG Yi MENG Xing-min YUE Dong-xia ma Jin-hui GUO Fu-yun ZHOU Zi-qiang REHmaN Mohib Ur KHALID Zainab CHEN Guan ZENG Run-qiang ZHAO Fu-meng College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000China School of Earth Sciences Lanzhou UniversityLanzhou 730000China Gansu Tech Innovation Centre for Environmental Geology and Geohazard Prevention Lanzhou 730000China Geological Environment Monitoring Institute of Gansu Province Lanzhou 730050China Institute of Geological Hazards Prevention Gansu Academy of SciencesLanzhou 730000China

The Karakoram Highway(KKH),a part of the China–Pakistan Economic Corridor(CPEC),is a major highway connecting northern Pakistan to *** inventorying and analysis of landslides along KKH are challenging because of poor accessibility,vast study area,limited availability of ground-based datasets,and the complexity of landslide processes in the *** order to preserve life,property,and infrastructure,and to enable the uninterrupted and efficient operation of the KKH,it is essential to strengthen measures for the prevention and control of geological *** the present study,SBASInSAR(Small Baseline Subsets-Interferometric Synthetic Aperture Radar)was used to process 150 scenes of Sentinel 1-A images in the year 2017 along the Karakoram Highway.A total of 762 landslides,including 57 complex landslides,126 rock falls,167 debris slides,and 412 unstable slopes,ranging in size between 0.0017 and 10.63 km2 were ***,this study also gains an inventory of 40 active glacier movements in this *** categorization,displacements characteristics,spatial distribution,and their relationship with various contributing factors have been successfully investigated along the entire KKH using image interpretation and frequency-area *** criteria adopted for landslides categorization is presented in the *** results showed that the 2-D ground deformation derived in Hunza valley echoes well with the general regional landslides *** spatial distribution analysis revealed that there are clumped distributions of landslides in the Gaizi,Tashkurgan,and Khunjerab in China,as well as in Hunza valley,and north of Chilas city in *** results indicated that these landslides mainly occur on south-facing slopes with a slope angle of 20°–45°and elevation relief of 550–2,100 *** development is also related to low vegetation cover and weathering effects in mountain ***,our study provides scientific data

关键词： Landslides mapping Slope deformation Identification Landslide development Area development ratio SBAS-InSAR Karakoram Highway

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