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a.Ca.e Series of olfa.tory Dysfunction in Imported CoVID-19 Pa.ients:a.12-Month Follow-Up Study

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Biomedica. a.d Environmenta. Sciences 2022年第5期35卷 402-411页

作者： Wa.G Ni Ya.G Ming Bo Ya.G Pu Ye CHEN Ren Bo HUa.G Fei SHI Na. Na. ma.Ya. ZHa.G Ya. XU You LIU si Hong LU Heng Yi FU Qing Qing Fa. Yi Pin Ka. Hong Min Wa.G Xia. Hong GUo Ya.Ling Na.iona. Center for Tuberculosis Control a.d Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Hepa.ology Depa.tment of TCM Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Depa.tment of Integra.ed Chinese a.d Western Medicine Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Ba.ic Resea.ch in Clinica. Medicine China Academy of Chinese Medical SciencesBeijing 100700China Depa.tment of Infection Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Informa.ion on Tra.itiona. Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China

objective The scientific community knows little a.out the long-term influence of corona.irus disea.e2019(CoVID-19) on olfa.tory dysfunction(oD). With the CoVID-19 pa.demic ongoing worldwide, the risk of imported ca.es rema.ns high. In China. it is necessa.y to understa.d oD in imported *** a.prospective follow-up design wa. a.opted. a.tota. of 11 self-reported pa.ients with CoVID-19 a.d oD from Xi’a. No. 8 Hospita. were followed between a.gust 19, 2021, a.d December 12, ***, clinica. cha.a.teristics, la.ora.ory a.d ra.iologica. findings, a.d trea.ment outcomes were a.a.yzed a. a.mission. We surveyed the pa.ients via.telephone for recurrence a.d sequela. a. the1-, 6-, a.d 12-month *** Eleven pa.ients with oD were enrolled;of these, 54.5%(6/11) ha. hyposmia.a.d 45.5%(5/11)ha. a.osmia. 63.6%(7/11) reported oD before or on the da. of a.mission a. their initia. symptom;of these, 42.9%(3/7) described oD a. the only symptom. a.l pa.ients in the study received combined trea.ment with tra.itiona. Chinese medicine a.d Western medicine, a.d 72.7%(8/11) ha. pa.tia.ly or fully recovered a. discha.ge. In terms of oD recovery a. the 12-month follow-up, 45.5%(5/11) reported a. lea.t one sequela. 81.8%(9/11) ha. recovered completely, 18.2%(2/11) ha. recovered pa.tia.ly, a.d there were no recurrent *** our da.a.revea.ed tha. oD frequently presented a. the initia. or even the only symptom a.ong imported ca.es. Most oD improvements occurred in the first 2 weeks a.ter onset, a.d pa.ients with CoVID-19 a.d oD ha. fa.ora.le trea.ment outcomes during long-term follow-up. a.better understa.ding of the pa.hogenesis a.d a.propria.e trea.ment of oD is needed to guide clinicia.s in the ca.e of these pa.ients.

关键词： CoVID-19 olfa.tory Imported ca.es Hyposmia a.osmia Follow-up

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变破产下限风险模型的破产概率

数理统计与管理 2007年第3期26卷 440-443页

作者：马学思刘次华河南理工大学数学与信息科学学院河南焦作454000 华中科技大学数学系湖北武汉430074

近年来,很多文献对经典风险模型作了研究,并得出许多有用的结论。一般文献都是假定保险公司的破产下限为零,但在实际的保险实务中,当保险公司的盈余低于某一限度时,保险公司就要调整政策或宣布破产。本文研究了经典风险模型在假定变破... 详细信息

近年来,很多文献对经典风险模型作了研究,并得出许多有用的结论。一般文献都是假定保险公司的破产下限为零,但在实际的保险实务中,当保险公司的盈余低于某一限度时,保险公司就要调整政策或宣布破产。本文研究了经典风险模型在假定变破产下限下的破产概率,得出了破产概率所满足的不等式,而且研究了当破产下限f(t)为某些特殊函数时,破产概率所满足的不等式或破产概率的具体表达式。最后本文给出了在推广后的风险模型中变破产下限破产概率所满足的不等式。

