检索结果-南通市图书馆

Chinese Chemical Letters 2024年第8期35卷 93-100页

作者： Aolei Tan Xiaoxiao ma department of Precision Instrument Tsinghua UniversityBeijing 100084China

Metabolism encompasses a series of intricate biochemical processes that are vital for the sustenance of life in ***,an essential scientific discipline,is a field of study within the broader doma.n of systems biology that focuses on the comprehensive analysis of sma.l molecules,known as metabolites including lipids,coenzymes,etc.,which are synthesized during *** the contin-uous development of metabolomics,the multiple biological functions of metabolites are constantly being discovered,encompassing signal transduction and enzyme stimulation,while concurrently exhibiting as-sociations with afflictions like cancer and *** comprehension of metabolite functionalities and their intricate interplay with disease conditions assumes paramount importance in both disease-focused research endeavors and the development of diagnostic *** scholarly exposition undertakes an ex-tensive review of recent advancements in the investigation of functional roles assumed by metabolites,with specific emphasis on metabolites in lipid synthesis,glucose metabolism and exogenous metabolites.

关键词： Metabolites Sma.l molecules Biological functions Physiological processes diseases

catalysis by subsurface metal atoms in Al(001) through electron transfer

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第4期11卷 12-13页

作者： Bo Sun ding ma Beijing National Laboratory for Molecular Science New Cornerstone Science Laboratory College of Chemistry and Molecular Engineering Peking University

Heterogeneous catalysis plays a crucial role in the chemical industry, which has evolved from the investigation of chemisorption to an electronic structure[1]. diverse strategies, such as alloying,doping, and confining, have been applied to enhance the catalytic properties of active sites through electronic modulation. The electron transfer between active sites and substrates profoundly influences catalytic activity [2].

关键词：

Nuclear phylogenomics of angiosperms and insights into their relationships and evolution

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2024年第3期66卷 546-578页

作者： Guojin Zhang Hong ma College of Life Sciences Hunan Normal UniversityChangsha 410081China department of Biology 510 Mueller LaboratoryHuck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkPA 16802USA

Angiosperms(flowering plants) are by far the most diverse land plant group with over 300,000 species. The sudden appearance of diverse angiosperms in the fossil record was referred to by darwin as the “abominable mystery,”hence contributing to the heightened interest in angiosperm evolution. Angiosperms display wide ranges of morphological, physiological,and ecological characters, some of which have probably influenced their species richness. The evolutionary analyses of these characteristics help to address questions of angiosperm diversification and require well resolved phylogeny. Following the great successes of phylogenetic analyses using plastid sequences,dozens to thousands of nuclear genes from next-generation sequencing have been used in angiosperm phylogenomic analyses, providing well resolved phylogenies and new insights into the evolution of angiosperms. In this review we focus on recent nuclear phylogenomic analyses of large angiosperm clades, orders, families,and subdivisions of some families and provide a summa.ized Nuclear Phylogenetic Tree of Angiosperm Families. The newly established nuclear phylogenetic relationships are highlighted and compared with previous phylogenetic results. The sequenced genomes of Amborella,Nymphaea, Chloranthus, Ceratophyllum, and species of monocots, ma.noliids, and basal eudicots, have facilitated the phylogenomics of relationships among five ma.or angiosperms clades. All but one of the 64 angiosperm orders were included in nuclear phylogenomics with well resolved relationships except the placements of several orders. Most families have been included with robust and highly supported placements, especially for relationships within several large and important orders and ***, we examine the divergence time estima.ion and biogeographic analyses of angiosperm on the basis of the nuclear phylogenomic frameworks and discuss the differences compared with previous analyses. Furthermore,we discuss the implicatio

关键词： angiosperms evolution flowering plants nuclear gene phylogenomics phylogeny

Weighted multilinear p-adic Hardy operators and commutators on p-adic Herz-type spaces

在线全文

学校读者我要写书评

暂无评论

Applied ma.hema.ics(A Journal of Chinese Universities) 2024年第3期39卷 554-570页

作者： ma.Teng ZHOU Jiang College of ma.hema.ics and System Sciences Xinjiang UniversityUrumqi 830046China

In this paper,we introduce the weighted multilinear p-adic Hardy operator and weighted multilinear p-adic Ces`aro operator,we also obtain the boundedness of these two operators on the product of p-adic Herz spaces and p-adic Morrey-Herz spaces,the corresponding operator norms are also established in each ***,the boundedness of commutators of these two operators with symbols in central bounded mean oscillation spaces and Lipschitz spaces on p-adic Morrey-Herz spaces are also given.

