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加强对地震伤挤压综合征救治的作用和意义

高原医学杂志 2010年第2期20卷 11-14页

作者：马四清褚以德杨正平许雪侠石青军孙斌林丽君刘晓琴青海省人民医院 810007

目的:探讨加强治疗对玉树地震伤挤压综合征(crush syndrome,CS)作用及意义。方法:分析3例严重CS致急性肾功能衰竭(acute renal fail,ARF)患者的临床及实验室特征,治疗体会。结果:3例均出现了骨筋膜室综合征合并ARF,均为藏族,男2例,女1例... 详细信息

目的:探讨加强治疗对玉树地震伤挤压综合征(crush syndrome,CS)作用及意义。方法:分析3例严重CS致急性肾功能衰竭(acute renal fail,ARF)患者的临床及实验室特征,治疗体会。结果:3例均出现了骨筋膜室综合征合并ARF,均为藏族,男2例,女1例,年龄(39.67±9.30)岁,地震伤后获救时间为(6.83±1.60)h,入院时尿素氮(BUN)为(32.02±6.94)mmol/L,血肌酐(Scr)(634.67±146.20)μmol/L,血清磷酸肌酸激酶(CK)(14279.67±4636.87)IU/L,血清钾(K+)(6.67±0.76)mmol/L,急性生理与慢性健康评分(APACHEⅡ)(25.33±1.53)分,入院后首次进行血液透析时间(92.67±3.06)h,共血透或血滤时间为(256.67±124.23)h,少尿期为(17.00±2.65)d,机械通气时间为(14.00±19.29)h。3例患者均存活,痊愈出院。结论:严重的CS易致ARF,早期积极液体复苏、实施有效清创和截肢术、血液净化治疗、有效抗感染会明显提高抢救成活率。

关键词：挤压综合征急性肾功能衰竭地震伤救治

Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder

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Acta Pharmaceutica Sinica B 2021年第7期11卷 2031-2047页

作者： Lulu Pang siqing Zhu Jinqiu ma Lin Zhu Yijing Liu Ge Ou Ruiteng Li Yaxin Wang Yi Liang Xu Jin Lina Du Yiguang Jin Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China College of Pharmacy Anhui Medical UniversityHefei 230001China Pharmacy Department Chinese PLA General HospitalBeijing 100853China Department of Anesthesiology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

Post-traumatic stress disorder(PTSD)is a psychiatric disease that seriously affects brain ***,selective serotonin reuptake inhibitors(SSRIs)are used to treat PTSD clinically but have decreased efficiency and increased side *** this study,nasal cannabidiol inclusion complex temperature-sensitive hydrogels(CBD TSGs)were prepared and evaluated to treat *** model of PTSD was established with conditional fear *** TSGs could significantly improve the spontaneous behavior,exploratory spirit and alleviate tension in open field box,relieve anxiety and tension in elevated plus maze,and reduce the freezing *** and eosin and c-FOS immunohistochemistry slides showed that the main injured brain areas in PTSD were the prefrontal cortex,amygdala,and hippocampus *** TSGs could reduce the level of tumor necrosis factor-a caused by *** blot analysis showed that CBD TSGs increased the expression of the 5-HT1 A *** administration of CBD TSGs was more efficient and had more obvious brain targeting effects than oral administration,as evidenced by the pharmacokinetics and brain tissue distribution of CBD ***,nasal CBD TSGs are safe and effective and have controlled *** are a novel promising option for the clinical treatment of PTSD.

关键词： Post-traumatic stress disorder Cannabidiol Hydroxypropyl-β-cyclodextrin Inclusion complex Hydrogels Brain targeting Blood-brain barrier Intranasal administration

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高炉放散煤气治理技术

河北冶金 2024年第7期 81-86页

作者：李永军冯燕波马广霄祁四清王得刚蒋雨锟中冶京诚工程技术有限公司北京100176 北京中北欧瑞智工程技术有限公司北京100062

总结了高炉均压放散煤气和休风放散煤气治理技术的研究进展和应用情况。高炉均压放散煤气干法回收技术自2014年起逐步在京津冀地区率先获得推广应用至今,经过多次迭代更新,最终形成了“三级除尘+高效引射+智能控制”的引射法均压煤气干... 详细信息