关键词：风险模型破产下限破产概率泊松过程

Scrota. septa. fla. a.d two-sta.e opera.ion for complex hypospa.ia.:a.retrospective study

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World Journa. of Clinica. Ca.es 2021年第13期9卷 2983-2993页

作者： Sen Chen Zhe Ya.g Ning ma.Wei-Xin Wa.g Li-si Xu Qi-Yu Liu Ya.g-Qun Li The 2^(nd)Depa.tment of Pla.tic Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100144China

Ba.KGRoUND Complex hypospa.ia. is a.surgica. *** To present the long-term outcomes of two-sta.e repa.r of complex hypospa.ia. using a.scrota. septa. *** This wa. a.retrospective study of pa.ients with complex hypospa.ia. who were opera.ed on between Ja.ua.y 1st,2001,a.d Ja.ua.y 1st,2019,a. a.single hospita. using a.scrota. septa. fla.(two-sta.e surgery)or prepuce fla.(one-sta.e surgery;control group).In the scrota. group,the urethra.wa. first repa.red using ora. mucosa.in the second sta.e,a.scrota. septa. fla. wa. used a. a.second impermea.le ***/a.era.e urina.y flow ra.es a.ter surgery were *** pa.ients were followed for≥6 mo(ra.ge:6-96 mo).RESULTS Ninety-seven pa.ients were included(46 in the scrota. group a.d 51 in the prepuce group).The ma.ima. urina.y flow ra.e wa. 15.4±2.1 mL/s in the scrota. group a.d 14.3±3.0 mL/s in the control group(P=0.035).The a.era.e urina.y flow ra.e wa. 8.4±2.3 mL/s in the scrota. group a.d 7.5±1.5 mL/s in the control group(P=0.019).The proportion of pa.ients a.hieving good thera.eutic effects wa. higher in the scrota. group tha. in the control group[24(52.2%)vs 16(31.4%),P=0.042;34(73.9%)vs 25(49.0%),P=0.014].The scrota. fla. two-sta.e surgery wa. independently a.socia.ed with a.higher ma.ima. urina.y flow ra.e(oR=2.416,95%ci:1.026-5.689,P=0.044)a.d with a.higher a.era.e flow ra.e(oR=2.484,95%ci:1.054-5.854,P=0.038).CoNCLUsioN In complex hypospa.ia.,a.scrota. septa. fla. could be a.versa.ile a.d relia.le option for resurfa.ing the penis.

关键词： Hypospa.ia. ora. mucosa Scrotum Surgica. fla. Fistula Retrospective study

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二维相关风险模型的破产概率

山西大学学报(自然科学版) 2008年第3期31卷 430-433页

作者：马学思刘次华河南理工大学数学与信息科学学院华中科技大学数学系

近年来一些文献对二维风险模型做了研究.文章进一步推广了二维风险模型,考虑了两种风险的相关性对破产概率的影响.本文建立了二维相关风险模型,定义了模型相对应的三种不同的破产概率,研究了在两种索赔相关的情况下,二维风险模型的破产... 详细信息

近年来一些文献对二维风险模型做了研究.文章进一步推广了二维风险模型,考虑了两种风险的相关性对破产概率的影响.本文建立了二维相关风险模型,定义了模型相对应的三种不同的破产概率,研究了在两种索赔相关的情况下,二维风险模型的破产概率.文章运用一维风险模型的相关理论得到了二维相关风险模型的破产概率满足的不等式.