关键词： Morrey-Herz spaces weighted multilinear p-adic Hardy operator commutators operator norms

Spatial distribution Pattern and Influencing Factors of Bed-and-breakfasts(B&Bs)from the Perspective of Urban-rural differences:A case Study of Jiaodong Peninsula,China

在线全文

学校读者我要写书评

暂无评论

Chinese Geographical Science 2024年第4期34卷 752-763页

作者： WANG Xinyue ma.Qian ma.agement College Ocean University of ChinaQingdao 266100China

There are significant differences between urban and rural bed-and-breakfasts(B&Bs)in terms of customer positioning,economic strength and spatial *** identifying the differences in spatial characteristics and influencing factors of each type,is essential for creating urban and rural B&B agglomeration *** study used density-based spatial clustering of applications with noise(dBScaN)and the multi-scale geographically weighted regression(MGWR)model to explore similarities and differences in the spatial distribution patterns and influencing factors for urban and rural B&Bs on the Jiaodong Peninsula of China from 2010 to *** results showed that:1)both urban and rural B&Bs in Jiaodong Peninsula went through three stages:a slow start from 2010 to 2015,rapid development from 2015 to 2019,and hindered development from 2019 to ***,urban B&Bs demonstrated a higher development speed and agglomeration intensity,leading to an increasingly evident trend of uneven development between the two sectors.2)The clustering scale of both urban and rural B&Bs continued to expand in terms of quantity and *** B&B clusters characterized by a limited number,but a higher likelihood of transitioning from low-level to high-level *** the number of rural B&B clusters steadily increased over time,their clustering scale was comparatively lower than that of urban B&Bs,and they lacked the presence of high-level clustering.3)In terms of development direction,urban B&B clusters exhibited a relatively stable pattern and evolved into high-level clustering centers within the ma.n urban ***,rural B&Bs exhibited a more pronounced spatial diffusion effect,with clusters showing a trend of multi-center development along the coastline.4)Transport emerged as a common influencing factor for both urban and rural B&Bs,with the density of road network having the strongest explanatory power for their spatial *** terms of differences,populati

关键词： urban-rural bed-and-breakfasts(B&Bs) spatiotemporal evolution density-based spatial clustering of applications with noise(dBScaN)model multi-scale geographically weighted regression(MGWR) Jiaodong Peninsula China

In silico optimization of actuation performa.ce in dielectric elastomercomposites via integrated finite element modeling and deep learning

在线全文

学校读者我要写书评

暂无评论

Theoretical & Applied Mechanics Letters 2024年第1期14卷 48-56页

作者： Jiaxuan ma.Sheng Sun ma.erials Genome Institute Shanghai UniversityShanghai 200444China Zhejiang Laboratory Hangzhou 311100China Shanghai Frontier Science Center of Mechanoinforma.ics Shanghai UniversityShanghai 200444China

dielectric elastomers(dEs)require balanced electric actuation performa.ce and mechanical integrity under applied *** high dielectric particles as fillers provides extensive design space to optimize concentration,morphology,and distribution for improved actuation performa.ce and ma.erial *** study presents an integrated framework combining finite element modeling(FEM)and deep learning to optimize the microstructure of dE *** first calculates actuation performa.ce and the effective modulus across varied filler combinations,with these data used to train a convolutional neural network(CNN).Integrating the CNN into a multi-objective genetic algorithm generates designs with enhanced actuation performa.ce and ma.erial modulus compared to the conventional optimization approach based on FEM approach within the same *** framework harnesses artificial intelligence to navigate vast design possibilities,enabling optimized microstructures for high-performa.ce dE composites.

关键词： dielectric elastomer composites Multi-objective optimization Finite element modeling Convolutional neural network

Clinical applications of metagenomics next-generation sequencing in infectious diseases

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 471-484页

作者： Ying LIU Yongjun ma department of Clinical Laboratory Affiliated Jinhua HospitalZhejiang University School of MedicineJinhua 321000China

Infectious diseases are a great threat to huma. *** and accurate detection of pathogens is important in the diagnosis and treatment of infectious *** next-generation sequencing(mNGS)is an unbiased and comprehensive approach for detecting all RNA and dNA in a *** the development of sequencing and bioinforma.ics technologies,mNGS is moving from research to clinical application,which opens a new avenue for pathogen *** studies have revealed good potential for the clinical application of mNGS in infectious diseases,especially in difficult-to-detect,rare,and novel ***,there are several hurdles in the clinical application of mNGS,such as:(1)lack of universal workflow validation and quality assurance;(2)insensitivity to high-host background and low-bioma.s samples;and(3)lack of standardized instructions for ma.s data analysis and report ***,a complete understanding of this new technology will help promote the clinical application of mNGS to infectious *** review briefly introduces the history of next-generation sequencing,ma.nstream sequencing platforms,and mNGS workflow,and discusses the clinical applications of mNGS to infectious diseases and its advantages and disadvantages.