总结了高炉均压放散煤气和休风放散煤气治理技术的研究进展和应用情况。高炉均压放散煤气干法回收技术自2014年起逐步在京津冀地区率先获得推广应用至今,经过多次迭代更新,最终形成了“三级除尘+高效引射+智能控制”的引射法均压煤气干法全回收技术,该技术成熟可靠,已在国内多数高炉上获得成功应用。对于高炉休风放散煤气治理技术的研究仍处于发展阶段,当前的主流技术路线是利用现有煤气净化设施,通过在调压阀组区域并联引射器,对高炉休风末期、炉顶放散阀开启前的炉内低压煤气强制回收进入管网,可实现休风煤气全量回收,达到应收尽收,在休风结束时,高炉炉顶放散阀开启前,炉顶压力可降至0~1 kPa。但该技术仅适用于长期休风和短期休风,不适用于降料线休风和事故紧急休风。鉴于高炉休风过程的煤气回收操作是一项危险性作业,对休风放散煤气的治理还需在确保安全的前提下谨慎选择。选择技术方案时,需要综合考虑节能环保、投资、运行维护成本对高炉生产的影响以及系统是否能安全可靠运行等多方面的因素,采用性价比高的技术实现钢铁企业的长期绿色发展。

关键词：高炉放散煤气回收均排压高炉休风

3D printing-based drug-loaded implanted prosthesis to prevent breast cancer recurrence post-conserving surgery

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Asian Journal of Pharmaceutical Sciences 2021年第1期16卷 86-96页

作者： Wenyan Hao Zengjuan Zheng Lin Zhu Lulu Pang Jinqiuma siqing Zhu Lina Du Yiguang Jin Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Weifang Medical University Weifang 261000China Shandong University of Traditional Chinese Medicine Jinan 250355China Anhui Medical University Hefei 230032China

Systemic chemotherapy of breast cancer is commonly delivered as a large dose and has toxic side *** chemotherapy would overcome the shortcomings of systemic reconstruction and could play an important role in breast cancer surgery according to personalized *** application of three-dimensional(3D)printing technology makes personalized customization *** designed and prepared a prosthesis containing paclitaxel(PTX)and doxorubicin(DOX)microspheres(PPDM)based on 3D printing to prevent tumor recurrence and metastasis after breast conserving *** has good biocompatibility and was used as a drug carrier in this *** average particle size of the PTX and DOX microspheres were approximately 3.1μm and 2.2μm,*** drug loading of PTX and DOX microspheres was 4.2% and 2.1%,*** vitro drug release studies demonstrated that the 3D-printed prosthesis loaded with PTX and DOXmicrospheres could release the drugs continuously for more than 3 weeks and thereby suppress cancer recurrence with reduced side *** PTX and DOX microspheres not only exerted a synergistic effect,but also achieved a good sustained release *** vivo evaluation showed that the PPDM could effectively inhibit breast cancer recurrence andmetastasis inmice with breast *** are expected to achieve postoperative chemotherapy for breast cancer and be highly efficient to prevent local breast cancer recurrence and metastasis.

关键词： Prosthesis Breast cancer Microspheres Paclitaxel Doxorubicin Metastasis

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病原微生物实验室生物安全标准体系框架研究

中华流行病学杂志 2024年第2期45卷 294-299页

作者：李晶陈震李思思陆兵赵四清王荣曹国庆王卫马春涛侯雪新王衍海赵赤鸿武桂珍中国疾病预防控制中心北京102206 军事科学院军事医学研究院北京100091 中国合格评定国家认可委员会北京100062 中国建筑科学研究院北京101119 中国医学科学院北京100730 中国疾病预防控制中心性病艾滋病预防控制中心北京102206 中国疾病预防控制中心传染病预防控制所北京102206 中国疾病预防控制中心病毒病预防控制所北京102206

制定和实施病原微生物实验室生物安全标准是实现病原微生物实验室科学化、效率化、规范化管理和运行的重要手段。本文通过对国内外病原微生物实验室生物安全标准化建设的现状进行分析,提出病原微生物实验室生物安全标准体系框架,主要包... 详细信息

制定和实施病原微生物实验室生物安全标准是实现病原微生物实验室科学化、效率化、规范化管理和运行的重要手段。本文通过对国内外病原微生物实验室生物安全标准化建设的现状进行分析,提出病原微生物实验室生物安全标准体系框架,主要包含基础标准、管理标准、技术标准和行业应用4个部分,为病原微生物实验室生物安全标准化工作提供参考,助力我国生物安全事业的规范发展。