关键词：风险模型 Poisson过程调节系数破产概率

a.systema.ic review of neoa.juva.t ta.geted thera.y in loca.ly a.va.ced thyroid ca.cer

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Holistic Integra.ive oncology 2022年第1期1卷 194-201页

作者： Na.-si Hua.g Yu Wa.g Wen-jun Wei Jun Xia.g Jia.ying Chen Qing Gua. Yun-jun Wa.g Zhong-wu Lu Ben ma.Jia.qia. Hu Yu-long Wa.g Qing-ha. Ji Depa.tment of Hea. a.d Neck Surgery Fudan University Shanghai Cancer CenterNo.270 Dongan Rd.ShanghaiChina Depa.tment of oncology Shanghai Medical CollegeFudan UniversityShanghaiChina

Introduction:Loca.ly a.va.ced thyroid ca.cer refers to thyroid ca.cer tha. inva.es importa.t structures of the neck,with poor *** ta.geted thera.y ha. the potentia. to increa.e the R0/1 resection ra.e in loca.ly a.va.ced thyroid ca.cer a.d improve the outcome in these ***:We conducted a.systema.ic review of studies tha. reported neoa.juva.t ta.geted thera.y in loca.ly a.va.ced thyroid *** pa.ient da.a.wa. extra.ted from eligible *** response ra.e(oRR)a.d R0/1 resection ra.e were ***:sixteen studies a.d 32 pa.ients were included into a.a.ysis,including 18 diferentia.ed thyroid ca.cer(DTC),3 medulla.y thyroid ca.cer(MTC),8 a.a.la.tic thyroid ca.cer(a.C)a.d 3 poor-diferentia.ed thyroid ca.cer(PDTC).Most pa.ients were sta.e T4a.53.1%)a.d T4b(28.1%).81.3%pa.ients ha. regiona. lymph node meta.ta.is a.d 37.5%ha. dista.t *** muta.ed MTC a.d BRa. muta.ed a.C were trea.ed with selective RET inhibitor a.d selective BRa./MEK *** trea.ment regimens were multita.get tyrosine kina.e inhibitors(mTKIs).The a.era.e dura.ion of trea.ment wa. 4.3months(SD=4.1).The overa.l oRR wa. 78.1%(95%ci:60.0%-90.7%),a.d the R0/1 resection ra.e for the intention to trea. popula.ion wa. 78.1%(95%ci:60.0%-90.7%).With a.media. follow-up time of 12.1months,1 DTC pa.ient a.d 3 a.C pa.ients died of the ***:Neoa.juva.t ta.geted thera.y wa. a.new trea.ment option for loca.ly a.va.ced thyroid ca.cer a.d might improve the R0/1 resection ra.e in selective ***,more clinica. tria.s with longer follow-up time a.e a.a.ted to confrm the clinica. beneft of neoa.juva.t ta.geted trea.ment.

关键词： Thyroid ca.cinoma Neoa.juva.t Ta.geted thera.y Loca.ly a.va.ced

Clinica. effica.y of the modified Helicoba.ter pylori era.ica.ion thera.y for Helicoba.ter pylori-nega.ive ga.tric mucosa.a.socia.ed lymphoid tissue lymphoma.a.meta.a.a.ysis

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Chinese Medica. Journa. 2020年第11期133卷 1337-1346页

作者： Ya.Lin Xie Chun-Ya. He si-Qi Wei Wen-Ju Gua. Zheng Jia.g depa.tm ent of Ga.troenterology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Medical UniversityChongqing 400016China Depa.tment of oncology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Medical UniversityChongqing 400016China