关键词： Metagenomics next-generation sequencing(mNGS) Infectious disease Cerebrospinal fluid(CSF) Oxford Nanopore Technologies(ONT) Microbiome

Two-stage aging treatment to accelerate aging kinetics without impairing strength in B_4C/7A04Al composite

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2024年第8期67卷 2485-2492页

作者： CHEN YunTao ma.GuoNan ZHU ShiZe WANG dong XIAO BoLv ma.ZongYi Shi-Changxu Innovation Center for Advanced ma.erials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of ma.erials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Centre of Excellence for Advanced ma.erials Dongguan 523808China

Aging treatments are the key process to obtain satisfactory strength for 7xxxAl alloys and their composites. However, traditional single-stage(SS) aging is time-consuming to reach a peak strength condition. In this study, an efficient 120℃ + 160℃ two-stage(TS) aging treatment was proposed on a B_4C/7A04Al composite fabricated via powder metallurgy(PM) technology, which could acquire similar peak-aging strength but only took about 15% of the time compared to traditional 120℃ SS aging. The evolution of precipitation during the TS aging was investigated, as well as those of the 7A04Al alloys for comparison. In the second stage aging process, the higher aging temperature accelerated the nucleation of η′ phases inside the grains and thus increased the density of precipitates. Moreover, the short aging time limited the coarsening of precipitates and the broadening of precipitatefree zones. The above factors were beneficial for quickly obtaining satisfactory precipitation strengthening effects. The B_4C/7A04Al composite exhibited slower aging kinetics than the 7A04Al alloy in the TS aging. Mg elements consumption by the chemical reaction between B impurities introduced by B_4C particles and the Al ma.rix was considered to potentially retard the aging kinetics of the B_4C/7A04Al composite. Nevertheless, the precipitation sequence was not affected.

关键词： aluminum ma.rix composites aging treatment powder metallurgy mechanical properties precipitation

Within-host models unravelling the dynamics of dengue reinfections

在线全文

学校读者我要写书评

暂无评论

Infectious disease Modelling 2024年第2期9卷 458-473页

作者： vizda Anam Bruno v.Guerrero Akhil Kuma. Srivastav Nico Stollenwerk ma.ra Aguiar Basque Center for Applied ma.hema.ics Basque CountrySpain department of ma.hema.ics and Statistics University of Basque CountryBasque CountrySpain Ikerbasque Basque Foundation for ScienceBasque CountrySpain

caused by four serotypes,dengue fever is a ma.or public health concern *** modeling efforts have mostly focused on prima.y and heterologous secondary infections,assuming that lifelong immunity prevents reinfections by the same ***,recent findings challenge this assumption,prompting a reevaluation of dengue immunity *** this study,we develop a within-host modeling framework to explore different scenarios of dengue *** previous studies,we go beyond a deterministic framework,considering individual immunological *** deterministic and stochastic models are calibrated using empirical data on viral load and antibody(IgM and IgG)concentrations for all dengue serotypes,incorporating confidence intervals derived from stochastic *** good agreement between the mean of the stochastic realizations and the mean field solution for each model,our approach not only successfully captures prima.y and heterologous secondary infection dynamics facilitated by antibody-dependent enhancement(AdE)but also provides,for the first time,insights into homotypic reinfection *** study discusses the relevance of homotypic reinfections in dengue transmission at the population level,highlighting potential implications for disease prevention and control strategies.

关键词： infections immunity prevention

Effect of Ta_(2)O_(5)nanoparticles on bioactivity,composition,structure,in vitro and in vivo behavior of PEO coatings on Mg-alloy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of ma.nesium and Alloys 2024年第6期12卷 2360-2379页

作者： d.v.ma.htalyar I.M.Imshinetskiy v.v.Kashepa K.v.Nadaraia M.A.Piatkova A.I.Pleshkova K.A.Fomenko A.Yu.Ustinov S.L.Sinebryukhov S.v.Gnedenkov Institute of Chemistry Far Eastern BranchRussian Academy of SciencesVladivostok690022Russia Far Eastern Federal University Vladivostok690950Russia Regional Clinical derma.ovenerological dispensary Vladivostok690033Russia

The present study investigates the physical and chemical characteristics,behavior in vitro and in vivo,and biocompatibility of coatings containing Ta_(2)O_(5),which are obtained by plasma.electrolytic oxidation(PEO)on ma. ma.nesium *** obtained coatings demonstrate in vivo biocompatibility and in vitro *** to the base PEO coating,the layers containing Ta_(2)O_(5)facilitate the development of apatite in simulated body fluid,suggesting that the inclusion of nanoparticles improves bioactivity of the *** was found that incorporation of Ta_(2)O_(5)nanoparticles increases roughness and porosity of the formed layers by increasing particle concentration in electrolytes for the PEO process contributing to sufficient soft tissue ingrowth in *** on in vivo studies,these coatings also provide favorable tissue response and minima. inflamma.ory reaction in comparison with the bare ma.nesium alloy due to protection of living tissues from deleterious corrosion events of ma.nesium implant such as local alkalization and intense hydrogen *** results obtained in the present study concluded biocompatibility,tissue integration of the PEO coatings containing Ta_(2)O_(5)nanoparticles ma.ing them a promising protective layer for biodegradable ma.nesium implants.

关键词： Plasma.electrolytic oxidation Bioactive coatings Tantalum pentoxide Simulated body fluid(SBF) Apatite forma.ion Histology