关键词：生物安全病原微生物实验室标准体系构建研究

Moisture stable and ultrahigh-rate Ni/Mn-based sodium-ion battery cathodes via K^(+)decoration

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Nano Research 2023年第5期16卷 6890-6902页

作者： Tao Yuan Yuanyuan Sun siqing Li Haiying Che Qinfeng Zheng Yongjian Ni Yixiao Zhang Jie Zou Xiaoxian Zang Shi-Hao Wei Yuepeng Pang Shuixin Xia Shiyou Zheng Liwei Chen Zi-Feng ma School of materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Zhejiang Natrium Energy Co. Ltd.Shaoxing 312000China In-situ Center for Physical Sciences Shanghai Electrochemical Energy Device Research CenterFrontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315000China Key Laboratory of Solar Energy Utilization&Energy Saving Technology of Zhejiang Province Zhejiang Energy R&D Institute Co.Ltd.Hangzhou 311121China

As one of the most promising cathodes for sodium-ion batteries(SIBs),the layered transition metal oxides have attracted great attentions due to their high specific capacities and facile ***,their applications are still hindered by the problems of poor moisture stability and sluggish Na^(+)diffusion caused by intrinsic structural Jahn–Teller ***,we demonstrate a new approach to settle the above issues through introducing K^(+)into the structures of Ni/Mn-based *** physicochemical characterizations reveal that K^(+)induces atomic surface reorganization to form the birnessite-type K_(2)Mn_(4)O_(8).Combining with the phosphate,the mixed coating layer protects the cathodes from moisture and hinders metal dissolution into the electrolyte ***,K^(+)substitution at Na site in the bulk structure can not only widen the lattice-spacing for favoring Na^(+)diffusion,but also work as the rivet to restrain the grain crack upon *** as achieved K^(+)-decorated P2-Na_(0.67)Mn_(0.75)Ni_(0.2)5O_(2)(NKMNO@KM/KP)cathodes are tested in both coin cell and pouch cell configurations using Na metal or hard carbon(HC)as ***,the NKMNO@KM/KP||Na half-cell demonstrates a high rate performance of 50 C and outstanding cycling performance of 90.1%capacity retention after 100 cycles at 5 ***,the NKMNO@KM/KP||HC fullcell performed a promising energy density of 213.9 Wh·kg^(−1).This performance significantly outperforms most reported state-ofthe-art ***,by adopting this strategy on O3-NaMn_(0.5)Ni_(0.5)O_(2),we further proved the universality of this method on layered cathodes for SIBs.

关键词： sodium-ion battery cathode layered oxide material K^(+)decoration

2017—2020年青海省人民医院综合ICU医院感染目标监测分析

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中华临床医师杂志（电子版） 2022年第1期16卷 33-37页

作者：刘佳微达哇卓玛冶挺赵晓宇王梅英马四清青海省人民医院医院感染管理科西宁810007 青海省人民医院医院科教处西宁810007 青海省人民医院医院重症医学科西宁810007

目的分析青海省人民医院综合重症监护室(ICU)医院感染目标性监测结果,为高原地区ICU医院感染目标预防策略提供依据。方法对2017—2020年青海省人民医院综合ICU目标监测结果和器械污染所致相关医院感染情况进行回顾性分析。结果共监测综... 详细信息

目的分析青海省人民医院综合重症监护室(ICU)医院感染目标性监测结果,为高原地区ICU医院感染目标预防策略提供依据。方法对2017—2020年青海省人民医院综合ICU目标监测结果和器械污染所致相关医院感染情况进行回顾性分析。结果共监测综合ICU患者6283例,医院感染发病率为6.20%,医院感染例次发病率为6.94%;感染类型以呼吸系统感染为主,占58.68%,其次为泌尿系统感染,占17.58%;呼吸机相关性肺炎(VAP)发病率为8.88‰,导尿管相关泌尿系感染(CAUTI)发病率为2.53‰,血管导管相关血流感染(CLABSI)发病率为0。日感染发病率2017年为15.09‰,2020年为8.38‰。结论青海省人民医院综合ICU日感染发病率降低,持续开展ICU医院感染目标性监测,及时发现危险因素并采取干预措施,可有效降低ICU医院感染发病率。