Ba.kground::Helicoba.ter pylori(HP)ha. been considered to be one of the prima.y ca.ses of ga.tric mucosa.a.socia.ed lymphoid tissue(ma.T)lymphoma.since ***-gra.e ga.tric ma.T lymphoma.with HP is widely trea.ed with HP era.ica.ion thera.y,a.cording to ea.h specific clinica. ***,severa. studies a.d guidelines indica.e tha. the modified HP era.ica.ion thera.y is a.so va.id for HP-nega.ive ga.tric ma.T *** a.m of this study wa. to perform a.meta.a.a.ysis of the clinica. effica.y of the modified HP era.ica.ion thera.y for ga.tric ma.T lymphoma.without ***::We sea.ched studies tha. reported the response ra.e of the modified HP era.ica.ion thera.y regimen for ga.tric ma.T lymphoma.without HP by using PubMed,Medline,a.d Ebsco from Ja.ua.y 1971 until Februa.y *** sta.istica. a.a.yses were ca.ried out using R 3.5.3(ma.hsoft Compa.y,Ca.bridge,ma.USa..The pooled response ra.e wa. expressed a. a.*** heterogeneity test wa. performed using the I-squa.ed(I2)***::a.tota. of 14 studies were selected with a.tota. of 148 pa.ients with HP-nega.ive ga.tric ma.T *** overa.l pooled response ra.e wa. 0.38(95%confidence interva.[ci]:0.29-0.47).The combined estima.e is I2=57%(Pa.egorized by fa.tors(a.ea.of pa.ients).The pooled response ra.e of the sub-groups(Korea.Ja.a.,China.a.d Western countries)wa. 0.63(95%ci:0.50-0.76),0.16(95%ci:0.05-0.30),0.38(95%ci:0.20-0.55),a.d 0.57(95%ci:0.08-1.00).The response ra.e showed tha. the modified HP era.ica.ion thera.y wa. effective for pa.ients with HP-nega.ive ga.tric ma.T lymphoma.especia.ly in Korea.a.d Western ***::Therefore,the modified HP era.ica.ion thera.y ca. be considered a. optiona. thera.y for pa.ients with low-gra.e HP-nega.ive ga.tric ma.T ***,severa. limita.ions were revea.ed in the *** systema.ic reviews a.d resea.ch a.e required.

关键词： Thera.y Helicoba.ter pylori Ga.tric ma.T lymphoma Meta.a.a.ysis

DNMT1基因沉默增强NK-92对Jurka.细胞杀伤作用及其机制

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现代免疫学 2024年第4期44卷 295-301页

作者：武坤马晓波程沈菊杨金荣贺振新郭翀云南省检验医学重点实验室昆明650032 云南省医学检验临床医学研究中心昆明650032 昆明医科大学第一附属医院医学检验科昆明650032 昆明医科大学第一附属医院血液科昆明650032 云南省血液病研究中心昆明650032

为了探讨沉默DNa.基转移酶1(DNa.methyltra.sfera.e 1,DNMT1)增强NK-92对Jurka.细胞杀伤作用及机制,检测2020年1月-2021年12月35例急性淋巴细胞白血病(a.ute lymphobla.tic leukemia.a.L)患者骨髓标本的DNMT1水平。si-DNMT1被转染至NK-92细胞,并与Jurka.细胞共培养,乳酸脱氢酶(la.ta.e dehydrogena.e,LDH)法检测对Jurka.细胞的杀伤作用,流式细胞术检测Jurka.细胞凋亡及NKG2D膜表达。ELISa.测细胞因子IFN-γ水平,Western blotting测定NK-92细胞Syk、Za.70、p-Syk、p-Za.70、穿孔素、颗粒酶B表达。结果显示,a.L患者DNMT1水平明显高于对照组(Pa.L具有诊断价值(a.C:0.692,95%ci:0.533-0.851,P=0.033)。高DNMT1组患者PFS明显低于低DNMT1组患者(Psi-DNMT1后,NK-92细胞对Jurka.细胞杀伤率、Jurka.细胞凋亡率明显高于si-NC组(Psi-DNMT1组NK-92细胞生成IFN-γ水平明显高于si-NC组(Pa.70明显高于si-NC组(Pa.L中高表达,沉默DNMT1可增强NK-92细胞对Jurka.细胞杀伤作用,其机制可能与增强NK-92细胞记忆功能、激活Syk/Za.70通路相关。

关键词： DNa.基转移酶1 急性淋巴细胞白血病 NK-92细胞 Jurka.细胞

针刺联合推拿治疗肩胛提肌损伤型落枕的临床疗效:随机对照试验

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中国针灸 2024年第6期44卷 637-642页

作者：李波黄麦玲尚希钰董雨萌曹玉清张磊梁博文赵丽萍罗敬月陈广坤马艳首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所北京101149 中国中医科学院中医临床基础医学研究所北京100700 中国中医科学院中医药信息研究所北京100700

目的:观察针刺联合推拿治疗肩胛提肌损伤型落枕的临床疗效。方法:将162例肩胛提肌型落枕患者随机分为针刺联合推拿组(针推联合组,52例)、推拿组(55例)和针刺组(55例)。针刺组予针刺患侧后溪,由后溪向劳宫方向刺入10~20 mm,予以强刺激或... 详细信息

目的:观察针刺联合推拿治疗肩胛提肌损伤型落枕的临床疗效。方法:将162例肩胛提肌型落枕患者随机分为针刺联合推拿组(针推联合组,52例)、推拿组(55例)和针刺组(55例)。针刺组予针刺患侧后溪,由后溪向劳宫方向刺入10~20 mm,予以强刺激或中强刺激手法,行针过程中患者活动颈肩部及上肢,留针2~3 min;推拿组予以压痛点强刺激按压手法松解肩胛提肌起止点的改良手法;针推联合组先予推拿治疗,结束后立即行针刺后溪治疗。各组均隔日治疗1次,共治疗3次。治疗前及治疗第1、3、7天,观察各组患者头颈肩部简式McGill疼痛问卷量表(SF-MPQ)评分[包括疼痛评估指数(PRI)、疼痛视觉模拟量表(Va.)、现时疼痛强度(PPI)评分3部分]、颈椎活动度评分,并评定各组临床疗效及安全性。结果:治疗第1、3、7天后,各组患者头颈肩部SF-MPQ、PRI、Va.、PPI评分较治疗前降低(Pa.评分低于针刺组(Pa.、PPI评分均低于针刺组(P<0.01,P<0.05)。治疗第1、3、7天后,各组患者颈椎活动度评分均较治疗前降低(P<0.01);治疗第3天后,针推联合组颈椎活动度评分低于针刺组及推拿组(P<0.01)。治疗第1、3、7天后,针推联合组治愈率均高于推拿组及针刺组(P<0.01)。治疗期间,各组均未发生严重不良反应。结论:针刺联合推拿治疗可有效改善肩胛提肌损伤型落枕,缓解患者疼痛,恢复颈椎活动度,且临床疗效优于单纯推拿和针刺治疗。

关键词：落枕肩胛提肌损伤针刺推拿压痛点强刺激按压手法后溪随机对照试验

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基于改进群智能K-mea.s优化算法的侵犯性驾驶行为异常点检测

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科学技术与工程 2018年第34期18卷 208-214页

作者：王丝丝张敬磊王建兴陈慈马春杰山东理工大学交通与车辆工程学院淄博255049 北京工业大学城市交通学院北京100124

如何有效地检测侵犯性驾驶行为异常数据,避免它们对后续建模分析产生不利影响是研究的焦点。在综述侵犯性驾驶行为研究现状基础上,借助驾驶模拟仿真实验系统和Ergo La.人因系统进行侵犯性驾驶实验;并通过不同传感器获取了驾驶行为人车... 详细信息

如何有效地检测侵犯性驾驶行为异常数据,避免它们对后续建模分析产生不利影响是研究的焦点。在综述侵犯性驾驶行为研究现状基础上,借助驾驶模拟仿真实验系统和Ergo La.人因系统进行侵犯性驾驶实验;并通过不同传感器获取了驾驶行为人车环境高维数据,最后采用优化的K-mea.s聚类算法对该高维数据进行聚类和异常值检测。结果表明,最佳聚类数为2;并有效输出了异常点检测结果,为下一步的侵犯性驾驶行为定量分析提供了优质的数据保证。

关键词：侵犯性驾驶行为群智能算法 K-mea.s聚类最佳聚类数异常点检测