关键词：重症监护病房医院感染目标监测器械相关感染

早期生长反应因子3对高脂诱导冠状动脉内皮细胞炎症及凋亡的影响

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中华实用诊断与治疗杂志 2024年第2期38卷 119-122页

作者：王思晴祖姆热提·阿布都克依木刘芳马燕玲田惠铭李霞新疆医科大学第五附属医院全科医学科新疆维吾尔自治区乌鲁木齐830000

目的观察高脂损伤冠状动脉内皮细胞早期生长反应因子3(Egr3)表达变化,探讨Egr3对高脂诱导冠状动脉内皮细胞炎症及凋亡的影响。方法对数生长期人冠状动脉内皮细胞分为对照组(正常培养)、高脂损伤组(氧化低密度脂蛋白处理)、Egr3空载组(si... 详细信息

目的观察高脂损伤冠状动脉内皮细胞早期生长反应因子3(Egr3)表达变化,探讨Egr3对高脂诱导冠状动脉内皮细胞炎症及凋亡的影响。方法对数生长期人冠状动脉内皮细胞分为对照组(正常培养)、高脂损伤组(氧化低密度脂蛋白处理)、Egr3空载组(siRNA-NC慢病毒转染+氧化低密度脂蛋白处理)、Egr3敲低组(siRNA-Egr3慢病毒转染+氧化低密度脂蛋白处理)。转染后取4组细胞,采用实时荧光定量PCR法检测细胞Egr3 mRNA相对表达量,采用Western blot法检测Egr3、caspase-3蛋白相对表达量,采用ELISA法检测细胞上清液肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平,采用CCK-8法检测细胞凋亡率。结果高脂损伤组、Egr3空载组细胞Egr3 mRNA相对表达量(1.56±0.48、1.53±0.56),Egr3(1.65±0.35、1.55±0.45)、caspase-3(2.43±0.43、2.36±0.29)蛋白相对表达量,细胞上清液TNF-α[(55.33±4.76)、(57.85±2.92)ng/L]、IL-6[(36.34±1.60)、(31.69±1.83)ng/L]水平及细胞凋亡率[(186.08±20.84)%、(174.34±29.98)%]均高于对照组[1.04±0.20、0.51±0.26、1.60±0.22、(46.10±1.52)ng/L、(23.35±1.69)ng/L、(100.01±8.64)%]、Egr3敲低组[0.16±0.03、0.23±0.07、1.05±0.29、(33.67±3.26)ng/L、(19.75±1.54)ng/L、(12.24±7.51)%](P0.05)。结论高脂可诱导冠状动脉内皮细胞炎症和凋亡,可能与Egr3表达增高有关;敲低Egr3表达可抑制冠状动脉内皮细胞炎症和凋亡。

关键词：动脉粥样硬化早期生长反应因子3 肿瘤坏死因子-α 白细胞介素-6 caspase-3 人冠状动脉内皮细胞

Space Weather Service for Chinese Space Science Satellites

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空间科学学报 2018年第5期38卷 781-787页

作者： LIU siqing ZHONG Qiuzhen GONG Jiancun SHI Liqin CHEN Dong MIAO Juan CAI Yanxia BAI Meng ma Wenzhen LI Zhitao LIU Fanghua CHEN Yanhong National Space Science Center Chinese Academy of Sciences Beijing 100190 University of Chinese Academy of Sciences Beijing 100049

Strategic Priority Research Program on Space Science has gained remarkable achievements. Space Environment Prediction Center(SEPC) affiliated with the National Space Science Center(NSSC) has been providing space weather services and helps secure space missions. Presently, SEPC is capable to offer a variety of space weather services covering many phases of space science missions including planning, design, launch,and orbital operation. The service packages consist of space weather forecasts, warnings, and effect analysis that can be utilized to avoid potential space weather hazard or reduce the damage caused by space storms,space radiation exposure for example. Extensive solar storms that occurred over Chinese Ghost Festival(CGF)in September 2017 led to a large enhancement of the solar energetic particle flux at 1 AU, which affected the near Earth radiation environment and brought great threat to orbiting satellites. Based on the space weather service by SEPC, satellite ground support groups collaborating with the space Tracking, Telemetering and Command system(TT&C) team were able to take immediate measures to react to the CGF solar storm event.

关键词：空间天气预报科学卫星服务中国空间科学空间环境暴风雨科学中心